SYRE

SEC source: 0002038798-26-000004 · wk-form4_1777685676.xml · nonDerivative · entry 7

Sloan Sheldon · CIK 0002038798 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 400

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F7 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $74.21 to $74.96, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0002038798-26-000004 · wk-form4_1777685676.xml · nonDerivative · entry 6

Sloan Sheldon · CIK 0002038798 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,459

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F6 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $73.21 to $74.20, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0002038798-26-000004 · wk-form4_1777685676.xml · nonDerivative · entry 5

Sloan Sheldon · CIK 0002038798 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,817

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F5 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $72.21 to $73.20, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0002038798-26-000004 · wk-form4_1777685676.xml · nonDerivative · entry 4

Sloan Sheldon · CIK 0002038798 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,594

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $71.21 to $72.19, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0002038798-26-000004 · wk-form4_1777685676.xml · nonDerivative · entry 3

Sloan Sheldon · CIK 0002038798 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 37,371

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $70.21 to $71.20, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0002038798-26-000004 · wk-form4_1777685676.xml · nonDerivative · entry 2

Sloan Sheldon · CIK 0002038798 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 57,027

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $69.21 to $70.16, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0002038798-26-000004 · wk-form4_1777685676.xml · nonDerivative · entry 1

Sloan Sheldon · CIK 0002038798 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 78,333

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

SEC source: 0001853327-26-000005 · wk-form4_1777685708.xml · derivative · entry 3

Burrows Scott L · CIK 0001853327 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 382,357

Underlying: Common Stock · 12,500 shares

Expires 2033-09-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025.

F3 · derivative.exercise_date: This option represents a right to purchase 404,857 shares of the Issuer's common stock (which have been adjusted to reflect the Issuer's 1-for-25 reverse stock split on September 8, 2023), one quarter of which vested and became exercisable on September 1, 2024, with the remaining three quarters vesting in monthly installments over the following three years, subject to the Reporting Person's continued employment with the Issuer.

SEC source: 0001853327-26-000005 · wk-form4_1777685708.xml · nonDerivative · entry 2

Burrows Scott L · CIK 0001853327 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 97,994

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025.

F2 · balance_after: Includes 67,476 restricted stock units ("RSUs"). Each RSU represents a contingent right to receive, upon vesting, one share of Common Stock. The RSUs vest in two equal installments on each of September 1, 2026 and 2027, subject to the Reporting Person's continued employment with the Issuer.

SEC source: 0001853327-26-000005 · wk-form4_1777685708.xml · nonDerivative · entry 1

Burrows Scott L · CIK 0001853327 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 110,494

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025.

SEC source: 0001758363-26-000009 · wk-form4_1777685648.xml · nonDerivative · entry 6

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 612,540

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F8 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $74.95 to $74.96, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 101,653 shares of common stock that vest in monthly installments through November 2026, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001758363-26-000009 · wk-form4_1777685648.xml · nonDerivative · entry 5

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 612,840

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F7 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $73.95 to $74.94, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 101,653 shares of common stock that vest in monthly installments through November 2026, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001758363-26-000009 · wk-form4_1777685648.xml · nonDerivative · entry 4

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 614,540

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F6 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $72.75 to $73.74, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 101,653 shares of common stock that vest in monthly installments through November 2026, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001758363-26-000009 · wk-form4_1777685648.xml · nonDerivative · entry 3

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 617,640

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F5 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $71.41 to $72.27, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 101,653 shares of common stock that vest in monthly installments through November 2026, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001758363-26-000009 · wk-form4_1777685648.xml · nonDerivative · entry 2

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 618,640

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $70.30 to $71.28, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 101,653 shares of common stock that vest in monthly installments through November 2026, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001758363-26-000009 · wk-form4_1777685648.xml · nonDerivative · entry 1

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 622,240

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $69.25 to $70.24, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 101,653 shares of common stock that vest in monthly installments through November 2026, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001636282-26-000030 · wk-form4_1775266209.xml · derivative · entry 3

Sloan Sheldon · CIK 0002038798 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 87,542

Underlying: Common Stock · 7,958 shares

Expires 2035-01-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F2 · derivative.exercise_date: This option represents a right to purchase 95,500 shares of the Issuer's common stock, which will vest in equal monthly installments over four years, subject to the Reporting Person's continued employment with the Issuer at each vesting date.

SEC source: 0001636282-26-000030 · wk-form4_1775266209.xml · nonDerivative · entry 2

Sloan Sheldon · CIK 0002038798 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

SEC source: 0001636282-26-000030 · wk-form4_1775266209.xml · nonDerivative · entry 1

Sloan Sheldon · CIK 0002038798 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,958

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

SEC source: 0001853327-26-000003 · wk-form4_1775266173.xml · derivative · entry 4

Burrows Scott L · CIK 0001853327 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 394,857

Underlying: Common Stock · 7,500 shares

Expires 2033-09-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025.

F5 · derivative.exercise_date: This option represents a right to purchase 404,857 shares of the Issuer's common stock (which have been adjusted to reflect the Issuer's 1-for-25 reverse stock split on September 8, 2023), one quarter of which vested and became exercisable on September 1, 2024, with the remaining three quarters vesting in monthly installments over the following three years, subject to the Reporting Person's continued employment with the Issuer.

SEC source: 0001853327-26-000003 · wk-form4_1775266173.xml · nonDerivative · entry 3

Burrows Scott L · CIK 0001853327 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 97,994

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $49.76 to $50.15, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F4 · balance_after: Includes 67,476 restricted stock units ("RSUs"). Each RSU represents a contingent right to receive, upon vesting, one share of Common Stock. The RSUs vest in two equal installments on each of September 1, 2026 and 2027, subject to the Reporting Person's continued employment with the Issuer.

SEC source: 0001853327-26-000003 · wk-form4_1775266173.xml · nonDerivative · entry 2

Burrows Scott L · CIK 0001853327 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 99,294

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $48.69 to $49.63, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001853327-26-000003 · wk-form4_1775266173.xml · nonDerivative · entry 1

Burrows Scott L · CIK 0001853327 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,494

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025.

SEC source: 0001758363-26-000007 · wk-form4_1775266241.xml · nonDerivative · entry 2

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 627,540

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $49.64 to $50.50, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 116,168 shares of common stock that vest in monthly installments through November 2026, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001758363-26-000007 · wk-form4_1775266241.xml · nonDerivative · entry 1

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 630,196

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $48.64 to $49.63, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 116,168 shares of common stock that vest in monthly installments through November 2026, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001636282-26-000028 · wk-form4_1772591549.xml · derivative · entry 4

Burrows Scott L · CIK 0001853327 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 402,357

Underlying: Common Stock · 2,500 shares

Expires 2033-09-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025.

F5 · derivative.exercise_date: This option represents a right to purchase 404,857 shares of the Issuer's common stock (which have been adjusted to reflect the Issuer's 1-for-25 reverse stock split on September 8, 2023), one quarter of which vested and became exercisable on September 1, 2024, with the remaining three quarters vesting in monthly installments over the following three years, subject to the Reporting Person's continued employment with the Issuer.

SEC source: 0001636282-26-000028 · wk-form4_1772591549.xml · nonDerivative · entry 3

Burrows Scott L · CIK 0001853327 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 97,994

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025.

F3 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $41.55 to $41.76, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F4 · balance_after: Includes 67,476 restricted stock units ("RSUs"). Each RSU represents a contingent right to receive, upon vesting, one share of Common Stock. The RSUs vest in two equal installments on each of September 1, 2026 and 2027, subject to the Reporting Person's continued employment with the Issuer.

SEC source: 0001636282-26-000028 · wk-form4_1772591549.xml · nonDerivative · entry 2

Burrows Scott L · CIK 0001853327 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 98,194

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $40.17 to $41.11, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001636282-26-000028 · wk-form4_1772591549.xml · nonDerivative · entry 1

Burrows Scott L · CIK 0001853327 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 100,494

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on November 10, 2025.

SEC source: 0001636282-26-000026 · wk-form4_1772591487.xml · nonDerivative · entry 2

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 642,540

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $42.23 to $42.93, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 130,683 shares of common stock that vest in monthly installments through November 2026, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001636282-26-000026 · wk-form4_1772591487.xml · nonDerivative · entry 1

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 651,640

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $41.23 to $42.19, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 130,683 shares of common stock that vest in monthly installments through November 2026, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001758363-26-000005 · wk-form4_1770258815.xml · nonDerivative · entry 2

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 657,540

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F5 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.48 to $33.35, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 145,198 shares of common stock that vest in monthly installments over approximately one year, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001758363-26-000005 · wk-form4_1770258815.xml · nonDerivative · entry 1

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 671,583

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.42 to $32.05, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 145,198 shares of common stock that vest in monthly installments over approximately one year, subject to the continuing service of the Reporting Person on each vesting date.

F4 · balance_after: Includes 633 shares acquired by the Reporting Person under the Issuer's 2016 Employee Stock Purchase Plan on August 15, 2024.

SEC source: 0001779990-26-000002 · wk-form4_1769221869.xml · nonDerivative · entry 1

HENDERSON MICHAEL THOMAS · CIK 0001779990 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 168,606

F1 · kind: Represents the pro-rata distribution of shares of common stock for no consideration from a limited liability company in which the Reporting Person is a member.

SEC source: 0001636282-26-000002 · wk-form4_1768357592.xml · derivative · entry 1

Sloan Sheldon · CIK 0002038798 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 140,000

Underlying: Common Stock · 140,000 shares

Expires 2036-01-09

F1 · derivative.exercise_date: This option represents a right to purchase 140,000 shares of the Issuer's common stock, which will vest in equal monthly installments over four years, subject to the Reporting Person's continued employment with the Issuer at each vesting date.

SEC source: 0001636282-26-000004 · wk-form4_1768357662.xml · derivative · entry 1

Burrows Scott L · CIK 0001853327 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 140,000

Underlying: Common Stock · 140,000 shares

Expires 2036-01-09

F1 · derivative.exercise_date: This option represents a right to purchase 140,000 shares of the Issuer's common stock, which will vest in equal monthly installments over four years, subject to the Reporting Person's continued employment with the Issuer at each vesting date.

SEC source: 0001636282-26-000003 · wk-form4_1768357625.xml · derivative · entry 1

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 528,000

Underlying: Common Stock · 528,000 shares

Expires 2036-01-09

F1 · derivative.exercise_date: This option represents a right to purchase 528,000 shares of the Issuer's common stock, which will vest in equal monthly installments over four years, subject to the Reporting Person's continued employment with the Issuer at each vesting date.

SEC source: 0001636282-26-000001 · wk-form4_1768357531.xml · derivative · entry 1

King-Jones Heidy · CIK 0001794898 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 140,000

Underlying: Common Stock · 140,000 shares

Expires 2036-01-09

F1 · derivative.exercise_date: This option represents a right to purchase 140,000 shares of the Issuer's common stock, which will vest in equal monthly installments over four years, subject to the Reporting Person's continued employment with the Issuer at each vesting date.

SEC source: 0001758363-26-000002 · wk-form4_1767753388.xml · nonDerivative · entry 3

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 671,907

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F5 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.34 to $32.41, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 159,713 shares of common stock that vest in monthly installments over approximately one year, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001758363-26-000002 · wk-form4_1767753388.xml · nonDerivative · entry 2

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 672,007

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.29 to $32.28, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 159,713 shares of common stock that vest in monthly installments over approximately one year, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001758363-26-000002 · wk-form4_1767753388.xml · nonDerivative · entry 1

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 674,198

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $30.20 to $31.00, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 159,713 shares of common stock that vest in monthly installments over approximately one year, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001758363-25-000003 · wk-form4_1764816738.xml · nonDerivative · entry 2

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 686,907

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.47 to $30.43, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 174,228 shares of common stock that vest in monthly installments over approximately one year, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001758363-25-000003 · wk-form4_1764816738.xml · nonDerivative · entry 1

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 690,912

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.45 to $29.44, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 174,228 shares of common stock that vest in monthly installments over approximately one year, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001636282-25-000106 · wk-form4_1762395302.xml · nonDerivative · entry 2

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 701,907

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F4 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $23.51 to $24.04, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 188,743 shares of common stock that vest in monthly installments over approximately one year, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001636282-25-000106 · wk-form4_1762395302.xml · nonDerivative · entry 1

Turtle Cameron · CIK 0001758363 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 718,752

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on June 20, 2025.

F2 · price: The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $22.51 to $23.50, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Includes 188,743 shares of common stock that vest in monthly installments over approximately one year, subject to the continuing service of the Reporting Person on each vesting date.

SEC source: 0001636282-25-000095 · wk-form4_1756939995.xml · nonDerivative · entry 1

Burrows Scott L · CIK 0001853327 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,994

F1 · shares: The transaction reported reflects the sale of shares of common stock, par value $0.0001 per share, of the Issuer ("Common Stock") in satisfaction of the Reporting Person's tax liability in connection with the settlement of 33,738 restricted stock units ("RSUs"). This sale was made to satisfy tax withholding obligations through a "sell to cover" transaction and does not represent a discretionary trade made by the Reporting Person.

F2 · price: The price reported is a weighted average sale price of the Common Stock. These shares were sold in multiple transactions at prices ranging from $16.26 to $16.30, inclusive. The Reporting Person undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: Includes 67,476 RSUs. Each RSU represents a contingent right to receive, upon vesting, one share of Common Stock. The RSUs vest in two equal installments on each of September 1, 2026 and 2027, subject to the Reporting Person's continued employment with the Issuer.

SEC source: 0001636282-25-000069 · wk-form4_1748896783.xml · derivative · entry 2

Fairmount Funds Management LLC · CIK 0001802528 · Director

Harwin Peter Evan · CIK 0001663607 · Director

Kiselak Tomas · CIK 0001830177 · Director

Fairmount Healthcare Fund II L.P. · CIK 0001769651 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By Tomas Kiselak

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2035-05-29

F3 · derivative.exercise_date: This option represents a right to purchase 25,000 shares of the Issuer's common stock, which will vest and become exercisable in 12 equal monthly installments following May 29, 2025 until such time as the option is 100% vested, subject to Tomas Kiselak's continuous service with the Issuer at each vesting date.

F4 · ownership.nature: Under Mr. Kiselak's arrangement with Fairmount Funds Management LLC (the "Adviser"), Mr. Kiselak holds the option for one or more investment vehicles managed by the Adviser (each, a "Fairmount Fund"). Mr. Kiselak is obligated to turn over to the Adviser any net cash or stock received from the option for the benefit of such Fairmount Fund. Mr. Kiselak therefore disclaims beneficial ownership of the option and underlying common stock, except to the extent of his pecuniary interest therein.

SEC source: 0001636282-25-000069 · wk-form4_1748896783.xml · derivative · entry 1

Fairmount Funds Management LLC · CIK 0001802528 · Director

Harwin Peter Evan · CIK 0001663607 · Director

Kiselak Tomas · CIK 0001830177 · Director

Fairmount Healthcare Fund II L.P. · CIK 0001769651 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By Peter Harwin

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2035-05-29

F1 · derivative.exercise_date: This option represents a right to purchase 25,000 shares of the Issuer's common stock, which will vest and become exercisable in 12 equal monthly installments following May 29, 2025 until such time as the option is 100% vested, subject to Peter Harwin's continuous service with the Issuer at each vesting date.

F2 · ownership.nature: Under Mr. Harwin's arrangement with Fairmount Funds Management LLC (the "Adviser"), Mr. Harwin holds the option for one or more investment vehicles managed by the Adviser (each, a "Fairmount Fund"). Mr. Harwin is obligated to turn over to the Adviser any net cash or stock received from the option for the benefit of such Fairmount Fund. Mr. Harwin therefore disclaims beneficial ownership of the option and underlying common stock, except to the extent of his pecuniary interest therein.

SEC source: 0001636282-25-000068 · wk-form4_1748896689.xml · derivative · entry 1

Stelzer Laurie · CIK 0001644348 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2035-05-29

F1 · derivative.exercise_date: This option represents a right to purchase 25,000 shares of the Issuer's common stock, which will vest and become exercisable in 12 equal monthly installments following May 29, 2025 until such time as the option is 100% vested, subject to the Reporting Person's continuous service with the Issuer at each vesting date.

SEC source: 0001636282-25-000067 · wk-form4_1748896627.xml · derivative · entry 1

Milligan Sandra · CIK 0001859810 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2035-05-29

F1 · derivative.exercise_date: This option represents a right to purchase 25,000 shares of the Issuer's common stock, which will vest and become exercisable in 12 equal monthly installments following May 29, 2025 until such time as the option is 100% vested, subject to the Reporting Person's continuous service with the Issuer at each vesting date.