TYRA

SEC source: 0000950170-24-116345 · ownership.xml · nonDerivative · entry 2

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,369,115

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F3 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $26.89 to $27.84. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000895345-24-000458 · form4.xml · derivative · entry 2

Boxer Capital Management, LLC · CIK 0002018299 · See remarks

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 2,705,280

Underlying: Common Stock · 2,000,000 shares

Expires not disclosed

F1 · kind: On October 18, 2024, Boxer Capital, LLC ("Boxer") entered into an exchange agreement with the Issuer, pursuant to which Boxer agreed to exchange 2,000,000 shares of the Issuer's Common Stock for a pre-funded warrant to purchase up to 2,000,000 shares of Common Stock (the "Pre-Funded Warrant"). The Pre-Funded Warrant was issued on October 22, 2024.

F1 · price: On October 18, 2024, Boxer Capital, LLC ("Boxer") entered into an exchange agreement with the Issuer, pursuant to which Boxer agreed to exchange 2,000,000 shares of the Issuer's Common Stock for a pre-funded warrant to purchase up to 2,000,000 shares of Common Stock (the "Pre-Funded Warrant"). The Pre-Funded Warrant was issued on October 22, 2024.

F3 · derivative.exercise_date: The Pre-Funded Warrant has no expiration date and is exercisable at any time after the date of issuance. A holder of the Pre-Funded Warrant may not exercise the Pre-Funded Warrant if the holder, together with other persons whose beneficial ownership is aggregated for purposes of Section 13 or Section 16 under the Securities Exchange Act of 1934, as amended, would beneficially own more than 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to such exercise.

F3 · derivative.expiration_date: The Pre-Funded Warrant has no expiration date and is exercisable at any time after the date of issuance. A holder of the Pre-Funded Warrant may not exercise the Pre-Funded Warrant if the holder, together with other persons whose beneficial ownership is aggregated for purposes of Section 13 or Section 16 under the Securities Exchange Act of 1934, as amended, would beneficially own more than 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to such exercise.

F2 · ownership.nature: These securities are beneficially owned indirectly by Boxer Capital Management, LLC ("BCM") as the investment manager of Boxer. BCM disclaims beneficial ownership of such securities except to the extent of its pecuniary interest therein.

SEC source: 0000895345-24-000458 · form4.xml · nonDerivative · entry 1

Boxer Capital Management, LLC · CIK 0002018299 · See remarks

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 4,448,359

F1 · kind: On October 18, 2024, Boxer Capital, LLC ("Boxer") entered into an exchange agreement with the Issuer, pursuant to which Boxer agreed to exchange 2,000,000 shares of the Issuer's Common Stock for a pre-funded warrant to purchase up to 2,000,000 shares of Common Stock (the "Pre-Funded Warrant"). The Pre-Funded Warrant was issued on October 22, 2024.

F1 · price: On October 18, 2024, Boxer Capital, LLC ("Boxer") entered into an exchange agreement with the Issuer, pursuant to which Boxer agreed to exchange 2,000,000 shares of the Issuer's Common Stock for a pre-funded warrant to purchase up to 2,000,000 shares of Common Stock (the "Pre-Funded Warrant"). The Pre-Funded Warrant was issued on October 22, 2024.

F2 · ownership.nature: These securities are beneficially owned indirectly by Boxer Capital Management, LLC ("BCM") as the investment manager of Boxer. BCM disclaims beneficial ownership of such securities except to the extent of its pecuniary interest therein.

SEC source: 0000950170-24-116345 · ownership.xml · nonDerivative · entry 1

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,375,011

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F2 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $26.60 to $27.51. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0001415889-24-025522 · form4-10222024_091047.xml · derivative · entry 4

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund, L.P. · CIK 0001780117 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 1,000,000

Underlying: Common Stock · 1,000,000 shares

Expires not disclosed

F1 · kind: On October 18, 2024, RA Capital Healthcare Fund, L.P. (the "Fund") entered into an Exchange Agreement with the Issuer pursuant to which the Fund exchanged, for no additional consideration, 1,000,000 shares of the Issuer's Common Stock for a pre-funded warrant exercisable for up to 1,000,000 shares of the Issuer's Common Stock at an exercise price of $0.001 per share (the "Exchange Warrant").

F1 · price: On October 18, 2024, RA Capital Healthcare Fund, L.P. (the "Fund") entered into an Exchange Agreement with the Issuer pursuant to which the Fund exchanged, for no additional consideration, 1,000,000 shares of the Issuer's Common Stock for a pre-funded warrant exercisable for up to 1,000,000 shares of the Issuer's Common Stock at an exercise price of $0.001 per share (the "Exchange Warrant").

F6 · derivative.exercise_date: The Exchange Warrant has no expiration date and is exercisable immediately. Notwithstanding the foregoing, the Reporting Persons shall not be entitled to exercise the Exchange Warrant if it would cause the aggregate number of shares of Common Stock beneficially owned by the Reporting Persons, their affiliates and any persons who are members of a Section 13(d) group with the Reporting Persons or their affiliates to exceed 19.99% of the total number of issued and outstanding shares of Common Stock of the Issuer following such exercise.

F6 · derivative.expiration_date: The Exchange Warrant has no expiration date and is exercisable immediately. Notwithstanding the foregoing, the Reporting Persons shall not be entitled to exercise the Exchange Warrant if it would cause the aggregate number of shares of Common Stock beneficially owned by the Reporting Persons, their affiliates and any persons who are members of a Section 13(d) group with the Reporting Persons or their affiliates to exceed 19.99% of the total number of issued and outstanding shares of Common Stock of the Issuer following such exercise.

F2 · ownership.nature: These securities are held directly by the Fund.

F3 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for the Fund, RA Capital Nexus Fund, L.P. (the "Nexus Fund"), and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

SEC source: 0001415889-24-025522 · form4-10222024_091047.xml · nonDerivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund, L.P. · CIK 0001780117 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 7,477,275

F1 · kind: On October 18, 2024, RA Capital Healthcare Fund, L.P. (the "Fund") entered into an Exchange Agreement with the Issuer pursuant to which the Fund exchanged, for no additional consideration, 1,000,000 shares of the Issuer's Common Stock for a pre-funded warrant exercisable for up to 1,000,000 shares of the Issuer's Common Stock at an exercise price of $0.001 per share (the "Exchange Warrant").

F1 · price: On October 18, 2024, RA Capital Healthcare Fund, L.P. (the "Fund") entered into an Exchange Agreement with the Issuer pursuant to which the Fund exchanged, for no additional consideration, 1,000,000 shares of the Issuer's Common Stock for a pre-funded warrant exercisable for up to 1,000,000 shares of the Issuer's Common Stock at an exercise price of $0.001 per share (the "Exchange Warrant").

F2 · ownership.nature: These securities are held directly by the Fund.

F3 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for the Fund, RA Capital Nexus Fund, L.P. (the "Nexus Fund"), and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

SEC source: 0000950170-24-115432 · ownership.xml · nonDerivative · entry 6

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,418,647

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

SEC source: 0000950170-24-115432 · ownership.xml · nonDerivative · entry 5

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,418,847

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F6 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $25.30 to $26.16. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-115432 · ownership.xml · nonDerivative · entry 4

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,434,041

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F5 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $26.79 to $27.08. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-115432 · ownership.xml · nonDerivative · entry 3

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,437,963

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F4 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $25.78 to $26.78. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-115432 · ownership.xml · nonDerivative · entry 2

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,462,438

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F3 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $24.72 to $25.59. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-115432 · ownership.xml · nonDerivative · entry 1

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,467,338

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F2 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $24.00 to $24.8667. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-111702 · ownership.xml · nonDerivative · entry 1

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,477,373

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

SEC source: 0000950170-24-109410 · ownership.xml · nonDerivative · entry 3

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,477,873

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F4 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $24.00 to $24.06. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-109410 · ownership.xml · nonDerivative · entry 2

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,478,473

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F3 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $24.00 to $24.14. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-109410 · ownership.xml · nonDerivative · entry 1

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,479,528

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F2 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $24.005 to $24.25. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-108533 · ownership.xml · nonDerivative · entry 4

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,489,620

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F3 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $24.00 to $24.8963. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-108533 · ownership.xml · nonDerivative · entry 3

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,496,729

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

SEC source: 0000950170-24-108533 · ownership.xml · nonDerivative · entry 2

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,496,756

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

F2 · price: Represents the weighted average sale price for the entire number of shares sold within a one dollar price range. The actual sale prices range between $24.00 to $24.9749. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-108533 · ownership.xml · nonDerivative · entry 1

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,502,427

F1 · kind: The sales reported were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in December 2022.

SEC source: 0000950170-24-107399 · ownership.xml · nonDerivative · entry 1

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,505,927

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0000950170-24-107391 · ownership.xml · nonDerivative · entry 1

Fuhrman Alan · CIK 0001303521 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,349

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0000950170-24-105200 · ownership.xml · derivative · entry 1

Warner Douglas J · CIK 0001941311 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 260,000

Underlying: Common Stock · 260,000 shares

Expires 2034-09-08

F1 · derivative.exercise_date: 25% of the shares subject to the option shall vest on September 9, 2025, and 1/36th of the remaining number of shares subject to the option vest monthly thereafter, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0000950170-24-098175 · ownership.xml · derivative · entry 1

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 390,000

Underlying: Common Stock · 390,000 shares

Expires 2034-08-13

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following August 14, 2024, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0000950170-24-098179 · ownership.xml · derivative · entry 1

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,000

Underlying: Common Stock · 115,000 shares

Expires 2034-08-13

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following August 14, 2024, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0000950170-24-098150 · ownership.xml · derivative · entry 1

Fuhrman Alan · CIK 0001303521 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,000

Underlying: Common Stock · 115,000 shares

Expires 2034-08-13

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly following August 14, 2024, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0000950170-24-074996 · ownership.xml · derivative · entry 2

KAPLAN GILLA · CIK 0001247024 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 61,392 shares

Expires 2030-01-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Fully vested.

SEC source: 0000950170-24-074996 · ownership.xml · nonDerivative · entry 1

KAPLAN GILLA · CIK 0001247024 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,623

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-24-071500 · ownership.xml · nonDerivative · entry 2

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 427,981

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022

F2 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $20.00 to $20.03. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-071500 · ownership.xml · nonDerivative · entry 1

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 431,483

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022

SEC source: 0000950170-24-067360 · ownership.xml · derivative · entry 1

Simson Jake · CIK 0001863094 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,600

Underlying: Common Stock · 18,600 shares

Expires 2034-05-28

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 29, 2024, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

F2 · ownership.direct: Under the Reporting Person's arrangement with RA Capital Management, L.P. (the "Adviser"), the Reporting Person holds the stock option for the benefit of the RA Capital Healthcare Fund, L.P. (the "Fund"), the RA Capital Nexus Fund, L.P. (the "Nexus Fund"), and a separately managed account (the "Account"). The Reporting Person is obligated to turn over to the Adviser any net cash or stock received upon exercise of the stock option, which will offset advisory fees owed by the Fund, the Nexus Fund, and the Account. The Reporting Person therefore disclaims beneficial ownership of the stock option and underlying Common Stock.

SEC source: 0001415889-24-015092 · form4-05312024_100503.xml · derivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund, L.P. · CIK 0001780117 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 18,600

Underlying: Common Stock · 18,600 shares

Expires 2034-05-28

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 29, 2024, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to Jake Simson's continuous service to the Issuer through each vesting date.

F2 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund, L.P. (the "Nexus Fund") and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, the Fund, the Nexus Fund, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

F3 · ownership.nature: Under Mr. Simson's arrangement with the Adviser, Mr. Simson holds the option for the benefit of the Fund, the Nexus Fund, and the Account. Mr. Simson is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund, the Nexus Fund, and the Account to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock except to the extent of their pecuniary interest.

SEC source: 0000950170-24-067363 · ownership.xml · derivative · entry 1

Subramony Siddarth · CIK 0001880624 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,600

Underlying: Common Stock · 18,600 shares

Expires 2034-05-28

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 29, 2024, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

F2 · ownership.direct: These securities are owned directly by the Reporting Person, who may be deemed to be a member of a "group" for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, consisting of (i) Boxer Capital, LLC, (ii) Boxer Asset Management Inc., (iii) MVA Investors, LLC, (iv) Joseph C. Lewis, (v) Aaron Davis and (vi) the Reporting Person (collectively, the "Boxer Group"). Each member of the Boxer Group other than the Reporting Person disclaims beneficial ownership of these securities to the extent it does not have a pecuniary interest therein

SEC source: 0000950170-24-067357 · ownership.xml · derivative · entry 1

Verjee Rehan · CIK 0001880637 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,600

Underlying: Common Stock · 18,600 shares

Expires 2034-05-28

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 29, 2024, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0000950170-24-067354 · ownership.xml · derivative · entry 1

KAPLAN GILLA · CIK 0001247024 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,600

Underlying: Common Stock · 18,600 shares

Expires 2034-05-28

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 29, 2024, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0000950170-24-067361 · ownership.xml · derivative · entry 1

MORE ROBERT J · CIK 0001207792 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,600

Underlying: Common Stock · 18,600 shares

Expires 2034-05-28

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 29, 2024, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0000950170-24-067351 · ownership.xml · derivative · entry 1

Kjellson Nina S · CIK 0001381980 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,600

Underlying: Common Stock · 18,600 shares

Expires 2034-05-28

F1 · derivative.exercise_date: The option was granted pursuant to the Issuer's Non-Employee Director Compensation Program. 1/12th of the total number of shares of common stock subject to the option vest monthly following May 29, 2024, the date of grant. In the event the next occurring annual meeting of the Issuer's stockholders occurs prior to the first anniversary of the date of grant, any remaining unvested portion of the option will vest on the date of such annual meeting of the Issuer's stockholders, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0000950170-24-057192 · ownership.xml · derivative · entry 1

Rothenberg Stephen Michael · CIK 0002022747 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,200

Underlying: Common Stock · 37,200 shares

Expires 2034-05-06

F1 · derivative.exercise_date: 1/36th of the total number of shares of common stock subject to the option vest monthly following May 7, 2024, the date of grant, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0000950170-24-057201 · ownership.xml · derivative · entry 1

Moran Susan · CIK 0001835225 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,200

Underlying: Common Stock · 37,200 shares

Expires 2034-05-06

F1 · derivative.exercise_date: 1/36th of the total number of shares of common stock subject to the option vest monthly following May 7, 2024, the date of grant, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0000950170-24-033848 · ownership.xml · nonDerivative · entry 1

Fuhrman Alan · CIK 0001303521 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,395

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0000950170-24-033814 · ownership.xml · nonDerivative · entry 1

Harris Todd · CIK 0001711463 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,504,577

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0000950170-24-033845 · ownership.xml · nonDerivative · entry 1

Tada Hiroomi · CIK 0001880593 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 86,435

F1 · kind: These shares were acquired under the Issuer's 2021 Employee Stock Purchase Plan.

SEC source: 0000950170-24-030932 · ownership.xml · nonDerivative · entry 1

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 431,683

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022.

SEC source: 0000950170-24-028807 · ownership.xml · nonDerivative · entry 2

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 431,883

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022.

SEC source: 0000950170-24-028807 · ownership.xml · nonDerivative · entry 1

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 431,951

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022.

F2 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $20.00 to $20.39. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-026365 · ownership.xml · nonDerivative · entry 3

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 433,684

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022.

F4 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $20.00 to $20.10. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-026365 · ownership.xml · nonDerivative · entry 2

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 434,873

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022.

F3 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $20.00 to $20.44. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-026365 · ownership.xml · nonDerivative · entry 1

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 439,936

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022.

F2 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $20.00 to $20.14. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-023406 · ownership.xml · nonDerivative · entry 3

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 442,836

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022.

F3 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $20.00 to $20.02. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.

SEC source: 0000950170-24-023406 · ownership.xml · nonDerivative · entry 2

Bensen Daniel · CIK 0001880946 · Chief Operating Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 444,886

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 7, 2022.

F2 · price: Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $20.00 to $20.50. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request.