TVTX

SEC source: 0001415889-25-010643 · form4-04142025_100426.xml · nonDerivative · entry 1

Cline Christopher R. · CIK 0001943192 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,990

F1 · kind: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the settlement of vested restricted stock units. This sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-25-003819 · form4-02132025_020211.xml · nonDerivative · entry 2

Inrig Jula · CIK 0001902368 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,602

F3 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the settlement of vested PSUs. This sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-25-003824 · form4-02132025_020257.xml · nonDerivative · entry 2

ROTE WILLIAM E. · CIK 0001698262 · SENIOR VICE PRESIDENT, R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 98,519

F3 · kind: This sale was made pursuant to a written plan adopted on March 15, 2024, meeting the requirements of Rule 10b5-1(c) of the Securities Exchange Act of 1934, as amended, and includes the sale of shares to cover the tax obligation that occurred upon the vesting of the PSUs.

SEC source: 0001415889-25-003823 · form4-02132025_020224.xml · nonDerivative · entry 2

REED ELIZABETH E · CIK 0001283303 · SVP, GC & CORPORATE SECRETARY

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 89,482

F3 · kind: This sale was made pursuant to a written plan adopted on March 15, 2024, meeting the requirements of Rule 10b5-1(c) of the Securities Exchange Act of 1934, as amended, and includes the sale of shares to cover the tax obligation that occurred upon the vesting of the PSUs.

SEC source: 0001415889-25-003821 · form4-02132025_020229.xml · nonDerivative · entry 3

Heerma Peter · CIK 0001789617 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 125,066

F4 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the settlement of vested PSUs. This sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-25-003822 · form4-02132025_020258.xml · derivative · entry 13

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 15,000 shares

Expires 2030-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The stock option is fully vested and exercisable.

SEC source: 0001415889-25-003822 · form4-02132025_020258.xml · derivative · entry 12

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,000 shares

Expires 2029-05-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The stock option is fully vested and exercisable.

SEC source: 0001415889-25-003822 · form4-02132025_020258.xml · derivative · entry 11

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,000 shares

Expires 2027-05-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The stock option is fully vested and exercisable.

SEC source: 0001415889-25-003822 · form4-02132025_020258.xml · derivative · entry 10

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,000 shares

Expires 2026-05-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The stock option is fully vested and exercisable.

SEC source: 0001415889-25-003822 · form4-02132025_020258.xml · nonDerivative · entry 9

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 54,410

F5 · kind: This sale was made pursuant to a written plan adopted on September 9, 2024, meeting the requirements of Rule 10b5-1(c) of the Securities Exchange Act of 1934, as amended.

SEC source: 0001415889-25-003822 · form4-02132025_020258.xml · nonDerivative · entry 8

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 63,654

F4 · kind: This sale was made pursuant to a written plan adopted on September 9, 2024, meeting the requirements of Rule 10b5-1(c) of the Securities Exchange Act of 1934, as amended, and consists of the sale of shares underlying a stock option grant to the Reporting Person on January 31, 2020 with an expiration date of January 31, 2030.

SEC source: 0001415889-25-003822 · form4-02132025_020258.xml · nonDerivative · entry 7

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 78,654

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-25-003822 · form4-02132025_020258.xml · nonDerivative · entry 6

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 63,654

F3 · kind: This sale was made pursuant to a written plan adopted on September 9, 2024, meeting the requirements of Rule 10b5-1(c) of the Securities Exchange Act of 1934, as amended, and consists of the sale of shares underlying a stock option grant to the Reporting Person on May 9, 2019 with an expiration date of May 9, 2029.

SEC source: 0001415889-25-003822 · form4-02132025_020258.xml · nonDerivative · entry 5

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 73,654

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-25-003822 · form4-02132025_020258.xml · nonDerivative · entry 4

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 63,654

F2 · kind: This sale was made pursuant to a written plan adopted on September 9, 2024, meeting the requirements of Rule 10b5-1(c) of the Securities Exchange Act of 1934, as amended, and consists of the sale of shares underlying a stock option grant to the Reporting Person on May 17, 2017 with an expiration date of May 17, 2027.

SEC source: 0001415889-25-003822 · form4-02132025_020258.xml · nonDerivative · entry 3

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 73,654

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-25-003822 · form4-02132025_020258.xml · nonDerivative · entry 2

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 63,654

F1 · kind: This sale was made pursuant to a written plan adopted on September 9, 2024, meeting the requirements of Rule 10b5-1(c) of the Securities Exchange Act of 1934, as amended, and consists of the sale of shares underlying a stock option grant to the Reporting Person on May 19, 2016 with an expiration date of May 19, 2026.

SEC source: 0001415889-25-003822 · form4-02132025_020258.xml · nonDerivative · entry 1

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 73,654

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-25-003821 · form4-02132025_020229.xml · nonDerivative · entry 2

Heerma Peter · CIK 0001789617 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 127,634

F3 · kind: This sale was made pursuant to a written plan adopted on March 15, 2024, meeting the requirements of Rule 10b5-1(c) of the Securities Exchange Act of 1934, as amended.

SEC source: 0001415889-25-003820 · form4-02132025_020239.xml · nonDerivative · entry 1

Dube Eric M · CIK 0001763494 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 419,173

F1 · kind: This sale was made pursuant to a written plan adopted on March 15, 2024, meeting the requirements of Rule 10b5-1(c) of the Securities Exchange Act of 1934, as amended.

SEC source: 0001415889-25-003819 · form4-02132025_020211.xml · derivative · entry 3

Inrig Jula · CIK 0001902368 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

F1 · kind: On January 31, 2022, the reporting person was granted performance restricted stock units (PSUs) covering 8,000 shares of the Issuer's common stock, to vest upon the satisfaction of certain clinical/regulatory performance criteria. On February 10, 2025, the PSUs vested upon the Issuer's confirmation that the clinical/regulatory performance criteria had been satisfied, including confirming a path forward for submitting an sNDA for traditional approval of FILSPARI (sparsentan) in FSGS.

F2 · derivative.exercise_date: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

F2 · derivative.expiration_date: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

SEC source: 0001415889-25-003819 · form4-02132025_020211.xml · nonDerivative · entry 1

Inrig Jula · CIK 0001902368 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 92,170

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On January 31, 2022, the reporting person was granted performance restricted stock units (PSUs) covering 8,000 shares of the Issuer's common stock, to vest upon the satisfaction of certain clinical/regulatory performance criteria. On February 10, 2025, the PSUs vested upon the Issuer's confirmation that the clinical/regulatory performance criteria had been satisfied, including confirming a path forward for submitting an sNDA for traditional approval of FILSPARI (sparsentan) in FSGS.

F2 · price: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

SEC source: 0001415889-25-003824 · form4-02132025_020257.xml · derivative · entry 3

ROTE WILLIAM E. · CIK 0001698262 · SENIOR VICE PRESIDENT, R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

F1 · kind: On January 31, 2022, the reporting person was granted performance restricted stock units (PSUs) covering 8,000 shares of the Issuer's common stock, to vest upon the satisfaction of certain clinical/regulatory performance criteria. On February 10, 2025, the PSUs vested upon the Issuer's confirmation that the clinical/regulatory performance criteria had been satisfied, including confirming a path forward for submitting an sNDA for traditional approval of FILSPARI (sparsentan) in FSGS.

F2 · derivative.exercise_date: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

F2 · derivative.expiration_date: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

SEC source: 0001415889-25-003824 · form4-02132025_020257.xml · nonDerivative · entry 1

ROTE WILLIAM E. · CIK 0001698262 · SENIOR VICE PRESIDENT, R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 103,719

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On January 31, 2022, the reporting person was granted performance restricted stock units (PSUs) covering 8,000 shares of the Issuer's common stock, to vest upon the satisfaction of certain clinical/regulatory performance criteria. On February 10, 2025, the PSUs vested upon the Issuer's confirmation that the clinical/regulatory performance criteria had been satisfied, including confirming a path forward for submitting an sNDA for traditional approval of FILSPARI (sparsentan) in FSGS.

F2 · price: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

SEC source: 0001415889-25-003823 · form4-02132025_020224.xml · derivative · entry 3

REED ELIZABETH E · CIK 0001283303 · SVP, GC & CORPORATE SECRETARY

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

F1 · kind: On January 31, 2022, the reporting person was granted performance restricted stock units (PSUs) covering 8,000 shares of the Issuer's common stock, to vest upon the satisfaction of certain clinical/regulatory performance criteria. On February 10, 2025, the PSUs vested upon the Issuer's confirmation that the clinical/regulatory performance criteria had been satisfied, including confirming a path forward for submitting an sNDA for traditional approval of FILSPARI (sparsentan) in FSGS.

F2 · derivative.exercise_date: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

F2 · derivative.expiration_date: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

SEC source: 0001415889-25-003823 · form4-02132025_020224.xml · nonDerivative · entry 1

REED ELIZABETH E · CIK 0001283303 · SVP, GC & CORPORATE SECRETARY

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 97,482

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On January 31, 2022, the reporting person was granted performance restricted stock units (PSUs) covering 8,000 shares of the Issuer's common stock, to vest upon the satisfaction of certain clinical/regulatory performance criteria. On February 10, 2025, the PSUs vested upon the Issuer's confirmation that the clinical/regulatory performance criteria had been satisfied, including confirming a path forward for submitting an sNDA for traditional approval of FILSPARI (sparsentan) in FSGS.

F2 · price: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

SEC source: 0001415889-25-003821 · form4-02132025_020229.xml · derivative · entry 4

Heerma Peter · CIK 0001789617 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

F1 · kind: On January 31, 2022, the reporting person was granted performance restricted stock units (PSUs) covering 8,000 shares of the Issuer's common stock, to vest upon the satisfaction of certain clinical/regulatory performance criteria. On February 10, 2025, the PSUs vested upon the Issuer's confirmation that the clinical/regulatory performance criteria had been satisfied, including confirming a path forward for submitting an sNDA for traditional approval of FILSPARI (sparsentan) in FSGS.

F2 · derivative.exercise_date: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

F2 · derivative.expiration_date: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

SEC source: 0001415889-25-003821 · form4-02132025_020229.xml · nonDerivative · entry 1

Heerma Peter · CIK 0001789617 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130,708

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On January 31, 2022, the reporting person was granted performance restricted stock units (PSUs) covering 8,000 shares of the Issuer's common stock, to vest upon the satisfaction of certain clinical/regulatory performance criteria. On February 10, 2025, the PSUs vested upon the Issuer's confirmation that the clinical/regulatory performance criteria had been satisfied, including confirming a path forward for submitting an sNDA for traditional approval of FILSPARI (sparsentan) in FSGS.

F2 · price: Each PSU represents a contingent right to receive one share of the common stock of the Issuer.

SEC source: 0001415889-25-003529 · form4-02102025_110214.xml · derivative · entry 3

Baynes Roy D. · CIK 0001680739 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,000 shares

Expires 2027-05-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option is fully vested and exercisable.

SEC source: 0001415889-25-003529 · form4-02102025_110214.xml · nonDerivative · entry 2

Baynes Roy D. · CIK 0001680739 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 31,000

F1 · kind: This sale was made pursuant to a written plan adopted on August 16, 2024, meeting the requirements of Rule 10b5-1(c) of the Securities Exchange Act of 1934, as amended, and consists of the sale of shares underlying a stock option granted to the Reporting Person on May 17, 2017, with an expiration date of May 17, 2027.

SEC source: 0001415889-25-003529 · form4-02102025_110214.xml · nonDerivative · entry 1

Baynes Roy D. · CIK 0001680739 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 41,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-25-003064 · form4-02042025_080213.xml · nonDerivative · entry 3

Inrig Jula · CIK 0001902368 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 84,170

F3 · kind: This sale was made pursuant to a written plan adopted on March 15, 2024, meeting the requirements of Rule 10b5-1(c) of the Securities Exchange Act of 1934, as amended, and includes the sale of shares to cover the tax obligation that occurred upon the vesting of restricted stock units.

SEC source: 0001415889-25-003061 · form4-02042025_080201.xml · nonDerivative · entry 2

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 63,654

F2 · kind: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the settlement of vested restricted stock units. This sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-25-003064 · form4-02042025_080213.xml · nonDerivative · entry 2

Inrig Jula · CIK 0001902368 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 85,236

F2 · kind: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the settlement of vested restricted stock units. This sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-25-003067 · form4-02042025_080224.xml · nonDerivative · entry 2

ROTE WILLIAM E. · CIK 0001698262 · SENIOR VICE PRESIDENT, R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 95,719

F2 · kind: This sale was made pursuant to a written plan adopted on March 15, 2024, meeting the requirements of Rule 10b5-1(c) of the Securities Exchange Act of 1934, as amended, and includes the sale of shares to cover the tax obligation that occurred upon the vesting of restricted stock units.

SEC source: 0001415889-25-003066 · form4-02042025_080220.xml · nonDerivative · entry 2

REED ELIZABETH E · CIK 0001283303 · SVP, GC & CORPORATE SECRETARY

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 89,482

F2 · kind: This sale was made pursuant to a written plan adopted on March 15, 2024, meeting the requirements of Rule 10b5-1(c) of the Securities Exchange Act of 1934, as amended, and includes the sale of shares to cover the tax obligation that occurred upon the vesting of restricted stock units.

SEC source: 0001415889-25-003065 · form4-02042025_080216.xml · nonDerivative · entry 2

Dube Eric M · CIK 0001763494 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 430,548

F2 · kind: This sale was made pursuant to a written plan adopted on March 15, 2024, meeting the requirements of Rule 10b5-1(c) of the Securities Exchange Act of 1934, as amended, and includes the sale of shares to cover the tax obligation that occurred upon the vesting of restricted stock units.

F3 · price: The weighted average sale price for the transaction reported was $20.2076, and the range of prices were between $19.76 and $20.56. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each price will be provided.

SEC source: 0001415889-25-003063 · form4-02042025_080209.xml · nonDerivative · entry 2

Heerma Peter · CIK 0001789617 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 122,708

F2 · kind: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the settlement of vested restricted stock units. This sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-25-003062 · form4-02042025_080206.xml · nonDerivative · entry 2

Cline Christopher R. · CIK 0001943192 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,038

F2 · kind: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the settlement of vested restricted stock units. This sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person.

SEC source: 0001415889-25-003061 · form4-02042025_080201.xml · derivative · entry 3

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,000

Underlying: Common Stock · 26,000 shares

Expires 2035-01-31

F3 · derivative.exercise_date: One-fourth of the shares subject to the stock option vest and become exercisable on the first anniversary of the date of grant, and the remaining shares vest in 36 equal monthly installments thereafter.

SEC source: 0001415889-25-003061 · form4-02042025_080201.xml · nonDerivative · entry 1

Calvin Sandra · CIK 0001882909 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,002

F1 · kind: Each restricted stock unit represents a contingent right to receive one share of the Common Stock of the Issuer.

SEC source: 0001415889-25-003064 · form4-02042025_080213.xml · derivative · entry 4

Inrig Jula · CIK 0001902368 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2035-01-31

F4 · derivative.exercise_date: One-fourth of the shares subject to the stock option vest and become exercisable on the first anniversary of the date of grant, and the remaining shares vest in 36 equal monthly installments thereafter.

SEC source: 0001415889-25-003064 · form4-02042025_080213.xml · nonDerivative · entry 1

Inrig Jula · CIK 0001902368 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 89,443

F1 · kind: Each restricted stock unit represents a contingent right to receive one share of the Common Stock of the Issuer.

SEC source: 0001415889-25-003067 · form4-02042025_080224.xml · derivative · entry 3

ROTE WILLIAM E. · CIK 0001698262 · SENIOR VICE PRESIDENT, R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 58,000

Underlying: Common Stock · 58,000 shares

Expires 2035-01-31

F3 · derivative.exercise_date: One-fourth of the shares subject to the stock option vest and become exercisable on the first anniversary of the date of grant, and the remaining shares vest in 36 equal monthly installments thereafter.

SEC source: 0001415889-25-003067 · form4-02042025_080224.xml · nonDerivative · entry 1

ROTE WILLIAM E. · CIK 0001698262 · SENIOR VICE PRESIDENT, R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 104,670

F1 · kind: Each restricted stock unit represents a contingent right to receive one share of the Common Stock of the Issuer.

SEC source: 0001415889-25-003066 · form4-02042025_080220.xml · derivative · entry 3

REED ELIZABETH E · CIK 0001283303 · SVP, GC & CORPORATE SECRETARY

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 58,000

Underlying: Common Stock · 58,000 shares

Expires 2035-01-31

F3 · derivative.exercise_date: One-fourth of the shares subject to the stock option vest and become exercisable on the first anniversary of the date of grant, and the remaining shares vest in 36 equal monthly installments thereafter.

SEC source: 0001415889-25-003066 · form4-02042025_080220.xml · nonDerivative · entry 1

REED ELIZABETH E · CIK 0001283303 · SVP, GC & CORPORATE SECRETARY

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 98,433

F1 · kind: Each restricted stock unit represents a contingent right to receive one share of the Common Stock of the Issuer.

SEC source: 0001415889-25-003065 · form4-02042025_080216.xml · derivative · entry 3

Dube Eric M · CIK 0001763494 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 260,000

Underlying: Common Stock · 260,000 shares

Expires 2035-01-31

F4 · derivative.exercise_date: One-fourth of the shares subject to the stock option vest and become exercisable on the first anniversary of the date of grant, and the remaining shares vest in 36 equal monthly installments thereafter.

SEC source: 0001415889-25-003065 · form4-02042025_080216.xml · nonDerivative · entry 1

Dube Eric M · CIK 0001763494 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 481,239

F1 · kind: Each restricted stock unit represents a contingent right to receive one share of the Common Stock of the Issuer.

SEC source: 0001415889-25-003063 · form4-02042025_080209.xml · derivative · entry 3

Heerma Peter · CIK 0001789617 · CHIEF COMMERCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,000

Underlying: Common Stock · 58,000 shares

Expires 2035-01-31

F3 · derivative.exercise_date: One-fourth of the shares subject to the stock option vest and become exercisable on the first anniversary of the date of grant, and the remaining shares vest in 36 equal monthly installments thereafter.