SDGR

SEC source: 0001209191-21-056425 · doc4.xml · derivative · entry 3

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,591

Underlying: Common Stock · 1,394 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2021.

F2 · derivative.exercise_date: This option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on December 31, 2019 and the remainder are scheduled to vest in equal monthly installments through December 31, 2022.

SEC source: 0001209191-21-056425 · doc4.xml · nonDerivative · entry 2

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2021.

SEC source: 0001209191-21-056425 · doc4.xml · nonDerivative · entry 1

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,394

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2021.

SEC source: 0001209191-21-055953 · doc4.xml · derivative · entry 4

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 110,357

Underlying: Common Stock · 15,602 shares

Expires 2030-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

F4 · derivative.exercise_date: This option was granted on February 5, 2020. The shares underlying the option vested with respect to 25% of the shares on February 5, 2021 and the remainder are scheduled to vest in equal monthly installments through February 5, 2024.

SEC source: 0001209191-21-055953 · doc4.xml · nonDerivative · entry 3

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.73 to $62.63, inclusive.

SEC source: 0001209191-21-055953 · doc4.xml · nonDerivative · entry 2

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,782

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.65 to $61.58, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (3) of this Form 4.

SEC source: 0001209191-21-055953 · doc4.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,602

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2021.

SEC source: 0001209191-21-054802 · doc4.xml · derivative · entry 6

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 83,608

Underlying: Common Stock · 3,874 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F4 · derivative.exercise_date: The option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on November 14, 2019 and the remainder vest in equal monthly installments through November 14, 2022.

SEC source: 0001209191-21-054802 · doc4.xml · nonDerivative · entry 4

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.45 to $64.90, inclusive.

SEC source: 0001209191-21-054802 · doc4.xml · nonDerivative · entry 3

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,874

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

SEC source: 0001209191-21-054802 · doc4.xml · derivative · entry 5

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,482

Underlying: Common Stock · 1,700 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F4 · derivative.exercise_date: The option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on November 14, 2019 and the remainder vest in equal monthly installments through November 14, 2022.

SEC source: 0001209191-21-054802 · doc4.xml · nonDerivative · entry 2

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.45 to $64.67, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (3) of this Form 4.

SEC source: 0001209191-21-054802 · doc4.xml · nonDerivative · entry 1

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,700

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

SEC source: 0001209191-21-051910 · doc4.xml · derivative · entry 8

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,378

Underlying: Common Stock · 13,377 shares

Expires 2028-08-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2021.

F6 · derivative.exercise_date: The option was granted on August 3, 2018. The shares underlying the option are scheduled to vest in equal yearly installments from May 14, 2018 through May 14, 2022.

SEC source: 0001209191-21-051910 · doc4.xml · derivative · entry 7

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,985

Underlying: Common Stock · 4,180 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2021.

F5 · derivative.exercise_date: This option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on December 31, 2019 and the remainder are scheduled to vest in equal monthly installments through December 31, 2022.

SEC source: 0001209191-21-051910 · doc4.xml · derivative · entry 6

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 180,478

Underlying: Common Stock · 20,181 shares

Expires 2030-02-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2021.

F4 · derivative.exercise_date: This option was granted on February 5, 2020. The shares underlying the option vested with respect to 25% of the shares on February 5, 2021 and the remainder are scheduled to vest in equal monthly installments through February 5, 2024.

SEC source: 0001209191-21-051910 · doc4.xml · nonDerivative · entry 5

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2021.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $57.905 to $58.86, inclusive.

SEC source: 0001209191-21-051910 · doc4.xml · nonDerivative · entry 4

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,047

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2021.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $56.90 to $57.89, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (3) of this Form 4.

SEC source: 0001209191-21-051910 · doc4.xml · nonDerivative · entry 3

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,738

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2021.

SEC source: 0001209191-21-051910 · doc4.xml · nonDerivative · entry 2

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,361

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2021.

SEC source: 0001209191-21-051910 · doc4.xml · nonDerivative · entry 1

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,181

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2021.

SEC source: 0001209191-21-049681 · doc4.xml · nonDerivative · entry 3

Tran Yvonne · CIK 0001797777 · EVP & Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,131

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $68.90 to $69.26, inclusive.

SEC source: 0001209191-21-049681 · doc4.xml · nonDerivative · entry 2

Tran Yvonne · CIK 0001797777 · EVP & Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,245

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $67.86 to $68.85, inclusive.

SEC source: 0001209191-21-049681 · doc4.xml · nonDerivative · entry 1

Tran Yvonne · CIK 0001797777 · EVP & Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,181

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $66.82 to $67.77, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (4) of this Form 4.

SEC source: 0001209191-21-047248 · doc4.xml · nonDerivative · entry 4

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,103,042

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F6 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $68.685 to $69.59, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-047248 · doc4.xml · nonDerivative · entry 3

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,115,028

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F5 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $67.685 to $68.675, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-047248 · doc4.xml · nonDerivative · entry 2

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,152,765

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F4 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $66.685 to $67.68 inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-047248 · doc4.xml · nonDerivative · entry 1

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,164,703

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F2 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $65.66 to $66.655, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046991 · doc4.xml · nonDerivative · entry 6

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,166,103

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F8 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $67.48 to $68.09, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046991 · doc4.xml · nonDerivative · entry 5

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,168,213

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F7 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $66.48 to $67.47, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046991 · doc4.xml · nonDerivative · entry 4

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,191,926

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F6 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $65.47 to $66.46, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046991 · doc4.xml · nonDerivative · entry 3

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,195,103

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F5 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $67.22 to $67.48, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046991 · doc4.xml · nonDerivative · entry 2

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,200,953

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F4 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $66.21 to $67.20 inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046991 · doc4.xml · nonDerivative · entry 1

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,245,181

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F2 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $65.21 to $66.20, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046696 · doc4.xml · nonDerivative · entry 11

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,254,461

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F12 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $69.03 to $69.92 inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046696 · doc4.xml · nonDerivative · entry 10

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,257,391

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F11 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $68.03 to $68.98 inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046696 · doc4.xml · nonDerivative · entry 9

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,271,341

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F10 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $67.00 to $67.98 inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046860 · doc4.xml · derivative · entry 5

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,182

Underlying: Common Stock · 5,574 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F5 · derivative.exercise_date: The option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on November 14, 2019 and the remainder vest in equal monthly installments through November 14, 2022.

SEC source: 0001209191-21-046860 · doc4.xml · nonDerivative · entry 4

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $69.30 to $69.56, inclusive.

SEC source: 0001209191-21-046860 · doc4.xml · nonDerivative · entry 3

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 305

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $68.04 to $68.85, inclusive.

SEC source: 0001209191-21-046860 · doc4.xml · nonDerivative · entry 2

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,067

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $67.04 to $67.95, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (4) of this Form 4.

SEC source: 0001209191-21-046860 · doc4.xml · nonDerivative · entry 1

Lebowitz Joel · CIK 0001797829 · EVP & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,574

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

SEC source: 0001209191-21-046696 · doc4.xml · nonDerivative · entry 8

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,288,512

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046696 · doc4.xml · nonDerivative · entry 7

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,288,812

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F9 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $72.13 to $73.125, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046696 · doc4.xml · nonDerivative · entry 6

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,293,566

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F8 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $71.13 to $72.12, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046696 · doc4.xml · nonDerivative · entry 5

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,307,435

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F7 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $70.125 to $71.12, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046696 · doc4.xml · nonDerivative · entry 4

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,321,505

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F6 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $69.12 to $70.115, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046696 · doc4.xml · nonDerivative · entry 3

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,339,725

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F5 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $75.96 to $76.48, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046696 · doc4.xml · nonDerivative · entry 2

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,340,625

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F4 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $74.95 to $75.81 inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-046696 · doc4.xml · nonDerivative · entry 1

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 6,342,108

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated May 13, 2021.

F2 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $73.82 to $74.815, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.