REPL

SEC source: 0001104659-20-101464 · a4.xml · nonDerivative · entry 1

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 117,700

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-20-096575 · a4.xml · nonDerivative · entry 2

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,036,524

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on June 12, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F3 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $23.07 to $23.27.

F4 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 1,036,524 shares of the Issuer's common stock. The reporting person also holds options to acquire 444,653 shares of the Issuer's common stock, 188,185 of which are exercisable as of the date hereof.

SEC source: 0001104659-20-096575 · a4.xml · nonDerivative · entry 1

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,042,488

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on June 12, 2020 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $23.29 to $24.28.

SEC source: 0001104659-20-085403 · a4.xml · derivative · entry 1

Pirzkall Andrea · CIK 0001818578 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2030-07-20

F1 · derivative.exercise_date: 25% of the shares underlying this stock option vest on July 20, 2021 and the remainder of the shares underlying this stock option vest in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-20-082857 · a4.xml · nonDerivative · entry 2

Coffin Robert · CIK 0001376492 · Director · President & Chief R&D Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,024,118

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F3 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 2,024,118 shares of the Issuer's common stock. The reporting person also holds options to acquire 977,599 shares of the Issuer's common stock, 384,438 of which are exercisable as of the date hereof.

SEC source: 0001104659-20-082857 · a4.xml · nonDerivative · entry 1

Coffin Robert · CIK 0001376492 · Director · President & Chief R&D Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,048,368

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · price: The price reported reflects a weighted average price. These shares were sold in multiple transactions at prices ranging from $21.8167 to $22.7299.

SEC source: 0001209191-20-041517 · doc4.xml · nonDerivative · entry 1

Atlas Venture Fund X, L.P. · CIK 0001628098 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,931,635

F1 · kind: Represent a pro rata distribution, and not a purchase or sale of securities, by Atlas Venture Fund X, L.P. to its general partner and limited partners without additional consideration. This distribution was effected pursuant to a plan adopted in accordance with Rule 10b5-1 on February 28, 2020.

SEC source: 0001209191-20-037603 · doc4.xml · nonDerivative · entry 1

Atlas Venture Fund X, L.P. · CIK 0001628098 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,376,974

F1 · kind: Represent a pro rata distribution, and not a purchase or sale of securities, by Atlas Venture Fund X, L.P. to its general partner and limited partners without additional consideration. This distribution was effected pursuant to a plan adopted in accordance with Rule 10b5-1 on February 28, 2020.

SEC source: 0001104659-20-042508 · a4.xml · derivative · entry 1

Weinand Dieter · CIK 0001744419 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,750

Underlying: Common Stock · 24,750 shares

Expires 2030-04-01

F1 · derivative.exercise_date: The shares underlying this option vest entirely on April 1, 2021.

SEC source: 0001104659-20-042500 · a4.xml · derivative · entry 1

Dhingra Kapil · CIK 0001456849 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2030-04-01

F1 · derivative.exercise_date: The shares underlying this option vest entirely on April 1, 2021.

SEC source: 0001104659-20-042501 · a4.xml · derivative · entry 1

Pucci Paolo · CIK 0001436861 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,000

Underlying: Common Stock · 33,000 shares

Expires 2030-04-01

F1 · derivative.exercise_date: 25% of the shares underlying this stock option vest on April 1, 2021, and the remainder of the shares underlying this stock option vest in 24 approximately equal monthly installments thereafter.

SEC source: 0001104659-20-042496 · a4.xml · derivative · entry 1

Astley-Sparke Philip · CIK 0001376491 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 265,000

Underlying: Common Stock · 265,000 shares

Expires 2030-04-01

F1 · derivative.exercise_date: 25% of the shares underlying this stock option vest on April 1, 2021, and the remainder of the shares underlying this stock option vest in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-20-042513 · a4.xml · derivative · entry 1

GORGOL STEPHEN A · CIK 0001287980 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 66,050

Underlying: Common Stock · 66,050 shares

Expires 2030-04-01

F1 · derivative.exercise_date: 25% of the shares underlying this stock option vest on April 1, 2021, and the remainder of the shares underlying this stock option vest in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-20-042506 · a4.xml · derivative · entry 1

SLATTERY JOSEPH P · CIK 0001246530 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,249

Underlying: Common Stock · 24,249 shares

Expires 2030-04-01

F1 · derivative.exercise_date: The shares underlying this option vest entirely on April 1, 2021.

SEC source: 0001104659-20-042502 · a4.xml · derivative · entry 1

Levitsky Hyam · CIK 0001375792 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2030-04-01

F1 · derivative.exercise_date: The shares underlying this option vest entirely on April 1, 2021.

SEC source: 0001104659-20-042511 · a4.xml · derivative · entry 1

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 116,550

Underlying: Common Stock · 116,550 shares

Expires 2030-04-01

F1 · derivative.exercise_date: 25% of the shares underlying this stock option vest on April 1, 2021, and the remainder of the shares underlying this stock option vest in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-20-042499 · a4.xml · derivative · entry 1

Coffin Robert · CIK 0001376492 · Director · Pres & Chief Res & Dev Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 265,000

Underlying: Common Stock · 265,000 shares

Expires 2030-04-01

F1 · derivative.exercise_date: 25% of the shares underlying this stock option vest on April 1, 2021, and the remainder of the shares underlying this stock option vest in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-20-042504 · a4.xml · derivative · entry 1

Rhodes Jason P · CIK 0001577014 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2030-04-01

F1 · derivative.exercise_date: This option was granted on April 1, 2020 with respect to 16,500 shares of the Issuer's common stock and vests in full on April 1, 2021.

F2 · ownership.direct: The Reporting Person is a member of Atlas Venture Associates X, LLC and is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the option to Atlas Venture Life Science Advisors, LLC. As such, the Reporting Person disclaims beneficial ownership of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001104659-20-042509 · a4.xml · derivative · entry 1

Franchi Jean M. · CIK 0001653053 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,350

Underlying: Common Stock · 56,350 shares

Expires 2030-04-01

F1 · derivative.exercise_date: 25% of the shares underlying this stock option vest on April 1, 2021, and the remainder of the shares underlying this stock option vest in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-20-042512 · a4.xml · derivative · entry 1

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,450

Underlying: Common Stock · 85,450 shares

Expires 2030-04-01

F1 · derivative.exercise_date: 25% of the shares underlying this stock option vest on April 1, 2021, and the remainder of the shares underlying this stock option vest in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-20-042507 · a4.xml · derivative · entry 1

Slootweg Hugo Alexander · CIK 0001744922 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires 2030-04-01

F1 · derivative.exercise_date: The shares underlying this option vest entirely on April 1, 2021.

SEC source: 0000899243-20-010144 · doc4.xml · derivative · entry 1

Omega Fund IV, L.P. · CIK 0001528382 · Director · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · 10% owner

Paster Anne-Mari · CIK 0001652863 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,500

Underlying: Common Stock · 16,500 shares

Expires not disclosed

F1 · derivative.exercise_date: The Common Stock Options (the "Options") were granted to Otello Stampacchia in his capacity as a director of the issuer on April 1, 2020 (the "Grant Date"), with the Options vesting on the first anniversary of the Grant Date. The Options expire on the tenth anniversary of the Grant Date. The Options are held directly by Mr. Stampacchia.

F1 · derivative.expiration_date: The Common Stock Options (the "Options") were granted to Otello Stampacchia in his capacity as a director of the issuer on April 1, 2020 (the "Grant Date"), with the Options vesting on the first anniversary of the Grant Date. The Options expire on the tenth anniversary of the Grant Date. The Options are held directly by Mr. Stampacchia.

F1 · balance_after: The Common Stock Options (the "Options") were granted to Otello Stampacchia in his capacity as a director of the issuer on April 1, 2020 (the "Grant Date"), with the Options vesting on the first anniversary of the Grant Date. The Options expire on the tenth anniversary of the Grant Date. The Options are held directly by Mr. Stampacchia.

F1 · ownership.direct: The Common Stock Options (the "Options") were granted to Otello Stampacchia in his capacity as a director of the issuer on April 1, 2020 (the "Grant Date"), with the Options vesting on the first anniversary of the Grant Date. The Options expire on the tenth anniversary of the Grant Date. The Options are held directly by Mr. Stampacchia.

SEC source: 0001104659-20-024250 · a4.xml · nonDerivative · entry 1

Coffin Robert · CIK 0001376492 · Director · Pres & Chief Res & Dev Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,193,868

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 2,193,868 shares of the Issuer's common stock. The reporting person also holds options to acquire 712,599 shares of the Issuer's common stock, 268,179 of which are exercisable as of the date hereof.

SEC source: 0001104659-20-021648 · a4.xml · nonDerivative · entry 2

Coffin Robert · CIK 0001376492 · Director · Pres & Chief Res & Dev Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,218,118

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 2,218,118 shares of the Issuer's common stock. The reporting person also holds options to acquire 712,599 shares of the Issuer's common stock, 264,534 of which are exercisable as of the date hereof.

SEC source: 0001104659-20-021648 · a4.xml · nonDerivative · entry 1

Coffin Robert · CIK 0001376492 · Director · Pres & Chief Res & Dev Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,242,368

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-19-075616 · a4.xml · derivative · entry 2

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 83,462

Underlying: Common Stock · 25,700 shares

Expires 2026-03-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The reporting person was granted a stock option to acquire 196,162 shares of the Issuer's common stock, subject to vesting. Approximately 183,878 shares underlying the stock option have vested as of the date hereof, with the remaining shares underlying the stock option to vest in 3 approximately equal monthly installments as of the 29th of each month.

SEC source: 0001104659-19-075616 · a4.xml · nonDerivative · entry 1

Esposito Pamela · CIK 0001744425 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 112,700

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-19-071921 · a4.xml · derivative · entry 1

Franchi Jean M. · CIK 0001653053 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 180,000

Underlying: Common Stock · 180,000 shares

Expires 2029-12-09

F1 · derivative.exercise_date: 25% of the shares underlying this stock option vest on December 9, 2020, and the remainder of the shares underlying this stock option vest in 36 approximately equal monthly installments thereafter.

SEC source: 0001104659-19-074340 · a4.xml · derivative · entry 2

Kaufman Howard · CIK 0001744424 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 91,135

Underlying: Common Stock · 58,067 shares

Expires 2027-09-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: On September 1, 2017 the Reporting Person was granted an option to purchase 149,202 shares of the Issuer's common stock, 25% of which vested on September 1, 2018 and the remainder of which vested or will vest in 36 equal monthly installments thereafter.

SEC source: 0001104659-19-074340 · a4.xml · nonDerivative · entry 1

Kaufman Howard · CIK 0001744424 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,067

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001179110-19-011905 · edgar.xml · nonDerivative · entry 1

Omega Fund IV, L.P. · CIK 0001528382 · 10% owner

Omega Fund IV GP, L.P. · CIK 0001528383 · 10% owner

Omega Fund IV G.P. Manager, Ltd. · CIK 0001624456 · 10% owner

Stampacchia Otello · CIK 0001361712 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,328,939

F1 · ownership.direct: The reported securities are held directly by Omega Fund IV, L.P. ("Omega IV"). The reported securities may be deemed to be beneficially owned by each of Omega Fund IV GP, L.P. ("Omega IV GP"), as the general partner of Omega IV, and Omega Fund IV GP Manager, Ltd. ("Omega IV GP Manager"), as the general partner of Omega IV GP. Otello Stampacchia, Anne-Mari Paster and Claudio Nessi (the "Omega Directors") are all the shareholders and directors of Omega IV GP Manager and have shared voting and investment power over the shares held by Omega IV. Each of Omega IV GP, Omega Fund IV GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is also a member of the issuer's board of directors.

SEC source: 0001209191-19-057475 · doc4.xml · nonDerivative · entry 1

Rhodes Jason P · CIK 0001577014 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,100,000

F1 · ownership.nature: The shares are held directly by Atlas Venture Opportunity Fund I, L.P. ("Atlas Venture Opportunity Fund I"). The general partner of Atlas Venture Opportunity Fund I is Atlas Venture Associates Opportunity I, L.P. ("AVAO I LP"). Atlas Venture Associates Opportunity I, LLC ("AVAO I LLC") is the general partner of AVAO I LP. Each of AVAO I LP and AVAO I LLC disclaims Section 16 beneficial ownership of the securities help by Atlas Venture Opportunity Fund I, except to the extent of its pecuniary interest therein. The Reporting Person is a member of AVAO I LLC and disclaims beneficial ownership of such securities held by Atlas Venture Opportunity Fund I, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001104659-19-061831 · a4.xml · nonDerivative · entry 2

Astley-Sparke Philip · CIK 0001376491 · Director · Executive Chairman

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,355,297

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 1,355,297 shares of the Issuer's common stock. The reporting person also holds options to acquire 382,571 shares of the Issuer's common stock, 94,103 of which are exercisable as of the date hereof.

SEC source: 0001104659-19-061831 · a4.xml · nonDerivative · entry 1

Astley-Sparke Philip · CIK 0001376491 · Director · Executive Chairman

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,369,797

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-19-061830 · a4.xml · nonDerivative · entry 2

Coffin Robert · CIK 0001376492 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,266,618

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 2,266,618 shares of the Issuer's common stock. The reporting person also holds options to acquire 712,599 shares of the Issuer's common stock, 233,709 of which are exercisable as of the date hereof.

SEC source: 0001104659-19-061830 · a4.xml · nonDerivative · entry 1

Coffin Robert · CIK 0001376492 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,290,868

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-19-061832 · a4.xml · nonDerivative · entry 2

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,051,524

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 1,051,524 shares of the Issuer's common stock. The reporting person also holds options to acquire 328,103 shares of the Issuer's common stock, 115,169 of which are exercisable as of the date hereof.

SEC source: 0001104659-19-061832 · a4.xml · nonDerivative · entry 1

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,062,774

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-19-060675 · a4.xml · nonDerivative · entry 2

Astley-Sparke Philip · CIK 0001376491 · Director · Executive Chairman

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,384,297

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 1,384,297 shares of the Issuer's common stock. The reporting person also holds options to acquire 382,571 shares of the Issuer's common stock, 94,103 of which are exercisable as of the date hereof.

SEC source: 0001104659-19-060675 · a4.xml · nonDerivative · entry 1

Astley-Sparke Philip · CIK 0001376491 · Director · Executive Chairman

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,398,797

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-19-060674 · a4.xml · nonDerivative · entry 2

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,074,024

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 1,074,024 shares of the Issuer's common stock. The reporting person also holds options to acquire 328,103 shares of the Issuer's common stock, 115,169 of which are exercisable as of the date hereof.

SEC source: 0001104659-19-060674 · a4.xml · nonDerivative · entry 1

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,085,274

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-19-060673 · a4.xml · nonDerivative · entry 2

Coffin Robert · CIK 0001376492 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,315,118

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sales reported on this Form 4, the reporting person continues to beneficially own 2,315,118 shares of the Issuer's common stock. The reporting person also holds options to acquire 712,599 shares of the Issuer's common stock, 233,709 of which are exercisable as of the date hereof.

SEC source: 0001104659-19-060673 · a4.xml · nonDerivative · entry 1

Coffin Robert · CIK 0001376492 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,339,368

F1 · kind: The sales reported on this Form 4 were made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

SEC source: 0001104659-19-059509 · a4.xml · nonDerivative · entry 1

Astley-Sparke Philip · CIK 0001376491 · Director · Executive Chairman

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,413,297

F1 · kind: The sale reported on this Form 4 was made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sale reported on this Form 4, the reporting person continues to beneficially own 1,413,297 shares of the Issuer's common stock. The reporting person also holds options to acquire 382,571 shares of the Issuer's common stock, 94,103 of which are exercisable as of the date hereof.

SEC source: 0001104659-19-059505 · a4.xml · nonDerivative · entry 1

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,096,524

F1 · kind: The sale reported on this Form 4 was made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sale reported on this Form 4, the reporting person continues to beneficially own 1,096,524 shares of the Issuer's common stock. The reporting person also holds options to acquire 328,103 shares of the Issuer's common stock, 115,169 of which are exercisable as of the date hereof.

SEC source: 0001104659-19-059510 · a4.xml · nonDerivative · entry 1

Coffin Robert · CIK 0001376492 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,363,618

F1 · kind: The sale reported on this Form 4 was made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sale reported on this Form 4, the reporting person continues to beneficially own 2,363,618 shares of the Issuer's common stock. The reporting person also holds options to acquire 712,599 shares of the Issuer's common stock, 233,709 of which are exercisable as of the date hereof.

SEC source: 0001104659-19-051355 · a4.xml · nonDerivative · entry 1

Astley-Sparke Philip · CIK 0001376491 · Director · Executive Chairman

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,427,797

F1 · kind: The sale reported on this Form 4 was made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sale reported on this Form 4, the reporting person continues to beneficially own 1,427,797 shares of the Issuer's common stock. The reporting person also holds options to acquire 382,571 shares of the Issuer's common stock, 87,457 of which are exercisable as of the date hereof.

SEC source: 0001104659-19-051354 · a4.xml · nonDerivative · entry 1

Love Colin · CIK 0001376493 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,107,774

F1 · kind: The sale reported on this Form 4 was made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sale reported on this Form 4, the reporting person continues to beneficially own 1,107,774 shares of the Issuer's common stock. The reporting person also holds options to acquire 328,103 shares of the Issuer's common stock, 106,870 of which are exercisable as of the date hereof.

SEC source: 0001104659-19-051350 · a4.xml · nonDerivative · entry 1

Coffin Robert · CIK 0001376492 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,387,868

F1 · kind: The sale reported on this Form 4 was made by the reporting person pursuant to a trading plan adopted on March 7, 2019 that is intended to comply with Rule 10b5-1(c) under the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Following the sale reported on this Form 4, the reporting person continues to beneficially own 2,387,868 shares of the Issuer's common stock. The reporting person also holds options to acquire 712,599 shares of the Issuer's common stock, 216,804 of which are exercisable as of the date hereof.