REGN

SEC source: 0001708138-19-000014 · edgardoc.xml · nonDerivative · entry 1

Fenimore Christopher R. · CIK 0001697422 · VP Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,597

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001237899-19-000039 · edgardoc.xml · nonDerivative · entry 1

VAGELOS P ROY · CIK 0001013064 · Director · Chairman of the Board

10b5-1 filing: Not disclosed

Ownership: Indirect · By 401(k) Plan

Disclosed balance after: 2,200

F1 · price: Represents volume-weighted average price of sales of 126 shares of Company stock on December 16, 2019 at prices ranging from $375.31 to $375.33. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 16, 2019 at each separate price.

SEC source: 0001237899-19-000038 · edgardoc.xml · nonDerivative · entry 9

Fenimore Christopher R. · CIK 0001697422 · VP Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,197

F3 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

SEC source: 0001237899-19-000038 · edgardoc.xml · nonDerivative · entry 8

Fenimore Christopher R. · CIK 0001697422 · VP Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,248

F3 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F7 · price: Represents volume-weighted average price of sales of 346 shares of Company stock on December 13, 2019 at prices ranging from $377.09 to $377.87. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 13, 2019 at each separate price.

SEC source: 0001237899-19-000038 · edgardoc.xml · nonDerivative · entry 7

Fenimore Christopher R. · CIK 0001697422 · VP Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,594

F3 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F6 · price: Represents volume-weighted average price of sales of 470 shares of Company stock on December 13, 2019 at prices ranging from $376.02 to $376.94. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 13, 2019 at each separate price.

SEC source: 0001237899-19-000038 · edgardoc.xml · nonDerivative · entry 6

Fenimore Christopher R. · CIK 0001697422 · VP Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,064

F3 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F5 · price: Represents volume-weighted average price of sales of 624 shares of Company stock on December 13, 2019 at prices ranging from $375.05 to $375.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 13, 2019 at each separate price.

SEC source: 0001237899-19-000038 · edgardoc.xml · nonDerivative · entry 5

Fenimore Christopher R. · CIK 0001697422 · VP Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,688

F3 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F4 · price: Represents volume-weighted average price of sales of 191 shares of Company stock on December 13, 2019 at prices ranging from $374.65 to $374.98. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 13, 2019 at each separate price.

SEC source: 0001237899-19-000037 · edgardoc.xml · nonDerivative · entry 9

VAGELOS P ROY · CIK 0001013064 · Director · Chairman of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 304,485

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F8 · price: Represents volume-weighted average price of sales of 33 shares of Company stock on December 13, 2019 at prices ranging from $379.06 to $379.19. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 13, 2019 at each separate price.

SEC source: 0001237899-19-000037 · edgardoc.xml · nonDerivative · entry 8

VAGELOS P ROY · CIK 0001013064 · Director · Chairman of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 304,518

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F7 · price: Represents volume-weighted average price of sales of 3,602 shares of Company stock on December 13, 2019 at prices ranging from $378.07 to $378.97. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 13, 2019 at each separate price.

SEC source: 0001237899-19-000037 · edgardoc.xml · nonDerivative · entry 7

VAGELOS P ROY · CIK 0001013064 · Director · Chairman of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 308,120

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F6 · price: Represents volume-weighted average price of sales of 5,732 shares of Company stock on December 13, 2019 at prices ranging from $377.01 to $377.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 13, 2019 at each separate price.

SEC source: 0001237899-19-000037 · edgardoc.xml · nonDerivative · entry 6

VAGELOS P ROY · CIK 0001013064 · Director · Chairman of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 313,852

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F5 · price: Represents volume-weighted average price of sales of 13,060 shares of Company stock on December 13, 2019 at prices ranging from $376.00 to $376.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 13, 2019 at each separate price.

SEC source: 0001237899-19-000037 · edgardoc.xml · nonDerivative · entry 5

VAGELOS P ROY · CIK 0001013064 · Director · Chairman of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 326,912

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F4 · price: Represents volume-weighted average price of sales of 21,910 shares of Company stock on December 13, 2019 at prices ranging from $375.02 to $375.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 13, 2019 at each separate price.

SEC source: 0001237899-19-000037 · edgardoc.xml · nonDerivative · entry 4

VAGELOS P ROY · CIK 0001013064 · Director · Chairman of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 348,822

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F3 · price: Represents volume-weighted average price of sales of 6,873 shares of Company stock on December 13, 2019 at prices ranging from $374.22 to $374.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 13, 2019 at each separate price.

SEC source: 0001237899-19-000037 · edgardoc.xml · nonDerivative · entry 3

VAGELOS P ROY · CIK 0001013064 · Director · Chairman of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 355,695

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F2 · price: Represents volume-weighted average price of sales of 632 shares of Company stock on December 13, 2019 at prices ranging from $373.21 to $373.51. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 13, 2019 at each separate price.

SEC source: 0001237899-19-000034 · edgardoc.xml · derivative · entry 7

BROWN MICHAEL S · CIK 0001174475 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,250

Underlying: Common Stock · 4,000 shares

Expires 2024-01-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F6 · derivative.exercise_date: The stock option becomes exercisable in three equal annual installments, commencing one year after the date of grant.

SEC source: 0001237899-19-000034 · edgardoc.xml · nonDerivative · entry 4

BROWN MICHAEL S · CIK 0001174475 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 323

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F4 · price: Represents volume-weighted average price of sales of 1,585 shares of Company stock on December 13, 2019 at prices ranging from $374.81 to $374.89. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 13, 2019 at each separate price.

SEC source: 0001237899-19-000034 · edgardoc.xml · nonDerivative · entry 3

BROWN MICHAEL S · CIK 0001174475 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,908

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F3 · price: Represents volume-weighted average price of sales of 1,400 shares of Company stock on December 13, 2019 at prices ranging from $373.73 to $374.21. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 13, 2019 at each separate price.

SEC source: 0001237899-19-000034 · edgardoc.xml · nonDerivative · entry 2

BROWN MICHAEL S · CIK 0001174475 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,308

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F2 · price: Represents volume-weighted average price of sales of 1,015 shares of Company stock on December 13, 2019 at prices ranging from $372.56 to $373.24. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on December 13, 2019 at each separate price.

SEC source: 0001237899-19-000034 · edgardoc.xml · nonDerivative · entry 1

BROWN MICHAEL S · CIK 0001174475 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,323

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

SEC source: 0001237899-19-000038 · edgardoc.xml · derivative · entry 14

Fenimore Christopher R. · CIK 0001697422 · VP Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,226

Underlying: Common Stock · 3,100 shares

Expires 2021-12-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F9 · derivative.exercise_date: The stock option award vests in four equal annual installments, commencing one year after the date of grant.

SEC source: 0001237899-19-000038 · edgardoc.xml · nonDerivative · entry 4

Fenimore Christopher R. · CIK 0001697422 · VP Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,879

F3 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

SEC source: 0001237899-19-000038 · edgardoc.xml · nonDerivative · entry 3

Fenimore Christopher R. · CIK 0001697422 · VP Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,297

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

SEC source: 0001237899-19-000037 · edgardoc.xml · derivative · entry 14

VAGELOS P ROY · CIK 0001013064 · Director · Chairman of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 107,655 shares

Expires 2019-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F10 · derivative.exercise_date: The stock option award (combined incentive stock option and non-qualified stock option) vests in four equal annual installments, commencing one year after the date of grant.

SEC source: 0001237899-19-000037 · edgardoc.xml · nonDerivative · entry 2

VAGELOS P ROY · CIK 0001013064 · Director · Chairman of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 356,327

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

SEC source: 0001237899-19-000037 · edgardoc.xml · nonDerivative · entry 1

VAGELOS P ROY · CIK 0001013064 · Director · Chairman of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 412,140

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

SEC source: 0000930413-19-003028 · ownership.xml · derivative · entry 20

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 150,000 shares

Expires 2019-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F6 · derivative.exercise_date: The option became exercisable on December 31, 2012, based upon the satisfaction by the company of certain performance criteria during the period ended December 31, 2012.

SEC source: 0000930413-19-003028 · ownership.xml · derivative · entry 19

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 95,295 shares

Expires 2019-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F5 · derivative.exercise_date: The stock option award (combined incentive stock option and non-qualified stock option) vested in four equal annual installments, commencing one year after the date of grant.

SEC source: 0000930413-19-003028 · ownership.xml · nonDerivative · entry 5

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 444,109

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

SEC source: 0000930413-19-003028 · ownership.xml · nonDerivative · entry 4

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 521,876

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

SEC source: 0000930413-19-003028 · ownership.xml · nonDerivative · entry 3

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 371,876

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

SEC source: 0000930413-19-003028 · ownership.xml · nonDerivative · entry 2

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 421,281

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

SEC source: 0001237899-19-000031 · edgardoc.xml · derivative · entry 8

SCHLEIFER LEONARD S · CIK 0001218629 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 187,500 shares

Expires 2019-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F3 · derivative.exercise_date: The option became exercisable with respect to all shares underlying the option on December 31, 2012, based upon the satisfaction by the company of certain performance criteria during the period ended December 31, 2012.

SEC source: 0001237899-19-000031 · edgardoc.xml · derivative · entry 7

SCHLEIFER LEONARD S · CIK 0001218629 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 187,500

Underlying: Common Stock · 124,900 shares

Expires 2019-12-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F2 · derivative.exercise_date: The stock option award vests in four equal annual installments, commencing one year after the date of grant.

SEC source: 0001237899-19-000031 · edgardoc.xml · nonDerivative · entry 4

SCHLEIFER LEONARD S · CIK 0001218629 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 474,499

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

SEC source: 0001237899-19-000031 · edgardoc.xml · nonDerivative · entry 3

SCHLEIFER LEONARD S · CIK 0001218629 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 571,708

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

SEC source: 0001237899-19-000031 · edgardoc.xml · nonDerivative · entry 2

SCHLEIFER LEONARD S · CIK 0001218629 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 384,208

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

SEC source: 0001237899-19-000031 · edgardoc.xml · nonDerivative · entry 1

SCHLEIFER LEONARD S · CIK 0001218629 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 448,962

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

SEC source: 0001237899-19-000038 · edgardoc.xml · derivative · entry 15

Fenimore Christopher R. · CIK 0001697422 · VP Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,120

Underlying: Common Stock · 6,120 shares

Expires 2029-12-11

F9 · derivative.exercise_date: The stock option award vests in four equal annual installments, commencing one year after the date of grant.

SEC source: 0001237899-19-000038 · edgardoc.xml · nonDerivative · entry 2

Fenimore Christopher R. · CIK 0001697422 · VP Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,197

F2 · kind: Award of Restricted Stock under the Amended and Restated 2014 Long-Term Incentive Plan that vests in its entirety on December 11, 2023.

SEC source: 0001237899-19-000038 · edgardoc.xml · nonDerivative · entry 1

Fenimore Christopher R. · CIK 0001697422 · VP Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,697

F1 · kind: Award of Restricted Stock under the Amended and Restated 2014 Long-Term Incentive Plan that vests 50% on December 11, 2021 and 50% on December 11, 2023.

SEC source: 0001237899-19-000037 · edgardoc.xml · derivative · entry 16

VAGELOS P ROY · CIK 0001013064 · Director · Chairman of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,086

Underlying: Common Stock · 9,086 shares

Expires not disclosed

F12 · derivative.exercise_price: Each performance-based restricted stock unit ("PSU") represents the contingent right to receive one share of the issuer's common stock at vesting. The amount reported reflects the maximum number of PSUs that may vest based upon the achievement of certain performance metrics related to total shareholder return over four-year and/or five-year performance periods ending on December 11, 2023 and December 11, 2024, respectively. Between 50% and 225% of the target number of PSUs (i.e., between 50% and 225% of 4,038 PSUs) may vest upon achievement of predetermined total shareholder return percentages derived from compound annual growth rates of 5% to 15% for the applicable performance period. If none of the performance metrics are achieved at the conclusion of the performance periods, the award expires.

F12 · derivative.exercise_date: Each performance-based restricted stock unit ("PSU") represents the contingent right to receive one share of the issuer's common stock at vesting. The amount reported reflects the maximum number of PSUs that may vest based upon the achievement of certain performance metrics related to total shareholder return over four-year and/or five-year performance periods ending on December 11, 2023 and December 11, 2024, respectively. Between 50% and 225% of the target number of PSUs (i.e., between 50% and 225% of 4,038 PSUs) may vest upon achievement of predetermined total shareholder return percentages derived from compound annual growth rates of 5% to 15% for the applicable performance period. If none of the performance metrics are achieved at the conclusion of the performance periods, the award expires.

F12 · derivative.expiration_date: Each performance-based restricted stock unit ("PSU") represents the contingent right to receive one share of the issuer's common stock at vesting. The amount reported reflects the maximum number of PSUs that may vest based upon the achievement of certain performance metrics related to total shareholder return over four-year and/or five-year performance periods ending on December 11, 2023 and December 11, 2024, respectively. Between 50% and 225% of the target number of PSUs (i.e., between 50% and 225% of 4,038 PSUs) may vest upon achievement of predetermined total shareholder return percentages derived from compound annual growth rates of 5% to 15% for the applicable performance period. If none of the performance metrics are achieved at the conclusion of the performance periods, the award expires.

SEC source: 0001237899-19-000037 · edgardoc.xml · derivative · entry 15

VAGELOS P ROY · CIK 0001013064 · Director · Chairman of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,177

Underlying: Common Stock · 29,177 shares

Expires 2029-12-11

F11 · derivative.exercise_date: The stock option award vests in four equal annual installments, commencing one year after the date of grant.

SEC source: 0000930413-19-003028 · ownership.xml · derivative · entry 22

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,155

Underlying: Common Stock · 25,155 shares

Expires not disclosed

F8 · derivative.exercise_price: Each performance-based restricted stock unit ("PSU") represents the contingent right to receive one share of the issuer's common stock at vesting. The amount reported reflects the maximum number of PSUs that may vest based upon the achievement of certain performance metrics related to total shareholder return over four-year and/or five-year performance periods ending on December 11, 2023 and December 11, 2024, respectively. Between 50% and 225% of the target number of PSUs (i.e., between 50% and 225% of 11,180 PSUs) may vest upon achievement of predetermined total shareholder return percentages derived from compound annual growth rates of 5% to 15% for the applicable performance period. If none of the performance metrics are achieved at the conclusion of the performance periods, the award expires.

F8 · derivative.exercise_date: Each performance-based restricted stock unit ("PSU") represents the contingent right to receive one share of the issuer's common stock at vesting. The amount reported reflects the maximum number of PSUs that may vest based upon the achievement of certain performance metrics related to total shareholder return over four-year and/or five-year performance periods ending on December 11, 2023 and December 11, 2024, respectively. Between 50% and 225% of the target number of PSUs (i.e., between 50% and 225% of 11,180 PSUs) may vest upon achievement of predetermined total shareholder return percentages derived from compound annual growth rates of 5% to 15% for the applicable performance period. If none of the performance metrics are achieved at the conclusion of the performance periods, the award expires.

F8 · derivative.expiration_date: Each performance-based restricted stock unit ("PSU") represents the contingent right to receive one share of the issuer's common stock at vesting. The amount reported reflects the maximum number of PSUs that may vest based upon the achievement of certain performance metrics related to total shareholder return over four-year and/or five-year performance periods ending on December 11, 2023 and December 11, 2024, respectively. Between 50% and 225% of the target number of PSUs (i.e., between 50% and 225% of 11,180 PSUs) may vest upon achievement of predetermined total shareholder return percentages derived from compound annual growth rates of 5% to 15% for the applicable performance period. If none of the performance metrics are achieved at the conclusion of the performance periods, the award expires.

SEC source: 0000930413-19-003028 · ownership.xml · derivative · entry 21

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 81,278

Underlying: Common Stock · 81,278 shares

Expires 2029-12-11

F7 · derivative.exercise_date: The stock option award vests in four equal annual installments, commencing one year after the date of grant.

SEC source: 0001237899-19-000036 · edgardoc.xml · derivative · entry 4

MURPHY ANDREW J · CIK 0001796226 · EVP Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,500

Underlying: Common Stock · 24,500 shares

Expires 2029-12-11

F3 · derivative.exercise_date: The stock option award vests in four equal annual installments, commencing one year after the date of grant.

SEC source: 0001237899-19-000036 · edgardoc.xml · nonDerivative · entry 2

MURPHY ANDREW J · CIK 0001796226 · EVP Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,951

F2 · kind: Award of Restricted Stock under the Amended and Restated 2014 Long-Term Incentive Plan that vests in its entirety on December 11, 2023.

SEC source: 0001237899-19-000036 · edgardoc.xml · nonDerivative · entry 1

MURPHY ANDREW J · CIK 0001796226 · EVP Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,951

F1 · kind: Award of Restricted Stock under the Amended and Restated 2014 Long-Term Incentive Plan that vests 50% on December 11, 2021 and 50% on December 11, 2023.

SEC source: 0001237899-19-000035 · edgardoc.xml · derivative · entry 3

LAROSA JOSEPH J · CIK 0001238303 · EVP General Counsel and Secret

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,500

Underlying: Common Stock · 24,500 shares

Expires 2029-12-11

F2 · derivative.exercise_date: The stock option award vests in four equal annual installments, commencing one year after the date of grant.

SEC source: 0001237899-19-000035 · edgardoc.xml · nonDerivative · entry 1

LAROSA JOSEPH J · CIK 0001238303 · EVP General Counsel and Secret

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,438

F1 · kind: Award of Restricted Stock under the Amended and Restated 2014 Long-Term Incentive Plan that vests 50% on December 11, 2021 and 50% on December 11, 2023.

SEC source: 0001237899-19-000031 · edgardoc.xml · derivative · entry 10

SCHLEIFER LEONARD S · CIK 0001218629 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,155

Underlying: Common Stock · 25,155 shares

Expires not disclosed

F4 · derivative.exercise_price: Each performance-based restricted stock unit ("PSU") represents the contingent right to receive one share of the issuer's common stock at vesting. The amount reported reflects the maximum number of PSUs that may vest based upon the achievement of certain performance metrics related to total shareholder return over four-year and/or five-year performance periods ending on December 11, 2023 and December 11, 2024, respectively. Between 50% and 225% of the target number of PSUs (i.e., between 50% and 225% of 11,180 PSUs) may vest upon achievement of predetermined total shareholder return percentages derived from compound annual growth rates of 5% to 15% for the applicable performance period. If none of the performance metrics are achieved at the conclusion of the performance periods, the award expires.

F4 · derivative.exercise_date: Each performance-based restricted stock unit ("PSU") represents the contingent right to receive one share of the issuer's common stock at vesting. The amount reported reflects the maximum number of PSUs that may vest based upon the achievement of certain performance metrics related to total shareholder return over four-year and/or five-year performance periods ending on December 11, 2023 and December 11, 2024, respectively. Between 50% and 225% of the target number of PSUs (i.e., between 50% and 225% of 11,180 PSUs) may vest upon achievement of predetermined total shareholder return percentages derived from compound annual growth rates of 5% to 15% for the applicable performance period. If none of the performance metrics are achieved at the conclusion of the performance periods, the award expires.

F4 · derivative.expiration_date: Each performance-based restricted stock unit ("PSU") represents the contingent right to receive one share of the issuer's common stock at vesting. The amount reported reflects the maximum number of PSUs that may vest based upon the achievement of certain performance metrics related to total shareholder return over four-year and/or five-year performance periods ending on December 11, 2023 and December 11, 2024, respectively. Between 50% and 225% of the target number of PSUs (i.e., between 50% and 225% of 11,180 PSUs) may vest upon achievement of predetermined total shareholder return percentages derived from compound annual growth rates of 5% to 15% for the applicable performance period. If none of the performance metrics are achieved at the conclusion of the performance periods, the award expires.