SCYX

SEC source: 0001209191-22-007727 · doc4.xml · derivative · entry 2

Angulo Gonzalez David · CIK 0001644071 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,000

Underlying: Common Stock · 85,000 shares

Expires 2032-02-03

F2 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly for 48 months as measured from the date of grant.

SEC source: 0001209191-22-007727 · doc4.xml · nonDerivative · entry 1

Angulo Gonzalez David · CIK 0001644071 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,981

F1 · shares: Represents restricted stock units that vest 50% per year over two years on the anniversary of the date of grant.

SEC source: 0001209191-21-041826 · doc4.xml · derivative · entry 1

Tinmouth Brian Philippe · CIK 0001797160 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2031-06-15

F1 · derivative.exercise_date: One-hundred percent (100%) of the shares subject to the option vest on the first anniversary of the date of grant, provided that the non-employee director is providing continuous services on the applicable vesting date.

SEC source: 0001209191-21-041825 · doc4.xml · derivative · entry 1

Macdonald Guy · CIK 0001296998 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2031-06-15

F1 · derivative.exercise_date: One-hundred percent (100%) of the shares subject to the option vest on the first anniversary of the date of grant, provided that the non-employee director is providing continuous services on the applicable vesting date.

SEC source: 0001209191-21-041824 · doc4.xml · derivative · entry 1

HASTINGS DAVID C · CIK 0001237401 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2031-06-15

F1 · derivative.exercise_date: One-hundred percent (100%) of the shares subject to the option vest on the first anniversary of the date of grant, provided that the non-employee director is providing continuous services on the applicable vesting date.

SEC source: 0001209191-21-041823 · doc4.xml · derivative · entry 1

HANHAM ANN · CIK 0001286338 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2031-06-15

F1 · derivative.exercise_date: One-hundred percent (100%) of the shares subject to the option vest on the first anniversary of the date of grant, provided that the non-employee director is providing continuous services on the applicable vesting date.

SEC source: 0001209191-21-041822 · doc4.xml · derivative · entry 1

GILMAN STEVEN C · CIK 0001379970 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2031-06-15

F1 · derivative.exercise_date: One-hundred percent (100%) of the shares subject to the option vest on the first anniversary of the date of grant, provided that the non-employee director is providing continuous services on the applicable vesting date.

SEC source: 0001209191-21-041821 · doc4.xml · derivative · entry 1

ANIDO ARMANDO · CIK 0001219866 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2031-06-15

F1 · derivative.exercise_date: One-hundred percent (100%) of the shares subject to the option vest on the first anniversary of the date of grant, provided that the non-employee director is providing continuous services on the applicable vesting date.

SEC source: 0001209191-21-032231 · doc4.xml · derivative · entry 2

Coyne Christine · CIK 0001861840 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2031-05-09

F2 · derivative.exercise_date: 25% of the shares subject to this option vests on the one-year anniversary of the grant date with the remainder vesting in equal monthly installments for thirty-six (36) months thereafter, provided the executive continues to provide continuous services to us.

SEC source: 0001209191-21-032231 · doc4.xml · nonDerivative · entry 1

Coyne Christine · CIK 0001861840 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

F1 · shares: Represents restricted stock units that vest 25% per year over four years.

SEC source: 0001209191-21-006718 · doc4.xml · derivative · entry 1

Taglietti Marco · CIK 0001408870 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 170,000

Underlying: Common Stock · 170,000 shares

Expires 2031-01-28

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly for 48 months as measured from the date of grant.

SEC source: 0001209191-21-006717 · doc4.xml · derivative · entry 1

Sukenick Scott · CIK 0001722886 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2031-01-28

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly for 48 months as measured from the date of grant.

SEC source: 0001209191-21-006716 · doc4.xml · derivative · entry 1

Francois Eric · CIK 0001656125 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Stock · 65,000 shares

Expires 2031-01-28

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly for 48 months as measured from the date of grant.

SEC source: 0001209191-21-006715 · doc4.xml · derivative · entry 1

Angulo Gonzalez David · CIK 0001644071 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Stock · 65,000 shares

Expires 2031-01-28

F1 · derivative.exercise_date: 1/48th of the shares subject to the option vest monthly for 48 months as measured from the date of grant.

SEC source: 0000899243-21-003426 · doc4.xml · nonDerivative · entry 4

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,800,000

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $8.62 to $9.07, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F5 · ownership.nature: The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0000899243-21-003426 · doc4.xml · nonDerivative · entry 3

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,833,849

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.62 to $8.61, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F5 · ownership.nature: The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0000899243-21-003426 · doc4.xml · nonDerivative · entry 2

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,120,000

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.27 to $7.50, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F5 · ownership.nature: The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0000899243-21-003426 · doc4.xml · nonDerivative · entry 1

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,215,000

F1 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $7.26 to $7.85, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F5 · ownership.nature: The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001209191-20-064961 · doc4.xml · derivative · entry 3

Tinmouth Brian Philippe · CIK 0001797160 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,000

Underlying: Common Stock · 4,000 shares

Expires 2024-06-21

F1 · price: Reflects the purchase on December 21, 2020 of 8,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064961 · doc4.xml · derivative · entry 2

Tinmouth Brian Philippe · CIK 0001797160 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,000

Underlying: Common Stock · 4,000 shares

Expires 2021-12-21

F1 · price: Reflects the purchase on December 21, 2020 of 8,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064961 · doc4.xml · nonDerivative · entry 1

Tinmouth Brian Philippe · CIK 0001797160 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

F1 · price: Reflects the purchase on December 21, 2020 of 8,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064960 · doc4.xml · derivative · entry 3

Taglietti Marco · CIK 0001408870 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2024-06-21

F1 · price: Reflects the purchase on December 21, 2020 of 40,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064960 · doc4.xml · derivative · entry 2

Taglietti Marco · CIK 0001408870 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2021-12-21

F1 · price: Reflects the purchase on December 21, 2020 of 40,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064960 · doc4.xml · nonDerivative · entry 1

Taglietti Marco · CIK 0001408870 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,668

F1 · price: Reflects the purchase on December 21, 2020 of 40,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064959 · doc4.xml · derivative · entry 3

Sukenick Scott · CIK 0001722886 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 800

Underlying: Common Stock · 800 shares

Expires 2024-06-21

F1 · price: Reflects the purchase on December 21, 2020 of 1,600 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064959 · doc4.xml · derivative · entry 2

Sukenick Scott · CIK 0001722886 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 800

Underlying: Common Stock · 800 shares

Expires 2021-12-21

F1 · price: Reflects the purchase on December 21, 2020 of 1,600 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064959 · doc4.xml · nonDerivative · entry 1

Sukenick Scott · CIK 0001722886 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,099

F1 · price: Reflects the purchase on December 21, 2020 of 1,600 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064958 · doc4.xml · derivative · entry 3

Macdonald Guy · CIK 0001296998 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,000

Underlying: Common Stock · 4,000 shares

Expires 2024-06-21

F1 · price: Reflects the purchase on December 21, 2020 of 8,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064958 · doc4.xml · derivative · entry 2

Macdonald Guy · CIK 0001296998 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,000

Underlying: Common Stock · 4,000 shares

Expires 2021-12-21

F1 · price: Reflects the purchase on December 21, 2020 of 8,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064958 · doc4.xml · nonDerivative · entry 1

Macdonald Guy · CIK 0001296998 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,000

F1 · price: Reflects the purchase on December 21, 2020 of 8,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064957 · doc4.xml · derivative · entry 3

HANHAM ANN · CIK 0001286338 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,600

Underlying: Common Stock · 1,600 shares

Expires 2024-06-21

F1 · price: Reflects the purchase on December 21, of 3,200 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064957 · doc4.xml · derivative · entry 2

HANHAM ANN · CIK 0001286338 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,600

Underlying: Common Stock · 1,600 shares

Expires 2021-12-21

F1 · price: Reflects the purchase on December 21, of 3,200 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064957 · doc4.xml · nonDerivative · entry 1

HANHAM ANN · CIK 0001286338 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,622

F1 · price: Reflects the purchase on December 21, of 3,200 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064955 · doc4.xml · derivative · entry 3

Francois Eric · CIK 0001656125 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300

Underlying: Common Stock · 300 shares

Expires 2024-06-21

F1 · price: Reflects the purchase on December 21, 2020 of 600 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064955 · doc4.xml · derivative · entry 2

Francois Eric · CIK 0001656125 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300

Underlying: Common Stock · 300 shares

Expires 2021-12-21

F1 · price: Reflects the purchase on December 21, 2020 of 600 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064955 · doc4.xml · nonDerivative · entry 1

Francois Eric · CIK 0001656125 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,732

F1 · price: Reflects the purchase on December 21, 2020 of 600 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064956 · doc4.xml · derivative · entry 3

GILMAN STEVEN C · CIK 0001379970 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,000

Underlying: Common Stock · 2,000 shares

Expires 2024-06-21

F1 · price: Reflects the purchase on December 21, 2020 of 4,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064956 · doc4.xml · derivative · entry 2

GILMAN STEVEN C · CIK 0001379970 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,000

Underlying: Common Stock · 2,000 shares

Expires 2021-12-21

F1 · price: Reflects the purchase on December 21, 2020 of 4,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064956 · doc4.xml · nonDerivative · entry 1

GILMAN STEVEN C · CIK 0001379970 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,000

F1 · price: Reflects the purchase on December 21, 2020 of 4,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064953 · doc4.xml · derivative · entry 3

Angulo Gonzalez David · CIK 0001644071 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 800

Underlying: Common Stock · 800 shares

Expires 2024-06-21

F1 · price: Reflects the purchase on December 21, 2020 of 1,600 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064953 · doc4.xml · derivative · entry 2

Angulo Gonzalez David · CIK 0001644071 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 800

Underlying: Common Stock · 800 shares

Expires 2021-12-21

F1 · price: Reflects the purchase on December 21, 2020 of 1,600 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064953 · doc4.xml · nonDerivative · entry 1

Angulo Gonzalez David · CIK 0001644071 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,780

F1 · price: Reflects the purchase on December 21, 2020 of 1,600 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064954 · doc4.xml · derivative · entry 3

ANIDO ARMANDO · CIK 0001219866 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,500

Underlying: Common Stock · 2,500 shares

Expires 2024-06-21

F1 · price: Reflects the purchase on December 21, of 5,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064954 · doc4.xml · derivative · entry 2

ANIDO ARMANDO · CIK 0001219866 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,500

Underlying: Common Stock · 2,500 shares

Expires 2021-12-21

F1 · price: Reflects the purchase on December 21, of 5,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-064954 · doc4.xml · nonDerivative · entry 1

ANIDO ARMANDO · CIK 0001219866 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

F1 · price: Reflects the purchase on December 21, of 5,000 shares of the issuer's common stock, par value $0.001 per share, at a public offering price of $6.25 per share of common stock and accompanying warrants to purchase 0.50 of a share of common stock (Series 1 warrant) and 0.50 of a share of common stock (Series 2 warrant).

SEC source: 0001209191-20-061879 · doc4.xml · nonDerivative · entry 2

Sukenick Scott · CIK 0001722886 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,499

F1 · shares: Represents the number of shares withheld by and surrendered to the Issuer to satisfy tax withholding obligations that arose in connection with a vesting event from a restricted stock unit award.

F2 · balance_after: Includes 200 shares acquired in 2020 by the reporting person under the Issuer's 2014 Employee Stock Purchase Plan: 100 shares on March 5, 2020 and 100 shares on September 5, 2020.

SEC source: 0001209191-20-061878 · doc4.xml · nonDerivative · entry 2

Francois Eric · CIK 0001656125 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,132

F1 · shares: Represents the number of shares withheld by and surrendered to the Issuer to satisfy tax withholding obligations that arose in connection with a vesting event from a restricted stock unit award.

F2 · balance_after: Includes 200 shares acquired in 2020 by the reporting person under the Issuer's 2014 Employee Stock Purchase Plan: 100 shares on March 5, 2020 and 100 shares on September 5, 2020.

SEC source: 0001209191-20-061876 · doc4.xml · nonDerivative · entry 2

Angulo Gonzalez David · CIK 0001644071 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,180

F1 · shares: Represents the number of shares withheld by and surrendered to the Issuer to satisfy tax withholding obligations that arose in connection with a vesting event from a restricted stock unit award.

F2 · balance_after: Includes 200 shares acquired in 2020 by the reporting person under the Issuer's 2014 Employee Stock Purchase Plan: 100 shares on March 5, 2020 and 100 shares on September 5, 2020.

SEC source: 0001209191-20-041744 · doc4.xml · derivative · entry 1

Tinmouth Brian Philippe · CIK 0001797160 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2030-07-05

F1 · derivative.exercise_date: One-hundred percent (100%) of the shares subject to the option vest on the first anniversary of the date of grant, provided that the non-employee director is providing continuous services on the applicable vesting date.

SEC source: 0001209191-20-041741 · doc4.xml · derivative · entry 1

Macdonald Guy · CIK 0001296998 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2030-07-05

F1 · derivative.exercise_date: One-hundred percent (100%) of the shares subject to the option vest on the first anniversary of the date of grant, provided that the non-employee director is providing continuous services on the applicable vesting date.