TSHA

SEC source: 0001415889-25-015571 · form4-06042025_040601.xml · nonDerivative · entry 1

Sepp-Lorenzino Laura · CIK 0001777421 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,843

F1 · shares: Represents a restricted stock unit ("RSU") award. The RSUs will vest on the earlier of June 2, 2026 or the next annual stockholders meeting, subject to the Reporting Person's continued service as a director through the applicable vesting date.

SEC source: 0001415889-25-015480 · form4-06042025_010624.xml · nonDerivative · entry 1

Manning Paul B · CIK 0001494695 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 2,841,704

F1 · ownership.nature: The shares are held directly by BKB Growth Investments, LLC ("BKB"). The Reporting Person is a co-manager of Tiger Lily Capital, LLC, the manager of BKB, and has shared voting and investment power with respect to the shares held by BKB.

SEC source: 0001415889-25-007997 · form4-03132025_040301.xml · nonDerivative · entry 1

Alam Kamran · CIK 0001793412 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,242,094

F1 · kind: Represents shares withheld by the Issuer to satisfy the tax withholding obligations triggered by the vesting and settlement of restricted stock units and does not represent a discretionary transaction by the Reporting Person.

SEC source: 0001415889-25-000599 · form4-01032025_100137.xml · derivative · entry 3

Nolan Sean P. · CIK 0001569926 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 892,500

Underlying: Common Stock · 892,500 shares

Expires 2035-01-02

F3 · derivative.exercise_date: 25% of the total number of shares underlying the option shall vest and become exercisable on January 2, 2026 and the remainder shall vest and become exercisable in 36 equal monthly installments thereafter, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001415889-25-000599 · form4-01032025_100137.xml · nonDerivative · entry 1

Nolan Sean P. · CIK 0001569926 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,078,358

F1 · shares: Represents a restricted stock unit ("RSU") award. The RSU grant was approved by the Issuer's compensation committee of the board of directors and will be effective as of the date the Issuer has an effective Registration Statement on Form S-8 registering the shares available for issuance under the 2020 Stock Incentive Plan. The RSUs will vest in four equal annual installments beginning on January 2, 2026, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001415889-25-000597 · form4-01032025_100136.xml · derivative · entry 2

Nagendran Sukumar · CIK 0001665124 · Director · President and Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 324,500

Underlying: Common Stock · 324,500 shares

Expires 2035-01-02

F2 · derivative.exercise_date: 25% of the total number of shares underlying the option shall vest and become exercisable on January 2, 2026 and the remainder shall vest and become exercisable in 36 equal monthly installments thereafter, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001415889-25-000597 · form4-01032025_100136.xml · nonDerivative · entry 1

Nagendran Sukumar · CIK 0001665124 · Director · President and Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,222,343

F1 · shares: Represents a restricted stock unit ("RSU") award. The RSU grant was approved by the Issuer's compensation committee of the board of directors and will be effective as of the date the Issuer has an effective Registration Statement on Form S-8 registering the shares available for issuance under the 2020 Stock Incentive Plan. The RSUs will vest in four equal annual installments beginning on January 2, 2026, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001415889-25-000595 · form4-01032025_100118.xml · derivative · entry 2

Alam Kamran · CIK 0001793412 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 431,000

Underlying: Common Stock · 431,000 shares

Expires 2035-01-02

F2 · derivative.exercise_date: 25% of the total number of shares underlying the option shall vest and become exercisable on January 2, 2026 and the remainder shall vest and become exercisable in 36 equal monthly installments thereafter, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001415889-25-000595 · form4-01032025_100118.xml · nonDerivative · entry 1

Alam Kamran · CIK 0001793412 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,271,937

F1 · shares: Represents a restricted stock unit ("RSU") award. The RSU grant was approved by the Issuer's compensation committee of the board of directors and will be effective as of the date the Issuer has an effective Registration Statement on Form S-8 registering the shares available for issuance under the 2020 Stock Incentive Plan. The RSUs will vest in four equal annual installments beginning on January 2, 2026, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001415889-24-018515 · form4-07012024_080703.xml · nonDerivative · entry 1

Manning Paul B · CIK 0001494695 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,333,333

SEC source: 0001415889-24-015041 · form4-05312024_040510.xml · derivative · entry 3

Stalfort John A III · CIK 0001709418 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,440

Underlying: Common Stock · 98,440 shares

Expires 2034-05-29

F3 · derivative.exercise_date: The shares vest on the earlier of May 29, 2025 or the next annual stockholders meeting, subject to the Reporting Person's continued service as a director through the applicable vesting date.

SEC source: 0001415889-24-015041 · form4-05312024_040510.xml · nonDerivative · entry 1

Stalfort John A III · CIK 0001709418 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,098,601

F1 · shares: Represents a restricted stock unit ("RSU") award. The RSUs will vest on the earlier of May 29, 2025 or the next annual stockholders meeting, subject to the Reporting Person's continued service as a director through the applicable vesting date.

SEC source: 0001415889-24-015040 · form4-05312024_040508.xml · derivative · entry 2

Long Alison S · CIK 0001891712 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,440

Underlying: Common Stock · 98,440 shares

Expires 2034-05-29

F2 · derivative.exercise_date: The shares vest on the earlier of May 29, 2025 or the next annual stockholders meeting, subject to the Reporting Person's continued service as a director through the applicable vesting date.

SEC source: 0001415889-24-015040 · form4-05312024_040508.xml · nonDerivative · entry 1

Long Alison S · CIK 0001891712 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,220

F1 · shares: Represents a restricted stock unit ("RSU") award. The RSUs will vest on the earlier of May 29, 2025 or the next annual stockholders meeting, subject to the Reporting Person's continued service as a director through the applicable vesting date.

SEC source: 0001415889-24-015039 · form4-05312024_040505.xml · derivative · entry 2

Donenberg Phillip B. · CIK 0001238120 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,440

Underlying: Common Stock · 98,440 shares

Expires 2034-05-29

F2 · derivative.exercise_date: The shares vest on the earlier of May 29, 2025 or the next annual stockholders meeting, subject to the Reporting Person's continued service as a director through the applicable vesting date.

SEC source: 0001415889-24-015039 · form4-05312024_040505.xml · nonDerivative · entry 1

Donenberg Phillip B. · CIK 0001238120 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 163,331

F1 · shares: Represents a restricted stock unit ("RSU") award. The RSUs will vest on the earlier of May 29, 2025 or the next annual stockholders meeting, subject to the Reporting Person's continued service as a director through the applicable vesting date.

SEC source: 0001415889-24-015038 · form4-05312024_040501.xml · derivative · entry 2

Sepp-Lorenzino Laura · CIK 0001777421 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,440

Underlying: Common Stock · 98,440 shares

Expires 2034-05-29

F2 · derivative.exercise_date: The shares vest on the earlier of May 29, 2025 or the next annual stockholders meeting, subject to the Reporting Person's continued service as a director through the applicable vesting date.

SEC source: 0001415889-24-015038 · form4-05312024_040501.xml · nonDerivative · entry 1

Sepp-Lorenzino Laura · CIK 0001777421 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,220

F1 · shares: Represents a restricted stock unit ("RSU") award. The RSUs will vest on the earlier of May 29, 2025 or the next annual stockholders meeting, subject to the Reporting Person's continued service as a director through the applicable vesting date.

SEC source: 0001415889-24-002809 · form4-02062024_090255.xml · nonDerivative · entry 1

Alam Kamran · CIK 0001793412 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 840,937

F1 · kind: Represents shares withheld by the Issuer to satisfy the tax withholding obligations triggered by the vesting of restricted stock units and does not represent a discretionary transaction by the Reporting Person.

SEC source: 0001209191-24-000811 · doc4.xml · derivative · entry 2

Alam Kamran · CIK 0001793412 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 590,413

Underlying: Common Stock · 590,413 shares

Expires 2034-01-02

F2 · derivative.exercise_date: 25% of the total number of shares underlying the option shall vest and become exercisable on January 2, 2025 and the remainder shall vest and become exercisable in 36 equal monthly installments thereafter, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001209191-24-000811 · doc4.xml · nonDerivative · entry 1

Alam Kamran · CIK 0001793412 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 842,225

F1 · shares: Represents a restricted stock unit ("RSU") award. The RSUs will vest in four equal annual installments beginning on January 2, 2025, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001209191-24-000809 · doc4.xml · derivative · entry 2

Nagendran Sukumar · CIK 0001665124 · Director · President and Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 863,617

Underlying: Common Stock · 863,617 shares

Expires 2034-01-02

F2 · derivative.exercise_date: 25% of the total number of shares underlying the option shall vest and become exercisable on January 2, 2025 and the remainder shall vest and become exercisable in 36 equal monthly installments thereafter, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001209191-24-000809 · doc4.xml · nonDerivative · entry 1

Nagendran Sukumar · CIK 0001665124 · Director · President and Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 897,843

F1 · shares: Represents a restricted stock unit ("RSU") award. The RSUs will vest in four equal annual installments beginning on January 2, 2025, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001209191-24-000807 · doc4.xml · derivative · entry 3

Nolan Sean P. · CIK 0001569926 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,184,688

Underlying: Common Stock · 1,184,688 shares

Expires 2034-01-02

F3 · derivative.exercise_date: 25% of the total number of shares underlying the option shall vest and become exercisable on January 2, 2025 and the remainder shall vest and become exercisable in 36 equal monthly installments thereafter, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001209191-24-000807 · doc4.xml · nonDerivative · entry 1

Nolan Sean P. · CIK 0001569926 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,185,858

F1 · shares: Represents a restricted stock unit ("RSU") award. The RSUs will vest in four equal annual installments beginning on January 2, 2025, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001209191-23-058977 · doc4.xml · derivative · entry 1

Alam Kamran · CIK 0001793412 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 187,582

Underlying: Common Stock · 187,582 shares

Expires 2033-12-14

F1 · derivative.exercise_date: The compensation committee of the board of directors of the Issuer certified achievement of certain performance criteria such that 70% of the option shares subject to the performance-based stock option award were earned. The shares underlying the earned potion of the option shall vest and become exercisable in three equal annual installments commencing on December 31, 2024, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001209191-23-058973 · doc4.xml · derivative · entry 1

Nagendran Sukumar · CIK 0001665124 · Director · President and Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 334,005

Underlying: Common Stock · 334,005 shares

Expires 2033-12-14

F1 · derivative.exercise_date: The compensation committee of the board of directors of the Issuer certified achievement of certain performance criteria such that 70% of the option shares subject to the performance-based stock option award were earned. The shares underlying the earned potion of the option shall vest and become exercisable in three equal annual installments commencing on December 31, 2024, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001209191-23-058971 · doc4.xml · derivative · entry 1

Nolan Sean P. · CIK 0001569926 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 466,550

Underlying: Common Stock · 466,550 shares

Expires 2033-12-14

F1 · derivative.exercise_date: The compensation committee of the board of directors of the Issuer certified achievement of certain performance criteria such that 70% of the option shares subject to the performance-based stock option award were earned. The shares underlying the earned potion of the option shall vest and become exercisable in three equal annual installments commencing on December 31, 2024, subject to the Reporting Person's continuous service through each applicable vesting date.

SEC source: 0001209191-23-055942 · doc4.xml · nonDerivative · entry 1

Manning Paul B · CIK 0001494695 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 16,566,667

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.57 to $1.68 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F2 · ownership.nature: The shares are held directly by The Paul B. Manning Revocable Trust dated May 10, 2000 (the "Revocable Trust"). The Reporting Person is the trustee of the Revocable Trust and has sole voting and investment power with respect to the shares held by the Revocable Trust.

SEC source: 0001209191-23-054339 · doc4.xml · derivative · entry 1

Long Alison S · CIK 0001891712 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,800

Underlying: Common Stock · 43,800 shares

Expires 2033-11-01

F1 · derivative.exercise_date: The shares vest in 36 equal monthly installments commencing on December 1, 2023 such that the shares will be fully vested on November 1, 2026, subject to the Reporting Person's continued service as a director through the applicable vesting date.

SEC source: 0001209191-23-047323 · doc4.xml · nonDerivative · entry 1

Alam Kamran · CIK 0001793412 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 258,042

F1 · kind: This sale was effected pursuant to a mandatory "sell to cover" arrangement adopted by the Reporting Person on May 26, 2023 in accordance with Rule 10b5-1 to satisfy the tax withholding obligations triggered by the vesting of restricted stock units and does not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.185 to $2.70 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-046154 · doc4.xml · nonDerivative · entry 1

Manning Paul B · CIK 0001494695 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 16,466,667

F1 · balance_after: The change in the total shares held prior to the transactions reported herein reflects a change in form of ownership and, therefore, was not required to be reported pursuant to Section 16.

F2 · ownership.nature: The shares are held directly by The Paul B. Manning Revocable Trust dated May 10, 2000 (the "Revocable Trust"). The Reporting Person is the trustee of the Revocable Trust and has sole voting and investment power with respect to the shares held by the Revocable Trust.

SEC source: 0001209191-23-046150 · doc4.xml · nonDerivative · entry 1

Nolan Sean P. · CIK 0001569926 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 1,535,545

F1 · ownership.nature: The securities are held by Nolan Capital, LLC (the "LLC"). The Reporting Person is the President of the LLC and has shared voting and investment power with respect to the shares held by the LLC.

SEC source: 0001209191-23-046152 · doc4.xml · nonDerivative · entry 3

Stalfort John A III · CIK 0001709418 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,049,381

SEC source: 0001209191-23-046152 · doc4.xml · nonDerivative · entry 2

Stalfort John A III · CIK 0001709418 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 999,381

SEC source: 0001209191-23-046152 · doc4.xml · nonDerivative · entry 1

Stalfort John A III · CIK 0001709418 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 884,290

F1 · ownership.nature: The securities are held by Gineane Holly Stalfort, as Trustee of the John A. Stalfort III 2018 Irrevocable Trust under agreement dated as of October 25, 2018.

SEC source: 0001209191-23-046148 · doc4.xml · nonDerivative · entry 1

Donenberg Phillip B. · CIK 0001238120 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 114,111

SEC source: 0000950170-23-032986 · ownership.xml · nonDerivative · entry 2

Session R.A. II · CIK 0001701846 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,871,747

SEC source: 0000950170-23-032986 · ownership.xml · nonDerivative · entry 1

Session R.A. II · CIK 0001701846 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,877,091

F1 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $0.70 - $0.73. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-016491 · doc4.xml · nonDerivative · entry 2

Session R.A. II · CIK 0001701846 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,957,619

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $0.70 - $0.716. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-23-039733 · doc4.xml · derivative · entry 1

Sepp-Lorenzino Laura · CIK 0001777421 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,200

Underlying: Common Stock · 36,200 shares

Expires 2033-06-22

F1 · derivative.exercise_date: The shares vest on the earlier of June 22, 2024 or the next annual stockholders meeting, subject to the Reporting Person's continued service as a director through the applicable vesting date.

SEC source: 0001209191-23-039732 · doc4.xml · derivative · entry 1

Reape Kathleen · CIK 0001832203 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,200

Underlying: Common Stock · 36,200 shares

Expires 2033-06-22

F1 · derivative.exercise_date: The shares vest on the earlier of June 22, 2024 or the next annual stockholders meeting, subject to the Reporting Person's continued service as a director through the applicable vesting date.

SEC source: 0001209191-23-039731 · doc4.xml · derivative · entry 1

Donenberg Phillip B. · CIK 0001238120 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,200

Underlying: Common Stock · 36,200 shares

Expires 2033-06-22

F1 · derivative.exercise_date: The shares vest on the earlier of June 22, 2024 or the next annual stockholders meeting, subject to the Reporting Person's continued service as a director through the applicable vesting date.

SEC source: 0001209191-23-039730 · doc4.xml · derivative · entry 1

Stalfort John A III · CIK 0001709418 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,800

Underlying: Common Stock · 43,800 shares

Expires 2033-06-22

F1 · derivative.exercise_date: The shares vest on the earlier of June 22, 2024 or the next annual stockholders meeting, subject to the Reporting Person's continued service as a director through the applicable vesting date.

SEC source: 0000899243-23-016491 · doc4.xml · nonDerivative · entry 1

Session R.A. II · CIK 0001701846 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,975,719

F1 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $0.70 - $0.7185. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-016232 · doc4.xml · nonDerivative · entry 2

Session R.A. II · CIK 0001701846 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,986,227

F2 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $0.70 - $0.719. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0000899243-23-016232 · doc4.xml · nonDerivative · entry 1

Session R.A. II · CIK 0001701846 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,125,189

F1 · price: The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $0.70 - $0.78. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001209191-23-033681 · doc4.xml · nonDerivative · entry 1

Alam Kamran · CIK 0001793412 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 291,042

F1 · shares: Represents a performance restricted stock unit ("PRSU") award. The PRSUs were awarded on February 2, 2023 by the Compensation Committee (the "Compensation Committee") of the Issuer's Board of Directors as annual incentive compensation for 2022 performance. On May 31, 2023, the Compensation Committee certified the achievement of a certain performance goal. The PRSUs covered by this report vested upon certification.

F2 · price: Each PRSU represented a contingent right to receive one share the Issuer's common stock.

SEC source: 0001415889-25-010539 · form4a-04102025_040408.xml · derivative · entry 1

Alam Kamran · CIK 0001793412 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,462

Underlying: Common Stock · 12,462 shares

Expires 2033-02-02

F1 · derivative.exercise_date: The option was awarded on February 2, 2023 by the Compensation Committee (the "Compensation Committee") of the Issuer's Board of Directors as annual incentive compensation for 2022 performance. On May 31, 2023, the Compensation Committee certified the achievement of a certain performance goal. The shares underlying the option covered by this report vested upon certification. This option was inadvertently omitted for the original Form 4.

SEC source: 0001209191-23-030661 · doc4.xml · nonDerivative · entry 1

Nagendran Sukumar · CIK 0001665124 · Director · President and Head of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,226

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.682 to $0.6879 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.