RLAY

SEC source: 0001209191-22-055112 · doc4.xml · nonDerivative · entry 1

Adams Brian · CIK 0001636994 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 61,820

F1 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 2,455 shares of restricted stock units ("RSUs") on October 27, 2022. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F2 · balance_after: Includes 41,826 shares underlying RSUs.

SEC source: 0001209191-23-005702 · doc5.xml · nonDerivative · entry 2

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By The SSP Irrevocable Trust of 2020

Disclosed balance after: 687,355

F1 · ownership.nature: These shares are held in an irrevocable trust for the benefit of the reporting person's family members. An independent trustee is trustee of this trust. The reporting person disclaims beneficial ownership of these securities, and the filing of this report is not an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

SEC source: 0001209191-23-005702 · doc5.xml · nonDerivative · entry 1

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

SEC source: 0001209191-22-053597 · doc4.xml · derivative · entry 11

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,175

Underlying: Common Stock · 14,000 shares

Expires 2028-03-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

F6 · derivative.exercise_date: The shares underlying this option shall vest in sixteen (16) equal quarterly installments after March 23, 2018, subject to the reporting person's continued employment through each applicable vesting date.

SEC source: 0001209191-22-053597 · doc4.xml · nonDerivative · entry 6

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 254,554

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

F4 · price: This transaction was executed in multiple trades at prices ranging from $20.28 to $20.81. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001209191-22-053597 · doc4.xml · nonDerivative · entry 5

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 268,554

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

SEC source: 0001209191-22-053597 · doc4.xml · derivative · entry 10

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,175

Underlying: Common Stock · 14,000 shares

Expires 2028-03-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

F6 · derivative.exercise_date: The shares underlying this option shall vest in sixteen (16) equal quarterly installments after March 23, 2018, subject to the reporting person's continued employment through each applicable vesting date.

SEC source: 0001209191-22-053597 · doc4.xml · nonDerivative · entry 4

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 254,554

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

F3 · price: This transaction was executed in multiple trades at prices ranging from $20.78 to $21.97. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001209191-22-053597 · doc4.xml · nonDerivative · entry 3

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 268,554

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

SEC source: 0001209191-22-053597 · doc4.xml · derivative · entry 9

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,175

Underlying: Common Stock · 14,000 shares

Expires 2028-03-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

F6 · derivative.exercise_date: The shares underlying this option shall vest in sixteen (16) equal quarterly installments after March 23, 2018, subject to the reporting person's continued employment through each applicable vesting date.

SEC source: 0001209191-22-053597 · doc4.xml · nonDerivative · entry 2

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 254,554

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

F2 · price: This transaction was executed in multiple trades at prices ranging from $20.76 to $21.94. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001209191-22-053597 · doc4.xml · nonDerivative · entry 1

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 268,554

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

SEC source: 0001209191-22-052221 · doc4.xml · derivative · entry 3

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 101,456

Underlying: Common Stock · 8,000 shares

Expires 2028-04-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Twenty-five percent (25%) of the shares underlying this option vested on April 2, 2019 and the remainder shall vest in equal quarterly installments over the remaining thirty-six (36) months, subject to the reporting person's continued employment through each vesting date.

SEC source: 0001209191-22-052221 · doc4.xml · nonDerivative · entry 2

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,683

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 7, 2022.

F3 · price: This transaction was executed in multiple trades at prices ranging from $22.09 to $22.98. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2 · balance_after: Includes 78,707 shares underlying restricted stock units.

SEC source: 0001209191-22-052221 · doc4.xml · nonDerivative · entry 1

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,683

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 7, 2022.

F2 · balance_after: Includes 78,707 shares underlying restricted stock units.

SEC source: 0001209191-22-051544 · doc4.xml · nonDerivative · entry 1

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,775

F1 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 992 shares of restricted stock units ("RSUs") on September 26, 2022. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F2 · balance_after: Includes 44,281 shares underlying RSUs.

SEC source: 0001209191-22-051549 · doc4.xml · nonDerivative · entry 1

Porter Andy · CIK 0001899340 · Chief Administrative Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,612

F1 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 875 shares of restricted stock units ("RSUs") on September 26, 2022. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F2 · balance_after: Includes 29,899 shares underlying RSUs.

SEC source: 0001209191-22-051539 · doc4.xml · nonDerivative · entry 1

Adams Brian · CIK 0001636994 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,548

F1 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 992 shares of restricted stock units ("RSUs") on September 26, 2022. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F2 · balance_after: Includes 44,281 shares underlying RSUs.

SEC source: 0001209191-22-051542 · doc4.xml · nonDerivative · entry 1

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,683

F1 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 2,187 shares of restricted stock units ("RSUs") on September 26, 2022. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F2 · balance_after: Includes 78,707 shares underlying RSUs.

SEC source: 0001209191-22-050182 · doc4.xml · derivative · entry 11

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,175

Underlying: Common Stock · 14,000 shares

Expires 2028-03-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

F6 · derivative.exercise_date: The shares underlying this option shall vest in sixteen (16) equal quarterly installments after March 23, 2018, subject to the reporting person's continued employment through each applicable vesting date.

SEC source: 0001209191-22-050182 · doc4.xml · nonDerivative · entry 6

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 254,554

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

F4 · price: This transaction was executed in multiple trades at prices ranging from $23.36 to $24.27. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001209191-22-050182 · doc4.xml · nonDerivative · entry 5

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 268,554

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

SEC source: 0001209191-22-050182 · doc4.xml · derivative · entry 10

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,175

Underlying: Common Stock · 14,000 shares

Expires 2028-03-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

F6 · derivative.exercise_date: The shares underlying this option shall vest in sixteen (16) equal quarterly installments after March 23, 2018, subject to the reporting person's continued employment through each applicable vesting date.

SEC source: 0001209191-22-050182 · doc4.xml · nonDerivative · entry 4

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 254,554

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

F3 · price: This transaction was executed in multiple trades at prices ranging from $22.89 to $24.29. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001209191-22-050182 · doc4.xml · nonDerivative · entry 3

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 268,554

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

SEC source: 0001209191-22-050182 · doc4.xml · derivative · entry 9

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,175

Underlying: Common Stock · 14,000 shares

Expires 2028-03-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

F6 · derivative.exercise_date: The shares underlying this option shall vest in sixteen (16) equal quarterly installments after March 23, 2018, subject to the reporting person's continued employment through each applicable vesting date.

SEC source: 0001209191-22-050182 · doc4.xml · nonDerivative · entry 2

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 254,554

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

F2 · price: This transaction was executed in multiple trades at prices ranging from $24.99 to $26.00. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001209191-22-050182 · doc4.xml · nonDerivative · entry 1

Patel Sanjiv · CIK 0001816210 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 268,554

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on July 22, 2022.

SEC source: 0001209191-22-049244 · doc4.xml · derivative · entry 3

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 26,257 shares

Expires 2028-04-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 11, 2021.

F3 · derivative.exercise_date: Twenty-five percent (25%) of the shares underlying this option vested on April 9, 2019 and the remainder shall vest in equal quarterly installments over the remaining thirty-six (36) months, subject to the reporting person's continued employment through each vesting date.

SEC source: 0001209191-22-049244 · doc4.xml · nonDerivative · entry 2

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,218

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 11, 2021.

F2 · balance_after: Includes 45,273 shares underlying restricted stock units.

SEC source: 0001209191-22-049244 · doc4.xml · nonDerivative · entry 1

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 78,475

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 11, 2021.

F2 · balance_after: Includes 45,273 shares underlying restricted stock units.

SEC source: 0001209191-22-049246 · doc4.xml · nonDerivative · entry 1

Murcko Mark · CIK 0001816130 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 996,952

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 12, 2022.

SEC source: 0001209191-22-049242 · doc4.xml · derivative · entry 3

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,456

Underlying: Common Stock · 25,000 shares

Expires 2028-04-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Twenty-five percent (25%) of the shares underlying this option vested on April 2, 2019 and the remainder shall vest in equal quarterly installments over the remaining thirty-six (36) months, subject to the reporting person's continued employment through each vesting date.

SEC source: 0001209191-22-049242 · doc4.xml · nonDerivative · entry 2

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,659

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 7, 2022.

F2 · balance_after: Includes 80,894 shares underlying restricted stock units.

SEC source: 0001209191-22-049242 · doc4.xml · nonDerivative · entry 1

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 114,659

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 7, 2022.

F2 · balance_after: Includes 80,894 shares underlying restricted stock units.

SEC source: 0001209191-22-048561 · doc4.xml · derivative · entry 3

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 134,456

Underlying: Common Stock · 4,900 shares

Expires 2028-04-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Twenty-five percent (25%) of the shares underlying this option vested on April 2, 2019 and the remainder shall vest in equal quarterly installments over the remaining thirty-six (36) months, subject to the reporting person's continued employment through each vesting date.

SEC source: 0001209191-22-048561 · doc4.xml · nonDerivative · entry 2

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,659

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 7, 2022.

F2 · balance_after: Includes 80,894 shares underlying restricted stock units.

SEC source: 0001209191-22-048561 · doc4.xml · nonDerivative · entry 1

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 94,559

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 7, 2022.

F2 · balance_after: Includes 80,894 shares underlying restricted stock units.

SEC source: 0001209191-22-048391 · doc4.xml · derivative · entry 3

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 139,356

Underlying: Common Stock · 8,100 shares

Expires 2028-04-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Twenty-five percent (25%) of the shares underlying this option vested on April 2, 2019 and the remainder shall vest in equal quarterly installments over the remaining thirty-six (36) months, subject to the reporting person's continued employment through each vesting date.

SEC source: 0001209191-22-048391 · doc4.xml · nonDerivative · entry 2

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,659

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 7, 2022.

F3 · price: This transaction was executed in multiple trades at prices ranging from $22.63 to $25.00. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F2 · balance_after: Includes 80,894 shares underlying restricted stock units.

SEC source: 0001209191-22-048391 · doc4.xml · nonDerivative · entry 1

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,759

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 7, 2022.

F2 · balance_after: Includes 80,894 shares underlying restricted stock units.

SEC source: 0001209191-22-047560 · doc4.xml · derivative · entry 3

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 147,456

Underlying: Common Stock · 15,000 shares

Expires 2028-04-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Twenty-five percent (25%) of the shares underlying this option vested on April 2, 2019 and the remainder shall vest in equal quarterly installments over the remaining thirty-six (36) months, subject to the reporting person's continued employment through each vesting date.

SEC source: 0001209191-22-047560 · doc4.xml · nonDerivative · entry 2

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,659

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 7, 2022.

F2 · balance_after: Includes 80,894 shares underlying restricted stock units.

SEC source: 0001209191-22-047560 · doc4.xml · nonDerivative · entry 1

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 104,659

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 7, 2022.

F2 · balance_after: Includes 80,894 shares underlying restricted stock units.

SEC source: 0001209191-22-044859 · doc4.xml · derivative · entry 3

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 162,456

Underlying: Common Stock · 8,000 shares

Expires 2028-04-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Twenty-five percent (25%) of the shares underlying this option vested on April 2, 2019 and the remainder shall vest in equal quarterly installments over the remaining thirty-six (36) months, subject to the reporting person's continued employment through each vesting date.

SEC source: 0001209191-22-044859 · doc4.xml · nonDerivative · entry 2

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,659

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 7, 2022.

F2 · balance_after: Includes 80,894 shares underlying restricted stock units.

SEC source: 0001209191-22-044859 · doc4.xml · nonDerivative · entry 1

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,659

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on January 7, 2022.

F2 · balance_after: Includes 80,894 shares underlying restricted stock units.

SEC source: 0001209191-22-043541 · doc4.xml · nonDerivative · entry 1

Catinazzo Thomas · CIK 0001818261 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,218

F1 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 2,454 shares of restricted stock units ("RSUs") on July 27, 2022. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F2 · balance_after: Includes 45,273 shares underlying RSUs.

SEC source: 0001209191-22-043543 · doc4.xml · nonDerivative · entry 1

Porter Andy · CIK 0001899340 · Chief Administrative Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,871

F1 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 1,511 shares of restricted stock units ("RSUs") on July 27, 2022. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F2 · balance_after: Includes 30,774 shares underlying RSUs.

SEC source: 0001209191-22-043536 · doc4.xml · nonDerivative · entry 1

Bergstrom Donald A · CIK 0001709772 · President, R&D

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 89,659

F1 · shares: Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 4,059 shares of restricted stock units ("RSUs") on July 27, 2022. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs.

F2 · balance_after: Includes 80,894 shares underlying RSUs.