Last 12 months
Inside the activity.
0 purchase rows · 83 sale rows
Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.Monthly counts
| Month | Purchases | Sales |
|---|---|---|
| Nov 2025 | 0 | 7 |
| Dec 2025 | 0 | 31 |
| Jan 2026 | 0 | 0 |
| Feb 2026 | 0 | 0 |
| Mar 2026 | 0 | 27 |
| Apr 2026 | 0 | 1 |
| May 2026 | 0 | 1 |
| Jun 2026 | 0 | 2 |
| Jul 2026 | 0 | 2 |
| Aug 2026 | 0 | 8 |
| Sep 2026 | 0 | 2 |
| Oct 2026 | 0 | 2 |
Latest available
Insider transactions
Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”
The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.
| Transaction date | Owner / reported role | Activity / security | Shares / units | Reported price | Reported value | Details |
|---|---|---|---|---|---|---|
| January 04, 2021 Filed Jan 6, 2021 22:26 UTC |
Nash Huw M.COO & CBO
|
SaleCommon Stock | 200 | $60.51 | $12,101.50 |
DisclosureSEC source: 0001209191-21-002246 · doc4.xml · nonDerivative · entry 5 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 32 F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F6 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.50 to $60.515 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
| January 04, 2021 Filed Jan 6, 2021 22:26 UTC |
Nash Huw M.COO & CBO
|
SaleCommon Stock | 1,800 | $59.85 | $107,724.42 |
DisclosureSEC source: 0001209191-21-002246 · doc4.xml · nonDerivative · entry 4 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 232 F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F5 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $59.395 to $60.33 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
| January 04, 2021 Filed Jan 6, 2021 22:26 UTC |
Nash Huw M.COO & CBO
|
SaleCommon Stock | 2,200 | $59.02 | $129,836.96 |
DisclosureSEC source: 0001209191-21-002246 · doc4.xml · nonDerivative · entry 3 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 2,032 F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F4 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $58.395 to $59.355 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
| January 04, 2021 Filed Jan 6, 2021 22:26 UTC |
Nash Huw M.COO & CBO
|
SaleCommon Stock | 1,500 | $57.66 | $86,494.05 |
DisclosureSEC source: 0001209191-21-002246 · doc4.xml · nonDerivative · entry 2 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 4,232 F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $57.33 to $58.13 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
| January 04, 2021 Filed Jan 6, 2021 22:26 UTC |
Nash Huw M.COO & CBO
|
Exercise / conversionCommon Stock | 5,700 | $2.19 | $12,483.00 |
DisclosureSEC source: 0001209191-21-002246 · doc4.xml · nonDerivative · entry 1 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 5,732 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · balance_after: Includes 32 shares of Common Stock acquired under the issuer's employee stock purchase plan on December 31, 2020. Read SEC document |
| December 30, 2020 Filed Jan 4, 2021 23:33 UTC |
Kaye Edward M. MDDirector · CEO
|
Exercise / conversionEmployee Stock Option (right to buy) · Derivative | 10,000 | $0.00 Strike: $0.60 | $0.00 |
DisclosureSEC source: 0001209191-21-000508 · doc4.xml · derivative · entry 2 Kaye Edward M. MD · CIK 0001522780 · Director · CEO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 637,801 Underlying: Common Stock · 10,000 shares Expires 2028-04-02 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · derivative.exercise_date: The option vested as to 1/4th of the total shares on October 17, 2018, and then 1/48th of the total shares vest monthly thereafter, subject to the reporting person's continued service to the issuer through each vesting date. Read SEC document |
| December 30, 2020 Filed Jan 4, 2021 23:33 UTC |
Kaye Edward M. MDDirector · CEO
|
Exercise / conversionCommon Stock | 10,000 | $0.60 | $6,000.00 |
DisclosureSEC source: 0001209191-21-000508 · doc4.xml · nonDerivative · entry 1 Kaye Edward M. MD · CIK 0001522780 · Director · CEO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 10,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| December 28, 2020 Filed Mar 4, 2021 22:00 UTC |
Liau GeneEVP Research & Preclinical Dev
|
Exercise / conversionEmployee Stock Option (right to buy) · Derivative | 8,000 | $0.00 Strike: $0.60 | $0.00 |
DisclosureSEC source: 0001209191-21-017869 · doc4.xml · derivative · entry 6 Liau Gene · CIK 0001780082 · EVP Research & Preclinical Dev 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 88,069 Underlying: Common Stock · 8,000 shares Expires 2028-04-02 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F4 · derivative.exercise_date: The option vested as to 1/4th of the total shares on January 16, 2018, and then 1/48th of the total shares vest monthly thereafter, subject to the reporting person's continued service to the issuer through each vesting date. Read SEC document |
| December 28, 2020 Filed Mar 4, 2021 22:00 UTC |
Liau GeneEVP Research & Preclinical Dev
|
SaleCommon Stock | 149 | $58.73 | $8,750.77 |
DisclosureSEC source: 0001209191-21-017869 · doc4.xml · nonDerivative · entry 2 Liau Gene · CIK 0001780082 · EVP Research & Preclinical Dev 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 21,351 Read SEC document |
| December 28, 2020 Filed Mar 4, 2021 22:00 UTC |
Liau GeneEVP Research & Preclinical Dev
|
Exercise / conversionCommon Stock | 8,000 | $0.60 | $4,800.00 |
DisclosureSEC source: 0001209191-21-017869 · doc4.xml · nonDerivative · entry 1 Liau Gene · CIK 0001780082 · EVP Research & Preclinical Dev 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 21,500 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| December 21, 2020 Filed Dec 21, 2020 21:53 UTC |
Ticho BarryChief Medical Officer
|
Exercise / conversionEmployee Stock Option (Right to Buy) · Derivative | 1,365 | $0.00 Strike: $2.19 | $0.00 |
DisclosureSEC source: 0001209191-20-064663 · doc4.xml · derivative · entry 5 Ticho Barry · CIK 0001780088 · Chief Medical Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 84,400 Underlying: Common Stock · 1,365 shares Expires 2028-12-12 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F6 · derivative.exercise_date: The option vested as to 1/48th of the total shares on November 22, 2018, and then 1/48th of the total shares vest monthly thereafter, subject to the reporting person's continued service to the issuer through each vesting date. Read SEC document |
| December 21, 2020 Filed Dec 21, 2020 21:53 UTC |
Ticho BarryChief Medical Officer
|
SaleCommon Stock | 365 | $59.00 | $21,534.23 |
DisclosureSEC source: 0001209191-20-064663 · doc4.xml · nonDerivative · entry 4 Ticho Barry · CIK 0001780088 · Chief Medical Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 173,402 F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F5 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $58.86 to $59.05 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
| December 21, 2020 Filed Dec 21, 2020 21:53 UTC |
Ticho BarryChief Medical Officer
|
SaleCommon Stock | 286 | $58.02 | $16,592.89 |
DisclosureSEC source: 0001209191-20-064663 · doc4.xml · nonDerivative · entry 3 Ticho Barry · CIK 0001780088 · Chief Medical Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 173,767 F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F4 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $57.74 to $58.395 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
| December 21, 2020 Filed Dec 21, 2020 21:53 UTC |
Ticho BarryChief Medical Officer
|
SaleCommon Stock | 714 | $56.76 | $40,526.93 |
DisclosureSEC source: 0001209191-20-064663 · doc4.xml · nonDerivative · entry 2 Ticho Barry · CIK 0001780088 · Chief Medical Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 174,053 F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $56.66 to $57.37 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
| December 21, 2020 Filed Dec 21, 2020 21:53 UTC |
Ticho BarryChief Medical Officer
|
Exercise / conversionCommon Stock | 1,365 | $2.19 | $2,989.35 |
DisclosureSEC source: 0001209191-20-064663 · doc4.xml · nonDerivative · entry 1 Ticho Barry · CIK 0001780088 · Chief Medical Officer 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 174,767 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · balance_after: Includes 740 shares of Common Stock acquired under the issuer's employee stock purchase plan on June 30, 2020. Read SEC document |
| December 18, 2020 Filed Dec 19, 2020 02:08 UTC |
Nash Huw M.COO & CBO
|
Exercise / conversionEmployee Stock Option (Right to Buy) · Derivative | 8,015 | $0.00 Strike: $0.60 | $0.00 |
DisclosureSEC source: 0001209191-20-064582 · doc4.xml · derivative · entry 6 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 172,371 Underlying: Common Stock · 8,015 shares Expires 2028-04-02 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F2 · derivative.exercise_date: The option vested as to 1/48th of the total shares on February 28, 2018, and then 1/48th of the total shares vest at the end of each month thereafter, subject to the reporting person's continued service to the issuer through each vesting date. Read SEC document |
| December 18, 2020 Filed Dec 19, 2020 02:08 UTC |
Nash Huw M.COO & CBO
|
SaleCommon Stock | 8,015 | $60.00 | $480,900.00 |
DisclosureSEC source: 0001209191-20-064582 · doc4.xml · nonDerivative · entry 4 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 0 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. Read SEC document |
| December 18, 2020 Filed Dec 19, 2020 02:08 UTC |
Nash Huw M.COO & CBO
|
Exercise / conversionCommon Stock | 8,015 | $0.60 | $4,809.00 |
DisclosureSEC source: 0001209191-20-064582 · doc4.xml · nonDerivative · entry 3 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 8,015 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| December 18, 2020 Filed Dec 19, 2020 02:07 UTC |
Kaye Edward M. MDDirector · CEO
|
SaleCommon Stock | 5,194 | $60.00 | $311,640.00 |
DisclosureSEC source: 0001209191-20-064581 · doc4.xml · nonDerivative · entry 2 Kaye Edward M. MD · CIK 0001522780 · Director · CEO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 0 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. Read SEC document |
| December 17, 2020 Filed Dec 19, 2020 02:08 UTC |
Nash Huw M.COO & CBO
|
Exercise / conversionEmployee Stock Option (Right to Buy) · Derivative | 41,985 | $0.00 Strike: $0.60 | $0.00 |
DisclosureSEC source: 0001209191-20-064582 · doc4.xml · derivative · entry 5 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 180,386 Underlying: Common Stock · 41,985 shares Expires 2028-04-02 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F2 · derivative.exercise_date: The option vested as to 1/48th of the total shares on February 28, 2018, and then 1/48th of the total shares vest at the end of each month thereafter, subject to the reporting person's continued service to the issuer through each vesting date. Read SEC document |
| December 17, 2020 Filed Dec 19, 2020 02:08 UTC |
Nash Huw M.COO & CBO
|
SaleCommon Stock | 41,985 | $60.00 | $2,519,100.00 |
DisclosureSEC source: 0001209191-20-064582 · doc4.xml · nonDerivative · entry 2 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 0 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. Read SEC document |
| December 17, 2020 Filed Dec 19, 2020 02:08 UTC |
Nash Huw M.COO & CBO
|
Exercise / conversionCommon Stock | 41,985 | $0.60 | $25,191.00 |
DisclosureSEC source: 0001209191-20-064582 · doc4.xml · nonDerivative · entry 1 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 41,985 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| December 17, 2020 Filed Dec 19, 2020 02:07 UTC |
Kaye Edward M. MDDirector · CEO
|
SaleCommon Stock | 19,806 | $60.00 | $1,188,360.00 |
DisclosureSEC source: 0001209191-20-064581 · doc4.xml · nonDerivative · entry 1 Kaye Edward M. MD · CIK 0001522780 · Director · CEO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 5,194 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. Read SEC document |
| December 01, 2020 Filed Dec 3, 2020 23:00 UTC |
Nash Huw M.COO & CBO
|
Exercise / conversionEmployee Stock Option (Right to Buy) · Derivative | 5,700 | $0.00 Strike: $2.19 | $0.00 |
DisclosureSEC source: 0001209191-20-061591 · doc4.xml · derivative · entry 6 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 131,097 Underlying: Common Stock · 5,700 shares Expires 2018-12-12 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F5 · derivative.exercise_date: The option vested as to 1/48th of the total shares on November 22, 2018, and then 1/48th of the total shares vest monthly thereafter, subject to the reporting person's continued service to the issuer through each vesting date. Read SEC document |
| December 01, 2020 Filed Dec 3, 2020 23:00 UTC |
Nash Huw M.COO & CBO
|
SaleCommon Stock | 400 | $52.72 | $21,088.00 |
DisclosureSEC source: 0001209191-20-061591 · doc4.xml · nonDerivative · entry 5 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 0 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F4 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $52.63 to $52.99 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
| December 01, 2020 Filed Dec 3, 2020 23:00 UTC |
Nash Huw M.COO & CBO
|
SaleCommon Stock | 100 | $51.45 | $5,145.00 |
DisclosureSEC source: 0001209191-20-061591 · doc4.xml · nonDerivative · entry 4 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 400 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. Read SEC document |
| December 01, 2020 Filed Dec 3, 2020 23:00 UTC |
Nash Huw M.COO & CBO
|
SaleCommon Stock | 2,481 | $50.02 | $124,103.09 |
DisclosureSEC source: 0001209191-20-061591 · doc4.xml · nonDerivative · entry 3 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 500 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.78 to $50.41 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
| December 01, 2020 Filed Dec 3, 2020 23:00 UTC |
Nash Huw M.COO & CBO
|
SaleCommon Stock | 2,719 | $49.19 | $133,743.53 |
DisclosureSEC source: 0001209191-20-061591 · doc4.xml · nonDerivative · entry 2 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 2,981 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $48.74 to $49.69 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
| December 01, 2020 Filed Dec 3, 2020 23:00 UTC |
Nash Huw M.COO & CBO
|
Exercise / conversionCommon Stock | 5,700 | $2.19 | $12,483.00 |
DisclosureSEC source: 0001209191-20-061591 · doc4.xml · nonDerivative · entry 1 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 5,700 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| November 27, 2020 Filed Nov 30, 2020 22:11 UTC |
Kaye Edward M. MDDirector · CEO
|
SaleCommon Stock | 12,152 | $50.00 | $607,600.00 |
DisclosureSEC source: 0001209191-20-060751 · doc4.xml · nonDerivative · entry 1 Kaye Edward M. MD · CIK 0001522780 · Director · CEO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 25,000 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. Read SEC document |
| November 25, 2020 Filed Nov 25, 2020 22:16 UTC |
Kaye Edward M. MDDirector · CEO
|
SaleCommon Stock | 12,848 | $50.00 | $642,400.00 |
DisclosureSEC source: 0001209191-20-060558 · doc4.xml · nonDerivative · entry 1 Kaye Edward M. MD · CIK 0001522780 · Director · CEO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 37,152 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. Read SEC document |
| November 24, 2020 Filed Nov 25, 2020 22:03 UTC |
Harrison Seth LoringDirector · 10% owner
|
PurchaseCommon Stock | 375,000 | $39.00 | $14,625,000.00 |
DisclosureSEC source: 0001209191-20-060543 · doc4.xml · nonDerivative · entry 1 Harrison Seth Loring · CIK 0001404955 · Director · 10% owner 10b5-1 filing: Not disclosed Ownership: Indirect · By Apple Tree Partners IV, L.P. Disclosed balance after: 17,161,713 F1 · ownership.nature: Represents shares held by Apple Tree Partners IV, L.P. ("ATP IV"). ATP III GP, Ltd. ("ATP III") is the sole general partner of ATP IV. The reporting person is the sole director of ATP III and may be deemed to have sole voting and dispositive power over the shares held by ATP IV, but disclaims beneficial ownership of the shares except to the extent of his pecuniary interest therein. Read SEC document |
| November 24, 2020 Filed Nov 25, 2020 22:01 UTC |
ATP Life Science Ventures, L.P.10% owner
ATP III GP, Ltd.10% owner
|
PurchaseCommon Stock | 375,000 | $39.00 | $14,625,000.00 |
DisclosureSEC source: 0001209191-20-060542 · doc4.xml · nonDerivative · entry 1 Apple Tree Partners IV, L.P. · CIK 0001593440 · 10% owner ATP III GP, Ltd. · CIK 0001593453 · 10% owner Joint disclosure: these amounts are not allocated separately to each reporting owner. 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 17,161,713 F1 · ownership.direct: Represents shares held by Apple Tree Partners IV, L.P. ("ATP IV"). ATP III GP, Ltd. ("ATP III") is the sole general partner of ATP IV. Seth Harrison, a director of the issuer, is the sole director of ATP III and may be deemed to have sole voting and dispositive power over the shares held by ATP IV, but disclaims beneficial ownership of the shares except to the extent of his pecuniary interest therein. Read SEC document |
| November 23, 2020 Filed Nov 25, 2020 22:09 UTC |
TZIANABOS ARTHURDirector
|
Exercise / conversionDirector Stock Option (Right to Buy) · Derivative | 20,000 | $0.00 Strike: $2.19 | $0.00 |
DisclosureSEC source: 0001209191-20-060549 · doc4.xml · derivative · entry 6 TZIANABOS ARTHUR · CIK 0001586226 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,447 Underlying: Common Stock · 20,000 shares Expires 2028-12-12 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F6 · derivative.exercise_date: The option vested as to 1/48th of the total shares on October 4, 2018 and then 1/48th of the total shares vest monthly thereafter, subject to the reporting person's continued service to the issuer through each vesting date. Read SEC document |
| November 23, 2020 Filed Nov 25, 2020 22:09 UTC |
TZIANABOS ARTHURDirector
|
SaleCommon Stock | 210 | $47.61 | $9,997.87 |
DisclosureSEC source: 0001209191-20-060549 · doc4.xml · nonDerivative · entry 5 TZIANABOS ARTHUR · CIK 0001586226 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 0 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F5 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $47.47 to $47.71 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
| November 23, 2020 Filed Nov 25, 2020 22:09 UTC |
TZIANABOS ARTHURDirector
|
SaleCommon Stock | 5,294 | $46.85 | $248,009.08 |
DisclosureSEC source: 0001209191-20-060549 · doc4.xml · nonDerivative · entry 4 TZIANABOS ARTHUR · CIK 0001586226 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 210 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F4 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $46.42 to $47.35 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
| November 23, 2020 Filed Nov 25, 2020 22:09 UTC |
TZIANABOS ARTHURDirector
|
SaleCommon Stock | 10,196 | $45.97 | $468,720.32 |
DisclosureSEC source: 0001209191-20-060549 · doc4.xml · nonDerivative · entry 3 TZIANABOS ARTHUR · CIK 0001586226 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 5,504 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $45.42 to $46.41 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
| November 23, 2020 Filed Nov 25, 2020 22:09 UTC |
TZIANABOS ARTHURDirector
|
SaleCommon Stock | 4,300 | $45.08 | $193,838.41 |
DisclosureSEC source: 0001209191-20-060549 · doc4.xml · nonDerivative · entry 2 TZIANABOS ARTHUR · CIK 0001586226 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 15,700 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $44.41 to $45.40 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
| November 23, 2020 Filed Nov 25, 2020 22:09 UTC |
TZIANABOS ARTHURDirector
|
Exercise / conversionCommon Stock | 20,000 | $2.19 | $43,800.00 |
DisclosureSEC source: 0001209191-20-060549 · doc4.xml · nonDerivative · entry 1 TZIANABOS ARTHUR · CIK 0001586226 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 20,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| November 10, 2020 Filed Nov 10, 2020 22:42 UTC |
Nash Huw M.COO & CBO
|
Exercise / conversionEmployee Stock Option (Right to Buy) · Derivative | 13,414 | $0.00 Strike: $2.19 | $0.00 |
DisclosureSEC source: 0001209191-20-057717 · doc4.xml · derivative · entry 5 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 136,797 Underlying: Common Stock · 13,414 shares Expires 2028-12-12 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F3 · derivative.exercise_date: The option vested as to 1/48th of the total shares on November 22, 2018, and then 1/48th of the total shares vest monthly thereafter, subject to the reporting person's continued service to the issuer through each vesting date. Read SEC document |
| November 10, 2020 Filed Nov 10, 2020 22:42 UTC |
Nash Huw M.COO & CBO
|
Exercise / conversionEmployee Stock Option (Right to Buy) · Derivative | 36,586 | $0.00 Strike: $0.60 | $0.00 |
DisclosureSEC source: 0001209191-20-057717 · doc4.xml · derivative · entry 4 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 222,371 Underlying: Common Stock · 36,586 shares Expires 2028-04-02 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F2 · derivative.exercise_date: The option vested as to 1/48th of the total shares on February 28, 2018, and then 1/48th of the total shares vest at the end of each month thereafter, subject to the reporting person's continued service to the issuer through each vesting date. Read SEC document |
| November 10, 2020 Filed Nov 10, 2020 22:42 UTC |
Nash Huw M.COO & CBO
|
SaleCommon Stock | 50,000 | $45.00 | $2,250,000.00 |
DisclosureSEC source: 0001209191-20-057717 · doc4.xml · nonDerivative · entry 3 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 0 F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. Read SEC document |
| November 10, 2020 Filed Nov 10, 2020 22:42 UTC |
Nash Huw M.COO & CBO
|
Exercise / conversionCommon Stock | 13,414 | $2.19 | $29,376.66 |
DisclosureSEC source: 0001209191-20-057717 · doc4.xml · nonDerivative · entry 2 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 50,000 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| November 10, 2020 Filed Nov 10, 2020 22:42 UTC |
Nash Huw M.COO & CBO
|
Exercise / conversionCommon Stock | 36,586 | $0.60 | $21,951.60 |
DisclosureSEC source: 0001209191-20-057717 · doc4.xml · nonDerivative · entry 1 Nash Huw M. · CIK 0001780085 · COO & CBO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 36,586 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| November 04, 2020 Filed Nov 4, 2020 22:31 UTC | Exercise / conversionEmployee Stock Option (Right to Buy) · Derivative | 33,268 | $0.00 Strike: $4.48 | $0.00 |
DisclosureSEC source: 0001209191-20-056953 · doc4.xml · derivative · entry 13 Tulipano Stephen J · CIK 0001360548 · CFO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 209,997 Underlying: Common Stock · 33,268 shares Expires 2029-03-18 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F9 · derivative.exercise_date: The option vested as to 1/4th of the total shares on March 15, 2020, and then 1/48th of the total shares vest monthly thereafter, subject to the reporting person's continued service to the issuer through each vesting date. Read SEC document |
|
| November 04, 2020 Filed Nov 4, 2020 22:31 UTC | SaleCommon Stock | 5,216 | $41.97 | $218,909.78 |
DisclosureSEC source: 0001209191-20-056953 · doc4.xml · nonDerivative · entry 10 Tulipano Stephen J · CIK 0001360548 · CFO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 602 F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F8 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $41.81 to $42.19 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
|
| November 04, 2020 Filed Nov 4, 2020 22:31 UTC | SaleCommon Stock | 11,111 | $41.42 | $460,214.29 |
DisclosureSEC source: 0001209191-20-056953 · doc4.xml · nonDerivative · entry 9 Tulipano Stephen J · CIK 0001360548 · CFO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 5,818 F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F7 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.78 to $41.74 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
|
| November 04, 2020 Filed Nov 4, 2020 22:31 UTC | SaleCommon Stock | 16,941 | $40.03 | $678,085.55 |
DisclosureSEC source: 0001209191-20-056953 · doc4.xml · nonDerivative · entry 8 Tulipano Stephen J · CIK 0001360548 · CFO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 16,929 F2 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. F6 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $39.76 to $40.73 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Read SEC document |
|
| November 04, 2020 Filed Nov 4, 2020 22:31 UTC | Exercise / conversionCommon Stock | 33,268 | $4.48 | $149,040.64 |
DisclosureSEC source: 0001209191-20-056953 · doc4.xml · nonDerivative · entry 7 Tulipano Stephen J · CIK 0001360548 · CFO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 33,870 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
|
| November 03, 2020 Filed Nov 4, 2020 22:31 UTC | Exercise / conversionEmployee Stock Option (Right to Buy) · Derivative | 1,732 | $0.00 Strike: $4.48 | $0.00 |
DisclosureSEC source: 0001209191-20-056953 · doc4.xml · derivative · entry 12 Tulipano Stephen J · CIK 0001360548 · CFO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 243,265 Underlying: Common Stock · 1,732 shares Expires 2029-03-18 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F9 · derivative.exercise_date: The option vested as to 1/4th of the total shares on March 15, 2020, and then 1/48th of the total shares vest monthly thereafter, subject to the reporting person's continued service to the issuer through each vesting date. Read SEC document |
Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.