RVMD

SEC source: 0000899243-21-022346 · doc4.xml · nonDerivative · entry 2

Exter Neil · CIK 0001620014 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F4 · shares: On June 4, 2021, TRV II sold 164,996 shares of Common Stock of the Issuer in multiple transactions at prices ranging from $30.10 to $30.76, inclusive, at a weighted average price per share of $30.23. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4).

F4 · price: On June 4, 2021, TRV II sold 164,996 shares of Common Stock of the Issuer in multiple transactions at prices ranging from $30.10 to $30.76, inclusive, at a weighted average price per share of $30.23. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4).

F5 · balance_after: After the above transaction, TRV II owned 0 shares of Common Stock of the Issuer.

F3 · ownership.nature: The Reporting Person is a partner of each of Third Rock Ventures GP II, L.P., TRV GP III, L.P. and Third Rock Ventures GP IV, L.P. which is the general partner of each of TRV II, Third Rock Ventures III, L.P. ("TRV III") and Third Rock Ventures IV, L.P. ("TRV IV" and collectively with TRV II and TRV III, "the Funds"), respectively. The Reporting Person disclaims beneficial ownership over the shares held by the Funds, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that he is the beneficial owner of such shares.

SEC source: 0000899243-21-022345 · doc4.xml · nonDerivative · entry 1

Third Rock Ventures II, L.P. · CIK 0001488495 · 10% owner

Third Rock Ventures GP II, L.P. · CIK 0001614061 · 10% owner

TRV GP II, LLC · CIK 0001614073 · 10% owner

STARR KEVIN P · CIK 0001192603 · 10% owner

TEPPER ROBERT I · CIK 0001192595 · 10% owner

LEVIN MARK J · CIK 0001180428 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 164,996

F1 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.00 to $30.50, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1).

F2 · ownership.direct: These shares are directly held by Third Rock Ventures II, L.P. ("TRV II"). The general partner of TRV II is Third Rock Ventures GP II, L.P. ("TRV GP II"). The general partner of TRV GP II is TRV GP II, LLC ("TRV GP II LLC"). The individual managers of TRV GP II LLC are Mark Levin ("Levin"), Kevin Starr ("Starr") and Dr. Robert Tepper ("Tepper"). Each of TRV GP II, TRV GP II LLC, Levin, Starr and Tepper disclaims beneficial ownership of the shares except to the extent of its or his pecuniary interest therein, if any, and this report shall not be deemed an admission that it or he is the beneficial owner of such shares.

SEC source: 0000899243-21-022346 · doc4.xml · nonDerivative · entry 1

Exter Neil · CIK 0001620014 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F1 · shares: On June 3, 2021, Third Rock Ventures II, L.P. ("TRV II") sold 378,117 shares of Common Stock of the Issuer in multiple transactions at prices ranging from $30.00 to $30.50, inclusive, at a weighted average price per share of $30.20. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1).

F1 · price: On June 3, 2021, Third Rock Ventures II, L.P. ("TRV II") sold 378,117 shares of Common Stock of the Issuer in multiple transactions at prices ranging from $30.00 to $30.50, inclusive, at a weighted average price per share of $30.20. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1).

F2 · balance_after: After the above transaction, TRV II owned 164,996 shares of Common Stock of the Issuer.

F3 · ownership.nature: The Reporting Person is a partner of each of Third Rock Ventures GP II, L.P., TRV GP III, L.P. and Third Rock Ventures GP IV, L.P. which is the general partner of each of TRV II, Third Rock Ventures III, L.P. ("TRV III") and Third Rock Ventures IV, L.P. ("TRV IV" and collectively with TRV II and TRV III, "the Funds"), respectively. The Reporting Person disclaims beneficial ownership over the shares held by the Funds, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that he is the beneficial owner of such shares.

SEC source: 0000899243-21-020885 · doc4.xml · nonDerivative · entry 2

Third Rock Ventures II, L.P. · CIK 0001488495 · 10% owner

Third Rock Ventures GP II, L.P. · CIK 0001614061 · 10% owner

TRV GP II, LLC · CIK 0001614073 · 10% owner

STARR KEVIN P · CIK 0001192603 · 10% owner

TEPPER ROBERT I · CIK 0001192595 · 10% owner

LEVIN MARK J · CIK 0001180428 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 543,113

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.50 to $31.14, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3).

F2 · ownership.direct: These shares are directly held by Third Rock Ventures II, L.P. ("TRV II"). The general partner of TRV II is Third Rock Ventures GP II, L.P. ("TRV GP II"). The general partner of TRV GP II is TRV GP II, LLC ("TRV GP II LLC"). The individual managers of TRV GP II LLC are Mark Levin ("Levin"), Kevin Starr ("Starr") and Dr. Robert Tepper ("Tepper"). Each of TRV GP II, TRV GP II LLC, Levin, Starr and Tepper disclaims beneficial ownership of the shares except to the extent of its or his pecuniary interest therein, if any, and this report shall not be deemed an admission that it or he is the beneficial owner of such shares

SEC source: 0000899243-21-020884 · doc4.xml · nonDerivative · entry 2

Exter Neil · CIK 0001620014 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 0

F4 · shares: On May 26, 2021, TRV II sold 1,231,204 shares of Common Stock of the Issuer in multiple transactions at prices ranging from $30.50 to $31.14, inclusive, at a weighted average price per share of $30.53. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4).

F4 · price: On May 26, 2021, TRV II sold 1,231,204 shares of Common Stock of the Issuer in multiple transactions at prices ranging from $30.50 to $31.14, inclusive, at a weighted average price per share of $30.53. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4).

F5 · balance_after: After the above transaction, TRV II owned 543,113 shares of Common Stock of the Issuer.

F3 · ownership.nature: The Reporting Person is a partner of each of Third Rock Ventures GP II, L.P., TRV GP III, L.P. and Third Rock Ventures GP IV, L.P. which is the general partner of each of TRV II, Third Rock Ventures III, L.P. ("TRV III") and Third Rock Ventures IV, L.P. ("TRV IV" and collectively with TRV II and TRV III, "the Funds"), respectively. The Reporting Person disclaims beneficial ownership over the shares held by the Funds, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that he is the beneficial owner of such shares.

SEC source: 0000899243-21-020885 · doc4.xml · nonDerivative · entry 1

Third Rock Ventures II, L.P. · CIK 0001488495 · 10% owner

Third Rock Ventures GP II, L.P. · CIK 0001614061 · 10% owner

TRV GP II, LLC · CIK 0001614073 · 10% owner

STARR KEVIN P · CIK 0001192603 · 10% owner

TEPPER ROBERT I · CIK 0001192595 · 10% owner

LEVIN MARK J · CIK 0001180428 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,774,317

F1 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.85 to $31.25, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1).

F2 · ownership.direct: These shares are directly held by Third Rock Ventures II, L.P. ("TRV II"). The general partner of TRV II is Third Rock Ventures GP II, L.P. ("TRV GP II"). The general partner of TRV GP II is TRV GP II, LLC ("TRV GP II LLC"). The individual managers of TRV GP II LLC are Mark Levin ("Levin"), Kevin Starr ("Starr") and Dr. Robert Tepper ("Tepper"). Each of TRV GP II, TRV GP II LLC, Levin, Starr and Tepper disclaims beneficial ownership of the shares except to the extent of its or his pecuniary interest therein, if any, and this report shall not be deemed an admission that it or he is the beneficial owner of such shares

SEC source: 0000899243-21-020884 · doc4.xml · nonDerivative · entry 1

Exter Neil · CIK 0001620014 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 0

F1 · shares: On May 25, 2021, Third Rock Ventures II, L.P. ("TRV II") sold 135,000 shares of Common Stock of the Issuer in multiple transactions at prices ranging from $30.85 to $31.25, inclusive, at a weighted average price per share of $30.93. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1).

F1 · price: On May 25, 2021, Third Rock Ventures II, L.P. ("TRV II") sold 135,000 shares of Common Stock of the Issuer in multiple transactions at prices ranging from $30.85 to $31.25, inclusive, at a weighted average price per share of $30.93. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1).

F2 · balance_after: After the above transaction, TRV II owned 1,774,317 shares of Common Stock of the Issuer.

F3 · ownership.nature: The Reporting Person is a partner of each of Third Rock Ventures GP II, L.P., TRV GP III, L.P. and Third Rock Ventures GP IV, L.P. which is the general partner of each of TRV II, Third Rock Ventures III, L.P. ("TRV III") and Third Rock Ventures IV, L.P. ("TRV IV" and collectively with TRV II and TRV III, "the Funds"), respectively. The Reporting Person disclaims beneficial ownership over the shares held by the Funds, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that he is the beneficial owner of such shares.

SEC source: 0000899243-21-017254 · doc4.xml · nonDerivative · entry 6

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,775,236

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III, LP ("TCG III LP").

F4 · ownership.nature: The securities are directly held by TCG III-A LP. TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-017254 · doc4.xml · nonDerivative · entry 5

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,571,963

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III, LP ("TCG III LP").

F2 · ownership.nature: The securities are directly held by TCG III LP. The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are David Goeddel, the Reporting Person, a member of the Issuer's board of directors, and Tim Kutzkey (collectively, the "Managing Partners"). The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-017254 · doc4.xml · nonDerivative · entry 4

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,775,289

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III, LP ("TCG III LP").

F4 · ownership.nature: The securities are directly held by TCG III-A LP. TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-017254 · doc4.xml · nonDerivative · entry 3

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,572,010

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III, LP ("TCG III LP").

F2 · ownership.nature: The securities are directly held by TCG III LP. The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are David Goeddel, the Reporting Person, a member of the Issuer's board of directors, and Tim Kutzkey (collectively, the "Managing Partners"). The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-017254 · doc4.xml · nonDerivative · entry 2

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,787,660

F3 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III-A, LP ("TCG III-A LP").

F4 · ownership.nature: The securities are directly held by TCG III-A LP. TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-017254 · doc4.xml · nonDerivative · entry 1

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,582,965

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III, LP ("TCG III LP").

F2 · ownership.nature: The securities are directly held by TCG III LP. The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are David Goeddel, the Reporting Person, a member of the Issuer's board of directors, and Tim Kutzkey (collectively, the "Managing Partners"). The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-015537 · doc4.xml · nonDerivative · entry 4

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,815,761

F3 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III-A, LP ("TCG III-A LP").

F4 · ownership.nature: The securities are directly held by TCG III-A LP. TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-015537 · doc4.xml · nonDerivative · entry 3

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,607,848

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III, LP ("TCG III LP").

F2 · ownership.nature: The securities are directly held by TCG III LP. The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are David Goeddel, the Reporting Person, a member of the Issuer's board of directors, and Tim Kutzkey (collectively, the "Managing Partners"). The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-015537 · doc4.xml · nonDerivative · entry 2

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,828,862

F3 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III-A, LP ("TCG III-A LP").

F4 · ownership.nature: The securities are directly held by TCG III-A LP. TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-015537 · doc4.xml · nonDerivative · entry 1

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,619,448

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III, LP ("TCG III LP").

F2 · ownership.nature: The securities are directly held by TCG III LP. The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are David Goeddel, the Reporting Person, a member of the Issuer's board of directors, and Tim Kutzkey (collectively, the "Managing Partners"). The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-015320 · doc4.xml · nonDerivative · entry 6

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,853,380

F3 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III-A, LP ("TCG III-A LP").

F4 · ownership.nature: The securities are directly held by TCG III-A LP. TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-015320 · doc4.xml · nonDerivative · entry 5

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,641,158

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III, LP ("TCG III LP").

F2 · ownership.nature: The securities are directly held by TCG III LP. The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are David Goeddel, the Reporting Person, a member of the Issuer's board of directors, and Tim Kutzkey (collectively, the "Managing Partners"). The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-015320 · doc4.xml · nonDerivative · entry 4

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,868,205

F3 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III-A, LP ("TCG III-A LP").

F4 · ownership.nature: The securities are directly held by TCG III-A LP. TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-015320 · doc4.xml · nonDerivative · entry 3

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,654,286

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III, LP ("TCG III LP").

F2 · ownership.nature: The securities are directly held by TCG III LP. The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are David Goeddel, the Reporting Person, a member of the Issuer's board of directors, and Tim Kutzkey (collectively, the "Managing Partners"). The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-015320 · doc4.xml · nonDerivative · entry 2

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,889,154

F3 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III-A, LP ("TCG III-A LP").

F4 · ownership.nature: The securities are directly held by TCG III-A LP. TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Managing Partners. The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-015320 · doc4.xml · nonDerivative · entry 1

Svennilson Peter · CIK 0001606074 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,672,837

F1 · kind: The sale of these shares was effected pursuant to a Rule 10b5-1 trading plan adopted by The Column Group III, LP ("TCG III LP").

F2 · ownership.nature: The securities are directly held by TCG III LP. The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are David Goeddel, the Reporting Person, a member of the Issuer's board of directors, and Tim Kutzkey (collectively, the "Managing Partners"). The Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0001567619-21-006887 · doc1.xml · derivative · entry 4

Miller Vincent A. · CIK 0001584999 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,785

Underlying: Common Stock · 1,600 shares

Expires 2029-08-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option is early exercisable. One twelfth (1/12th) of the shares initially subject to the option will vest on each monthly anniversary measured from September 27, 2019 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the first anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001567619-21-006887 · doc1.xml · derivative · entry 3

Miller Vincent A. · CIK 0001584999 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,397

Underlying: Common Stock · 1,600 shares

Expires 2029-08-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option is early exercisable. One twenty-fourth (1/24th) of the shares initially subject to the option will vest on each monthly anniversary measured from August 9, 2019 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the second anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001567619-21-006887 · doc1.xml · nonDerivative · entry 2

Miller Vincent A. · CIK 0001584999 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,133

F1 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-21-006887 · doc1.xml · nonDerivative · entry 1

Miller Vincent A. · CIK 0001584999 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,333

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 1,808 Restricted Stock Units.

SEC source: 0001567619-21-005846 · doc1.xml · derivative · entry 2

Wang Xiaolin · CIK 0001849181 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,200

Underlying: Common Stock · 39,200 shares

Expires 2031-03-03

F2 · derivative.exercise_date: One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 4, 2021 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001567619-21-005846 · doc1.xml · nonDerivative · entry 1

Wang Xiaolin · CIK 0001849181 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,944

F1 · balance_after: Includes 11,200 Restricted Stock Units.

SEC source: 0001567619-21-005847 · doc1.xml · derivative · entry 2

Anders Jack · CIK 0001800668 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,900

Underlying: Common Stock · 25,900 shares

Expires 2031-03-03

F3 · derivative.exercise_date: One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 4, 2021 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001567619-21-005847 · doc1.xml · nonDerivative · entry 1

Anders Jack · CIK 0001800668 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,904

F1 · balance_after: Includes 7,400 Restricted Stock Units.

F2 · balance_after: Includes 504 shares acquired under the Issuer's Employee Stock Purchase Plan on November 30, 2020.

SEC source: 0001567619-21-005848 · doc1.xml · derivative · entry 2

Kelsey Stephen Michael · CIK 0001462808 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,500

Underlying: Common Stock · 52,500 shares

Expires 2031-03-03

F3 · derivative.exercise_date: One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 4, 2021 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001567619-21-005848 · doc1.xml · nonDerivative · entry 1

Kelsey Stephen Michael · CIK 0001462808 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 252,073

F1 · balance_after: Includes 15,000 Restricted Stock Units.

F2 · balance_after: Includes 744 shares acquired under the Issuer's Employee Stock Purchase Plan on November 30, 2020.

SEC source: 0001567619-21-005850 · doc1.xml · derivative · entry 3

Horn Margaret A · CIK 0001294192 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,500

Underlying: Common Stock · 52,500 shares

Expires 2031-03-03

F3 · derivative.exercise_date: This option is early exercisable. One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from August 9, 2019 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001567619-21-005850 · doc1.xml · nonDerivative · entry 2

Horn Margaret A · CIK 0001294192 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,198

F2 · balance_after: Includes 15,000 Restricted Stock Units.

SEC source: 0001567619-21-005849 · doc1.xml · derivative · entry 5

GOLDSMITH MARK A · CIK 0001246842 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 169,000

Underlying: Common Stock · 169,000 shares

Expires 2031-03-03

F5 · derivative.exercise_date: One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 4, 2021 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001567619-21-005849 · doc1.xml · nonDerivative · entry 1

GOLDSMITH MARK A · CIK 0001246842 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,744

F1 · balance_after: Includes 48,000 Restricted Stock Units.

SEC source: 0001567619-21-005602 · doc1.xml · derivative · entry 6

GOLDSMITH MARK A · CIK 0001246842 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,486

Underlying: Common Stock · 5,000 shares

Expires 2028-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F9 · derivative.exercise_date: This option is early exercisable. One forty-eighth (1/48th) of the shares subject to the option will vest on each monthly anniversary measured from March 29, 2018 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001567619-21-005602 · doc1.xml · nonDerivative · entry 2

GOLDSMITH MARK A · CIK 0001246842 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 744

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: This transaction was executed in multiple trades at prices ranging from $45.51 to $46.46. The price reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001567619-21-005602 · doc1.xml · nonDerivative · entry 1

GOLDSMITH MARK A · CIK 0001246842 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,744

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0000899243-21-008465 · doc4.xml · nonDerivative · entry 1

Third Rock Ventures III, L.P. · CIK 0001569705 · 10% owner

Third Rock Ventures GP III, L.P. · CIK 0001637300 · 10% owner

TRV GP III, LLC · CIK 0001637299 · 10% owner

STARR KEVIN P · CIK 0001192603 · 10% owner

TEPPER ROBERT I · CIK 0001192595 · 10% owner

LEVIN MARK J · CIK 0001180428 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,524,031

F1 · kind: On February 24, 2021, Third Rock Ventures III, L.P. ("TRV III") distributed for no consideration, 1,500,000 shares of Common Stock of the Issuer (the "Shares") to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP II"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended.

F1 · price: On February 24, 2021, Third Rock Ventures III, L.P. ("TRV III") distributed for no consideration, 1,500,000 shares of Common Stock of the Issuer (the "Shares") to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP II"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended.

F2 · ownership.direct: These shares are directly held by TRV III. The general partner of TRV III is TRV GP III. The general partner of TRV GP III is TRV GP III, LLC ("TRV GP III LLC"). The individual managers of TRV GP III LLC are Mark Levin ("Levin"), Kevin Starr ("Starr") and Dr. Robert Tepper ("Tepper"). Each of TRV GP III, TRV GP III LLC, Levin, Starr and Tepper disclaims beneficial ownership of the shares except to the extent of its or his pecuniary interest therein, if any, and this report shall not be deemed an admission that it or he is the beneficial owner of such shares

SEC source: 0000899243-21-008467 · doc4.xml · nonDerivative · entry 1

Exter Neil · CIK 0001620014 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F1 · kind: On February 24, 2020, Third Rock Ventures III, L.P. ("TRV III") distributed for no consideration 1,500,000 shares of Common Stock of the Issuer (the "Shares") to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP III"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended. After such distribution, TRV III directly held 5,524,031 shares of Common Stock of the Issuer.

F1 · shares: On February 24, 2020, Third Rock Ventures III, L.P. ("TRV III") distributed for no consideration 1,500,000 shares of Common Stock of the Issuer (the "Shares") to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP III"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended. After such distribution, TRV III directly held 5,524,031 shares of Common Stock of the Issuer.

F1 · price: On February 24, 2020, Third Rock Ventures III, L.P. ("TRV III") distributed for no consideration 1,500,000 shares of Common Stock of the Issuer (the "Shares") to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP III"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended. After such distribution, TRV III directly held 5,524,031 shares of Common Stock of the Issuer.

F1 · balance_after: On February 24, 2020, Third Rock Ventures III, L.P. ("TRV III") distributed for no consideration 1,500,000 shares of Common Stock of the Issuer (the "Shares") to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP III"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended. After such distribution, TRV III directly held 5,524,031 shares of Common Stock of the Issuer.

F2 · ownership.nature: The Reporting Person is a partner of each of Third Rock Ventures GP II, L.P., TRV GP III and Third Rock Ventures GP IV, L.P. which is the general partner of each of Third Rock Ventures II, L.P. ("TRV II"), TRV III and Third Rock Ventures IV, L.P. ("TRV IV" and collectively with TRV II and TRV III, "the Funds"), respectively. The Reporting Person disclaims beneficial ownership over the shares held by the Funds, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed an admission that he is the beneficial owner of such shares.

SEC source: 0001209191-22-016484 · doc4.xml · nonDerivative · entry 4

Schroeder Thilo · CIK 0001776412 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Nextech VI Oncology SCSp

Disclosed balance after: 300,000

F3 · ownership.nature: Nextech Invest AG is the investment advisor of Nextech VI Oncology SCSp ("Nextech VI"). The reporting person is a managing member at Nextech Invest AG and may therefore be deemed to be the beneficial owner of shares held by Nextech VI. The reporting person disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001567619-21-002502 · doc1.xml · derivative · entry 4

Horn Margaret A · CIK 0001294192 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 189,800

Underlying: Common Stock · 35,000 shares

Expires 2029-08-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F4 · derivative.exercise_date: This option is early exercisable. One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from August 9, 2019 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001567619-21-002502 · doc1.xml · nonDerivative · entry 3

Horn Margaret A · CIK 0001294192 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,198

F2 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F3 · balance_after: Includes 744 shares acquired under the Issuer's Employee Stock Purchase Plan on November 30, 2020.

SEC source: 0001567619-21-002502 · doc1.xml · nonDerivative · entry 2

Horn Margaret A · CIK 0001294192 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,198

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F3 · balance_after: Includes 744 shares acquired under the Issuer's Employee Stock Purchase Plan on November 30, 2020.

SEC source: 0001567619-21-002501 · doc1.xml · derivative · entry 6

GOLDSMITH MARK A · CIK 0001246842 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,486

Underlying: Common Stock · 15,000 shares

Expires 2028-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F6 · derivative.exercise_date: This option is early exercisable. One forty-eighth (1/48th) of the shares subject to the option will vest on each monthly anniversary measured from March 29, 2018 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001567619-21-002501 · doc1.xml · nonDerivative · entry 2

GOLDSMITH MARK A · CIK 0001246842 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 744

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · balance_after: Includes 744 shares acquired under the Issuer's Employee Stock Purchase Plan on November 30, 2020.

SEC source: 0001567619-21-002501 · doc1.xml · nonDerivative · entry 1

GOLDSMITH MARK A · CIK 0001246842 · Director · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,744

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F2 · balance_after: Includes 744 shares acquired under the Issuer's Employee Stock Purchase Plan on November 30, 2020.

SEC source: 0001567619-21-002350 · doc1.xml · derivative · entry 4

Weber Barbara · CIK 0001800670 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,997

Underlying: Common Stock · 5,000 shares

Expires 2029-08-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person.

F5 · derivative.exercise_date: This option is early exercisable. One thirtieth (1/30th) of the shares subject to the option will vest on each monthly anniversary measured from August 9, 2019 (the "Vesting Commencement Date") so that 100% of the shares subject to the option will be fully vested as of two and a half years following the Vesting Commencement Date, subject to the Reporting Person's continued service through each such vesting date.