SDGR

SEC source: 0000899243-20-032772 · doc4.xml · derivative · entry 5

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,296

Underlying: Common Stock · 1,923 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F4 · derivative.exercise_date: This option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on December 31, 2019 and the remainder are scheduled to vest in equal monthly installments through December 31, 2022.

SEC source: 0000899243-20-032772 · doc4.xml · nonDerivative · entry 4

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,688

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.60 to $66.47, inclusive.

SEC source: 0000899243-20-032772 · doc4.xml · nonDerivative · entry 3

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,355

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.59 to $65.51, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (3) of this Form 4.

SEC source: 0000899243-20-032772 · doc4.xml · nonDerivative · entry 2

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,644

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

SEC source: 0000899243-20-032772 · doc4.xml · nonDerivative · entry 1

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,611

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

SEC source: 0000899243-20-032672 · doc4.xml · derivative · entry 15

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,821

Underlying: Common Stock · 10,033 shares

Expires 2027-04-07

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F10 · derivative.exercise_date: This option was granted on April 7, 2017. The shares underlying the option are scheduled to vest in equal yearly installments from February 22, 2017 through February 22, 2021.

SEC source: 0000899243-20-032672 · doc4.xml · derivative · entry 14

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,219

Underlying: Common Stock · 1,923 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F9 · derivative.exercise_date: This option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on December 31, 2019 and the remainder are scheduled to vest in equal monthly installments through December 31, 2022.

SEC source: 0000899243-20-032672 · doc4.xml · nonDerivative · entry 11

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,688

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F8 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $66.29 to $66.83, inclusive.

SEC source: 0000899243-20-032672 · doc4.xml · nonDerivative · entry 10

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,588

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.29 to $66.28, inclusive.

SEC source: 0000899243-20-032672 · doc4.xml · nonDerivative · entry 9

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,144

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.21 to $64.96, inclusive.

SEC source: 0000899243-20-032672 · doc4.xml · nonDerivative · entry 8

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,644

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

SEC source: 0000899243-20-032672 · doc4.xml · nonDerivative · entry 7

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,611

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

SEC source: 0001209191-20-061857 · doc4.xml · nonDerivative · entry 3

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,088,076

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F5 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $66.11 to $66.89, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-20-061857 · doc4.xml · nonDerivative · entry 2

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,104,444

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F4 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $65.11 to $66.105, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-20-061857 · doc4.xml · nonDerivative · entry 1

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,143,621

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F2 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $64.11 to $65.10, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0000899243-20-032672 · doc4.xml · derivative · entry 13

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,854

Underlying: Common Stock · 10,032 shares

Expires 2027-04-07

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F10 · derivative.exercise_date: This option was granted on April 7, 2017. The shares underlying the option are scheduled to vest in equal yearly installments from February 22, 2017 through February 22, 2021.

SEC source: 0000899243-20-032672 · doc4.xml · derivative · entry 12

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,142

Underlying: Common Stock · 1,923 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F9 · derivative.exercise_date: This option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on December 31, 2019 and the remainder are scheduled to vest in equal monthly installments through December 31, 2022.

SEC source: 0000899243-20-032672 · doc4.xml · nonDerivative · entry 6

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,688

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $70.43 to $70.94, inclusive.

SEC source: 0000899243-20-032672 · doc4.xml · nonDerivative · entry 5

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,488

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $69.40 to $70.30, inclusive.

SEC source: 0000899243-20-032672 · doc4.xml · nonDerivative · entry 4

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,812

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $68.37 to $69.17, inclusive.

SEC source: 0000899243-20-032672 · doc4.xml · nonDerivative · entry 3

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,038

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $67.36 to $68.32, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (8) of this Form 4.

SEC source: 0000899243-20-032672 · doc4.xml · nonDerivative · entry 2

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,643

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

SEC source: 0000899243-20-032672 · doc4.xml · nonDerivative · entry 1

Daniel Jennifer · CIK 0001797725 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,611

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

SEC source: 0000899243-20-032373 · doc4.xml · derivative · entry 6

D'Cruz Cony · CIK 0001797727 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,804

Underlying: Common Stock · 2,061 shares

Expires 2027-06-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 18, 2020.

F3 · derivative.exercise_date: This option was granted on June 1, 2017. The shares underlying the option are scheduled to vest in equal yearly installments from January 1, 2017 through January 1, 2021.

SEC source: 0000899243-20-032373 · doc4.xml · derivative · entry 5

D'Cruz Cony · CIK 0001797727 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,065

Underlying: Common Stock · 2,314 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 18, 2020.

F2 · derivative.exercise_date: This option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on December 31, 2019 and the remainder are scheduled to vest in equal monthly installments through December 31, 2022.

SEC source: 0000899243-20-032373 · doc4.xml · nonDerivative · entry 4

D'Cruz Cony · CIK 0001797727 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Indirect · By Cony and Pearl D'Cruz Revocable Trust dated August 20, 2019, and any amendments thereto

Disclosed balance after: 169,082

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 18, 2020.

SEC source: 0000899243-20-032373 · doc4.xml · nonDerivative · entry 3

D'Cruz Cony · CIK 0001797727 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 18, 2020.

SEC source: 0000899243-20-032373 · doc4.xml · nonDerivative · entry 2

D'Cruz Cony · CIK 0001797727 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,375

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 18, 2020.

SEC source: 0000899243-20-032373 · doc4.xml · nonDerivative · entry 1

D'Cruz Cony · CIK 0001797727 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,314

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 18, 2020.

SEC source: 0000899243-21-006342 · doc5.xml · nonDerivative · entry 1

Friesner Richard · CIK 0001798426 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 540,450

SEC source: 0001209191-20-060594 · doc4.xml · nonDerivative · entry 14

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,150,683

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F16 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $66.605 to $66.665, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-20-060594 · doc4.xml · nonDerivative · entry 13

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,151,749

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F15 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $65.30 to $66.25, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-20-060594 · doc4.xml · nonDerivative · entry 12

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,175,807

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F14 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $64.30 to $65.295, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-20-060594 · doc4.xml · nonDerivative · entry 11

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,191,287

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F13 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $63.30 to $64.29, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-20-060594 · doc4.xml · nonDerivative · entry 10

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,251,047

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F12 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $68.88 to $69.10, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-20-060594 · doc4.xml · nonDerivative · entry 9

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,258,661

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F11 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $67.82 to $68.80, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-20-060594 · doc4.xml · nonDerivative · entry 8

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,321,732

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F10 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $66.82 to $67.815, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-20-060594 · doc4.xml · nonDerivative · entry 7

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,349,771

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F9 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $65.82 to $66.815, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001104659-20-130013 · a4.xml · derivative · entry 3

BILL & MELINDA GATES FOUNDATION TRUST · CIK 0001166559 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,164,193

Underlying: Common stock · 4,000,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: All shares of the Issuer's limited common stock have no expiration date and may be exchanged at the election of Bill & Melinda Gates Foundation Trust into the Issuer's common stock on a 1-for-1 basis without payment of further consideration. Exempt from the operations of Section 16(b) of the Securities Exchange Act of 1934, as amended, pursuant to Rule 16b-6(b) thereunder.

F1 · price: All shares of the Issuer's limited common stock have no expiration date and may be exchanged at the election of Bill & Melinda Gates Foundation Trust into the Issuer's common stock on a 1-for-1 basis without payment of further consideration. Exempt from the operations of Section 16(b) of the Securities Exchange Act of 1934, as amended, pursuant to Rule 16b-6(b) thereunder.

F1 · derivative.exercise_date: All shares of the Issuer's limited common stock have no expiration date and may be exchanged at the election of Bill & Melinda Gates Foundation Trust into the Issuer's common stock on a 1-for-1 basis without payment of further consideration. Exempt from the operations of Section 16(b) of the Securities Exchange Act of 1934, as amended, pursuant to Rule 16b-6(b) thereunder.

F1 · derivative.expiration_date: All shares of the Issuer's limited common stock have no expiration date and may be exchanged at the election of Bill & Melinda Gates Foundation Trust into the Issuer's common stock on a 1-for-1 basis without payment of further consideration. Exempt from the operations of Section 16(b) of the Securities Exchange Act of 1934, as amended, pursuant to Rule 16b-6(b) thereunder.

SEC source: 0001104659-20-130013 · a4.xml · nonDerivative · entry 2

BILL & MELINDA GATES FOUNDATION TRUST · CIK 0001166559 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,981,664

SEC source: 0001104659-20-130013 · a4.xml · nonDerivative · entry 1

BILL & MELINDA GATES FOUNDATION TRUST · CIK 0001166559 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,981,664

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: All shares of the Issuer's limited common stock have no expiration date and may be exchanged at the election of Bill & Melinda Gates Foundation Trust into the Issuer's common stock on a 1-for-1 basis without payment of further consideration. Exempt from the operations of Section 16(b) of the Securities Exchange Act of 1934, as amended, pursuant to Rule 16b-6(b) thereunder.

SEC source: 0000899243-20-032037 · doc4.xml · derivative · entry 4

Lebowitz Joel · CIK 0001797829 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 133,773

Underlying: Common Stock · 16,722 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F4 · derivative.exercise_date: The option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on November 14, 2019 and the remainder vest in equal monthly installments through November 14, 2022.

SEC source: 0000899243-20-032037 · doc4.xml · nonDerivative · entry 3

Lebowitz Joel · CIK 0001797829 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.46 to $65.54, inclusive.

SEC source: 0000899243-20-032037 · doc4.xml · nonDerivative · entry 2

Lebowitz Joel · CIK 0001797829 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 891

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.45 to $65.44, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) and (3) of this Form 4.

SEC source: 0000899243-20-032037 · doc4.xml · nonDerivative · entry 1

Lebowitz Joel · CIK 0001797829 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,722

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 21, 2020.

SEC source: 0001209191-20-060594 · doc4.xml · nonDerivative · entry 6

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,423,387

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F8 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $68.95 to $69.45, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-20-060594 · doc4.xml · nonDerivative · entry 5

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,503,745

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F7 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $67.85 to $68.65, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-20-060594 · doc4.xml · nonDerivative · entry 4

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,720,006

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F6 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $66.85 to $67.84, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-20-060594 · doc4.xml · nonDerivative · entry 3

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,845,947

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F5 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $65.85 to $66.845, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-20-060594 · doc4.xml · nonDerivative · entry 2

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 10,946,853

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F4 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $64.79 to $65.685, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.