SDGR

SEC source: 0001209191-21-026304 · doc4.xml · nonDerivative · entry 1

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,166,989

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F2 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $74.495 to $75.49, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-024259 · doc4.xml · nonDerivative · entry 12

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,182,009

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F14 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $81.30 to $81.41, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-024259 · doc4.xml · nonDerivative · entry 11

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,182,235

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F13 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $80.24 to $81.22, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-024259 · doc4.xml · nonDerivative · entry 10

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,188,084

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F12 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $79.24 to $80.215, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-024259 · doc4.xml · nonDerivative · entry 9

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,205,620

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F11 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $78.225 to $79.22, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-024664 · doc4.xml · derivative · entry 4

Weiser Jorg · CIK 0001797782 · EVP & Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,196

Underlying: Common Stock · 418 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 1, 2020

F3 · derivative.exercise_date: This option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on December 31, 2019 and the remainder are scheduled to vest in equal monthly installments through December 31, 2022.

SEC source: 0001209191-21-024664 · doc4.xml · nonDerivative · entry 2

Weiser Jorg · CIK 0001797782 · EVP & Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 117,052

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 1, 2020

SEC source: 0001209191-21-024664 · doc4.xml · nonDerivative · entry 1

Weiser Jorg · CIK 0001797782 · EVP & Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 117,470

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 1, 2020

SEC source: 0001209191-21-024661 · doc4.xml · derivative · entry 6

Tran Yvonne · CIK 0001797777 · EVP & Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 13,377 shares

Expires 2025-07-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F6 · derivative.exercise_date: The option was granted on July 20, 2015 and is fully vested.

SEC source: 0001209191-21-024661 · doc4.xml · nonDerivative · entry 5

Tran Yvonne · CIK 0001797777 · EVP & Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,131

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $81.31 to $81.44, inclusive.

SEC source: 0001209191-21-024661 · doc4.xml · nonDerivative · entry 4

Tran Yvonne · CIK 0001797777 · EVP & Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,531

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $80.27 to $80.71, inclusive.

SEC source: 0001209191-21-024661 · doc4.xml · nonDerivative · entry 3

Tran Yvonne · CIK 0001797777 · EVP & Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,931

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $79.24 to $80.23, inclusive.

SEC source: 0001209191-21-024661 · doc4.xml · nonDerivative · entry 2

Tran Yvonne · CIK 0001797777 · EVP & Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,088

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $78.23 to $79.22, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) through (5) of this Form 4.

SEC source: 0001209191-21-024661 · doc4.xml · nonDerivative · entry 1

Tran Yvonne · CIK 0001797777 · EVP & Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,508

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

SEC source: 0001209191-21-024662 · doc4.xml · derivative · entry 3

Daniel Jennifer · CIK 0001797725 · EVP & Chief HR Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,779

Underlying: Common Stock · 418 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

F2 · derivative.exercise_date: This option was granted on November 29, 2018. The shares underlying the option vested with respect to 25% of the shares on December 31, 2019 and the remainder are scheduled to vest in equal monthly installments through December 31, 2022.

SEC source: 0001209191-21-024662 · doc4.xml · nonDerivative · entry 2

Daniel Jennifer · CIK 0001797725 · EVP & Chief HR Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,688

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

SEC source: 0001209191-21-024662 · doc4.xml · nonDerivative · entry 1

Daniel Jennifer · CIK 0001797725 · EVP & Chief HR Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,106

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 14, 2020.

SEC source: 0001209191-21-024259 · doc4.xml · nonDerivative · entry 8

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,244,730

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F10 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $76.60 to $77.25, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-024259 · doc4.xml · nonDerivative · entry 7

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,277,830

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F9 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $75.60 to $76.595, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-024259 · doc4.xml · nonDerivative · entry 6

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,311,806

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F8 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $74.59 to $75.58, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-024259 · doc4.xml · nonDerivative · entry 5

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,325,062

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F7 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $73.23 to $74.21, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-024259 · doc4.xml · nonDerivative · entry 4

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,326,052

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F6 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $71.50 to $72.29, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-024259 · doc4.xml · nonDerivative · entry 3

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,340,780

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F5 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $70.50 to $71.49, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-024259 · doc4.xml · nonDerivative · entry 2

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,354,741

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F4 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $69.45 to $70.36, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-024259 · doc4.xml · nonDerivative · entry 1

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,361,585

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F2 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $68.285 to $69.26, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 20

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,366,052

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F20 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $72.11 to $72.52, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 19

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,366,849

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F19 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $71.10 to $72.08, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 18

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,368,906

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F18 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $70.01 to $70.98, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 17

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,374,345

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F17 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $69.00 to $69.99, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 16

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,386,919

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F16 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $68.00 to $68.96, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 15

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,396,165

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F15 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $67.00 to $67.99, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 14

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,416,052

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 13

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,416,152

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 12

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,416,252

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F14 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $76.43 to $77.20, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 11

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,418,652

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F13 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $75.38 to $76.33, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 10

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,420,670

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F12 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $74.38 to $75.34, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 9

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,432,161

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F11 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $73.38 to $74.37, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 8

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,446,697

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F10 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $72.34 to $73.335, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 7

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,452,348

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F9 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $71.34 to $72.335, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 6

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,456,199

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F8 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $70.31 to $71.26, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022868 · doc4.xml · derivative · entry 4

D'Cruz Cony · CIK 0001797727 · EVP & Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,479

Underlying: Common Stock · 2,800 shares

Expires 2026-05-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 18, 2020.

F2 · derivative.exercise_date: The option was granted on May 11, 2016 and is fully vested.

SEC source: 0001209191-21-022868 · doc4.xml · nonDerivative · entry 3

D'Cruz Cony · CIK 0001797727 · EVP & Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · By Cony and Pearl D'Cruz Revocable Trust dated August 20, 2019, and any amendments thereto

Disclosed balance after: 147,082

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 18, 2020.

SEC source: 0001209191-21-022868 · doc4.xml · nonDerivative · entry 2

D'Cruz Cony · CIK 0001797727 · EVP & Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 18, 2020.

SEC source: 0001209191-21-022868 · doc4.xml · nonDerivative · entry 1

D'Cruz Cony · CIK 0001797727 · EVP & Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,800

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 18, 2020.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 5

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,466,052

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F7 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $83.49 to $83.64, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 4

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,466,552

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F6 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $82.40 to $83.35, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 3

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,473,736

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F5 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $81.40 to $82.39, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 2

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,493,097

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F4 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $80.39 to $81.38, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-022925 · doc4.xml · nonDerivative · entry 1

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,504,945

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F2 · price: This is a weighted average sale price for the transactions reported on this line. Sales ranged in price from $79.39 to $80.38, inclusive. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.

SEC source: 0001209191-21-021855 · doc4.xml · nonDerivative · entry 16

SHAW DAVID E · CIK 0001023870 · 10% owner

Schrodinger Equity Holdings, LLC · CIK 0001801739 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by Schrodinger Equity Holdings, LLC

Disclosed balance after: 8,516,052

F1 · kind: The transactions reported in this line of this Form 4 were effected pursuant to a Rule 10b5-1 sales plan dated August 13, 2020.

F3 · ownership.nature: Schrodinger Equity Holdings, LLC, which holds these securities, is owned in its entirety through a trust of which David E. Shaw is the trustee and beneficiary.