REPL

SEC source: 0000899243-22-011332 · doc4.xml · nonDerivative · entry 5

Omega Fund IV, L.P. · CIK 0001528382 · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,673,380

F1 · kind: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any.

F1 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any.

SEC source: 0000899243-22-011332 · doc4.xml · nonDerivative · entry 4

Omega Fund IV, L.P. · CIK 0001528382 · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,712,142

F1 · kind: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any.

F1 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any.

SEC source: 0000899243-22-011332 · doc4.xml · nonDerivative · entry 3

Omega Fund IV, L.P. · CIK 0001528382 · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,718,380

F1 · kind: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any.

F1 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any.

SEC source: 0000899243-22-011332 · doc4.xml · derivative · entry 6

Omega Fund IV, L.P. · CIK 0001528382 · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Otello Stampacchia

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2030-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Stock options vested 100% on April 1, 2021.

F2 · ownership.nature: The reported securities are held directly by Otello Stampacchia, a shareholder and director of Omega Fund IV GP Manager.

SEC source: 0000899243-22-011332 · doc4.xml · nonDerivative · entry 2

Omega Fund IV, L.P. · CIK 0001528382 · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Otello Stampacchia

Disclosed balance after: 4,763,380

F2 · ownership.nature: The reported securities are held directly by Otello Stampacchia, a shareholder and director of Omega Fund IV GP Manager.

SEC source: 0000899243-22-011332 · doc4.xml · nonDerivative · entry 1

Omega Fund IV, L.P. · CIK 0001528382 · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Otello Stampacchia

Disclosed balance after: 4,779,880

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · ownership.nature: The reported securities are held directly by Otello Stampacchia, a shareholder and director of Omega Fund IV GP Manager.

SEC source: 0001104659-21-146472 · tm2134480-2_4seq1.xml · derivative · entry 1

Oliger Christy J. · CIK 0001822092 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,000

Underlying: Common Stock · 33,000 shares

Expires 2031-12-01

F1 · derivative.exercise_date: 25% of the shares underlying this stock option vest on December 1, 2022, and the remainder of the shares underlying this stock option vest in 24 approximately equal monthly installments thereafter.

SEC source: 0000899243-21-045798 · doc4.xml · nonDerivative · entry 3

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,763,380

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $34.50 to $35.01 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F5 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-045798 · doc4.xml · nonDerivative · entry 2

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,773,542

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $34.80 to $34.81 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F5 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-045798 · doc4.xml · nonDerivative · entry 1

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,773,959

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.77 to $34.76 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F5 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-045302 · doc4.xml · nonDerivative · entry 2

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,808,804

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.50 to $33.56 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F4 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-045301 · doc4.xml · nonDerivative · entry 2

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,808,804

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.50 to $33.56 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F4 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-045302 · doc4.xml · nonDerivative · entry 1

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,811,245

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F2 · price: The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F4 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-045301 · doc4.xml · nonDerivative · entry 1

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,811,245

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F2 · price: The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F4 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-044774 · doc4.xml · nonDerivative · entry 2

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,811,398

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.50 to $33.67 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F4 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-044774 · doc4.xml · nonDerivative · entry 1

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,812,180

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.50 to $33.99 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F4 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-044322 · doc4.xml · nonDerivative · entry 2

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,835,415

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.50 to $33.73 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F4 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-044322 · doc4.xml · nonDerivative · entry 1

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,853,694

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F2 · price: The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F4 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-043855 · doc4.xml · nonDerivative · entry 2

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,853,705

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.50 to $34.02 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F4 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-043855 · doc4.xml · nonDerivative · entry 1

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,861,242

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.50 to $33.61 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F4 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-043456 · doc4.xml · nonDerivative · entry 2

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,865,059

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.50 to $33.62 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F4 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-043456 · doc4.xml · nonDerivative · entry 1

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,870,849

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.50 to $33.85 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was affected.

F4 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0001104659-21-127727 · tm2130435-1_4seq1.xml · nonDerivative · entry 3

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 745,809

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on June 12, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F4 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $29.32 to $29.96. The reporting person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F5 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 745,809 shares of the Issuer's common stock. The reporting person also holds options to acquire 503,578 shares of the Issuer's common stock, 323,448 of which are exercisable as of the date hereof.

SEC source: 0001104659-21-127727 · tm2130435-1_4seq1.xml · nonDerivative · entry 2

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 758,520

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on June 12, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F3 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $29.97 to $30.69. The reporting person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-21-127727 · tm2130435-1_4seq1.xml · nonDerivative · entry 1

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 773,609

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on June 12, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.90 to $31.72. The reporting person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0000899243-21-037893 · doc4.xml · nonDerivative · entry 1

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · Director · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · Director · 10% owner

Stampacchia Otello · CIK 0001361712 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,896,074

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.50 to $33.71 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-036546 · doc4.xml · nonDerivative · entry 3

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,908,245

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $33.51 to $33.95 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F5 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-036546 · doc4.xml · nonDerivative · entry 2

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,923,710

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.50 to $33.49 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F5 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0000899243-21-036546 · doc4.xml · nonDerivative · entry 1

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,002,708

F1 · kind: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F1 · price: Shares were sold pursuant to a Rule 10b5-1 trading plan.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $32.50 to $32.63 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F5 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia and Anne-Mari Paster are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer.

SEC source: 0001104659-21-117070 · tm2127933-1_4seq1.xml · nonDerivative · entry 1

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 775,809

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on June 12, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.86 to $31.77. The reporting person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 775,809 shares of the Issuer's common stock. The reporting person also holds options to acquire 503,578 shares of the Issuer's common stock, 315,211 of which are exercisable as of the date hereof.

SEC source: 0001104659-21-107453 · tm2125440-1_4seq1.xml · nonDerivative · entry 2

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 805,809

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on June 12, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F3 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $29.05 to $29.39. The reporting person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F4 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 805,809 shares of the Issuer's common stock. The reporting person also holds options to acquire 503,578 shares of the Issuer's common stock, 309,057 of which are exercisable as of the date hereof.

SEC source: 0001104659-21-107453 · tm2125440-1_4seq1.xml · nonDerivative · entry 1

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 808,509

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on June 12, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $29.42 to $30.39. The reporting person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-21-101719 · tm2124335-1_4seq1.xml · derivative · entry 6

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,750

Underlying: Common Stock · 25,800 shares

Expires 2029-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: 25% of the shares underlying this stock option vested on April 1, 2020, and the remainder of the shares underlying this stock option vested or will vest, as applicable, in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-21-101719 · tm2124335-1_4seq1.xml · nonDerivative · entry 4

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 210,159

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on December 14, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F3 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $35 to $35.38. The reporting person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F4 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 210,159 shares of the Issuer's common stock. The reporting person also holds options to acquire an aggregate of 458,102 shares of the Issuer's common stock, 300,811 of which are exercisable as of the date hereof.

SEC source: 0001104659-21-101719 · tm2124335-1_4seq1.xml · nonDerivative · entry 3

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 235,959

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-21-101719 · tm2124335-1_4seq1.xml · derivative · entry 5

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,550

Underlying: Common Stock · 4,200 shares

Expires 2029-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: 25% of the shares underlying this stock option vested on April 1, 2020, and the remainder of the shares underlying this stock option vested or will vest, as applicable, in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-21-101719 · tm2124335-1_4seq1.xml · nonDerivative · entry 2

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 210,159

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on December 14, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $35 to $35.05. The reporting person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-21-101719 · tm2124335-1_4seq1.xml · nonDerivative · entry 1

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 214,359

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-21-095084 · tm2123078-1_4seq1.xml · derivative · entry 6

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,203

Underlying: Common Stock · 12,538 shares

Expires 2025-11-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The reporting person was granted an option to purchase 149,203 shares of the Issuer's common stock on November 1, 2015. All of the shares underlying such stock option have vested and are exercisable as of the date hereof.

SEC source: 0001104659-21-095084 · tm2123078-1_4seq1.xml · nonDerivative · entry 4

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 210,159

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on December 14, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 210,159 shares of the Issuer's common stock. The reporting person also holds options to acquire an aggregate of 488,102 shares of the Issuer's common stock, 324,649 of which are exercisable as of the date hereof. Due to scrivener's error, footnote 2 of the Form 4 filed on behalf of the reporting person on July 19, 2021 inadvertently overstated the number of options held by the Reporting Person following the transaction reported therein. The amounts stated in this footnote 2 set forth the correct number of options held by the Reporting Person following the transaction reported herein.

SEC source: 0001104659-21-095084 · tm2123078-1_4seq1.xml · nonDerivative · entry 3

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 222,697

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-21-095084 · tm2123078-1_4seq1.xml · derivative · entry 5

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,741

Underlying: Common Stock · 4,862 shares

Expires 2025-11-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The reporting person was granted an option to purchase 149,203 shares of the Issuer's common stock on November 1, 2015. All of the shares underlying such stock option have vested and are exercisable as of the date hereof.

SEC source: 0001104659-21-095084 · tm2123078-1_4seq1.xml · nonDerivative · entry 2

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 210,159

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on December 14, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-21-095084 · tm2123078-1_4seq1.xml · nonDerivative · entry 1

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 215,021

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-21-093195 · tm2122438-1_4seq1.xml · nonDerivative · entry 1

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 835,809

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on June 12, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 835,809 shares of the Issuer's common stock. The reporting person also holds options to acquire 503,578 shares of the Issuer's common stock, 299,790 of which are exercisable as of the date hereof.

SEC source: 0001104659-21-093671 · tm2122438-2_4seq1.xml · derivative · entry 3

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 68,603

Underlying: Common Stock · 4,600 shares

Expires 2025-11-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The reporting person was granted an option to purchase 149,203 shares of the Issuer's common stock on November 1, 2015. All of the shares underlying such stock option have vested and are exercisable as of the date hereof.

SEC source: 0001104659-21-093671 · tm2122438-2_4seq1.xml · nonDerivative · entry 2

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 210,159

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on December 14, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 210,159 shares of the Issuer's common stock. The reporting person also holds options to acquire an aggregate of 544,267 shares of the Issuer's common stock, 345,191 of which are exercisable as of the date hereof.

SEC source: 0001104659-21-093671 · tm2122438-2_4seq1.xml · nonDerivative · entry 1

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 214,759

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-21-089919 · tm2121160-2_4seq1.xml · nonDerivative · entry 1

Coffin Robert · CIK 0001376492 · Director · President & Chief R&D Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,775,684

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on November 16, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.00 to $40.13. The reporting person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 1,775,684 shares of the Issuer's common stock. The reporting person also holds options to acquire 1,092,899 shares of the Issuer's common stock, 645,394 of which are exercisable as of the date hereof.

SEC source: 0001104659-21-087803 · tm2121160-1_4seq1.xml · nonDerivative · entry 2

Coffin Robert · CIK 0001376492 · Director · President & Chief R&D Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,783,494

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on November 16, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F3 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.00 to $40.21. The reporting person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F4 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 1,783,494 shares of the Issuer's common stock. The reporting person also holds options to acquire 1,092,899 shares of the Issuer's common stock, 635,306 of which are exercisable as of the date hereof.