STOK

SEC source: 0001966716-26-000014 · form4-10022026_091025.xml · nonDerivative · entry 1

Allan Jonathan · CIK 0001966716 · GENERAL COUNSEL & CORP SEC

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,598

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 10, 2025.

SEC source: 0001780088-26-000023 · form4-10022026_091051.xml · nonDerivative · entry 1

Ticho Barry · CIK 0001780088 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,059

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 19, 2025.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.91 to $26.51 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001685994-26-000009 · form4-09252026_080935.xml · derivative · entry 1

Cumbo Alexander · CIK 0001685994 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,674

Underlying: Common Stock · 39,674 shares

Expires 2036-09-22

F1 · derivative.exercise_date: The option award shall vest as to 1/12th of the total award quarterly on the 23rd calendar day of each December, March, June, and September, with the first tranche vesting on December 23, 2026, subject to the reporting person's continued service to the Issuer through each vesting date.

SEC source: 0001780088-26-000021 · form4-09032026_080910.xml · nonDerivative · entry 2

Ticho Barry · CIK 0001780088 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,110

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 19, 2025.

F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.96 to $31.20 per share, inclusive.

SEC source: 0001780088-26-000021 · form4-09032026_080910.xml · nonDerivative · entry 1

Ticho Barry · CIK 0001780088 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,710

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 19, 2025.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $29.94 to $30.92 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 3 of this Form 4.

SEC source: 0001780088-26-000019 · form4-08192026_120845.xml · nonDerivative · entry 3

Ticho Barry · CIK 0001780088 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,655

F1 · kind: The reported transaction represents an Issuer mandated sale to satisfy tax withholding liabilities in connection with the vesting and settlement of restricted stock units.

F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.44 to $32.54 per share, inclusive.

SEC source: 0001780088-26-000019 · form4-08192026_120845.xml · nonDerivative · entry 2

Ticho Barry · CIK 0001780088 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,897

F1 · kind: The reported transaction represents an Issuer mandated sale to satisfy tax withholding liabilities in connection with the vesting and settlement of restricted stock units.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $31.40 to $32.36 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 3 of this Form 4.

SEC source: 0001522780-26-000007 · form4-08192026_120851.xml · nonDerivative · entry 3

Kaye Edward M. MD · CIK 0001522780 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 124,557

F1 · kind: The reported transaction represents an Issuer mandated sale to satisfy tax withholding liabilities in connection with the vesting and settlement of restricted stock units.

F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.44 to $32.54 per share, inclusive.

SEC source: 0001522780-26-000007 · form4-08192026_120851.xml · nonDerivative · entry 2

Kaye Edward M. MD · CIK 0001522780 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,194

F1 · kind: The reported transaction represents an Issuer mandated sale to satisfy tax withholding liabilities in connection with the vesting and settlement of restricted stock units.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $31.40 to $32.36 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 3 of this Form 4.

SEC source: 0001966716-26-000012 · form4-08192026_120818.xml · nonDerivative · entry 3

Allan Jonathan · CIK 0001966716 · GENERAL COUNSEL & CORP SEC

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,225

F1 · kind: The reported transaction represents an Issuer mandated sale to satisfy tax withholding liabilities in connection with the vesting and settlement of restricted stock units.

F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.44 to $32.54 per share, inclusive.

SEC source: 0001966716-26-000012 · form4-08192026_120818.xml · nonDerivative · entry 2

Allan Jonathan · CIK 0001966716 · GENERAL COUNSEL & CORP SEC

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,370

F1 · kind: The reported transaction represents an Issuer mandated sale to satisfy tax withholding liabilities in connection with the vesting and settlement of restricted stock units.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $31.40 to $32.36 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 3 of this Form 4.

SEC source: 0001780088-26-000019 · form4-08192026_120845.xml · derivative · entry 4

Ticho Barry · CIK 0001780088 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,000 shares

Expires 2026-08-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each performance stock unit represents a right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: Achievement of this performance stock unit award was certified on August 14, 2025. Pursuant to the terms of the award agreement between the reporting person and the Issuer, half the award vested on August 14, 2025 and the remainder vests on August 14, 2026, subject to the reporting person's continued service to the Issuer on the relevant vesting date.

SEC source: 0001780088-26-000019 · form4-08192026_120845.xml · nonDerivative · entry 1

Ticho Barry · CIK 0001780088 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,422

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001522780-26-000007 · form4-08192026_120851.xml · derivative · entry 4

Kaye Edward M. MD · CIK 0001522780 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 26,250 shares

Expires 2026-08-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each performance stock unit represents a right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: Achievement of this performance stock unit award was certified on August 14, 2025. Pursuant to the terms of the award agreement between the reporting person and the Issuer, half the award vested on August 14, 2025 and the remainder vests on August 14, 2026, subject to the reporting person's continued service to the Issuer on the relevant vesting date.

SEC source: 0001522780-26-000007 · form4-08192026_120851.xml · nonDerivative · entry 1

Kaye Edward M. MD · CIK 0001522780 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 137,124

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001966716-26-000012 · form4-08192026_120818.xml · derivative · entry 4

Allan Jonathan · CIK 0001966716 · GENERAL COUNSEL & CORP SEC

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 6,000 shares

Expires 2026-08-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: Each performance stock unit represents a right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: Achievement of this performance stock unit award was certified on August 14, 2025. Pursuant to the terms of the award agreement between the reporting person and the Issuer, half the award vested on August 14, 2025 and the remainder vests on August 14, 2026, subject to the reporting person's continued service to the Issuer on the relevant vesting date.

SEC source: 0001966716-26-000012 · form4-08192026_120818.xml · nonDerivative · entry 1

Allan Jonathan · CIK 0001966716 · GENERAL COUNSEL & CORP SEC

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,086

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001780088-26-000017 · form4-08052026_080835.xml · nonDerivative · entry 2

Ticho Barry · CIK 0001780088 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,422

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 19, 2025.

F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $29.36 to $29.54 per share, inclusive.

SEC source: 0001780088-26-000017 · form4-08052026_080835.xml · nonDerivative · entry 1

Ticho Barry · CIK 0001780088 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,691

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 19, 2025.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $28.36 to $29.35 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 3 of this Form 4.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 16

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 17,786

Underlying: Common Stock · 17,786 shares

Expires 2036-06-02

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F10 · derivative.exercise_date: The option shall vest in full on the earlier of: (i) June 3, 2027 or (ii) the date of the Issuer's next annual meeting of its stockholders, subject to the reporting person's continued service to the Issuer on the vesting date.

F3 · ownership.nature: The securities are directly held by the East Pillar 2026 Irrevocable Trust (the "Trust"). The reporting person is a member of the board of managers of the Trust's trustee and may be deemed to exercise voting discretion, as well as shared investment discretion, in such capacity. The reporting person and certain of his immediate family members are beneficiaries of the Trust.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 15

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 17,786 shares

Expires 2036-06-02

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F10 · derivative.exercise_date: The option shall vest in full on the earlier of: (i) June 3, 2027 or (ii) the date of the Issuer's next annual meeting of its stockholders, subject to the reporting person's continued service to the Issuer on the vesting date.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 14

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 29,747

Underlying: Common Stock · 29,747 shares

Expires 2035-06-02

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F9 · derivative.exercise_date: This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 3, 2026.

F3 · ownership.nature: The securities are directly held by the East Pillar 2026 Irrevocable Trust (the "Trust"). The reporting person is a member of the board of managers of the Trust's trustee and may be deemed to exercise voting discretion, as well as shared investment discretion, in such capacity. The reporting person and certain of his immediate family members are beneficiaries of the Trust.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 13

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 29,747 shares

Expires 2035-06-02

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F9 · derivative.exercise_date: This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 3, 2026.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 12

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 7,639

Underlying: Common Stock · 7,639 shares

Expires 2034-06-04

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F8 · derivative.exercise_date: This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 3, 2025.

F3 · ownership.nature: The securities are directly held by the East Pillar 2026 Irrevocable Trust (the "Trust"). The reporting person is a member of the board of managers of the Trust's trustee and may be deemed to exercise voting discretion, as well as shared investment discretion, in such capacity. The reporting person and certain of his immediate family members are beneficiaries of the Trust.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 11

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,639 shares

Expires 2034-06-04

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F8 · derivative.exercise_date: This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 3, 2025.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 10

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 19,441

Underlying: Common Stock · 19,441 shares

Expires 2033-06-12

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F7 · derivative.exercise_date: This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 13, 2024.

F3 · ownership.nature: The securities are directly held by the East Pillar 2026 Irrevocable Trust (the "Trust"). The reporting person is a member of the board of managers of the Trust's trustee and may be deemed to exercise voting discretion, as well as shared investment discretion, in such capacity. The reporting person and certain of his immediate family members are beneficiaries of the Trust.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 9

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 19,441 shares

Expires 2033-06-12

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F7 · derivative.exercise_date: This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 13, 2024.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 8

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 21,000

Underlying: Common Stock · 21,000 shares

Expires 2032-06-06

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F6 · derivative.exercise_date: This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 7, 2023.

F3 · ownership.nature: The securities are directly held by the East Pillar 2026 Irrevocable Trust (the "Trust"). The reporting person is a member of the board of managers of the Trust's trustee and may be deemed to exercise voting discretion, as well as shared investment discretion, in such capacity. The reporting person and certain of his immediate family members are beneficiaries of the Trust.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 7

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 21,000 shares

Expires 2032-06-06

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F6 · derivative.exercise_date: This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 7, 2023.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 6

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 11,650

Underlying: Common Stock · 11,650 shares

Expires 2031-06-07

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F5 · derivative.exercise_date: This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 8, 2022.

F3 · ownership.nature: The securities are directly held by the East Pillar 2026 Irrevocable Trust (the "Trust"). The reporting person is a member of the board of managers of the Trust's trustee and may be deemed to exercise voting discretion, as well as shared investment discretion, in such capacity. The reporting person and certain of his immediate family members are beneficiaries of the Trust.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 5

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 11,650 shares

Expires 2031-06-07

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F5 · derivative.exercise_date: This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 8, 2022.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 4

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 14,777

Underlying: Common Stock · 14,777 shares

Expires 2030-06-02

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F4 · derivative.exercise_date: This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 3, 2021.

F3 · ownership.nature: The securities are directly held by the East Pillar 2026 Irrevocable Trust (the "Trust"). The reporting person is a member of the board of managers of the Trust's trustee and may be deemed to exercise voting discretion, as well as shared investment discretion, in such capacity. The reporting person and certain of his immediate family members are beneficiaries of the Trust.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 3

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 14,777 shares

Expires 2030-06-02

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F4 · derivative.exercise_date: This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 3, 2021.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 2

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 29,555

Underlying: Common Stock · 29,555 shares

Expires 2029-09-09

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F2 · derivative.exercise_date: This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on March 21, 2022.

F3 · ownership.nature: The securities are directly held by the East Pillar 2026 Irrevocable Trust (the "Trust"). The reporting person is a member of the board of managers of the Trust's trustee and may be deemed to exercise voting discretion, as well as shared investment discretion, in such capacity. The reporting person and certain of his immediate family members are beneficiaries of the Trust.

SEC source: 0001404955-26-000006 · form4-07172026_080716.xml · derivative · entry 1

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 29,555 shares

Expires 2029-09-09

F1 · kind: The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

F2 · derivative.exercise_date: This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on March 21, 2022.

SEC source: 0001858760-26-000008 · form4-07172026_080754.xml · derivative · entry 1

McCauley Thomas · CIK 0001858760 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 225,000

Underlying: Common Stock · 225,000 shares

Expires 2036-07-14

F1 · derivative.exercise_date: The stock option vests as to 1/4 of the total award on July 15, 2027, and as to 1/48 of the total award monthly thereafter, subject to the reporting person's continued service to the Issuer on each vesting date.

SEC source: 0001780088-26-000015 · form4-07062026_080747.xml · nonDerivative · entry 2

Ticho Barry · CIK 0001780088 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 27,598

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 19, 2025.

F3 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.23 to $33.37 per share, inclusive.

SEC source: 0001780088-26-000015 · form4-07062026_080747.xml · nonDerivative · entry 1

Ticho Barry · CIK 0001780088 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,098

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 19, 2025.

F2 · price: The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.18 to $33.05 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 3 of this Form 4.

SEC source: 0001966716-26-000010 · form4-06182026_080652.xml · nonDerivative · entry 1

Allan Jonathan · CIK 0001966716 · GENERAL COUNSEL & CORP SEC

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,086

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 10, 2025.

SEC source: 0001780081-26-000006 · form4-06052026_080620.xml · derivative · entry 1

Krainer Adrian R. · CIK 0001780081 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,786

Underlying: Common Stock · 17,786 shares

Expires 2036-06-02

F1 · derivative.exercise_date: The option shall vest in full on the earlier of: (i) June 3, 2027 or (ii) the date of the issuer's next annual meeting of its stockholders, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001181556-26-000007 · form4-06052026_080631.xml · derivative · entry 1

LEVIN ARTHUR A · CIK 0001181556 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,786

Underlying: Common Stock · 17,786 shares

Expires 2036-06-02

F1 · derivative.exercise_date: The option shall vest in full on the earlier of: (i) June 3, 2027 or (ii) the date of the issuer's next annual meeting of its stockholders, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001586226-26-000004 · form4-06052026_080612.xml · derivative · entry 1

TZIANABOS ARTHUR · CIK 0001586226 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,786

Underlying: Common Stock · 17,786 shares

Expires 2036-06-02

F1 · derivative.exercise_date: The option shall vest in full on the earlier of: (i) June 3, 2027 or (ii) the date of the issuer's next annual meeting of its stockholders, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001522780-26-000004 · form4-06052026_080652.xml · derivative · entry 1

Kaye Edward M. MD · CIK 0001522780 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,786

Underlying: Common Stock · 17,786 shares

Expires 2036-06-02

F1 · derivative.exercise_date: The option shall vest in full on the earlier of: (i) June 3, 2027 or (ii) the date of the issuer's next annual meeting of its stockholders, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001557928-26-000002 · form4-06052026_080637.xml · derivative · entry 1

Smith Julie · CIK 0001557928 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,786

Underlying: Common Stock · 17,786 shares

Expires 2036-06-02

F1 · derivative.exercise_date: The option shall vest in full on the earlier of: (i) June 3, 2027 or (ii) the date of the issuer's next annual meeting of its stockholders, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001404955-26-000002 · form4-06052026_080609.xml · derivative · entry 1

Harrison Seth Loring · CIK 0001404955 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,786

Underlying: Common Stock · 17,786 shares

Expires 2036-06-02

F1 · derivative.exercise_date: The option shall vest in full on the earlier of: (i) June 3, 2027 or (ii) the date of the issuer's next annual meeting of its stockholders, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001640069-26-000002 · form4-06052026_080621.xml · derivative · entry 1

Burstein Jennifer · CIK 0001640069 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,786

Underlying: Common Stock · 17,786 shares

Expires 2036-06-02

F1 · derivative.exercise_date: The option shall vest in full on the earlier of: (i) June 3, 2027 or (ii) the date of the issuer's next annual meeting of its stockholders, subject to the reporting person's continued service to the issuer on the vesting date.

SEC source: 0001780088-26-000013 · form4-06032026_090641.xml · nonDerivative · entry 1

Ticho Barry · CIK 0001780088 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 34,826

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 19, 2025.

SEC source: 0001780088-26-000011 · form4-05052026_080522.xml · nonDerivative · entry 1

Ticho Barry · CIK 0001780088 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 36,621

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 19, 2025.

SEC source: 0001849236-26-000004 · form4-04072026_110410.xml · derivative · entry 1

Kahn Clare · CIK 0001849236 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,782

Underlying: Common Stock · 30,782 shares

Expires 2036-04-02

F1 · derivative.exercise_date: The option award shall vest as to 1/12 of the total award quarterly on the first calendar day of each July, October, January, and April, with the first tranche vesting on July 1, 2026, subject to the reporting person's continued service to the Issuer through each vesting date.

SEC source: 0001780088-26-000009 · form4-04032026_080432.xml · nonDerivative · entry 1

Ticho Barry · CIK 0001780088 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 38,864

F1 · kind: This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 19, 2025.