Last 12 months
Inside the activity.
0 purchase rows · 78 sale rows
Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.Monthly counts
| Month | Purchases | Sales |
|---|---|---|
| Nov 2025 | 0 | 2 |
| Dec 2025 | 0 | 0 |
| Jan 2026 | 0 | 1 |
| Feb 2026 | 0 | 35 |
| Mar 2026 | 0 | 13 |
| Apr 2026 | 0 | 9 |
| May 2026 | 0 | 12 |
| Jun 2026 | 0 | 0 |
| Jul 2026 | 0 | 1 |
| Aug 2026 | 0 | 2 |
| Sep 2026 | 0 | 3 |
| Oct 2026 | 0 | 0 |
Latest available
Insider transactions
Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”
The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.
| Transaction date | Owner / reported role | Activity / security | Shares / units | Reported price | Reported value | Details |
|---|---|---|---|---|---|---|
| February 01, 2021 Filed Feb 2, 2021 21:06 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 30 | $506.44 | $15,193.20 |
DisclosureSEC source: 0001708138-21-000014 · edgardoc.xml · nonDerivative · entry 3 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,735 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F4 · price: Represents volume-weighted average price of sales of 30 shares of Company stock on February 1, 2021 at prices ranging from $506.00 to $506.98. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on February 1, 2021 at each separate price. Read SEC document |
| February 01, 2021 Filed Feb 2, 2021 21:06 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 17 | $505.60 | $8,595.20 |
DisclosureSEC source: 0001708138-21-000014 · edgardoc.xml · nonDerivative · entry 2 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,765 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F3 · price: Represents volume-weighted average price of sales of 17 shares of Company stock on February 1, 2021 at prices ranging from $505.14 to $505.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on February 1, 2021 at each separate price. Read SEC document |
| February 01, 2021 Filed Feb 2, 2021 21:06 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 9 | $504.68 | $4,542.12 |
DisclosureSEC source: 0001708138-21-000014 · edgardoc.xml · nonDerivative · entry 1 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,782 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F2 · price: Represents volume-weighted average price of sales of 9 shares of Company stock on February 1, 2021 at prices ranging from $504.32 to $504.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on February 1, 2021 at each separate price. Read SEC document |
| January 25, 2021 Filed Jan 27, 2021 21:06 UTC |
BROWN MICHAEL SDirector
|
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative | 2,480 | $0.00 Strike: $380.95 | $0.00 |
DisclosureSEC source: 0001708138-21-000012 · edgardoc.xml · derivative · entry 5 BROWN MICHAEL S · CIK 0001174475 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 2,479 Underlying: Common Stock · 2,480 shares Expires 2028-01-02 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F3 · derivative.exercise_date: The stock option becomes exercisable in three equal annual installments, commencing one year after the date of grant. Read SEC document |
| January 25, 2021 Filed Jan 27, 2021 21:06 UTC |
BROWN MICHAEL SDirector
|
SaleCommon Stock | 2,480 | $554.32 | $1,374,713.60 |
DisclosureSEC source: 0001708138-21-000012 · edgardoc.xml · nonDerivative · entry 2 BROWN MICHAEL S · CIK 0001174475 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 891 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). Read SEC document |
| January 25, 2021 Filed Jan 27, 2021 21:06 UTC |
BROWN MICHAEL SDirector
|
Exercise / conversionCommon Stock | 2,480 | $380.95 | $944,756.00 |
DisclosureSEC source: 0001708138-21-000012 · edgardoc.xml · nonDerivative · entry 1 BROWN MICHAEL S · CIK 0001174475 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 3,371 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). Read SEC document |
| January 19, 2021 Filed Feb 24, 2021 21:02 UTC |
VAGELOS P ROYDirector
|
GiftCommon Stock | 414 | $0.00 | $0.00 |
DisclosureSEC source: 0001708138-21-000016 · edgardoc.xml · nonDerivative · entry 4 VAGELOS P ROY · CIK 0001013064 · Director 10b5-1 filing: Not disclosed Ownership: Indirect · by CLAT Disclosed balance after: 142,796 Read SEC document |
| January 12, 2021 Filed Jun 23, 2021 20:02 UTC |
YANCOPOULOS GEORGEDirector · President and Chief Scientific
|
GiftCommon Stock | 82,108 | $0.00 | $0.00 |
DisclosureSEC source: 0001708138-21-000026 · edgardoc.xml · nonDerivative · entry 1 YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific 10b5-1 filing: Not disclosed Ownership: Indirect · By Trust for Chldn. Disclosed balance after: 82,108 F1 · ownership.nature: As investment trustee of trusts for the benefit of the reporting person's children. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:32 UTC |
SING GEORGE LDirector
|
GrantNon-Qualified Stock Option (right to buy) · Derivative | 3,613 | $0.00 Strike: $482.68 | $0.00 |
DisclosureSEC source: 0001237899-21-000003 · edgardoc.xml · derivative · entry 5 SING GEORGE L · CIK 0001225471 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 3,613 Underlying: Common Stock · 3,613 shares Expires 2031-01-04 F2 · derivative.exercise_date: On the date of the Issuer's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that has passed from the date of grant shall then become exercisable, and the remainder shall become exercisable on the first anniversary of the date of grant. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:32 UTC |
SING GEORGE LDirector
|
GrantCommon Stock | 248 | $0.00 | $0.00 |
DisclosureSEC source: 0001237899-21-000003 · edgardoc.xml · nonDerivative · entry 1 SING GEORGE L · CIK 0001225471 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 54,663 F1 · kind: Reflects an acquisition of time-based vesting restricted stock units each representing a contingent right to receive one share of the Issuer's common stock. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:53 UTC |
BROWN MICHAEL SDirector
|
GrantNon-Qualified Stock Option (right to buy) · Derivative | 3,613 | $0.00 Strike: $482.68 | $0.00 |
DisclosureSEC source: 0001237899-21-000004 · edgardoc.xml · derivative · entry 4 BROWN MICHAEL S · CIK 0001174475 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 3,613 Underlying: Common Stock · 3,613 shares Expires 2031-01-04 F3 · derivative.exercise_date: On the date of the Issuer's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that has passed from the date of grant shall then become exercisable, and the remainder shall become exercisable on the first anniversary of the date of grant. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:53 UTC |
BROWN MICHAEL SDirector
|
GrantCommon Stock | 248 | $0.00 | $0.00 |
DisclosureSEC source: 0001237899-21-000004 · edgardoc.xml · nonDerivative · entry 1 BROWN MICHAEL S · CIK 0001174475 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 891 F1 · kind: Reflects an acquisition of time-based vesting restricted stock units each representing a contingent right to receive one share of the Issuer's common stock. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:11 UTC |
Tessier-Lavigne MarcDirector
|
GrantNon-Qualified Stock Option (right to buy) · Derivative | 3,613 | $0.00 Strike: $482.68 | $0.00 |
DisclosureSEC source: 0001708138-21-000009 · edgardoc.xml · derivative · entry 2 Tessier-Lavigne Marc · CIK 0001437435 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 3,613 Underlying: Common Stock · 3,613 shares Expires 2031-01-04 F2 · derivative.exercise_date: On the date of the Issuer's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that has passed from the date of grant shall then become exercisable, and the remainder shall become exercisable on the first anniversary of the date of grant. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:11 UTC |
Tessier-Lavigne MarcDirector
|
GrantCommon Stock | 248 | $0.00 | $0.00 |
DisclosureSEC source: 0001708138-21-000009 · edgardoc.xml · nonDerivative · entry 1 Tessier-Lavigne Marc · CIK 0001437435 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 2,078 F1 · kind: Reflects an acquisition of time-based vesting restricted stock units each representing a contingent right to receive one share of the Issuer's common stock. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:11 UTC |
Zoghbi Huda YDirector
|
GrantNon-Qualified Stock Option (right to buy) · Derivative | 3,613 | $0.00 Strike: $482.68 | $0.00 |
DisclosureSEC source: 0001708138-21-000010 · edgardoc.xml · derivative · entry 2 Zoghbi Huda Y · CIK 0001681643 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 3,613 Underlying: Common Stock · 3,613 shares Expires 2031-01-04 F2 · derivative.exercise_date: On the date of the Issuer's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that has passed from the date of grant shall then become exercisable, and the remainder shall become exercisable on the first anniversary of the date of grant. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:11 UTC |
Zoghbi Huda YDirector
|
GrantCommon Stock | 248 | $0.00 | $0.00 |
DisclosureSEC source: 0001708138-21-000010 · edgardoc.xml · nonDerivative · entry 1 Zoghbi Huda Y · CIK 0001681643 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 891 F1 · kind: Reflects an acquisition of time-based vesting restricted stock units each representing a contingent right to receive one share of the Issuer's common stock. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:11 UTC |
POON CHRISTINE ADirector
|
GrantNon-Qualified Stock Option (right to buy) · Derivative | 3,613 | $0.00 Strike: $482.68 | $0.00 |
DisclosureSEC source: 0001708138-21-000008 · edgardoc.xml · derivative · entry 2 POON CHRISTINE A · CIK 0001189014 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 3,613 Underlying: Common Stock · 3,613 shares Expires 2031-01-04 F2 · derivative.exercise_date: On the date of the Issuer's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that has passed from the date of grant shall then become exercisable, and the remainder shall become exercisable on the first anniversary of the date of grant. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:11 UTC |
POON CHRISTINE ADirector
|
GrantCommon Stock | 248 | $0.00 | $0.00 |
DisclosureSEC source: 0001708138-21-000008 · edgardoc.xml · nonDerivative · entry 1 POON CHRISTINE A · CIK 0001189014 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 1,681 F1 · kind: Reflects an acquisition of time-based vesting restricted stock units each representing a contingent right to receive one share of the Issuer's common stock. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:11 UTC |
Bassler Bonnie LDirector
|
GrantNon-Qualified Stock Option (right to buy) · Derivative | 3,613 | $0.00 Strike: $482.68 | $0.00 |
DisclosureSEC source: 0001708138-21-000006 · edgardoc.xml · derivative · entry 2 Bassler Bonnie L · CIK 0001683607 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 3,613 Underlying: Common Stock · 3,613 shares Expires 2031-01-04 F2 · derivative.exercise_date: On the date of the Issuer's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that has passed from the date of grant shall then become exercisable, and the remainder shall become exercisable on the first anniversary of the date of grant. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:11 UTC |
Bassler Bonnie LDirector
|
GrantCommon Stock | 248 | $0.00 | $0.00 |
DisclosureSEC source: 0001708138-21-000006 · edgardoc.xml · nonDerivative · entry 1 Bassler Bonnie L · CIK 0001683607 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 891 F1 · kind: Reflects an acquisition of time-based vesting restricted stock units each representing a contingent right to receive one share of the Issuer's common stock. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:11 UTC |
COLES N ANTHONYDirector
|
GrantNon-Qualified Stock Option (right to buy) · Derivative | 3,613 | $0.00 Strike: $482.68 | $0.00 |
DisclosureSEC source: 0001708138-21-000007 · edgardoc.xml · derivative · entry 2 COLES N ANTHONY · CIK 0001197018 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 3,613 Underlying: Common Stock · 3,613 shares Expires 2031-01-04 F2 · derivative.exercise_date: On the date of the Issuer's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that has passed from the date of grant shall then become exercisable, and the remainder shall become exercisable on the first anniversary of the date of grant. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:11 UTC |
COLES N ANTHONYDirector
|
GrantCommon Stock | 248 | $0.00 | $0.00 |
DisclosureSEC source: 0001708138-21-000007 · edgardoc.xml · nonDerivative · entry 1 COLES N ANTHONY · CIK 0001197018 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 902 F1 · kind: Reflects an acquisition of time-based vesting restricted stock units each representing a contingent right to receive one share of the Issuer's common stock. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
GrantNon-Qualified Stock Option (right to buy) · Derivative | 3,613 | $0.00 Strike: $482.68 | $0.00 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · derivative · entry 17 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 3,613 Underlying: Common Stock · 3,613 shares Expires 2031-01-04 F16 · derivative.exercise_date: On the date of the Company's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that has passed from the date of grant shall then become exercisable, and the remainder shall become exercisable on the first anniversary of the date of grant. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
GrantCommon Stock | 248 | $0.00 | $0.00 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 16 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,791 F15 · kind: Reflects an acquisition of time-based vesting restricted stock units each representing a contingent right to receive one share of the Company's common stock. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 1 | $491.36 | $491.36 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 15 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,543 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 4 | $490.69 | $1,962.76 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 14 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,544 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F14 · price: Represents volume-weighted average price of sales of 4 shares of Company stock on January 4, 2021 at prices ranging from $490.45 to $490.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on January 4, 2021 at each separate price. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 2 | $489.41 | $978.82 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 13 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,548 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F13 · price: Represents volume-weighted average price of sales of 2 shares of Company stock on January 4, 2021 at prices ranging from $489.32 to $489.49. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on January 4, 2021 at each separate price. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 5 | $488.26 | $2,441.30 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 12 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,550 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F12 · price: Represents volume-weighted average price of sales of 5 shares of Company stock on January 4, 2021 at prices ranging from $488.02 to $488.58. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on January 4, 2021 at each separate price. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 5 | $487.63 | $2,438.15 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 11 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,555 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F11 · price: Represents volume-weighted average price of sales of 5 shares of Company stock on January 4, 2021 at prices ranging from $487.04 to $487.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on January 4, 2021 at each separate price. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 5 | $486.77 | $2,433.85 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 10 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,560 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F10 · price: Represents volume-weighted average price of sales of 5 shares of Company stock on January 4, 2021 at prices ranging from $486.63 to $486.96. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on January 4, 2021 at each separate price. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 12 | $485.50 | $5,826.00 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 9 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,565 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F9 · price: Represents volume-weighted average price of sales of 12 shares of Company stock on January 4, 2021 at prices ranging from $485.00 to $485.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on January 4, 2021 at each separate price. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 7 | $484.79 | $3,393.53 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 8 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,577 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F8 · price: Represents volume-weighted average price of sales of 7 shares of Company stock on January 4, 2021 at prices ranging from $484.27 to $484.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on January 4, 2021 at each separate price. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 9 | $483.37 | $4,350.33 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 7 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,584 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F7 · price: Represents volume-weighted average price of sales of 9 shares of Company stock on January 4, 2021 at prices ranging from $483.02 to $483.92. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on January 4, 2021 at each separate price. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 13 | $482.30 | $6,269.90 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 6 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,593 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F6 · price: Represents volume-weighted average price of sales of 13 shares of Company stock on January 4, 2021 at prices ranging from $482.04 to $482.73. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on January 4, 2021 at each separate price. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 13 | $481.48 | $6,259.24 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 5 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,606 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F5 · price: Represents volume-weighted average price of sales of 13 shares of Company stock on January 4, 2021 at prices ranging from $481.06 to $481.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on January 4, 2021 at each separate price. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 14 | $480.57 | $6,727.98 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 4 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,619 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F4 · price: Represents volume-weighted average price of sales of 14 shares of Company stock on January 4, 2021 at prices ranging from $480.00 to $480.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on January 4, 2021 at each separate price. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 5 | $479.54 | $2,397.70 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 3 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,633 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F3 · price: Represents volume-weighted average price of sales of 5 shares of Company stock on January 4, 2021 at prices ranging from $479.11 to $479.96. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on January 4, 2021 at each separate price. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 1 | $478.89 | $478.89 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 2 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,638 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:09 UTC |
RYAN ARTHUR FDirector
|
SaleCommon Stock | 4 | $477.58 | $1,910.32 |
DisclosureSEC source: 0001237899-21-000002 · edgardoc.xml · nonDerivative · entry 1 RYAN ARTHUR F · CIK 0001187443 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 23,639 F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c). F2 · price: Represents volume-weighted average price of sales of 4 shares of Company stock on January 4, 2021 at prices ranging from $477.37 to $477.83. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on January 4, 2021 at each separate price. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:07 UTC |
GOLDSTEIN JOSEPH LDirector
|
GrantNon-Qualified Stock Option (right to buy) · Derivative | 3,613 | $0.00 Strike: $482.68 | $0.00 |
DisclosureSEC source: 0001237899-21-000001 · edgardoc.xml · derivative · entry 2 GOLDSTEIN JOSEPH L · CIK 0001225474 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 3,613 Underlying: Common Stock · 3,613 shares Expires 2031-01-04 F2 · derivative.exercise_date: On the date of the Issuer's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that has passed from the date of grant shall then become exercisable, and the remainder shall become exercisable on the first anniversary of the date of grant. Read SEC document |
| January 04, 2021 Filed Jan 5, 2021 21:07 UTC |
GOLDSTEIN JOSEPH LDirector
|
GrantCommon Stock | 248 | $0.00 | $0.00 |
DisclosureSEC source: 0001237899-21-000001 · edgardoc.xml · nonDerivative · entry 1 GOLDSTEIN JOSEPH L · CIK 0001225474 · Director 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 5,891 F1 · kind: Reflects an acquisition of time-based vesting restricted stock units each representing a contingent right to receive one share of the Issuer's common stock. Read SEC document |
| December 31, 2020 Filed Jan 5, 2021 21:04 UTC |
YANCOPOULOS GEORGEDirector · President and Chief Scientific
|
GrantPerformance Stock Units · Derivative | 620,270 | $0.00 | $0.00 |
DisclosureSEC source: 0001104659-21-000904 · tm211598-2_4seq1.xml · derivative · entry 1 YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 620,270 Underlying: Common Stock · 620,270 shares Expires not disclosed F1 · derivative.exercise_price: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of Company stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain total shareholder return ("TSR") goals derived from compound annual growth rates of 5.6% to 19.2% over a five-year performance period ending on December 31, 2025 (or in some cases at earlier times). Between 50% and 250% of the target number of 248,108 PSUs may be earned upon achievement of such TSR goals but shall only vest at the end of the five-year performance period if the reporting person's service to the Company continues through such date, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change in control ("CIC")). Earned PSUs are subject to a mandatory holding period of three years after vesting, which ends early upon the reporting person's death or disability or a CIC. F1 · derivative.exercise_date: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of Company stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain total shareholder return ("TSR") goals derived from compound annual growth rates of 5.6% to 19.2% over a five-year performance period ending on December 31, 2025 (or in some cases at earlier times). Between 50% and 250% of the target number of 248,108 PSUs may be earned upon achievement of such TSR goals but shall only vest at the end of the five-year performance period if the reporting person's service to the Company continues through such date, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change in control ("CIC")). Earned PSUs are subject to a mandatory holding period of three years after vesting, which ends early upon the reporting person's death or disability or a CIC. F1 · derivative.expiration_date: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of Company stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain total shareholder return ("TSR") goals derived from compound annual growth rates of 5.6% to 19.2% over a five-year performance period ending on December 31, 2025 (or in some cases at earlier times). Between 50% and 250% of the target number of 248,108 PSUs may be earned upon achievement of such TSR goals but shall only vest at the end of the five-year performance period if the reporting person's service to the Company continues through such date, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change in control ("CIC")). Earned PSUs are subject to a mandatory holding period of three years after vesting, which ends early upon the reporting person's death or disability or a CIC. Read SEC document |
| December 31, 2020 Filed Jan 5, 2021 21:04 UTC |
SCHLEIFER LEONARD SDirector · President & CEO
|
GrantPerformance Stock Units · Derivative | 620,270 | $0.00 | $0.00 |
DisclosureSEC source: 0001104659-21-000901 · tm211598-1_4seq1.xml · derivative · entry 1 SCHLEIFER LEONARD S · CIK 0001218629 · Director · President & CEO 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 620,270 Underlying: Common Stock · 620,270 shares Expires not disclosed F1 · derivative.exercise_price: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of Company stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain total shareholder return ("TSR") goals derived from compound annual growth rates of 5.6% to 19.2% over a five-year performance period ending on December 31, 2025 (or in some cases at earlier times). Between 50% and 250% of the target number of 248,108 PSUs may be earned upon achievement of such TSR goals but shall only vest at the end of the five-year performance period if the reporting person's service to the Company continues through such date, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change in control ("CIC")). Earned PSUs are subject to a mandatory holding period of three years after vesting, which ends early upon the reporting person's death or disability or a CIC. F1 · derivative.exercise_date: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of Company stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain total shareholder return ("TSR") goals derived from compound annual growth rates of 5.6% to 19.2% over a five-year performance period ending on December 31, 2025 (or in some cases at earlier times). Between 50% and 250% of the target number of 248,108 PSUs may be earned upon achievement of such TSR goals but shall only vest at the end of the five-year performance period if the reporting person's service to the Company continues through such date, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change in control ("CIC")). Earned PSUs are subject to a mandatory holding period of three years after vesting, which ends early upon the reporting person's death or disability or a CIC. F1 · derivative.expiration_date: Each performance restricted stock unit ("PSU") represents a contingent right to receive one share of Company stock. The amount reported is the maximum number of PSUs that may be earned upon achievement of certain total shareholder return ("TSR") goals derived from compound annual growth rates of 5.6% to 19.2% over a five-year performance period ending on December 31, 2025 (or in some cases at earlier times). Between 50% and 250% of the target number of 248,108 PSUs may be earned upon achievement of such TSR goals but shall only vest at the end of the five-year performance period if the reporting person's service to the Company continues through such date, except in certain limited cases (such as if service to the Company is terminated by the Company without cause or in case of a change in control ("CIC")). Earned PSUs are subject to a mandatory holding period of three years after vesting, which ends early upon the reporting person's death or disability or a CIC. Read SEC document |
| December 30, 2020 Filed Dec 31, 2020 22:30 UTC |
YANCOPOULOS GEORGEDirector · President and Chief Scientific
|
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative | 158,079 | $0.00 Strike: $52.03 | $0.00 |
DisclosureSEC source: 0001708138-20-000118 · edgardoc.xml · derivative · entry 9 YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 0 Underlying: Common Stock · 158,079 shares Expires 2021-12-16 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · derivative.exercise_date: With respect to 240,000 underlying shares (of which 0 remain outstanding), the option became exercisable on December 31, 2014, based upon the satisfaction by the company of certain performance criteria during the period ended December 31, 2014. With respect to 158,079 underlying shares (of which 0 remain outstanding), the stock option award vested in four equal annual installments, commencing one year after the date of grant. Read SEC document |
| December 30, 2020 Filed Dec 31, 2020 22:30 UTC |
YANCOPOULOS GEORGEDirector · President and Chief Scientific
|
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative | 240,000 | $0.00 Strike: $52.03 | $0.00 |
DisclosureSEC source: 0001708138-20-000118 · edgardoc.xml · derivative · entry 8 YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 158,079 Underlying: Common Stock · 240,000 shares Expires 2021-12-16 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. F1 · derivative.exercise_date: With respect to 240,000 underlying shares (of which 0 remain outstanding), the option became exercisable on December 31, 2014, based upon the satisfaction by the company of certain performance criteria during the period ended December 31, 2014. With respect to 158,079 underlying shares (of which 0 remain outstanding), the stock option award vested in four equal annual installments, commencing one year after the date of grant. Read SEC document |
| December 30, 2020 Filed Dec 31, 2020 22:30 UTC |
YANCOPOULOS GEORGEDirector · President and Chief Scientific
|
Tax withholdingCommon Stock | 86,096 | $483.25 | $41,605,892.00 |
DisclosureSEC source: 0001708138-20-000118 · edgardoc.xml · nonDerivative · entry 4 YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 822,207 Read SEC document |
| December 30, 2020 Filed Dec 31, 2020 22:30 UTC |
YANCOPOULOS GEORGEDirector · President and Chief Scientific
|
Exercise / conversionCommon Stock | 158,079 | $52.03 | $8,224,850.37 |
DisclosureSEC source: 0001708138-20-000118 · edgardoc.xml · nonDerivative · entry 3 YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 908,303 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| December 30, 2020 Filed Dec 31, 2020 22:30 UTC |
YANCOPOULOS GEORGEDirector · President and Chief Scientific
|
Tax withholdingCommon Stock | 130,714 | $483.25 | $63,167,540.50 |
DisclosureSEC source: 0001708138-20-000118 · edgardoc.xml · nonDerivative · entry 2 YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 750,224 Read SEC document |
| December 30, 2020 Filed Dec 31, 2020 22:30 UTC |
YANCOPOULOS GEORGEDirector · President and Chief Scientific
|
Exercise / conversionCommon Stock | 240,000 | $52.03 | $12,487,200.00 |
DisclosureSEC source: 0001708138-20-000118 · edgardoc.xml · nonDerivative · entry 1 YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 880,938 Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event. Read SEC document |
| December 09, 2020 Filed Dec 11, 2020 21:07 UTC |
MURPHY ANDREW JEVP Research
|
GrantNon-Qualified Stock Option (right to buy) · Derivative | 25,000 | $0.00 Strike: $492.00 | $0.00 |
DisclosureSEC source: 0001237899-20-000053 · edgardoc.xml · derivative · entry 4 MURPHY ANDREW J · CIK 0001796226 · EVP Research 10b5-1 filing: Not disclosed Ownership: Direct Disclosed balance after: 25,000 Underlying: Common Stock · 25,000 shares Expires 2030-12-09 F3 · derivative.exercise_date: The stock option award vests in four equal annual installments, commencing one year after the date of grant. Read SEC document |
Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.