STTK

SEC source: 0000899243-21-019308 · doc4.xml · nonDerivative · entry 4

Hornblower Josiah · CIK 0001827315 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Hornblower Capital Holdings, LLC

Disclosed balance after: 3,274,385

F3 · price: This transaction was executed pursuant to a Rule 10b5-1 trading plan in multiple trades at prices ranging from $26.335 to $27.89. The price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000899243-21-019310 · doc4.xml · nonDerivative · entry 2

Schreiber Taylor · CIK 0001601942 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · By Houghton Capital Holdings, LLC

Disclosed balance after: 2,682,779

F2 · price: This transaction was executed pursuant to a Rule 10b5-1 trading plan in multiple trades at prices ranging from $25.76 to $28.77. The price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000899243-21-019308 · doc4.xml · nonDerivative · entry 3

Hornblower Josiah · CIK 0001827315 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Hornblower Capital Holdings, LLC

Disclosed balance after: 3,288,442

F2 · price: This transaction was executed pursuant to a Rule 10b5-1 trading plan in multiple trades at prices ranging from $25.76 to $28.585. The price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000899243-21-019310 · doc4.xml · nonDerivative · entry 1

Schreiber Taylor · CIK 0001601942 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · By Houghton Capital Holdings, LLC

Disclosed balance after: 2,697,562

F1 · price: This transaction was executed pursuant to a Rule 10b5-1 trading plan in multiple trades at prices ranging from $26.035 to $29.31. The price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000899243-21-019308 · doc4.xml · nonDerivative · entry 2

Hornblower Josiah · CIK 0001827315 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Hornblower Capital Holdings, LLC

Disclosed balance after: 3,303,482

F1 · price: This transaction was executed pursuant to a Rule 10b5-1 trading plan in multiple trades at prices ranging from $26.035 to $29.11. The price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000899243-21-017648 · doc4.xml · nonDerivative · entry 1

Neill Andrew R · CIK 0001827204 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,103

F1 · price: This transaction was executed pursuant to a Rule 10b5-1 trading plan in multiple trades at prices ranging from $35.00 to $35.18. The price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000899243-21-017649 · doc4.xml · nonDerivative · entry 1

Thomson Erin Ator · CIK 0001827202 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,259

F1 · price: This transaction was executed pursuant to a Rule 10b5-1 trading plan.

SEC source: 0000899243-21-016249 · doc4.xml · nonDerivative · entry 1

Neill Andrew R · CIK 0001827204 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,103

F1 · price: This transaction was executed pursuant to a Rule 10b5-1 trading plan in multiple trades at prices ranging from $29.72 to $33.03. The price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000899243-21-016247 · doc4.xml · nonDerivative · entry 1

Thomson Erin Ator · CIK 0001827202 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,259

F1 · price: This transaction was executed pursuant to a Rule 10b5-1 trading plan in multiple trades at prices ranging from $29.72 to $33.03. The price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000899243-21-019308 · doc4.xml · nonDerivative · entry 1

Hornblower Josiah · CIK 0001827315 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Hornblower Capital Holdings, LLC

Disclosed balance after: 3,311,709

SEC source: 0000899243-21-002399 · doc4.xml · derivative · entry 2

Pandite Arundathy N. · CIK 0001827232 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,259

Underlying: Common Stock · 1,604 shares

Expires 2027-12-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: This option represents a right to purchase a total of 5,863 shares of the Issuer's common stock and will vest in equal monthly installments through July 24, 2021, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-21-002399 · doc4.xml · nonDerivative · entry 1

Pandite Arundathy N. · CIK 0001827232 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 101,907

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-20-035210 · doc4.xml · derivative · entry 1

Pandite Arundathy N. · CIK 0001827232 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,563

Underlying: Common Stock · 27,563 shares

Expires 2030-12-22

F1 · derivative.exercise_date: This option represents a right to purchase a total of 27,563 shares of the Issuer's common stock, one quarter of which will vest on December 22, 2021, with the remaining three quarters vesting in equal monthly installments through December 22, 2024, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-20-035191 · doc4.xml · derivative · entry 1

Boudreau Helen M · CIK 0001661481 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,286

Underlying: Common Stock · 1,286 shares

Expires 2030-12-22

F1 · derivative.exercise_date: This option represents a right to purchase a total of 1,286 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the next annual meeting of the Issuer's shareholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-20-139775 · tm2039412d1_4.xml · derivative · entry 1

Redmile Group, LLC · CIK 0001425738 · Director · 10% owner

Green Jeremy · CIK 0001650527 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,286

Underlying: Common Stock · 1,286 shares

Expires 2030-12-22

F1 · derivative.exercise_date: This option represents a right to purchase a total of 1,286 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the next annual meeting of the Issuer's shareholders, subject to Michael Lee's continued service to the Issuer.

F2 · ownership.nature: The stock option was granted to Michael Lee, a managing director of Redmile Group, LLC ("Redmile"), in connection with his service as a member of the Board of Directors of the Issuer. Pursuant to the policies of Redmile, Mr. Lee holds this stock option as a nominee on behalf, and for the sole benefit, of Redmile and has assigned all economic, pecuniary and voting rights in respect of the stock option to Redmile. Mr. Lee disclaims beneficial ownership of the stock option, and the filing of this Form 4 shall not be deemed an admission that Mr. Lee is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F3 · ownership.nature: The stock option may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. Redmile and Mr. Green disclaim beneficial ownership of the stock option except to the extent of their pecuniary interest therein, and this Form 4 shall not be deemed an admission that Redmile or Mr. Green is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F4 · ownership.nature: Mr. Lee, a member of the board of directors of the Issuer and a managing director of Redmile, was elected to the board of the Issuer as a representative of Redmile. As a result, the Reporting Persons are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0000899243-20-035204 · doc4.xml · derivative · entry 1

Gibson Neil W · CIK 0001555918 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,286

Underlying: Common Stock · 1,286 shares

Expires 2030-12-22

F1 · derivative.exercise_date: This option represents a right to purchase a total of 1,286 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the next annual meeting of the Issuer's shareholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-20-035206 · doc4.xml · derivative · entry 1

Golumbeski George · CIK 0001586660 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,286

Underlying: Common Stock · 1,286 shares

Expires 2030-12-22

F1 · derivative.exercise_date: This option represents a right to purchase a total of 1,286 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the next annual meeting of the Issuer's shareholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-20-035187 · doc4.xml · derivative · entry 1

Schreiber Taylor · CIK 0001601942 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,563

Underlying: Common Stock · 27,563 shares

Expires 2030-12-22

F1 · derivative.exercise_date: This option represents a right to purchase a total of 27,563 shares of the Issuer's common stock, one quarter of which will vest on December 22, 2021, with the remaining three quarters vesting in equal monthly installments through December 22, 2024, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-20-035212 · doc4.xml · derivative · entry 1

DeYoung Casi · CIK 0001652066 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,743

Underlying: Common Stock · 18,743 shares

Expires 2030-12-22

F1 · derivative.exercise_date: This option represents a right to purchase a total of 18,743 shares of the Issuer's common stock, one quarter of which will vest on December 22, 2021, with the remaining three quarters vesting in equal monthly installments through December 22, 2024, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-20-035214 · doc4.xml · derivative · entry 1

Thomson Erin Ator · CIK 0001827202 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,608

Underlying: Common Stock · 14,608 shares

Expires 2030-12-22

F1 · derivative.exercise_date: This option represents a right to purchase a total of 14,608 shares of the Issuer's common stock, one quarter of which will vest on December 22, 2021, with the remaining three quarters vesting in equal monthly installments through December 22, 2024, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-20-035209 · doc4.xml · derivative · entry 3

Neill Andrew R · CIK 0001827204 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,608

Underlying: Common Stock · 14,608 shares

Expires 2030-12-22

F2 · derivative.exercise_date: This option represents a right to purchase a total of 14,608 shares of the Issuer's common stock, one quarter of which will vest on December 22, 2021, with the remaining three quarters vesting in equal monthly installments through December 22, 2024, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-20-035209 · doc4.xml · derivative · entry 2

Neill Andrew R · CIK 0001827204 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,063

Underlying: Common Stock · 4,426 shares

Expires 2027-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: This option represents a right to purchase a total of 17,700 shares of the Issuer's common stock and will vest in equal monthly installments through May 22, 2021, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-20-035209 · doc4.xml · nonDerivative · entry 1

Neill Andrew R · CIK 0001827204 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,103

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-20-035207 · doc4.xml · derivative · entry 1

Hornblower Josiah · CIK 0001827315 · Director · Chairman

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,954

Underlying: Common Stock · 12,954 shares

Expires 2030-12-22

F1 · derivative.exercise_date: This option represents a right to purchase a total of 12,954 shares of the Issuer's common stock, one quarter of which will vest on December 22, 2021, with the remaining three quarters vesting in equal monthly installments through December 22, 2024, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001104659-20-139777 · tm2039412d2_4.xml · derivative · entry 1

Lee Michael Stewart · CIK 0001748010 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,286

Underlying: Common Stock · 1,286 shares

Expires 2030-12-22

F1 · derivative.exercise_date: This option represents a right to purchase a total of 1,286 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the next annual meeting of the Issuer's shareholders, subject to the Reporting Person's continued service to the Issuer.

F2 · ownership.direct: The stock option was granted to Mr. Lee in connection with his service as a member of the Board of Directors of the Issuer. Mr. Lee, a managing director of Redmile, was elected to the board of the Issuer as a representative of Redmile Group, LLC ("Redmile"). Pursuant to the policies of Redmile, Mr. Lee holds this stock option as a nominee on behalf, and for the sole benefit, of Redmile and has assigned all economic, pecuniary and voting rights in respect of the stock option to Redmile. Mr. Lee disclaims beneficial ownership of the stock option, and the filing of this Form 4 shall not be deemed an admission that Mr. Lee is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F3 · ownership.direct: The stock option may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. Redmile and Mr. Green disclaim beneficial ownership of the stock option except to the extent of their pecuniary interest therein, and this Form 4 shall not be deemed an admission that Redmile or Mr. Green is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F4 · ownership.direct: Mr. Lee was elected to the board of directors of the Issuer as a representative of Redmile. As a result, Redmile and Mr. Green are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0000899243-20-035193 · doc4.xml · derivative · entry 1

Brous Tyler · CIK 0001827387 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,286

Underlying: Common Stock · 1,286 shares

Expires 2030-12-22

F1 · derivative.exercise_date: This option represents a right to purchase a total of 1,286 shares of the Issuer's common stock, which will vest in full on the earlier of the one-year anniversary of the grant date or immediately prior to the next annual meeting of the Issuer's shareholders, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-20-030628 · doc4.xml · derivative · entry 2

Thomson Erin Ator · CIK 0001827202 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,952 shares

Expires 2027-12-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: All of the shares of the Issuer's common stock underlying this option are vested and exercisable as of the date hereof.

SEC source: 0000899243-20-030628 · doc4.xml · nonDerivative · entry 1

Thomson Erin Ator · CIK 0001827202 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 107,259

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-20-030627 · doc4.xml · derivative · entry 2

Neill Andrew R · CIK 0001827204 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,489

Underlying: Common Stock · 2,211 shares

Expires 2027-05-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: This option represents a right to purchase a total of 17,700 shares of the Issuer's common stock and will vest in equal monthly installments through May 22, 2021, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0000899243-20-030627 · doc4.xml · nonDerivative · entry 1

Neill Andrew R · CIK 0001827204 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,677

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-115357 · tm2033178d1_4.xml · derivative · entry 8

Redmile Group, LLC · CIK 0001425738 · Director · 10% owner

Green Jeremy · CIK 0001650527 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 2,178,738 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $17.57 to $18.57, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased at each separate price.

F4 · derivative.exercise_date: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $17.57 to $18.57, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased at each separate price.

F4 · derivative.expiration_date: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $17.57 to $18.57, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased at each separate price.

F2 · ownership.nature: These securities are directly owned by certain private investment vehicles managed by Redmile Group, LLC ("Redmile") and may be deemed beneficially owned by Redmile as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. The Reporting Persons disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F3 · ownership.nature: Michael Lee, a member of the board of directors of the Issuer and a managing director of Redmile, was elected to the board of the Issuer as a representative of Redmile. As a result, the Reporting Persons are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-20-115357 · tm2033178d1_4.xml · nonDerivative · entry 7

Redmile Group, LLC · CIK 0001425738 · Director · 10% owner

Green Jeremy · CIK 0001650527 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 5,619,914

F2 · ownership.nature: These securities are directly owned by certain private investment vehicles managed by Redmile Group, LLC ("Redmile") and may be deemed beneficially owned by Redmile as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. The Reporting Persons disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F3 · ownership.nature: Michael Lee, a member of the board of directors of the Issuer and a managing director of Redmile, was elected to the board of the Issuer as a representative of Redmile. As a result, the Reporting Persons are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-20-115357 · tm2033178d1_4.xml · nonDerivative · entry 6

Redmile Group, LLC · CIK 0001425738 · Director · 10% owner

Green Jeremy · CIK 0001650527 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 5,569,914

F7 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $20.60 to $21.39, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased at each separate price.

F2 · ownership.nature: These securities are directly owned by certain private investment vehicles managed by Redmile Group, LLC ("Redmile") and may be deemed beneficially owned by Redmile as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. The Reporting Persons disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F3 · ownership.nature: Michael Lee, a member of the board of directors of the Issuer and a managing director of Redmile, was elected to the board of the Issuer as a representative of Redmile. As a result, the Reporting Persons are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-20-115357 · tm2033178d1_4.xml · nonDerivative · entry 5

Redmile Group, LLC · CIK 0001425738 · Director · 10% owner

Green Jeremy · CIK 0001650527 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 5,538,219

F6 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $19.59 to $20.55, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased at each separate price.

F2 · ownership.nature: These securities are directly owned by certain private investment vehicles managed by Redmile Group, LLC ("Redmile") and may be deemed beneficially owned by Redmile as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. The Reporting Persons disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F3 · ownership.nature: Michael Lee, a member of the board of directors of the Issuer and a managing director of Redmile, was elected to the board of the Issuer as a representative of Redmile. As a result, the Reporting Persons are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-20-115357 · tm2033178d1_4.xml · nonDerivative · entry 4

Redmile Group, LLC · CIK 0001425738 · Director · 10% owner

Green Jeremy · CIK 0001650527 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 5,473,172

F5 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $18.58 to $19.58, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased at each separate price.

F2 · ownership.nature: These securities are directly owned by certain private investment vehicles managed by Redmile Group, LLC ("Redmile") and may be deemed beneficially owned by Redmile as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. The Reporting Persons disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F3 · ownership.nature: Michael Lee, a member of the board of directors of the Issuer and a managing director of Redmile, was elected to the board of the Issuer as a representative of Redmile. As a result, the Reporting Persons are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-20-115357 · tm2033178d1_4.xml · nonDerivative · entry 3

Redmile Group, LLC · CIK 0001425738 · Director · 10% owner

Green Jeremy · CIK 0001650527 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 5,278,014

F4 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $17.57 to $18.57, inclusive. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer full information regarding the number of shares purchased at each separate price.

F2 · ownership.nature: These securities are directly owned by certain private investment vehicles managed by Redmile Group, LLC ("Redmile") and may be deemed beneficially owned by Redmile as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. The Reporting Persons disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F3 · ownership.nature: Michael Lee, a member of the board of directors of the Issuer and a managing director of Redmile, was elected to the board of the Issuer as a representative of Redmile. As a result, the Reporting Persons are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-20-115357 · tm2033178d1_4.xml · nonDerivative · entry 2

Redmile Group, LLC · CIK 0001425738 · Director · 10% owner

Green Jeremy · CIK 0001650527 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 5,119,914

F2 · ownership.nature: These securities are directly owned by certain private investment vehicles managed by Redmile Group, LLC ("Redmile") and may be deemed beneficially owned by Redmile as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. The Reporting Persons disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F3 · ownership.nature: Michael Lee, a member of the board of directors of the Issuer and a managing director of Redmile, was elected to the board of the Issuer as a representative of Redmile. As a result, the Reporting Persons are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-20-115357 · tm2033178d1_4.xml · nonDerivative · entry 1

Redmile Group, LLC · CIK 0001425738 · Director · 10% owner

Green Jeremy · CIK 0001650527 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,178,738

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The Series B-1 Preferred Stock converted into shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering on a 1-for-6.85 basis and had no expiration date.

F2 · ownership.nature: These securities are directly owned by certain private investment vehicles managed by Redmile Group, LLC ("Redmile") and may be deemed beneficially owned by Redmile as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. The Reporting Persons disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

F3 · ownership.nature: Michael Lee, a member of the board of directors of the Issuer and a managing director of Redmile, was elected to the board of the Issuer as a representative of Redmile. As a result, the Reporting Persons are directors by deputization for purposes of Section 16 of the Securities Exchange Act of 1934, as amended.

SEC source: 0000899243-20-028341 · doc4.xml · derivative · entry 5

Schreiber Taylor · CIK 0001601942 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,719 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each share of Series B Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the IPO and had no expiration date.

F1 · derivative.exercise_date: Each share of Series A Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering (the "IPO") and had no expiration date.

F2 · derivative.expiration_date: Each share of Series B Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the IPO and had no expiration date.

SEC source: 0000899243-20-028341 · doc4.xml · derivative · entry 4

Schreiber Taylor · CIK 0001601942 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,555 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering (the "IPO") and had no expiration date.

F1 · derivative.exercise_date: Each share of Series A Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering (the "IPO") and had no expiration date.

F2 · derivative.expiration_date: Each share of Series B Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the IPO and had no expiration date.

SEC source: 0000899243-20-028341 · doc4.xml · nonDerivative · entry 2

Schreiber Taylor · CIK 0001601942 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,274

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Each share of Series B Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the IPO and had no expiration date.

SEC source: 0000899243-20-028341 · doc4.xml · nonDerivative · entry 1

Schreiber Taylor · CIK 0001601942 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,555

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Series A Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering (the "IPO") and had no expiration date.

SEC source: 0000899243-20-028346 · doc4.xml · derivative · entry 2

Thomson Erin Ator · CIK 0001827202 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,096 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering and had no expiration date.

F1 · derivative.exercise_date: Each share of Series A Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering and had no expiration date.

F1 · derivative.expiration_date: Each share of Series A Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering and had no expiration date.

SEC source: 0000899243-20-028346 · doc4.xml · nonDerivative · entry 1

Thomson Erin Ator · CIK 0001827202 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,307

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Series A Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering and had no expiration date.

SEC source: 0000899243-20-028343 · doc4.xml · derivative · entry 9

Brous Tyler · CIK 0001827387 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 87,132 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_price: Each share of Series B-1 Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the IPO and had no expiration date.

F6 · derivative.exercise_date: Each share of Series B-1 Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the IPO and had no expiration date.

F6 · derivative.expiration_date: Each share of Series B-1 Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the IPO and had no expiration date.

F7 · ownership.nature: These shares are held directly by Lennox Dallas Holdings, LLC - Series 10. The Reporting Person is the Manager of Lennox Dallas Holdings, LLC - Series 10. The Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except the extent of his pecuniary interest therein.

SEC source: 0000899243-20-028343 · doc4.xml · derivative · entry 8

Brous Tyler · CIK 0001827387 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 27,235 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each share of Series B Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the IPO and had no expiration date.

F4 · derivative.exercise_date: Each share of Series B Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the IPO and had no expiration date.

F4 · derivative.expiration_date: Each share of Series B Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the IPO and had no expiration date.

F5 · ownership.nature: These shares are held directly by Lennox Dallas Holdings, LLC - Series 9. The Reporting Person is the Manager of Lennox Dallas Holdings, LLC - Series 9. The Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except the extent of his pecuniary interest therein.

SEC source: 0000899243-20-028343 · doc4.xml · derivative · entry 7

Brous Tyler · CIK 0001827387 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 16,440 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering (the "IPO") and had no expiration date.

F1 · derivative.exercise_date: Each share of Series A Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering (the "IPO") and had no expiration date.

F1 · derivative.expiration_date: Each share of Series A Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering (the "IPO") and had no expiration date.

F3 · ownership.nature: These shares are held directly by Lennox Dallas Holdings, LLC - Series 3. The Reporting Person is the Manager of Lennox Dallas Holdings, LLC - Series 3. The Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except the extent of his pecuniary interest therein.

SEC source: 0000899243-20-028343 · doc4.xml · derivative · entry 6

Brous Tyler · CIK 0001827387 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 629,432 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering (the "IPO") and had no expiration date.

F1 · derivative.exercise_date: Each share of Series A Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering (the "IPO") and had no expiration date.

F1 · derivative.expiration_date: Each share of Series A Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the Issuer's initial public offering (the "IPO") and had no expiration date.

F2 · ownership.nature: These shares are held directly by Lennox Dallas Partners, LP ("Lennox Partners"). The Reporting Person is the vice president of RS Holdings, Inc., the general partner of Lennox Partners. The Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except the extent of his pecuniary interest therein.

SEC source: 0000899243-20-028343 · doc4.xml · nonDerivative · entry 4

Brous Tyler · CIK 0001827387 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 87,132

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · price: Each share of Series B-1 Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the IPO and had no expiration date.

F7 · ownership.nature: These shares are held directly by Lennox Dallas Holdings, LLC - Series 10. The Reporting Person is the Manager of Lennox Dallas Holdings, LLC - Series 10. The Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except the extent of his pecuniary interest therein.

SEC source: 0000899243-20-028343 · doc4.xml · nonDerivative · entry 3

Brous Tyler · CIK 0001827387 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 27,235

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: Each share of Series B Preferred Stock automatically converted into 6.85 shares of the Issuer's common stock immediately prior to the closing of the IPO and had no expiration date.

F5 · ownership.nature: These shares are held directly by Lennox Dallas Holdings, LLC - Series 9. The Reporting Person is the Manager of Lennox Dallas Holdings, LLC - Series 9. The Reporting Person disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except the extent of his pecuniary interest therein.