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Nasdaq · USD

SLN

Silence Therapeutics plc

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Tapewire entity
5028
SEC CIK
0001479615
Parsed reports
52

Last 12 months

Inside the activity.

0 purchase rows · 0 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202500
Dec 202500
Jan 202600
Feb 202600
Mar 202600
Apr 202600
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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
May 26, 2025 Filed May 29, 2025 15:21 UTC PurchaseAmerican Depositary Shares · Derivative 26,669 Not disclosed Strike: $4.91 Not disclosed
Disclosure

SEC source: 0001104659-25-054045 · tm2516482-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,262,906

Underlying: Ordinary Shares · 80,007 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
May 23, 2025 Filed May 27, 2025 12:35 UTC PurchaseAmerican Depositary Shares · Derivative 17,187 Not disclosed Strike: $4.92 Not disclosed
Disclosure

SEC source: 0001104659-25-052749 · tm2516192-1_4seq1.xml · derivative · entry 2

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,236,237

Underlying: Ordinary Shares · 51,561 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
May 22, 2025 Filed May 27, 2025 12:35 UTC PurchaseAmerican Depositary Shares · Derivative 19,174 Not disclosed Strike: $5.04 Not disclosed
Disclosure

SEC source: 0001104659-25-052749 · tm2516192-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,219,050

Underlying: Ordinary Shares · 57,522 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
May 20, 2025 Filed May 21, 2025 10:49 UTC PurchaseAmerican Depositary Shares · Derivative 16,000 Not disclosed Strike: $4.07 Not disclosed
Disclosure

SEC source: 0001104659-25-051284 · tm2515795-1_4seq1.xml · derivative · entry 3

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,199,876

Underlying: Ordinary Shares · 48,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
May 19, 2025 Filed May 21, 2025 10:49 UTC PurchaseAmerican Depositary Shares · Derivative 26,000 Not disclosed Strike: $4.07 Not disclosed
Disclosure

SEC source: 0001104659-25-051284 · tm2515795-1_4seq1.xml · derivative · entry 2

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,183,876

Underlying: Ordinary Shares · 78,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
May 18, 2025 Filed May 21, 2025 10:49 UTC PurchaseAmerican Depositary Shares · Derivative 37,023 Not disclosed Strike: $4.01 Not disclosed
Disclosure

SEC source: 0001104659-25-051284 · tm2515795-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,157,876

Underlying: Ordinary Shares · 111,069 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
May 14, 2025 Filed May 15, 2025 20:51 UTC PurchaseAmerican Depositary Shares · Derivative 55,766 Not disclosed Strike: $4.07 Not disclosed
Disclosure

SEC source: 0001104659-25-049572 · tm2515252-1_4seq1.xml · derivative · entry 2

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,120,853

Underlying: Ordinary Shares · 167,298 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
May 13, 2025 Filed May 15, 2025 20:51 UTC PurchaseAmerican Depositary Shares · Derivative 94,234 Not disclosed Strike: $4.01 Not disclosed
Disclosure

SEC source: 0001104659-25-049572 · tm2515252-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,065,087

Underlying: Ordinary Shares · 282,702 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
May 07, 2025 Filed May 8, 2025 11:08 UTC PurchaseAmerican Depositary Shares · Derivative 50,000 Not disclosed Strike: $3.81 Not disclosed
Disclosure

SEC source: 0001104659-25-045874 · tm2514463-1_4seq1.xml · derivative · entry 3

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,970,853

Underlying: Ordinary Shares · 150,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
May 06, 2025 Filed May 8, 2025 11:08 UTC PurchaseAmerican Depositary Shares · Derivative 100,000 Not disclosed Strike: $3.96 Not disclosed
Disclosure

SEC source: 0001104659-25-045874 · tm2514463-1_4seq1.xml · derivative · entry 2

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,920,850

Underlying: Ordinary Shares · 300,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
May 05, 2025 Filed May 8, 2025 11:08 UTC PurchaseAmerican Depositary Shares · Derivative 100,000 Not disclosed Strike: $3.94 Not disclosed
Disclosure

SEC source: 0001104659-25-045874 · tm2514463-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,820,853

Underlying: Ordinary Shares · 300,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
May 05, 2025 Filed May 20, 2025 20:14 UTC GrantShare Option (Right to Buy) · Derivative 48,000 $0.00 Strike: $1.30 $0.00
Disclosure

SEC source: 0001415889-25-013796 · form4-05202025_080507.xml · derivative · entry 1

MCINERNEY TIMOTHY · CIK 0001226020 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,000

Underlying: Ordinary Shares · 48,000 shares

Expires 2035-05-05

F1 · derivative.exercise_date: This option shall vest in equal monthly installments over a three-year period measured from one month following May 5, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date.

Read SEC document
May 01, 2025 Filed May 2, 2025 14:28 UTC PurchaseAmerican Depositary Shares · Derivative 75,266 Not disclosed Strike: $3.97 Not disclosed
Disclosure

SEC source: 0001104659-25-043878 · tm2513902-1_4seq1.xml · derivative · entry 2

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,720,853

Underlying: Ordinary Shares · 225,798 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
April 30, 2025 Filed May 2, 2025 14:28 UTC PurchaseAmerican Depositary Shares · Derivative 34,309 Not disclosed Strike: $3.66 Not disclosed
Disclosure

SEC source: 0001104659-25-043878 · tm2513902-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,645,587

Underlying: Ordinary Shares · 102,927 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
April 29, 2025 Filed Apr 30, 2025 11:13 UTC PurchaseAmerican Depositary Shares · Derivative 54,768 Not disclosed Strike: $3.49 Not disclosed
Disclosure

SEC source: 0001104659-25-041787 · tm2513649-1_4seq1.xml · derivative · entry 2

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,611,278

Underlying: Ordinary Shares · 164,304 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
April 28, 2025 Filed Apr 30, 2025 11:13 UTC PurchaseAmerican Depositary Shares · Derivative 95,211 Not disclosed Strike: $3.43 Not disclosed
Disclosure

SEC source: 0001104659-25-041787 · tm2513649-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,556,510

Underlying: Ordinary Shares · 285,633 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
April 25, 2025 Filed Apr 28, 2025 10:50 UTC PurchaseAmerican Depositary Shares · Derivative 59,568 Not disclosed Strike: $3.54 Not disclosed
Disclosure

SEC source: 0001104659-25-039744 · tm2513337-1_4seq1.xml · derivative · entry 2

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,461,299

Underlying: Ordinary Shares · 178,704 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
April 24, 2025 Filed Apr 28, 2025 10:50 UTC PurchaseAmerican Depositary Shares · Derivative 90,432 Not disclosed Strike: $3.42 Not disclosed
Disclosure

SEC source: 0001104659-25-039744 · tm2513337-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,401,731

Underlying: Ordinary Shares · 271,296 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
April 23, 2025 Filed Apr 24, 2025 11:16 UTC PurchaseAmerican Depositary Shares · Derivative 50,000 Not disclosed Strike: $3.18 Not disclosed
Disclosure

SEC source: 0001104659-25-038340 · tm2513097-1_4seq1.xml · derivative · entry 2

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,311,299

Underlying: Ordinary Shares · 150,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
April 22, 2025 Filed Apr 24, 2025 11:16 UTC PurchaseAmerican Depositary Shares · Derivative 50,000 Not disclosed Strike: $3.10 Not disclosed
Disclosure

SEC source: 0001104659-25-038340 · tm2513097-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,261,299

Underlying: Ordinary Shares · 150,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
April 21, 2025 Filed Apr 22, 2025 14:35 UTC PurchaseAmerican Depositary Shares · Derivative 100,000 Not disclosed Strike: $3.12 Not disclosed
Disclosure

SEC source: 0001104659-25-037215 · tm2512870-1_4seq1.xml · derivative · entry 2

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,211,299

Underlying: Ordinary Shares · 300,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
April 17, 2025 Filed Apr 22, 2025 14:35 UTC PurchaseAmerican Depositary Shares · Derivative 50,000 Not disclosed Strike: $3.14 Not disclosed
Disclosure

SEC source: 0001104659-25-037215 · tm2512870-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,111,299

Underlying: Ordinary Shares · 150,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
April 15, 2025 Filed Apr 15, 2025 18:17 UTC PurchaseAmerican Depositary Shares · Derivative 27,918 Not disclosed Strike: $2.78 Not disclosed
Disclosure

SEC source: 0001104659-25-035039 · tm2512383-1_4seq1.xml · derivative · entry 5

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,061,299

Underlying: Ordinary Shares · 83,754 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
April 14, 2025 Filed Apr 15, 2025 18:17 UTC PurchaseAmerican Depositary Shares · Derivative 50,000 Not disclosed Strike: $2.65 Not disclosed
Disclosure

SEC source: 0001104659-25-035039 · tm2512383-1_4seq1.xml · derivative · entry 4

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,033,381

Underlying: Ordinary Shares · 150,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
April 14, 2025 Filed Apr 15, 2025 18:17 UTC PurchaseAmerican Depositary Shares · Derivative 40,409 Not disclosed Strike: $2.71 Not disclosed
Disclosure

SEC source: 0001104659-25-035039 · tm2512383-1_4seq1.xml · derivative · entry 3

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,983,381

Underlying: Ordinary Shares · 121,227 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
April 11, 2025 Filed Apr 15, 2025 18:17 UTC PurchaseAmerican Depositary Shares · Derivative 56,480 Not disclosed Strike: $2.33 Not disclosed
Disclosure

SEC source: 0001104659-25-035039 · tm2512383-1_4seq1.xml · derivative · entry 2

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,942,972

Underlying: Ordinary Shares · 169,440 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
April 10, 2025 Filed Apr 15, 2025 18:17 UTC PurchaseAmerican Depositary Shares · Derivative 25,193 Not disclosed Strike: $2.14 Not disclosed
Disclosure

SEC source: 0001104659-25-035039 · tm2512383-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,886,492

Underlying: Ordinary Shares · 75,579 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
March 31, 2025 Filed Mar 31, 2025 14:47 UTC PurchaseAmerican Depositary Shares · Derivative 100,000 Not disclosed Strike: $3.46 Not disclosed
Disclosure

SEC source: 0001104659-25-029715 · tm2510904-1_4seq1.xml · derivative · entry 3

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Cream Capital Limited

Disclosed balance after: 9,761,299

Underlying: Ordinary Shares · 300,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F2 · ownership.nature: The securities transactions listed were made by Cream Capital Limited ("Cream"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Read SEC document
March 31, 2025 Filed Apr 1, 2025 11:50 UTC PurchaseAmerican Depositary Shares · Derivative 100,000 Not disclosed Strike: $2.83 Not disclosed
Disclosure

SEC source: 0001104659-25-030241 · tm2511054-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Cream Capital Limited

Disclosed balance after: 9,861,299

Underlying: Ordinary Shares · 300,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F2 · ownership.nature: The securities transactions listed were made by Cream Capital Limited ("Cream"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Read SEC document
March 28, 2025 Filed Mar 31, 2025 14:47 UTC PurchaseAmerican Depositary Shares · Derivative 50,000 Not disclosed Strike: $3.58 Not disclosed
Disclosure

SEC source: 0001104659-25-029715 · tm2510904-1_4seq1.xml · derivative · entry 2

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Cream Capital Limited

Disclosed balance after: 9,661,299

Underlying: Ordinary Shares · 150,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F2 · ownership.nature: The securities transactions listed were made by Cream Capital Limited ("Cream"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

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March 27, 2025 Filed Mar 31, 2025 14:47 UTC PurchaseAmerican Depositary Shares · Derivative 50,000 Not disclosed Strike: $3.32 Not disclosed
Disclosure

SEC source: 0001104659-25-029715 · tm2510904-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Cream Capital Limited

Disclosed balance after: 9,611,299

Underlying: Ordinary Shares · 150,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F2 · ownership.nature: The securities transactions listed were made by Cream Capital Limited ("Cream"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

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March 05, 2025 Filed Mar 6, 2025 16:03 UTC PurchaseAmerican Depositary Shares · Derivative 22,632 Not disclosed Strike: $4.50 Not disclosed
Disclosure

SEC source: 0001104659-25-021245 · tm258471-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Cream Capital Limited

Disclosed balance after: 9,561,299

Underlying: Ordinary Shares · 67,896 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F2 · ownership.nature: The securities are held by Cream Capital Limited ("Cream"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

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February 18, 2025 Filed Feb 25, 2025 15:59 UTC PurchaseAmerican Depositary Shares · Derivative 60,000 Not disclosed Strike: $4.85 Not disclosed
Disclosure

SEC source: 0001104659-25-016802 · tm257556-1_4seq1.xml · derivative · entry 8

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,538,667

Underlying: Ordinary Shares · 180,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

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February 13, 2025 Filed Feb 25, 2025 15:59 UTC PurchaseAmerican Depositary Shares · Derivative 60,000 Not disclosed Strike: $4.17 Not disclosed
Disclosure

SEC source: 0001104659-25-016802 · tm257556-1_4seq1.xml · derivative · entry 7

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,478,667

Underlying: Ordinary Shares · 180,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

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February 13, 2025 Filed Feb 25, 2025 15:59 UTC PurchaseAmerican Depositary Shares · Derivative 92,774 Not disclosed Strike: $4.29 Not disclosed
Disclosure

SEC source: 0001104659-25-016802 · tm257556-1_4seq1.xml · derivative · entry 6

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Cream Capital Limited

Disclosed balance after: 9,418,667

Underlying: Ordinary Shares · 278,322 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F2 · ownership.nature: The securities are held by Cream Capital Limited ("Cream"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

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January 23, 2025 Filed Feb 25, 2025 15:59 UTC PurchaseAmerican Depositary Shares · Derivative 12,226 Not disclosed Strike: $5.35 Not disclosed
Disclosure

SEC source: 0001104659-25-016802 · tm257556-1_4seq1.xml · derivative · entry 5

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Cream Capital Limited

Disclosed balance after: 9,325,893

Underlying: Ordinary Shares · 36,678 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F2 · ownership.nature: The securities are held by Cream Capital Limited ("Cream"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

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January 21, 2025 Filed Feb 25, 2025 15:59 UTC PurchaseAmerican Depositary Shares · Derivative 20,000 Not disclosed Strike: $5.48 Not disclosed
Disclosure

SEC source: 0001104659-25-016802 · tm257556-1_4seq1.xml · derivative · entry 4

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Cream Capital Limited

Disclosed balance after: 9,313,667

Underlying: Ordinary Shares · 60,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F2 · ownership.nature: The securities are held by Cream Capital Limited ("Cream"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

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January 21, 2025 Filed Feb 25, 2025 15:59 UTC PurchaseAmerican Depositary Shares · Derivative 25,000 Not disclosed Strike: $5.20 Not disclosed
Disclosure

SEC source: 0001104659-25-016802 · tm257556-1_4seq1.xml · derivative · entry 3

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Cream Capital Limited

Disclosed balance after: 9,293,667

Underlying: Ordinary Shares · 75,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F2 · ownership.nature: The securities are held by Cream Capital Limited ("Cream"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

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January 17, 2025 Filed Feb 25, 2025 15:59 UTC PurchaseAmerican Depositary Shares · Derivative 150,000 Not disclosed Strike: $5.35 Not disclosed
Disclosure

SEC source: 0001104659-25-016802 · tm257556-1_4seq1.xml · derivative · entry 2

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Cream Capital Limited

Disclosed balance after: 9,268,667

Underlying: Ordinary Shares · 450,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F2 · ownership.nature: The securities are held by Cream Capital Limited ("Cream"). Mr Griffiths is a director and the controlling shareholder of Cream. Mr Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

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January 08, 2025 Filed Feb 25, 2025 15:59 UTC PurchaseAmerican Depositary Shares · Derivative 30,000 Not disclosed Strike: $6.48 Not disclosed
Disclosure

SEC source: 0001104659-25-016802 · tm257556-1_4seq1.xml · derivative · entry 1

Griffiths Richard Ian · CIK 0001846370 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,118,667

Underlying: Ordinary Shares · 90,000 shares

Expires not disclosed

F1 · price: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.exercise_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

F1 · derivative.expiration_date: Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

Read SEC document
January 02, 2025 Filed Jan 6, 2025 16:15 UTC GrantShare Option (Right to Buy) · Derivative 48,000 $0.00 Strike: $2.40 $0.00
Disclosure

SEC source: 0001415889-25-000748 · form4-01062025_040113.xml · derivative · entry 1

Ede-Golightly James · CIK 0002048873 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,000

Underlying: Ordinary Shares · 48,000 shares

Expires 2035-01-02

F1 · derivative.exercise_date: This option shall vest in equal monthly installments over a three-year period measured from one month following January 2, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date.

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January 02, 2025 Filed Jan 6, 2025 21:15 UTC GrantShare Option (Right to Buy) · Derivative 48,000 $0.00 Strike: $2.40 $0.00
Disclosure

SEC source: 0001415889-25-000749 · form4-01062025_040115.xml · derivative · entry 1

Davidson Michael H. · CIK 0001573785 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,000

Underlying: Ordinary Shares · 48,000 shares

Expires 2035-01-02

F1 · derivative.exercise_date: This option shall vest in equal monthly installments over a three-year period measured from one month following January 2, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date.

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January 02, 2025 Filed Jan 6, 2025 21:15 UTC
Ross IainDirector
GrantShare Option (Right to Buy) · Derivative 90,000 $0.00 Strike: $2.40 $0.00
Disclosure

SEC source: 0001415889-25-000747 · form4-01062025_040111.xml · derivative · entry 1

Ross Iain · CIK 0001307218 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 90,000

Underlying: Ordinary Shares · 90,000 shares

Expires 2035-01-02

F1 · derivative.exercise_date: This option shall vest in equal monthly installments over a three-year period measured from one month following January 2, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date.

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January 02, 2025 Filed Jan 6, 2025 21:15 UTC
Lemus DavidDirector
GrantShare Option (Right to Buy) · Derivative 48,000 $0.00 Strike: $2.40 $0.00
Disclosure

SEC source: 0001415889-25-000746 · form4-01062025_040109.xml · derivative · entry 1

Lemus David · CIK 0001717972 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,000

Underlying: Ordinary Shares · 48,000 shares

Expires 2035-01-02

F1 · derivative.exercise_date: This option shall vest in equal monthly installments over a three-year period measured from one month following January 2, 2025, subject to the Reporting Person's continuous service as of each applicable vesting date.

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January 02, 2025 Filed Jan 6, 2025 21:15 UTC
Romano Steven J.EVP and Chief R&D Officer
GrantEmployee Share Option (Right to Buy) · Derivative 285,000 $0.00 Strike: $2.40 $0.00
Disclosure

SEC source: 0001415889-25-000745 · form4-01062025_040106.xml · derivative · entry 1

Romano Steven J. · CIK 0001639860 · EVP and Chief R&D Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 285,000

Underlying: Ordinary Shares · 285,000 shares

Expires 2035-01-02

F1 · derivative.exercise_date: One fourth (1/4th) of the shares subject to the option shall vest on January 2, 2026 and the remaining shares subject to the option shall vest in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continuous service with the Issuer on each such vesting date.

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January 02, 2025 Filed Jan 6, 2025 21:15 UTC
HELLUMS RHONDA LYNETTEChief Financial Officer
GrantEmployee Share Option (Right to Buy) · Derivative 375,000 $0.00 Strike: $2.40 $0.00
Disclosure

SEC source: 0001415889-25-000744 · form4-01062025_040104.xml · derivative · entry 1

HELLUMS RHONDA LYNETTE · CIK 0001766456 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 375,000

Underlying: Ordinary Shares · 375,000 shares

Expires 2035-01-02

F1 · derivative.exercise_date: One fourth (1/4th) of the shares subject to the option shall vest on January 2, 2026 and the remaining shares subject to the option shall vest in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continuous service with the Issuer on each such vesting date.

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January 02, 2025 Filed Jan 6, 2025 21:15 UTC
TOOMAN CRAIG ADirector · President and CEO
GrantEmployee Share Option (Right to Buy) · Derivative 900,000 $0.00 Strike: $2.40 $0.00
Disclosure

SEC source: 0001415889-25-000743 · form4-01062025_040101.xml · derivative · entry 1

TOOMAN CRAIG A · CIK 0001201050 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 900,000

Underlying: Ordinary Shares · 900,000 shares

Expires 2035-01-02

F1 · derivative.exercise_date: One fourth (1/4th) of the shares subject to the option shall vest on January 2, 2026 and the remaining shares subject to the option shall vest in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continuous service with the Issuer on each such vesting date.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.