REPL

SEC source: 0001104659-24-043259 · tm2410652-12_4seq1.xml · derivative · entry 1

Peeples-Dyer Veleka · CIK 0001978705 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,000

Underlying: Common Stock · 32,000 shares

Expires 2034-04-01

F1 · derivative.exercise_date: The shares underlying this option vest entirely on April 1, 2025.

SEC source: 0001104659-24-043250 · tm2410652-3_4seq1.xml · derivative · entry 2

Sarchi Christopher · CIK 0001986597 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,675

Underlying: Common Stock · 66,675 shares

Expires 2034-04-01

F2 · derivative.exercise_date: 25% of the shares underlying this stock option vest on April 1, 2025, and the remainder of the shares underlying this stock option vest in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-24-043250 · tm2410652-3_4seq1.xml · nonDerivative · entry 1

Sarchi Christopher · CIK 0001986597 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 94,470

F1 · shares: Represents shares of the Issuer's common stock issuable upon settlement of restricted stock units ("RSUs") granted to the Reporting Person. Each RSU represents a contingent right to receive one share of the Issuer's common stock. 25% of the RSUs will vest on May 15, 2025 and the remainder will vest in three approximately equal annual installments thereafter until May 15, 2028, subject to the Reporting Person's continuous service to the Issuer.

SEC source: 0001104659-24-043248 · tm2410652-2_4seq1.xml · derivative · entry 1

Oliger Christy J. · CIK 0001822092 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,000

Underlying: Common Stock · 32,000 shares

Expires 2034-04-01

F1 · derivative.exercise_date: The shares underlying this option vest entirely on April 1, 2025.

SEC source: 0001104659-24-043246 · tm2410652-1_4seq1.xml · derivative · entry 2

Schwendenman Andrew · CIK 0001977879 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,325

Underlying: Common Stock · 53,325 shares

Expires 2034-04-01

F2 · derivative.exercise_date: 25% of the shares underlying this stock option vest on April 1, 2025, and the remainder of the shares underlying this stock option vest in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-24-043246 · tm2410652-1_4seq1.xml · nonDerivative · entry 1

Schwendenman Andrew · CIK 0001977879 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,536

F1 · shares: Represents shares of the Issuer's common stock issuable upon settlement of restricted stock units ("RSUs") granted to the Reporting Person. Each RSU represents a contingent right to receive one share of the Issuer's common stock. 25% of the RSUs will vest on May 15, 2025 and the remainder will vest in three approximately equal annual installments thereafter until May 15, 2028, subject to the Reporting Person's continuous service to the Issuer.

SEC source: 0001104659-23-119646 · tm2331094-1_4seq1.xml · nonDerivative · entry 1

Xynos Konstantinos · CIK 0001956241 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 112,714

F1 · shares: Represents shares of the Issuer's common stock sold to cover tax withholding obligations in connection with the partial vesting of the Reporting Person's Restricted Stock Units ("RSU"). The transaction reported herein was made in accordance with the irrevocable "sell to cover" provision set forth in the award agreement under which the RSU was granted and does not represent a discretionary sale by the Reporting Person.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.92 to $11.09. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-23-119645 · tm2331094-2_4seq1.xml · nonDerivative · entry 1

Sarchi Christopher · CIK 0001986597 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 72,245

F1 · shares: Represents shares of the Issuer's common stock sold to cover tax withholding obligations in connection with the partial vesting of the Reporting Person's Restricted Stock Units ("RSU"). The transaction reported herein was made in accordance with the irrevocable "sell to cover" provision set forth in the award agreement under which the RSU was granted and does not represent a discretionary sale by the Reporting Person.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.92 to $11.21. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-23-102485 · tm2326425-2_4seq1.xml · derivative · entry 2

Hill Emily Luisa · CIK 0001778279 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2033-09-18

F2 · derivative.exercise_date: 25% of the shares underlying this stock option vest on September 18, 2024, and the remainder of the shares underlying this stock option vest in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-23-102485 · tm2326425-2_4seq1.xml · nonDerivative · entry 1

Hill Emily Luisa · CIK 0001778279 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 83,330

F1 · shares: Represents shares of the Issuer's common stock issuable upon settlement of restricted stock units ("RSUs") granted to the Reporting Person. Each RSU represents a contingent right to receive one share of the Issuer's common stock. 25% of the RSUs will vest on August 15, 2024 and the remainder will vest in three approximately equal annual installments thereafter until August 15, 2027, subject to the Reporting Person's continuous service to the Issuer.

SEC source: 0001104659-23-100560 · tm2325969-1_4seq1.xml · derivative · entry 6

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 86,033

Underlying: Common Stock · 300 shares

Expires 2027-07-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The reporting person was granted an option to purchase 134,281 shares of the Issuer's common stock on July 26, 2017. All of the shares underlying such stock option have vested and are exercisable as of the date hereof.

SEC source: 0001104659-23-100560 · tm2325969-1_4seq1.xml · nonDerivative · entry 4

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 263,436

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 15, 2023, that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F3 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 263,436 shares of the Issuer's common stock, including restricted stock units. The reporting person also holds options to acquire an aggregate of 491,569 shares of the Issuer's common stock, 376,774 of which are exercisable as of the date hereof.

SEC source: 0001104659-23-100560 · tm2325969-1_4seq1.xml · nonDerivative · entry 3

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 263,736

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-23-100560 · tm2325969-1_4seq1.xml · derivative · entry 5

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 86,333

Underlying: Common Stock · 5,358 shares

Expires 2027-07-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The reporting person was granted an option to purchase 134,281 shares of the Issuer's common stock on July 26, 2017. All of the shares underlying such stock option have vested and are exercisable as of the date hereof.

SEC source: 0001104659-23-100560 · tm2325969-1_4seq1.xml · nonDerivative · entry 2

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 263,436

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 15, 2023, that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $20.00 to $20.05. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-23-100560 · tm2325969-1_4seq1.xml · nonDerivative · entry 1

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 268,794

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-23-094997 · tm2324763-1_4seq1.xml · derivative · entry 5

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 35,750

Underlying: Common Stock · 5,000 shares

Expires 2029-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The reporting person was granted an option to purchase 75,750 shares of the Issuer's common stock on April 1, 2019. All of the shares underlying such stock option have vested and are exercisable as of the date hereof.

SEC source: 0001104659-23-094997 · tm2324763-1_4seq1.xml · derivative · entry 4

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 91,691

Underlying: Common Stock · 13,600 shares

Expires 2027-07-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The reporting person was granted an option to purchase 134,281 shares of the Issuer's common stock on July 26, 2017. All of the shares underlying such stock option have vested and are exercisable as of the date hereof.

SEC source: 0001104659-23-094997 · tm2324763-1_4seq1.xml · nonDerivative · entry 3

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 263,436

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 15, 2023, that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $20.00 to $20.04. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F3 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 263,436 shares of the Issuer's common stock, including restricted stock units. The reporting person also holds options to acquire an aggregate of 497,227 shares of the Issuer's common stock, 378,873 of which are exercisable as of the date hereof.

SEC source: 0001104659-23-094997 · tm2324763-1_4seq1.xml · nonDerivative · entry 2

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 282,036

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-23-094997 · tm2324763-1_4seq1.xml · nonDerivative · entry 1

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 277,036

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-23-092111 · tm2323841-1_4seq1.xml · derivative · entry 3

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,291

Underlying: Common Stock · 1,400 shares

Expires 2027-07-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The reporting person was granted an option to purchase 134,281 shares of the Issuer's common stock on July 26, 2017. All of the shares underlying such stock option have vested and are exercisable as of the date hereof.

SEC source: 0001104659-23-092111 · tm2323841-1_4seq1.xml · nonDerivative · entry 2

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 263,436

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 15, 2023, that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 263,436 shares of the Issuer's common stock, including restricted stock units. The reporting person also holds options to acquire an aggregate of 515,827 shares of the Issuer's common stock, 397,473 of which are exercisable as of the date hereof.

SEC source: 0001104659-23-092111 · tm2323841-1_4seq1.xml · nonDerivative · entry 1

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 264,836

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-23-080113 · tm2321083-1_4seq1.xml · derivative · entry 6

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,750

Underlying: Common Stock · 5,000 shares

Expires 2029-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The reporting person was granted an option to purchase 75,750 shares of the Issuer's common stock on April 1, 2019. All of the shares underlying such stock option have vested and are exercisable as of the date hereof.

SEC source: 0001104659-23-080113 · tm2321083-1_4seq1.xml · derivative · entry 5

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 106,691

Underlying: Common Stock · 15,000 shares

Expires 2027-07-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The reporting person was granted an option to purchase 134,281 shares of the Issuer's common stock on July 26, 2017. All of the shares underlying such stock option have vested and are exercisable as of the date hereof.

SEC source: 0001104659-23-080113 · tm2321083-1_4seq1.xml · nonDerivative · entry 4

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 263,436

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 15, 2023, that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F3 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $21.09 to $21.17. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F4 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 263,436 shares of the Issuer's common stock. The reporting person also holds options to acquire an aggregate of 517,227 shares of the Issuer's common stock, 395,314 of which are exercisable as of the date hereof.

SEC source: 0001104659-23-080113 · tm2321083-1_4seq1.xml · nonDerivative · entry 3

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 265,513

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 15, 2023, that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $21.18 to $22.17. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-23-080113 · tm2321083-1_4seq1.xml · nonDerivative · entry 2

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 283,436

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-23-080113 · tm2321083-1_4seq1.xml · nonDerivative · entry 1

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 278,436

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-23-071772 · tm2318878-1_4seq1.xml · nonDerivative · entry 2

Patel Sushil · CIK 0001860609 · Chief Strategy Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 148,873

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 15, 2023, that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F3 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $23.29 to $23.53. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F4 · balance_after: Following the sales reported on this form 4, the reporting person continues to beneficially own 148,873 shares of the Issuer's common stock. The reporting person also holds options to acquire an aggregate of 263,750 shares of the Issuer's common stock, 88,072 of which are exercisable as of the date hereof.

SEC source: 0001104659-23-071772 · tm2318878-1_4seq1.xml · nonDerivative · entry 1

Patel Sushil · CIK 0001860609 · Chief Strategy Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 149,426

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 15, 2023, that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $23.80 to $24.54. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-23-071774 · tm2318878-2_4seq1.xml · nonDerivative · entry 2

Lewis Tanya · CIK 0001451038 · Chief Dev. Op. Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 135,293

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 15, 2023, that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F3 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $23.34 to $23.55. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

F4 · balance_after: Following the sales reported on this form 4, the reporting person continues to beneficially own 135,293 shares of the Issuer's common stock. The reporting person also holds options to acquire an aggregate of 248,750 shares of the Issuer's common stock, 80,259 of which are exercisable as of the date hereof.

SEC source: 0001104659-23-071774 · tm2318878-2_4seq1.xml · nonDerivative · entry 1

Lewis Tanya · CIK 0001451038 · Chief Dev. Op. Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 136,110

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 15, 2023, that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $23.59 to $24.57. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-23-067858 · tm2317689-2_4seq1.xml · derivative · entry 1

Peeples-Dyer Veleka · CIK 0001978705 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,400

Underlying: Common Stock · 50,400 shares

Expires 2033-06-01

F1 · derivative.exercise_date: 25% of the shares underlying this stock option vest on June 1, 2024, and the remainder of the shares underlying this stock option vest in 24 approximately equal monthly installments thereafter.

SEC source: 0001104659-23-062373 · tm2316199-4_4seq1.xml · nonDerivative · entry 1

Xynos Konstantinos · CIK 0001956241 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,027

F1 · shares: Represents shares of the Issuer's common stock sold to cover tax withholding obligations in connection with the partial vesting of the Reporting Person's Restricted Stock Units ("RSU"). The transaction reported herein was made in accordance with the irrevocable "sell to cover" provision set forth in the award agreement under which the RSU was granted and does not represent a discretionary sale by the Reporting Person.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.05 to $18.21. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-23-062378 · tm2316199-9_4seq1.xml · nonDerivative · entry 1

Patel Sushil · CIK 0001860609 · Chief Strategy Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 154,571

F1 · shares: Represents shares of the Issuer's common stock sold to cover tax withholding obligations in connection with the partial vesting of the Reporting Person's Restricted Stock Units ("RSU"). The transaction reported herein was made in accordance with the irrevocable "sell to cover" provision set forth in the award agreement under which the RSU was granted and does not represent a discretionary sale by the Reporting Person.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.05 to $18.23. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-23-062376 · tm2316199-7_4seq1.xml · nonDerivative · entry 1

Lewis Tanya · CIK 0001451038 · Chief Dev. Op. Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 148,153

F1 · shares: Represents shares of the Issuer's common stock sold to cover tax withholding obligations in connection with the partial vesting of the Reporting Person's Restricted Stock Units ("RSU"). The transaction reported herein was made in accordance with the irrevocable "sell to cover" provision set forth in the award agreement under which the RSU was granted and does not represent a discretionary sale by the Reporting Person.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.05 to $18.23. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-23-062370 · tm2316199-2_4seq1.xml · nonDerivative · entry 1

Astley-Sparke Philip · CIK 0001376491 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,525,278

F1 · shares: Represents shares of the Issuer's common stock sold to cover tax withholding obligations in connection with the partial vesting of the Reporting Person's Restricted Stock Units ("RSU"). The transaction reported herein was made in accordance with the irrevocable "sell to cover" provision set forth in the award agreement under which the RSU was granted and does not represent a discretionary sale by the Reporting Person.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.05 to $18.23. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-23-062375 · tm2316199-6_4seq1.xml · nonDerivative · entry 1

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 794,960

F1 · shares: Represents shares of the Issuer's common stock sold to cover tax withholding obligations in connection with the partial vesting of the Reporting Person's Restricted Stock Units ("RSU"). The transaction reported herein was made in accordance with the irrevocable "sell to cover" provision set forth in the award agreement under which the RSU was granted and does not represent a discretionary sale by the Reporting Person.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.05 to $18.25. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-23-062377 · tm2316199-8_3seq1.xml · nonDerivative · entry 1

Coffin Robert · CIK 0001376492 · Director · President & Chief R&D Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,833,336

F1 · shares: Represents shares of the Issuer's common stock sold to cover tax withholding obligations in connection with the partial vesting of the Reporting Person's Restricted Stock Units ("RSU"). The transaction reported herein was made in accordance with the irrevocable "sell to cover" provision set forth in the award agreement under which the RSU was granted and does not represent a discretionary sale by the Reporting Person.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.05 to $18.23. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-23-062374 · tm2316199-5_4seq1.xml · nonDerivative · entry 1

Franchi Jean M. · CIK 0001653053 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 128,748

F1 · shares: Represents shares of the Issuer's common stock sold to cover tax withholding obligations in connection with the partial vesting of the Reporting Person's Restricted Stock Units ("RSU"). The transaction reported herein was made in accordance with the irrevocable "sell to cover" provision set forth in the award agreement under which the RSU was granted and does not represent a discretionary sale by the Reporting Person.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.05 to $18.23. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-23-062372 · tm2316199-3_4seq1.xml · nonDerivative · entry 1

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 263,436

F1 · shares: Represents shares of the Issuer's common stock sold to cover tax withholding obligations in connection with the partial vesting of the Reporting Person's Restricted Stock Units ("RSU"). The transaction reported herein was made in accordance with the irrevocable "sell to cover" provision set forth in the award agreement under which the RSU was granted and does not represent a discretionary sale by the Reporting Person.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $18.05 to $18.32. The Reporting Person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range.

SEC source: 0001104659-23-041726 · tm2311410-7_4seq1.xml · derivative · entry 2

Xynos Konstantinos · CIK 0001956241 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2033-04-01

F2 · derivative.exercise_date: 25% of the shares underlying this stock option vest on April 1, 2024, and the remainder of the shares underlying this stock option vest in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-23-041726 · tm2311410-7_4seq1.xml · nonDerivative · entry 1

Xynos Konstantinos · CIK 0001956241 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 120,798

F1 · shares: Represents shares of the Issuer's common stock issuable upon settlement of restricted stock units ("RSUs") granted to the Reporting Person. Each RSU represents a contingent right to receive one share of the Issuer's common stock. 25% of the RSUs will vest on May 15, 2024 and the remainder will vest in three approximately equal annual installments thereafter until May 15, 2027, subject to the Reporting Person's continuous service to the Issuer.

SEC source: 0001104659-23-041719 · tm2311410-3_4seq1.xml · derivative · entry 2

Patel Sushil · CIK 0001860609 · Chief Strategy Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires 2033-04-01

F2 · derivative.exercise_date: 25% of the shares underlying this stock option vest on April 1, 2024, and the remainder of the shares underlying this stock option vest in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-23-041719 · tm2311410-3_4seq1.xml · nonDerivative · entry 1

Patel Sushil · CIK 0001860609 · Chief Strategy Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 170,146

F1 · shares: Represents shares of the Issuer's common stock issuable upon settlement of restricted stock units ("RSUs") granted to the Reporting Person. Each RSU represents a contingent right to receive one share of the Issuer's common stock. 25% of the RSUs will vest on May 15, 2024 and the remainder will vest in three approximately equal annual installments thereafter until May 15, 2027, subject to the Reporting Person's continuous service to the Issuer.

SEC source: 0001104659-23-041730 · tm2311410-10_4seq1.xml · derivative · entry 1

Weinand Dieter · CIK 0001744419 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,800

Underlying: Common Stock · 37,800 shares

Expires 2033-04-01

F1 · derivative.exercise_date: The shares underlying this option vest entirely on April 1, 2024.

SEC source: 0001104659-23-041733 · tm2311410-13_4seq1.xml · derivative · entry 1

Dhingra Kapil · CIK 0001456849 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,200

Underlying: Common Stock · 25,200 shares

Expires 2033-04-01

F1 · derivative.exercise_date: The shares underlying this option vest entirely on April 1, 2024.

SEC source: 0001104659-23-041720 · tm2311410-4_4seq1.xml · derivative · entry 2

Lewis Tanya · CIK 0001451038 · Chief Dev. Op. Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires 2033-04-01

F2 · derivative.exercise_date: 25% of the shares underlying this stock option vest on April 1, 2024, and the remainder of the shares underlying this stock option vest in 36 approximately equal monthly installments thereafter.