TXG

SEC source: 0000899243-20-009021 · doc4.xml · nonDerivative · entry 6

Foresite Capital Management I, LLC · CIK 0001581219 · 10% owner

Foresite Capital Fund I, L.P. · CIK 0001562157 · 10% owner

Foresite Capital Management II, LLC · CIK 0001594912 · 10% owner

Foresite Capital Fund II, L.P. · CIK 0001594914 · 10% owner

Tananbaum James B. · CIK 0001581754 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 241,619

F5 · kind: The shares were obtained pursuant to a pro rata distribution from FCF I, for no consideration.

F5 · price: The shares were obtained pursuant to a pro rata distribution from FCF I, for no consideration.

F6 · ownership.nature: The shares are owned by FCM I the general partner of FCF I and may be deemed to have sole voting and dispositive power over these shares. Mr. Tananbaum, in his capacity as managing member of FCM I, may be deemed to have sole voting and dispositive power over these shares. Each Reporting Person disclaims the existence of a "group." Each of FCM I and its members and Mr. Tananbaum disclaims beneficial ownership of any of these shares except to the extent of any pecuniary interest therein, and the filing of this report is not an admission that FCM I and its members or Mr. Tananbaum is the beneficial owner of these shares for purposes of Section 16 or any other purpose.

SEC source: 0000899243-20-009021 · doc4.xml · nonDerivative · entry 5

Foresite Capital Management I, LLC · CIK 0001581219 · 10% owner

Foresite Capital Fund I, L.P. · CIK 0001562157 · 10% owner

Foresite Capital Management II, LLC · CIK 0001594912 · 10% owner

Foresite Capital Fund II, L.P. · CIK 0001594914 · 10% owner

Tananbaum James B. · CIK 0001581754 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 187,500

F4 · kind: The shares were distributed on a pro rata basis by FCF I, for no consideration.

F4 · price: The shares were distributed on a pro rata basis by FCF I, for no consideration.

F2 · ownership.nature: The shares are owned directly by Foresite Capital Fund I, L.P. ("FCF I"). Foresite Capital Management I, LLC ("FCM I"), the general partner of FCF I, may be deemed to have sole voting and dispositive power over these shares. Mr. Tananbaum, in his capacity as managing member of FCM I, may be deemed to have sole voting and dispositive power over these shares. Each Reporting Person disclaims the existence of a "group." Each of FCM I and its members and Mr. Tananbaum disclaims beneficial ownership of any of these shares except to the extent of any pecuniary interest therein, and the filing of this report is not an admission that FCM I and its members or Mr. Tananbaum is the beneficial owner of these shares for purposes of Section 16 or any other purpose.

SEC source: 0000899243-20-009021 · doc4.xml · nonDerivative · entry 4

Foresite Capital Management I, LLC · CIK 0001581219 · 10% owner

Foresite Capital Fund I, L.P. · CIK 0001562157 · 10% owner

Foresite Capital Management II, LLC · CIK 0001594912 · 10% owner

Foresite Capital Fund II, L.P. · CIK 0001594914 · 10% owner

Tananbaum James B. · CIK 0001581754 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 433,725

F3 · ownership.nature: The shares are owned directly by Foresite Capital Fund II, L.P. ("FCF II"). Foresite Capital Management II, LLC ("FCM II"), the general partner of FCF II, may be deemed to have sole voting and dispositive power over these shares. Mr. Tananbaum, in his capacity as managing member of FCM II, may be deemed to have sole voting and dispositive power over these shares. Each Reporting Person disclaims the existence of a "group." Each of FCM II and its members and Mr. Tananbaum disclaims beneficial ownership of any of these shares except to the extent of any pecuniary interest therein, and the filing of this report is not an admission that FCM II and its members or Mr. Tananbaum is the beneficial owner of these shares for purposes of Section 16 or any other purpose.

SEC source: 0000899243-20-009021 · doc4.xml · nonDerivative · entry 3

Foresite Capital Management I, LLC · CIK 0001581219 · 10% owner

Foresite Capital Fund I, L.P. · CIK 0001562157 · 10% owner

Foresite Capital Management II, LLC · CIK 0001594912 · 10% owner

Foresite Capital Fund II, L.P. · CIK 0001594914 · 10% owner

Tananbaum James B. · CIK 0001581754 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 1,134,579

F2 · ownership.nature: The shares are owned directly by Foresite Capital Fund I, L.P. ("FCF I"). Foresite Capital Management I, LLC ("FCM I"), the general partner of FCF I, may be deemed to have sole voting and dispositive power over these shares. Mr. Tananbaum, in his capacity as managing member of FCM I, may be deemed to have sole voting and dispositive power over these shares. Each Reporting Person disclaims the existence of a "group." Each of FCM I and its members and Mr. Tananbaum disclaims beneficial ownership of any of these shares except to the extent of any pecuniary interest therein, and the filing of this report is not an admission that FCM I and its members or Mr. Tananbaum is the beneficial owner of these shares for purposes of Section 16 or any other purpose.

SEC source: 0000899243-21-003990 · doc4.xml · nonDerivative · entry 3

Paladin Capital Management, LLC · CIK 0001788497 · 10% owner

Paladin Holdings III, L.P. · CIK 0001788495 · 10% owner

Paladin Holdings III (Cayman Islands), L.P. · CIK 0001788494 · 10% owner

Paladin Cyber Holdings, L.P. · CIK 0001788496 · 10% owner

Paladin Capital Group III, LLC · CIK 0001788499 · 10% owner

Paladin Homeland Security Corp III, Ltd. · CIK 0001788523 · 10% owner

Paladin Capital Cyber Group, LLC · CIK 0001788486 · 10% owner

Steed Michael Robert · CIK 0001788487 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 6,618,151

F3 · kind: On March 16 and 17, 2020, Co-Investment and International distributed an aggregate of 2,146,547 shares of Class A Common Stock to their respective members on a pro rata basis for no consideration.

F3 · ownership.direct: On March 16 and 17, 2020, Co-Investment and International distributed an aggregate of 2,146,547 shares of Class A Common Stock to their respective members on a pro rata basis for no consideration.

F4 · ownership.nature: The reported securities are held directly by the Paladin Shareholders. Paladin Capital Management, LLC ("Paladin Adviser") is the discretionary investment adviser to the US Funds, the Cayman Fund and International. Paladin Holdings III, L.P. ("Paladin GP") is the general partner of the US Funds and the managing member of Co-Investment. Paladin Holdings III (Cayman Islands), L.P. ("Paladin Cayman GP") is the general partner of the Cayman Fund. Paladin Cyber Holdings, L.P. ("Paladin Cyber") is the managing member of International. Paladin Capital Group III, LLC ("Capital III") is the general partner of Paladin GP, Paladin Homeland Security Corporation III, Ltd. ("Paladin III") is the general partner of Paladin Cayman GP, and Paladin Capital Cyber Group, LLC ("Cyber III") is the general partner of Paladin Cyber. Capital III, Paladin III and Cyber III are ultimately controlled by Michael Steed, who is also the Managing Partner of Paladin Adviser.

F5 · ownership.nature: (Continued from Footnote 4) Each of Paladin Adviser, Paladin GP, Paladin Cayman GP, Paladin Cyber, Capital III, Paladin III, Cyber III, and Mr. Steed (collectively, the "Paladin Managers") may be deemed to have voting and dispositive power over the reported securities held of record by one or more of the Paladin Shareholders. Each of the Paladin Managers disclaims beneficial ownership of the reported securities for purposes of Section 16 of the Exchange Act, except the extent of their respective pecuniary interest in the reported securities.

SEC source: 0000899243-21-003990 · doc4.xml · nonDerivative · entry 2

Paladin Capital Management, LLC · CIK 0001788497 · 10% owner

Paladin Holdings III, L.P. · CIK 0001788495 · 10% owner

Paladin Holdings III (Cayman Islands), L.P. · CIK 0001788494 · 10% owner

Paladin Cyber Holdings, L.P. · CIK 0001788496 · 10% owner

Paladin Capital Group III, LLC · CIK 0001788499 · 10% owner

Paladin Homeland Security Corp III, Ltd. · CIK 0001788523 · 10% owner

Paladin Capital Cyber Group, LLC · CIK 0001788486 · 10% owner

Steed Michael Robert · CIK 0001788487 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 8,055,861

F3 · kind: On March 16 and 17, 2020, Co-Investment and International distributed an aggregate of 2,146,547 shares of Class A Common Stock to their respective members on a pro rata basis for no consideration.

F3 · ownership.direct: On March 16 and 17, 2020, Co-Investment and International distributed an aggregate of 2,146,547 shares of Class A Common Stock to their respective members on a pro rata basis for no consideration.

F4 · ownership.nature: The reported securities are held directly by the Paladin Shareholders. Paladin Capital Management, LLC ("Paladin Adviser") is the discretionary investment adviser to the US Funds, the Cayman Fund and International. Paladin Holdings III, L.P. ("Paladin GP") is the general partner of the US Funds and the managing member of Co-Investment. Paladin Holdings III (Cayman Islands), L.P. ("Paladin Cayman GP") is the general partner of the Cayman Fund. Paladin Cyber Holdings, L.P. ("Paladin Cyber") is the managing member of International. Paladin Capital Group III, LLC ("Capital III") is the general partner of Paladin GP, Paladin Homeland Security Corporation III, Ltd. ("Paladin III") is the general partner of Paladin Cayman GP, and Paladin Capital Cyber Group, LLC ("Cyber III") is the general partner of Paladin Cyber. Capital III, Paladin III and Cyber III are ultimately controlled by Michael Steed, who is also the Managing Partner of Paladin Adviser.

F5 · ownership.nature: (Continued from Footnote 4) Each of Paladin Adviser, Paladin GP, Paladin Cayman GP, Paladin Cyber, Capital III, Paladin III, Cyber III, and Mr. Steed (collectively, the "Paladin Managers") may be deemed to have voting and dispositive power over the reported securities held of record by one or more of the Paladin Shareholders. Each of the Paladin Managers disclaims beneficial ownership of the reported securities for purposes of Section 16 of the Exchange Act, except the extent of their respective pecuniary interest in the reported securities.

SEC source: 0001209191-20-017551 · doc4.xml · derivative · entry 10

CRUTCHFIELD BRADFORD · CIK 0001246406 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 783,000

Underlying: Class A Common Stock · 17,000 shares

Expires 2027-02-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F9 · derivative.exercise_date: This option, originally for 800,000 shares, of which 17,000 shares have been exercised, vested as to one-fourth of the shares on February 2, 2018 and one forty-eighth of the shares subject to the option vest each month thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001209191-20-017551 · doc4.xml · nonDerivative · entry 9

CRUTCHFIELD BRADFORD · CIK 0001246406 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

SEC source: 0001209191-20-017551 · doc4.xml · nonDerivative · entry 8

CRUTCHFIELD BRADFORD · CIK 0001246406 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F8 · price: This transaction was executed in multiple trades at prices ranging from $69.00 to $69.99. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017551 · doc4.xml · nonDerivative · entry 7

CRUTCHFIELD BRADFORD · CIK 0001246406 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,841

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F7 · price: This transaction was executed in multiple trades at prices ranging from $67.69 to $68.61. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017551 · doc4.xml · nonDerivative · entry 6

CRUTCHFIELD BRADFORD · CIK 0001246406 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,387

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F6 · price: This transaction was executed in multiple trades at prices ranging from $66.65 to $67.50. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017551 · doc4.xml · nonDerivative · entry 5

CRUTCHFIELD BRADFORD · CIK 0001246406 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,987

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F5 · price: This transaction was executed in multiple trades at prices ranging from $65.34 to $66.27. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017551 · doc4.xml · nonDerivative · entry 4

CRUTCHFIELD BRADFORD · CIK 0001246406 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,187

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F4 · price: This transaction was executed in multiple trades at prices ranging from $64.29 to $65.28. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017551 · doc4.xml · nonDerivative · entry 3

CRUTCHFIELD BRADFORD · CIK 0001246406 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,700

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F3 · price: This transaction was executed in multiple trades at prices ranging from $63.16 to $64.09. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017551 · doc4.xml · nonDerivative · entry 2

CRUTCHFIELD BRADFORD · CIK 0001246406 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,810

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $62.07 to $63.05. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017551 · doc4.xml · nonDerivative · entry 1

CRUTCHFIELD BRADFORD · CIK 0001246406 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

SEC source: 0001209191-20-017552 · doc4.xml · derivative · entry 9

McAnear Justin J. · CIK 0001786386 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 590,000

Underlying: Class A Common Stock · 10,000 shares

Expires 2028-11-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F9 · derivative.exercise_date: This option, originally for 600,000 shares, of which 10,000 shares have been exercised, vested as to one-fourth of the shares on October 8, 2019 and one forty-eighth of the shares subject to the option vest each month thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001209191-20-017552 · doc4.xml · nonDerivative · entry 8

McAnear Justin J. · CIK 0001786386 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F8 · price: This transaction was executed in multiple trades at prices ranging from $69.42 to $70.38. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017552 · doc4.xml · nonDerivative · entry 7

McAnear Justin J. · CIK 0001786386 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,225

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F7 · price: This transaction was executed in multiple trades at prices ranging from $67.69 to $68.52. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017552 · doc4.xml · nonDerivative · entry 6

McAnear Justin J. · CIK 0001786386 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,125

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F6 · price: This transaction was executed in multiple trades at prices ranging from $66.39 to $67.00. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017552 · doc4.xml · nonDerivative · entry 5

McAnear Justin J. · CIK 0001786386 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,725

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F5 · price: This transaction was executed in multiple trades at prices ranging from $65.25 to $65.95. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017552 · doc4.xml · nonDerivative · entry 4

McAnear Justin J. · CIK 0001786386 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,425

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F4 · price: This transaction was executed in multiple trades at prices ranging from $64.105 to $65.00. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017552 · doc4.xml · nonDerivative · entry 3

McAnear Justin J. · CIK 0001786386 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,365

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F3 · price: This transaction was executed in multiple trades at prices ranging from $63.10 to $64.08. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017552 · doc4.xml · nonDerivative · entry 2

McAnear Justin J. · CIK 0001786386 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,200

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $62.07 to $63.06. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017552 · doc4.xml · nonDerivative · entry 1

McAnear Justin J. · CIK 0001786386 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

SEC source: 0001209191-20-017554 · doc4.xml · derivative · entry 12

Saxonov Serge · CIK 0001786720 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 142,083

Underlying: Class A Common Stock · 1,667 shares

Expires 2027-10-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercises and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F11 · derivative.exercise_date: This option, originally for 300,000 shares, of which 157,917 have been exercised, vested as to one-fourth of the shares on October 1, 2017, and one forty-eighth of the shares subject to the option vest each month thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001209191-20-017554 · doc4.xml · derivative · entry 11

Saxonov Serge · CIK 0001786720 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,334

Underlying: Class A Common Stock · 8,333 shares

Expires 2026-11-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercises and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F10 · derivative.exercise_date: This option, originally for 200,000 shares, of which 166,666 have been exercised, vested as to one-fourth of the shares on August 1, 2017, and one forty-eighth of the shares subject to the option vest each month thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001209191-20-017554 · doc4.xml · nonDerivative · entry 10

Saxonov Serge · CIK 0001786720 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 938,014

F1 · kind: The option exercises and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F9 · price: This transaction was executed in multiple trades at prices ranging from $69.78 to $70.33. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017554 · doc4.xml · nonDerivative · entry 9

Saxonov Serge · CIK 0001786720 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 938,461

F1 · kind: The option exercises and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F8 · price: This transaction was executed in multiple trades at prices ranging from $68.70 to $69.55. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017554 · doc4.xml · nonDerivative · entry 8

Saxonov Serge · CIK 0001786720 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 939,283

F1 · kind: The option exercises and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F7 · price: This transaction was executed in multiple trades at prices ranging from $67.69 to $68.60. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017554 · doc4.xml · nonDerivative · entry 7

Saxonov Serge · CIK 0001786720 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 939,901

F1 · kind: The option exercises and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F6 · price: This transaction was executed in multiple trades at prices ranging from $66.65 to $67.50. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017554 · doc4.xml · nonDerivative · entry 6

Saxonov Serge · CIK 0001786720 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 940,501

F1 · kind: The option exercises and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F5 · price: This transaction was executed in multiple trades at prices ranging from $65.51 to $66.00. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017554 · doc4.xml · nonDerivative · entry 5

Saxonov Serge · CIK 0001786720 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 941,301

F1 · kind: The option exercises and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F4 · price: This transaction was executed in multiple trades at prices ranging from $64.40 to $65.24. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017554 · doc4.xml · nonDerivative · entry 4

Saxonov Serge · CIK 0001786720 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 942,399

F1 · kind: The option exercises and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F3 · price: This transaction was executed in multiple trades at prices ranging from $63.405 to $64.38. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017554 · doc4.xml · nonDerivative · entry 3

Saxonov Serge · CIK 0001786720 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 946,166

F1 · kind: The option exercises and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $62.39 to $63.25. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017554 · doc4.xml · nonDerivative · entry 2

Saxonov Serge · CIK 0001786720 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 948,014

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercises and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

SEC source: 0001209191-20-017554 · doc4.xml · nonDerivative · entry 1

Saxonov Serge · CIK 0001786720 · Director · Chief Executive Officer · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 946,347

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercises and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

SEC source: 0001209191-20-017553 · doc4.xml · derivative · entry 10

Hindson Benjamin J. · CIK 0001786391 · Director · See Remarks · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 348,750

Underlying: Class A Common Stock · 33,750 shares

Expires 2025-10-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F10 · derivative.exercise_date: All of the shares subject to the option are fully vested and exercisable as of the date hereof.

SEC source: 0001209191-20-017553 · doc4.xml · nonDerivative · entry 9

Hindson Benjamin J. · CIK 0001786391 · Director · See Remarks · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,500

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F9 · price: This transaction was executed in multiple trades at prices ranging from $69.53 to $70.44. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017553 · doc4.xml · nonDerivative · entry 8

Hindson Benjamin J. · CIK 0001786391 · Director · See Remarks · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,345

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F8 · price: This transaction was executed in multiple trades at prices ranging from $68.52 to $69.50. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017553 · doc4.xml · nonDerivative · entry 7

Hindson Benjamin J. · CIK 0001786391 · Director · See Remarks · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,444

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F7 · price: This transaction was executed in multiple trades at prices ranging from $67.50 to $68.49. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017553 · doc4.xml · nonDerivative · entry 6

Hindson Benjamin J. · CIK 0001786391 · Director · See Remarks · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,744

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F6 · price: This transaction was executed in multiple trades at prices ranging from $66.35 to $67.25. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017553 · doc4.xml · nonDerivative · entry 5

Hindson Benjamin J. · CIK 0001786391 · Director · See Remarks · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,744

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F5 · price: This transaction was executed in multiple trades at prices ranging from $65.35 to $66.26. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017553 · doc4.xml · nonDerivative · entry 4

Hindson Benjamin J. · CIK 0001786391 · Director · See Remarks · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 81,560

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F4 · price: This transaction was executed in multiple trades at prices ranging from $64.34 to $65.29. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017553 · doc4.xml · nonDerivative · entry 3

Hindson Benjamin J. · CIK 0001786391 · Director · See Remarks · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,760

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F3 · price: This transaction was executed in multiple trades at prices ranging from $63.335 to $64.30. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017553 · doc4.xml · nonDerivative · entry 2

Hindson Benjamin J. · CIK 0001786391 · Director · See Remarks · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,462

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $62.31 to $63.28. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.

SEC source: 0001209191-20-017553 · doc4.xml · nonDerivative · entry 1

Hindson Benjamin J. · CIK 0001786391 · Director · See Remarks · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 101,250

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan entered into by the Reporting Person.

SEC source: 0000899243-20-009021 · doc4.xml · derivative · entry 10

Foresite Capital Management I, LLC · CIK 0001581219 · 10% owner

Foresite Capital Fund I, L.P. · CIK 0001562157 · 10% owner

Foresite Capital Management II, LLC · CIK 0001594912 · 10% owner

Foresite Capital Fund II, L.P. · CIK 0001594914 · 10% owner

Tananbaum James B. · CIK 0001581754 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 6,153,528

Underlying: Class A Common Stock · 683,725 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Class B Common Stock is convertible, for no additional consideration, into one (1) share of Class A Common Stock at any time at the holder's election.

F1 · price: Each share of Class B Common Stock is convertible, for no additional consideration, into one (1) share of Class A Common Stock at any time at the holder's election.

F1 · derivative.exercise_date: Each share of Class B Common Stock is convertible, for no additional consideration, into one (1) share of Class A Common Stock at any time at the holder's election.

F10 · derivative.expiration_date: The Class B Common Stock has no expiration date.

F3 · ownership.nature: The shares are owned directly by Foresite Capital Fund II, L.P. ("FCF II"). Foresite Capital Management II, LLC ("FCM II"), the general partner of FCF II, may be deemed to have sole voting and dispositive power over these shares. Mr. Tananbaum, in his capacity as managing member of FCM II, may be deemed to have sole voting and dispositive power over these shares. Each Reporting Person disclaims the existence of a "group." Each of FCM II and its members and Mr. Tananbaum disclaims beneficial ownership of any of these shares except to the extent of any pecuniary interest therein, and the filing of this report is not an admission that FCM II and its members or Mr. Tananbaum is the beneficial owner of these shares for purposes of Section 16 or any other purpose.

SEC source: 0000899243-20-009021 · doc4.xml · derivative · entry 9

Foresite Capital Management I, LLC · CIK 0001581219 · 10% owner

Foresite Capital Fund I, L.P. · CIK 0001562157 · 10% owner

Foresite Capital Management II, LLC · CIK 0001594912 · 10% owner

Foresite Capital Fund II, L.P. · CIK 0001594914 · 10% owner

Tananbaum James B. · CIK 0001581754 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 5,600,817

Underlying: Class A Common Stock · 1,447,079 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Class B Common Stock is convertible, for no additional consideration, into one (1) share of Class A Common Stock at any time at the holder's election.

F1 · price: Each share of Class B Common Stock is convertible, for no additional consideration, into one (1) share of Class A Common Stock at any time at the holder's election.

F1 · derivative.exercise_date: Each share of Class B Common Stock is convertible, for no additional consideration, into one (1) share of Class A Common Stock at any time at the holder's election.

F10 · derivative.expiration_date: The Class B Common Stock has no expiration date.

F2 · ownership.nature: The shares are owned directly by Foresite Capital Fund I, L.P. ("FCF I"). Foresite Capital Management I, LLC ("FCM I"), the general partner of FCF I, may be deemed to have sole voting and dispositive power over these shares. Mr. Tananbaum, in his capacity as managing member of FCM I, may be deemed to have sole voting and dispositive power over these shares. Each Reporting Person disclaims the existence of a "group." Each of FCM I and its members and Mr. Tananbaum disclaims beneficial ownership of any of these shares except to the extent of any pecuniary interest therein, and the filing of this report is not an admission that FCM I and its members or Mr. Tananbaum is the beneficial owner of these shares for purposes of Section 16 or any other purpose.

SEC source: 0000899243-20-009021 · doc4.xml · nonDerivative · entry 2

Foresite Capital Management I, LLC · CIK 0001581219 · 10% owner

Foresite Capital Fund I, L.P. · CIK 0001562157 · 10% owner

Foresite Capital Management II, LLC · CIK 0001594912 · 10% owner

Foresite Capital Fund II, L.P. · CIK 0001594914 · 10% owner

Tananbaum James B. · CIK 0001581754 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 683,725

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Class B Common Stock is convertible, for no additional consideration, into one (1) share of Class A Common Stock at any time at the holder's election.

F3 · ownership.nature: The shares are owned directly by Foresite Capital Fund II, L.P. ("FCF II"). Foresite Capital Management II, LLC ("FCM II"), the general partner of FCF II, may be deemed to have sole voting and dispositive power over these shares. Mr. Tananbaum, in his capacity as managing member of FCM II, may be deemed to have sole voting and dispositive power over these shares. Each Reporting Person disclaims the existence of a "group." Each of FCM II and its members and Mr. Tananbaum disclaims beneficial ownership of any of these shares except to the extent of any pecuniary interest therein, and the filing of this report is not an admission that FCM II and its members or Mr. Tananbaum is the beneficial owner of these shares for purposes of Section 16 or any other purpose.