SGMT

SEC source: 0001104659-25-010584 · tm255919-1_4seq1.xml · derivative · entry 2

Chauche Thierry · CIK 0001895174 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,000

Underlying: Series A Common Stock · 69,000 shares

Expires 2035-02-05

F2 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable over forty-eight equal monthly installments following February 6, 2025, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-25-010584 · tm255919-1_4seq1.xml · nonDerivative · entry 1

Chauche Thierry · CIK 0001895174 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,000

F1 · shares: Represents restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Series A Common Stock upon vesting and settlement. The RSUs shall vest over four equal annual installments following February 6, 2025, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-25-010589 · tm255919-4_4seq1.xml · derivative · entry 2

Martins Eduardo Bruno · CIK 0001670431 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 138,000

Underlying: Series A Common Stock · 138,000 shares

Expires 2035-02-05

F2 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable over forty-eight equal monthly installments following February 6, 2025, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-25-010589 · tm255919-4_4seq1.xml · nonDerivative · entry 1

Martins Eduardo Bruno · CIK 0001670431 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,213

F1 · shares: Represents restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Series A Common Stock upon vesting and settlement. The RSUs shall vest over four equal annual installments following February 6, 2025, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-25-010587 · tm255919-3_4seq1.xml · derivative · entry 2

Happel David · CIK 0001623567 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 472,000

Underlying: Series A Common Stock · 472,000 shares

Expires 2035-02-05

F2 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable over forty-eight equal monthly installments following February 6, 2025, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-25-010587 · tm255919-3_4seq1.xml · nonDerivative · entry 1

Happel David · CIK 0001623567 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 755,200

F1 · shares: Represents restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Series A Common Stock upon vesting and settlement. The RSUs shall vest over four equal annual installments following February 6, 2025, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-25-010586 · tm255919-2_4seq1.xml · derivative · entry 2

Rozek Elizabeth · CIK 0001975022 · General Counsel and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 138,000

Underlying: Series A Common Stock · 138,000 shares

Expires 2035-02-05

F2 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable over forty-eight equal monthly installments following February 6, 2025, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-25-010586 · tm255919-2_4seq1.xml · nonDerivative · entry 1

Rozek Elizabeth · CIK 0001975022 · General Counsel and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 194,506

F1 · shares: Represents restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Series A Common Stock upon vesting and settlement. The RSUs shall vest over four equal annual installments following February 6, 2025, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-24-085820 · tm2420761-4_4seq1.xml · derivative · entry 1

Jarrett Jennifer · CIK 0001671311 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 113,895

Underlying: Series A Common Stock · 113,895 shares

Expires 2034-07-31

F1 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable over thirty-six (36) equal monthly installments following August 1, 2024, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-24-085818 · tm2420761-3_4seq1.xml · derivative · entry 1

Phillips Anne M. · CIK 0001627680 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 113,895

Underlying: Series A Common Stock · 113,895 shares

Expires 2034-07-31

F1 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable over thirty-six (36) equal monthly installments following August 1, 2024, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-24-082630 · tm2420121-1_4seq1.xml · nonDerivative · entry 1

Kemble George · CIK 0001858176 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 118,693

F1 · kind: These sales were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.07 to $3.26, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001104659-24-081892 · tm2420000-3_4seq1.xml · nonDerivative · entry 1

Martins Eduardo Bruno · CIK 0001670431 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 81,213

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. These sales were automatic and not in the discretion of the Reporting Person.

SEC source: 0001104659-24-081891 · tm2420000d2_4seq1.xml · nonDerivative · entry 1

Rozek Elizabeth · CIK 0001975022 · General Counsel and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 160,506

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. These sales were automatic and not in the discretion of the Reporting Person.

SEC source: 0001104659-24-081887 · tm2420000-1_4.xml · nonDerivative · entry 1

Kemble George · CIK 0001858176 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 142,318

F1 · kind: Represents shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. These sales were automatic and not in the discretion of the Reporting Person.

SEC source: 0001104659-24-069632 · tm2416701-2_4seq1.xml · derivative · entry 1

Hoelscher Paul W. · CIK 0001611468 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,279

Underlying: Series A Common Stock · 9,279 shares

Expires 2034-06-04

F1 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable over twelve (12) equal monthly installments following June 5, 2024, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-24-069637 · tm2416701-4_4seq1.xml · derivative · entry 1

SEIDENBERG BETH C · CIK 0001184592 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,459

Underlying: Series A Common Stock · 51,459 shares

Expires 2034-06-04

F1 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable over twelve (12) equal monthly installments following June 5, 2024, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-24-069626 · tm2416701-1_4seq1.xml · derivative · entry 1

GRAMMER ELIZABETH A · CIK 0001213041 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,459

Underlying: Series A Common Stock · 51,459 shares

Expires 2034-06-04

F1 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable over twelve (12) equal monthly installments following June 5, 2024, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-24-069639 · tm2416701-5_4seq1.xml · derivative · entry 1

Walbert Timothy P · CIK 0001349376 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,279

Underlying: Series A Common Stock · 9,279 shares

Expires 2034-06-04

F1 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable over twelve (12) equal monthly installments following June 5, 2024, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-24-069636 · tm2416701-3_4seq1.xml · derivative · entry 1

Parsey Merdad · CIK 0001792150 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,459

Underlying: Series A Common Stock · 51,459 shares

Expires 2034-06-04

F1 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable over twelve (12) equal monthly installments following June 5, 2024, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-24-058661 · tm2413886-2_4seq1.xml · derivative · entry 1

Chauche Thierry · CIK 0001895174 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 587,181

Underlying: Series A Common Stock · 587,181 shares

Expires 2034-05-05

F1 · derivative.exercise_date: 25% of the shares underlying this option shall vest and become exercisable on May 6, 2025, with the remainder vesting over thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-24-043263 · tm2410971-3_4seq1.xml · derivative · entry 1

Hoelscher Paul W. · CIK 0001611468 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 73,014

Underlying: Series A Common Stock · 73,014 shares

Expires 2034-03-31

F1 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable over thirty-six (36) equal monthly installments following April 1, 2024, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-24-043264 · tm2410971-4_4seq1.xml · derivative · entry 1

Walbert Timothy P · CIK 0001349376 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 73,014

Underlying: Series A Common Stock · 73,014 shares

Expires 2034-03-31

F1 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable over thirty-six (36) equal monthly installments following April 1, 2024, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-24-040517 · tm2410115-1_4seq1.xml · nonDerivative · entry 1

Happel David · CIK 0001623567 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 639,200

F1 · price: Reflects the weighted average price. The shares were purchased in multiple transactions at prices ranging from $5.24 per share to $5.2999 per share. The Reporting Person will provide, upon request by the SEC, the issuer or a security holder of the issuer, full information regarding the number of shares purchased at each price.

SEC source: 0001209191-24-002498 · doc4.xml · nonDerivative · entry 3

NEA Partners 13, Limited Partnership · CIK 0001460752 · 10% owner

NEA 13 GP, Ltd · CIK 0001460751 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F5 · kind: NEA Partners 13 made a pro rata distribution for no consideration of an aggregate of 260,950 shares of Series A Common Stock of the Issuer to its limited partners on January 29, 2024.

F4 · ownership.direct: The securities are directly held by NEA Partners 13 and indirectly held by NEA 13 LTD, the sole general partner of NEA Partners 13, and the Directors (NEA 13 LTD and the Directors together, the "NEA Partners 13 Indirect Reporting Persons"). The NEA Partners 13 Indirect Reporting Persons disclaim beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA Partners 13 in which the NEA Partners 13 Indirect Reporting Persons have no pecuniary interest.

SEC source: 0001209191-24-002498 · doc4.xml · nonDerivative · entry 2

NEA Partners 13, Limited Partnership · CIK 0001460752 · 10% owner

NEA 13 GP, Ltd · CIK 0001460751 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 260,950

F3 · kind: NEA Partners 13 received 260,950 shares of Series A Common Stock of the Issuer in the distribution made by NEA 13 on January 29, 2024.

F4 · ownership.direct: The securities are directly held by NEA Partners 13 and indirectly held by NEA 13 LTD, the sole general partner of NEA Partners 13, and the Directors (NEA 13 LTD and the Directors together, the "NEA Partners 13 Indirect Reporting Persons"). The NEA Partners 13 Indirect Reporting Persons disclaim beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA Partners 13 in which the NEA Partners 13 Indirect Reporting Persons have no pecuniary interest.

SEC source: 0001209191-24-002498 · doc4.xml · nonDerivative · entry 1

NEA Partners 13, Limited Partnership · CIK 0001460752 · 10% owner

NEA 13 GP, Ltd · CIK 0001460751 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 2

Disclosed balance after: 3,000,275

F1 · kind: New Enterprise Associates 13, L.P. ("NEA 13") made a pro rata distribution of 850,000 shares of Series A Common Stock of the Issuer to its general partner and limited partners for no consideration on January 29, 2024.

F2 · ownership.nature: The securities are directly held by NEA 13 and are indirectly held by NEA Partners 13, L.P. ("NEA Partners 13"), the sole general partner of NEA 13, NEA 13 GP, LTD ("NEA 13 LTD"), the sole general partner of NEA Partners 13, and the individual directors of NEA 13 LTD (NEA Partners 13, NEA 13 LTD and the individual directors (collectively, the "Directors"), together, the "Indirect Reporting Persons"). The Directors of NEA 13 LTD are Forest Baskett, Patrick J. Kerins and Scott D. Sandell. The Indirect Reporting Persons disclaim beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA 13 in which the Indirect Reporting Persons have no pecuniary interest.

SEC source: 0001209191-24-002497 · doc4.xml · nonDerivative · entry 1

NEW ENTERPRISE ASSOCIATES 13 LP · CIK 0001452907 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,000,275

F1 · kind: New Enterprise Associates 13, L.P. ("NEA 13") made a pro rata distribution of 850,000 shares of Series A Common Stock of the Issuer to its general partner and limited partners for no consideration on January 29, 2024.

F2 · ownership.direct: The securities are directly held by NEA 13 and are indirectly held by NEA Partners 13, L.P. ("NEA Partners 13"), the sole general partner of NEA 13, NEA 13 GP, LTD ("NEA 13 LTD"), the sole general partner of NEA Partners 13, and the individual directors of NEA 13 LTD (NEA Partners 13, NEA 13 LTD and the individual directors of NEA 13 LTD (collectively, the "Directors"), together, the "Indirect Reporting Persons"). The Directors of NEA 13 LTD are Forest Baskett, Patrick J. Kerins and Scott D. Sandell. The Indirect Reporting Persons disclaim beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA 13 in which the Indirect Reporting Persons have no pecuniary interest.

SEC source: 0001209191-24-002501 · doc4.xml · nonDerivative · entry 4

SANDELL SCOTT D · CIK 0001237289 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 7

Disclosed balance after: 6,997

F6 · kind: The Reporting Person, as Trustee of the Blue Mountain Trust, dated April 29, 2019 (the "Blue Mountain Trust") received 6,997 shares of Series A Common Stock of the Issuer in the distribution by NEA Partners 13 on January 29, 2024.

F7 · ownership.nature: The Reporting Person is Trustee of the Blue Mountain Trust, which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by the Blue Mountain Trust in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-24-002501 · doc4.xml · nonDerivative · entry 3

SANDELL SCOTT D · CIK 0001237289 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 4

Disclosed balance after: 0

F5 · kind: NEA Partners 13 made a pro rata distribution for no consideration of an aggregate of 260,950 shares of Series A Common Stock of the Issuer to its limited partners on January 29, 2024.

F4 · ownership.nature: The Reporting Person is a director of NEA 13 LTD, the sole general partner of NEA Partners 13, the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA Partners 13 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-24-002501 · doc4.xml · nonDerivative · entry 2

SANDELL SCOTT D · CIK 0001237289 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 4

Disclosed balance after: 260,950

F3 · kind: NEA Partners 13 received 260,950 shares of Series A Common Stock of the Issuer in the distribution made by NEA 13 on January 29, 2024.

F4 · ownership.nature: The Reporting Person is a director of NEA 13 LTD, the sole general partner of NEA Partners 13, the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA Partners 13 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-24-002501 · doc4.xml · nonDerivative · entry 1

SANDELL SCOTT D · CIK 0001237289 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 2

Disclosed balance after: 3,000,275

F1 · kind: New Enterprise Associates 13, L.P. ("NEA 13") made a pro rata distribution of 850,000 shares of Series A Common Stock of the Issuer to its general partner and limited partners for no consideration on January 29, 2024.

F2 · ownership.nature: The Reporting Person is a director of NEA 13 GP, LTD ("NEA 13 LTD"), which is the sole general partner of NEA Partners 13, L.P. ("NEA Partners 13"). NEA Partners 13 is the sole general partner of NEA 13, which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA 13 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-24-002500 · doc4.xml · nonDerivative · entry 4

KERINS PATRICK J · CIK 0001235112 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,139

F6 · kind: The Reporting Person received 13,139 shares of Series A Common Stock of the Issuer in the distribution by NEA Partners 13 on January 29, 2024.

SEC source: 0001209191-24-002500 · doc4.xml · nonDerivative · entry 3

KERINS PATRICK J · CIK 0001235112 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 4

Disclosed balance after: 0

F5 · kind: NEA Partners 13 made a pro rata distribution for no consideration of an aggregate of 260,950 shares of Series A Common Stock of the Issuer to its limited partners on January 29, 2024.

F4 · ownership.nature: The Reporting Person is a director of NEA 13 LTD, the sole general partner of NEA Partners 13, the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA Partners 13 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-24-002500 · doc4.xml · nonDerivative · entry 2

KERINS PATRICK J · CIK 0001235112 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 4

Disclosed balance after: 260,950

F3 · kind: NEA Partners 13 received 260,950 shares of Series A Common Stock of the Issuer in the distribution made by NEA 13 on January 29, 2024.

F4 · ownership.nature: The Reporting Person is a director of NEA 13 LTD, the sole general partner of NEA Partners 13, the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA Partners 13 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-24-002500 · doc4.xml · nonDerivative · entry 1

KERINS PATRICK J · CIK 0001235112 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 2

Disclosed balance after: 3,000,275

F1 · kind: New Enterprise Associates 13, L.P. ("NEA 13") made a pro rata distribution of 850,000 shares of Series A Common Stock of the Issuer to its general partner and limited partners for no consideration on January 29, 2024.

F2 · ownership.nature: The Reporting Person is a director of NEA 13 GP, LTD ("NEA 13 LTD"), which is the sole general partner of NEA Partners 13, L.P. ("NEA Partners 13"). NEA Partners 13 is the sole general partner of NEA 13, which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA 13 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-24-002499 · doc4.xml · nonDerivative · entry 4

BASKETT FOREST · CIK 0001277631 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 7

Disclosed balance after: 11,300

F6 · kind: The Reporting Person, as Trustee of the Baskett-McKay Family Trust dated March 12, 2014 (the "Baskett-McKay Family Trust"), received 11,300 shares of Series A Common Stock of the Issuer in the distribution by NEA Partners 13 on January 29, 2024.

F7 · ownership.nature: The securities are held directly by the Baskett-McKay Family Trust. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by the Baskett-McKay Family Trust in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-24-002499 · doc4.xml · nonDerivative · entry 3

BASKETT FOREST · CIK 0001277631 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 4

Disclosed balance after: 0

F5 · kind: NEA Partners 13 made a pro rata distribution for no consideration of an aggregate of 260,950 shares of Series A Common Stock of the Issuer to its limited partners on January 29, 2024.

F4 · ownership.nature: The Reporting Person is a director of NEA 13 LTD, the sole general partner of NEA Partners 13, the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA Partners 13 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-24-002499 · doc4.xml · nonDerivative · entry 2

BASKETT FOREST · CIK 0001277631 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 4

Disclosed balance after: 260,950

F3 · kind: NEA Partners 13 received 260,950 shares of Series A Common Stock of the Issuer in the distribution made by NEA 13 on January 29, 2024.

F4 · ownership.nature: The Reporting Person is a director of NEA 13 LTD, the sole general partner of NEA Partners 13, the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA Partners 13 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-24-002499 · doc4.xml · nonDerivative · entry 1

BASKETT FOREST · CIK 0001277631 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · See Note 2

Disclosed balance after: 3,000,275

F1 · kind: New Enterprise Associates 13, L.P. ("NEA 13") made a pro rata distribution of 850,000 shares of Series A Common Stock of the Issuer to its general partner and limited partners for no consideration on January 29, 2024.

F2 · ownership.nature: The Reporting Person is a director of NEA 13 GP, LTD ("NEA 13 LTD"), which is the sole general partner of NEA Partners 13, L.P. ("NEA Partners 13"). NEA Partners 13 is the sole general partner of NEA 13, which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA 13 in which the Reporting Person has no pecuniary interest.

SEC source: 0001104659-23-124678 · tm2332520-1_4seq1.xml · nonDerivative · entry 1

Happel David · CIK 0001623567 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 627,100

F1 · price: Reflects the weighted average price. The shares were purchased in multiple transactions at prices ranging from $4.02 per share to $4.16 per share. The Reporting Person will provide, upon request by the SEC, the issuer or a security holder of the issuer, full information regarding the number of shares purchased at each price.

SEC source: 0001104659-23-120375 · tm2331048-3_4seq1.xml · nonDerivative · entry 1

Martins Eduardo Bruno · CIK 0001670431 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,570

F1 · shares: Represents restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Series A Common Stock upon vesting and settlement. 25% of the RSUs shall vest on July 18, 2024, with the remainder vesting in three equal annual installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-23-120372 · tm2331048-1_4seq1.xml · nonDerivative · entry 1

Happel David · CIK 0001623567 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 625,500

F1 · shares: Represents restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Series A Common Stock upon vesting and settlement. 25% of the RSUs shall vest on July 18, 2024, with the remainder vesting in three equal annual installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-23-120374 · tm2331048-2_4seq1.xml · nonDerivative · entry 1

Kemble George · CIK 0001858176 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 156,380

F1 · shares: Represents restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Series A Common Stock upon vesting and settlement. 25% of the RSUs shall vest on July 18, 2024, with the remainder vesting in three equal annual installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-23-120377 · tm2331048-4_4seq1.xml · nonDerivative · entry 1

Rozek Elizabeth · CIK 0001975022 · General Counsel and CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 171,420

F1 · shares: Represents restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of the Issuer's Series A Common Stock upon vesting and settlement. 25% of the RSUs shall vest on July 18, 2024, with the remainder vesting in three equal annual installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-23-120027 · tm2331267-1_4seq1.xml · nonDerivative · entry 1

Happel David · CIK 0001623567 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 590

F1 · price: Reflects the weighted average price. The shares were purchased in multiple transactions at prices ranging from $2.31 per share to $2.40 per share. The Reporting Person will provide, upon request by the SEC, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each price.

SEC source: 0001104659-23-099310 · tm2325723-1_4seq1.xml · derivative · entry 2

Kemble George · CIK 0001858176 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Series A Common Stock · 5,630 shares

Expires 2023-09-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: This option is fully vested and exercisable as of the date hereof.

SEC source: 0001104659-23-099310 · tm2325723-1_4seq1.xml · nonDerivative · entry 1

Kemble George · CIK 0001858176 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,630

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-23-082735 · tm2321276-22_4seq1.xml · derivative · entry 5

Wu Jinzi Jason · CIK 0001858174 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,216

Underlying: Series A Common Stock · 23,216 shares

Expires 2029-04-27

F3 · kind: Pursuant to a reclassification exempt under Rule 16b-7 and Rule 16b-3, each share of Common Stock was reclassified into one share of Series A Common Stock.

F4 · derivative.exercise_date: The shares underlying this option are fully vested and exercisable as of the date hereof.

SEC source: 0001104659-23-082735 · tm2321276-22_4seq1.xml · derivative · entry 4

Wu Jinzi Jason · CIK 0001858174 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 23,216 shares

Expires 2029-04-27

F3 · kind: Pursuant to a reclassification exempt under Rule 16b-7 and Rule 16b-3, each share of Common Stock was reclassified into one share of Series A Common Stock.

F4 · derivative.exercise_date: The shares underlying this option are fully vested and exercisable as of the date hereof.

SEC source: 0001104659-23-082735 · tm2321276-22_4seq1.xml · derivative · entry 3

Wu Jinzi Jason · CIK 0001858174 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By AP11 Limited

Disclosed balance after: 0

Underlying: Series A Common Stock · 289,908 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Upon closing of the Issuer's initial public offering, each share of Series E Preferred Stock and Series F Preferred Stock (collectively, the "Preferred Stock") automatically converted on a 79.4784-to-one basis into shares of the Issuer's Series A Common Stock. The Preferred Stock had no expiration date.

F1 · kind: Upon closing of the Issuer's initial public offering, each share of Series E Preferred Stock and Series F Preferred Stock (collectively, the "Preferred Stock") automatically converted on a 79.4784-to-one basis into shares of the Issuer's Series A Common Stock. The Preferred Stock had no expiration date.

F1 · derivative.exercise_date: Upon closing of the Issuer's initial public offering, each share of Series E Preferred Stock and Series F Preferred Stock (collectively, the "Preferred Stock") automatically converted on a 79.4784-to-one basis into shares of the Issuer's Series A Common Stock. The Preferred Stock had no expiration date.

F1 · derivative.expiration_date: Upon closing of the Issuer's initial public offering, each share of Series E Preferred Stock and Series F Preferred Stock (collectively, the "Preferred Stock") automatically converted on a 79.4784-to-one basis into shares of the Issuer's Series A Common Stock. The Preferred Stock had no expiration date.

F2 · ownership.nature: Shares held directly by AP11 Limited, a subsidiary of Ascletis Pharma Inc. ("Ascletis"). The Reporting Person is founder, chairman and chief executive officer of Ascletis. The Reporting Person disclaims Section 16 beneficial ownership of the shares reported herein except to the extent of his pecuniary interest therein, if any, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of any of the reported shares for purposes of Section 16 or any other purpose.