TMDX

SEC source: 0000899243-23-011646 · doc4.xml · nonDerivative · entry 6

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Khayal Family 2021 Irrevocable Trust

Disclosed balance after: 17,001

F6 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan entered into on December 12, 2022.

F7 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $90.00 to $90.16, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-011646 · doc4.xml · nonDerivative · entry 5

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,375

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan entered into on December 2, 2022.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $90.00 to $90.07, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F5 · balance_after: Includes 13,075 restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0000899243-23-011646 · doc4.xml · nonDerivative · entry 4

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,401

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan entered into on December 2, 2022.

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $86.01 to $86.18, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-011646 · doc4.xml · nonDerivative · entry 3

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,701

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan entered into on December 2, 2022.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $85.00 to $85.95, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-011646 · doc4.xml · nonDerivative · entry 2

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,401

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan entered into on December 2, 2022.

SEC source: 0000899243-23-011646 · doc4.xml · nonDerivative · entry 1

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,375

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan entered into on December 2, 2022.

SEC source: 0000899243-23-010442 · doc4.xml · nonDerivative · entry 3

Hassanein Waleed H · CIK 0001430466 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 566,691

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan entered into on December 14, 2022.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $75.62 to $75.93, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F5 · balance_after: Includes 37,332 restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0000899243-23-010442 · doc4.xml · nonDerivative · entry 2

Hassanein Waleed H · CIK 0001430466 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 567,255

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan entered into on December 14, 2022.

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $74.61 to $75.60, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-010442 · doc4.xml · nonDerivative · entry 1

Hassanein Waleed H · CIK 0001430466 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 570,832

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan entered into on December 14, 2022.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $73.60 to $74.59, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-007901 · ownership.xml · derivative · entry 2

Hassanein Waleed H · CIK 0001430466 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1

Underlying: Common Stock · 193,074 shares

Expires 2027-06-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents the reporting person's cash exercise of a stock option.

F3 · derivative.exercise_date: The option is fully vested.

SEC source: 0000950170-23-007901 · ownership.xml · nonDerivative · entry 1

Hassanein Waleed H · CIK 0001430466 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 574,191

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Represents the reporting person's cash exercise of a stock option.

F2 · balance_after: Includes 37,332 restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0000899243-23-006759 · doc4.xml · nonDerivative · entry 2

Hassanein Waleed H · CIK 0001430466 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 381,117

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $80.53 to $81.51, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F4 · balance_after: Includes 37,332 restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0000899243-23-006759 · doc4.xml · nonDerivative · entry 1

Hassanein Waleed H · CIK 0001430466 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 386,017

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $79.47 to $80.46, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-006758 · doc4.xml · derivative · entry 3

Gordon Stephen · CIK 0001774274 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,728

Underlying: Common Stock · 5,000 shares

Expires 2030-02-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F3 · derivative.exercise_date: The option vests at a rate of 2.0833% of the total number of shares each month until the option is fully vested on February 27, 2024.

SEC source: 0000899243-23-006758 · doc4.xml · nonDerivative · entry 2

Gordon Stephen · CIK 0001774274 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,789

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F2 · balance_after: Includes 13,075 restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0000899243-23-006758 · doc4.xml · nonDerivative · entry 1

Gordon Stephen · CIK 0001774274 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,789

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

SEC source: 0000899243-23-006755 · doc4.xml · nonDerivative · entry 1

Basile Edward M · CIK 0001773661 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,314

F1 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $80.00 to $80.43, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-006757 · doc4.xml · derivative · entry 5

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,249

Underlying: Common Stock · 10,000 shares

Expires 2030-02-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F5 · derivative.exercise_date: The option vests at a rate of 2.0833% of the total number of shares each month until the option is fully vested on the fourth anniversary of the vesting commencement date, February 27, 2020.

SEC source: 0000899243-23-006757 · doc4.xml · nonDerivative · entry 3

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · By the Khayal Family 2021 Irrevocable Trust

Disclosed balance after: 19,776

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $80.00 to $80.24, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-006757 · doc4.xml · nonDerivative · entry 2

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,375

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $80.00 to $80.85, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 13,075 restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0000899243-23-006757 · doc4.xml · nonDerivative · entry 1

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,375

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

SEC source: 0000899243-23-006756 · doc4.xml · nonDerivative · entry 2

KANIA EDWIN M JR · CIK 0001255927 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 256,751

F2 · kind: The reporting person withdrew 96,876 shares of the Issuer from Kania 2021 GRAT B, a grantor retained annuity trust, in exchange for cash. The withdrawal of shares from the trust resulted in a decrease in the number of shares the reporting person beneficially owns indirectly through the trust and a corresponding increase in the number of shares the reporting person beneficially owns directly. The reporting person believes that his withdrawal of shares from the trust constitutes a change in form of beneficial ownership of the shares, exempted by Rule 16a-13 under the Securities Exchange Act of 1934.

SEC source: 0000899243-23-006756 · doc4.xml · nonDerivative · entry 1

KANIA EDWIN M JR · CIK 0001255927 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 159,875

F1 · kind: The reporting person withdrew 145,601 shares of the Issuer from Kania 2021 GRAT A, a grantor retained annuity trust, in exchange for cash. The withdrawal of shares from the trust resulted in a decrease in the number of shares the reporting person beneficially owns indirectly through the trust and a corresponding increase in the number of shares the reporting person beneficially owns directly. The reporting person believes that his withdrawal of shares from the trust constitutes a change in form of beneficial ownership of the shares, exempted by Rule 16a-13 under the Securities Exchange Act of 1934.

SEC source: 0000950170-23-005194 · ownership.xml · derivative · entry 4

Weill David · CIK 0001774270 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 5,934 shares

Expires 2030-06-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option is fully vested.

SEC source: 0000950170-23-005194 · ownership.xml · nonDerivative · entry 3

Weill David · CIK 0001774270 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $76.44 to $76.65, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: A Form 4 filed by the reporting person on November 14, 2022 inadvertently overstated the total number of shares held by the reporting person by 3,500 shares. The updated amounts reported here correct that error and reflect the reporting person's holdings.

SEC source: 0000950170-23-005194 · ownership.xml · nonDerivative · entry 2

Weill David · CIK 0001774270 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,970

F1 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $77.63 to $77.76, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-005194 · ownership.xml · nonDerivative · entry 1

Weill David · CIK 0001774270 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,934

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-23-005192 · ownership.xml · nonDerivative · entry 3

Basile Edward M · CIK 0001773661 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,814

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $79.25 to $79.50, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-005192 · ownership.xml · nonDerivative · entry 2

Basile Edward M · CIK 0001773661 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,814

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $78.00 to $78.50, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-005192 · ownership.xml · nonDerivative · entry 1

Basile Edward M · CIK 0001773661 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,314

F1 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $76.00 to $76.54, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-006280 · doc4.xml · derivative · entry 12

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,249

Underlying: Common Stock · 3,751 shares

Expires 2030-02-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F10 · derivative.exercise_date: The option vests at a rate of 2.0833% of the total number of shares each month until the option is fully vested on the fourth anniversary of the vesting commencement date, February 27, 2020.

SEC source: 0000899243-23-006280 · doc4.xml · derivative · entry 11

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,036

Underlying: Common Stock · 32,179 shares

Expires 2029-05-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F9 · derivative.exercise_date: The option vests in equal monthly installments over four years beginning on the date of grant, May 1, 2019.

SEC source: 0000899243-23-006280 · doc4.xml · nonDerivative · entry 8

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,375

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F7 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $75.00 to $75.50, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F8 · balance_after: Includes 13,075 restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0000899243-23-006280 · doc4.xml · nonDerivative · entry 7

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,375

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F6 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $74.07 to $74.90, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-006280 · doc4.xml · nonDerivative · entry 6

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,228

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $73.00 to $73.99, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-006280 · doc4.xml · nonDerivative · entry 5

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,005

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $72.00 to $72.95, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-006280 · doc4.xml · nonDerivative · entry 4

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,223

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $71.06 to $71.68, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-006280 · doc4.xml · nonDerivative · entry 3

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,986

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $70.00 to $70.92, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-006280 · doc4.xml · nonDerivative · entry 2

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,305

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

SEC source: 0000899243-23-006280 · doc4.xml · nonDerivative · entry 1

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,554

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

SEC source: 0000899243-23-006282 · doc4.xml · nonDerivative · entry 5

Hassanein Waleed H · CIK 0001430466 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 388,617

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F6 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $75.00 to $75.50, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F7 · balance_after: Includes 37,332 restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0000899243-23-006282 · doc4.xml · nonDerivative · entry 4

Hassanein Waleed H · CIK 0001430466 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 408,617

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F5 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $74.00 to $74.90, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-006282 · doc4.xml · nonDerivative · entry 3

Hassanein Waleed H · CIK 0001430466 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 411,860

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $73.10 to $73.93, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-006282 · doc4.xml · nonDerivative · entry 2

Hassanein Waleed H · CIK 0001430466 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 415,437

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $71.00 to $71.63, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-006282 · doc4.xml · nonDerivative · entry 1

Hassanein Waleed H · CIK 0001430466 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 420,244

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $70.00 to $70.85, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-006281 · doc4.xml · nonDerivative · entry 1

TOBIN JAMES R · CIK 0001190128 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By the James R. Tobin 2012 Trust

Disclosed balance after: 243,591

F1 · kind: The reported transactions were effected pursuant to a Rule 10b5-1 trading plan.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $75.00 to $75.59, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-005898 · doc4.xml · derivative · entry 4

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,022

Underlying: Common Stock · 20,022 shares

Expires 2033-02-20

F2 · derivative.exercise_date: The option vests at a rate of 2.0833% of the total number of shares subject to the option each month following February 20, 2023 until the option is fully vested on February 20, 2027, subject to continued service.

SEC source: 0000899243-23-005898 · doc4.xml · nonDerivative · entry 1

Khayal Tamer I · CIK 0001430462 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,375

F1 · shares: Includes 13,075 restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0000899243-23-005895 · doc4.xml · derivative · entry 2

Hassanein Waleed H · CIK 0001430466 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,165

Underlying: Common Stock · 57,165 shares

Expires 2033-02-20

F2 · derivative.exercise_date: The option vests at a rate of 2.0833% of the total number of shares subject to the option each month following February 20, 2023 until the option is fully vested on February 20, 2027, subject to continued service.

SEC source: 0000899243-23-005895 · doc4.xml · nonDerivative · entry 1

Hassanein Waleed H · CIK 0001430466 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 426,444

F1 · shares: Includes 37,332 restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's common stock.