Tapewire

Nasdaq · USD

REGN

REGENERON PHARMACEUTICALS, INC.

Export transactions ↓
Tapewire entity
2010
SEC CIK
0000872589
Parsed reports
687

Last 12 months

Inside the activity.

0 purchase rows · 78 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202502
Dec 202500
Jan 202601
Feb 2026035
Mar 2026013
Apr 202609
May 2026012
Jun 202600
Jul 202601
Aug 202602
Sep 202603
Oct 202600

Latest available

Insider transactions

JSON API
Reset

Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
August 02, 2021 Filed Aug 4, 2021 20:05 UTC SaleCommon Stock 3 $580.33 $1,740.99
Disclosure

SEC source: 0001708138-21-000040 · edgardoc.xml · nonDerivative · entry 9

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,391

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F10 · price: Represents volume-weighted average price of sales of 3 shares of Company stock on August 2, 2021 at prices ranging from $580.02 to $580.85. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on August 2, 2021 at each separate price.

Read SEC document
August 02, 2021 Filed Aug 4, 2021 20:05 UTC SaleCommon Stock 39 $579.35 $22,594.65
Disclosure

SEC source: 0001708138-21-000040 · edgardoc.xml · nonDerivative · entry 8

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,394

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F9 · price: Represents volume-weighted average price of sales of 39 shares of Company stock on August 2, 2021 at prices ranging from $579.00 to $579.82. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on August 2, 2021 at each separate price.

Read SEC document
August 02, 2021 Filed Aug 4, 2021 20:05 UTC SaleCommon Stock 28 $578.67 $16,202.76
Disclosure

SEC source: 0001708138-21-000040 · edgardoc.xml · nonDerivative · entry 7

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,433

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F8 · price: Represents volume-weighted average price of sales of 28 shares of Company stock on August 2, 2021 at prices ranging from $578.08 to $578.93. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on August 2, 2021 at each separate price.

Read SEC document
August 02, 2021 Filed Aug 4, 2021 20:05 UTC SaleCommon Stock 5 $577.42 $2,887.10
Disclosure

SEC source: 0001708138-21-000040 · edgardoc.xml · nonDerivative · entry 6

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,461

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F7 · price: Represents volume-weighted average price of sales of 5 shares of Company stock on August 2, 2021 at prices ranging from $577.12 to $577.76. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on August 2, 2021 at each separate price.

Read SEC document
August 02, 2021 Filed Aug 4, 2021 20:05 UTC SaleCommon Stock 3 $576.51 $1,729.53
Disclosure

SEC source: 0001708138-21-000040 · edgardoc.xml · nonDerivative · entry 5

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,466

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F6 · price: Represents volume-weighted average price of sales of 3 shares of Company stock on August 2, 2021 at prices ranging from $576.05 to $576.79. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on August 2, 2021 at each separate price.

Read SEC document
August 02, 2021 Filed Aug 4, 2021 20:05 UTC SaleCommon Stock 5 $575.24 $2,876.20
Disclosure

SEC source: 0001708138-21-000040 · edgardoc.xml · nonDerivative · entry 4

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,469

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F5 · price: Represents volume-weighted average price of sales of 5 shares of Company stock on August 2, 2021 at prices ranging from $575.01 to $575.47. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on August 2, 2021 at each separate price.

Read SEC document
August 02, 2021 Filed Aug 4, 2021 20:05 UTC SaleCommon Stock 13 $574.70 $7,471.10
Disclosure

SEC source: 0001708138-21-000040 · edgardoc.xml · nonDerivative · entry 3

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,474

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F4 · price: Represents volume-weighted average price of sales of 13 shares of Company stock on August 2, 2021 at prices ranging from $574.33 to $574.95. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on August 2, 2021 at each separate price.

Read SEC document
August 02, 2021 Filed Aug 4, 2021 20:05 UTC SaleCommon Stock 2 $573.20 $1,146.40
Disclosure

SEC source: 0001708138-21-000040 · edgardoc.xml · nonDerivative · entry 2

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,487

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F3 · price: Represents volume-weighted average price of sales of 2 shares of Company stock on August 2, 2021 at prices ranging from $573.01 to $573.40. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on August 2, 2021 at each separate price.

Read SEC document
August 02, 2021 Filed Aug 4, 2021 20:05 UTC SaleCommon Stock 2 $572.94 $1,145.88
Disclosure

SEC source: 0001708138-21-000040 · edgardoc.xml · nonDerivative · entry 1

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,489

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F2 · price: Represents volume-weighted average price of sales of 2 shares of Company stock on August 2, 2021 at prices ranging from $572.91 to $572.97. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on August 2, 2021 at each separate price.

Read SEC document
August 02, 2021 Filed Aug 4, 2021 20:03 UTC
McCourt MarionEVP Commercial
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 1,000 $0.00 Strike: $342.93 $0.00
Disclosure

SEC source: 0001708138-21-000039 · edgardoc.xml · derivative · entry 4

McCourt Marion · CIK 0001663758 · EVP Commercial

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Common Stock · 1,000 shares

Expires 2028-02-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F2 · derivative.exercise_date: The stock option award vests in four equal annual installments, commencing one year after the date of grant.

Read SEC document
August 02, 2021 Filed Aug 4, 2021 20:03 UTC
McCourt MarionEVP Commercial
SaleCommon Stock 1,000 $577.12 $577,120.00
Disclosure

SEC source: 0001708138-21-000039 · edgardoc.xml · nonDerivative · entry 2

McCourt Marion · CIK 0001663758 · EVP Commercial

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,038

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

Read SEC document
August 02, 2021 Filed Aug 4, 2021 20:03 UTC
McCourt MarionEVP Commercial
Exercise / conversionCommon Stock 1,000 $342.93 $342,930.00
Disclosure

SEC source: 0001708138-21-000039 · edgardoc.xml · nonDerivative · entry 1

McCourt Marion · CIK 0001663758 · EVP Commercial

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,038

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

Read SEC document
July 06, 2021 Filed Jul 7, 2021 20:01 UTC
LAROSA JOSEPH JEVP General Counsel and Secret
SaleCommon Stock 3,398 $580.00 $1,970,840.00
Disclosure

SEC source: 0001708138-21-000036 · edgardoc.xml · nonDerivative · entry 3

LAROSA JOSEPH J · CIK 0001238303 · EVP General Counsel and Secret

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,182

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

Read SEC document
July 02, 2021 Filed Jul 7, 2021 20:01 UTC
LAROSA JOSEPH JEVP General Counsel and Secret
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 10,000 $0.00 Strike: $179.13 $0.00
Disclosure

SEC source: 0001708138-21-000036 · edgardoc.xml · derivative · entry 6

LAROSA JOSEPH J · CIK 0001238303 · EVP General Counsel and Secret

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 10,000 shares

Expires 2022-12-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F2 · derivative.exercise_date: The stock option award vests in four equal annual installments, commencing one year after the date of grant.

Read SEC document
July 02, 2021 Filed Jul 7, 2021 20:01 UTC
LAROSA JOSEPH JEVP General Counsel and Secret
Tax withholdingCommon Stock 6,602 $582.20 $3,843,684.40
Disclosure

SEC source: 0001708138-21-000036 · edgardoc.xml · nonDerivative · entry 2

LAROSA JOSEPH J · CIK 0001238303 · EVP General Counsel and Secret

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,580

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

Read SEC document
July 02, 2021 Filed Jul 7, 2021 20:01 UTC
LAROSA JOSEPH JEVP General Counsel and Secret
Exercise / conversionCommon Stock 10,000 $179.13 $1,791,300.00
Disclosure

SEC source: 0001708138-21-000036 · edgardoc.xml · nonDerivative · entry 1

LAROSA JOSEPH J · CIK 0001238303 · EVP General Counsel and Secret

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,182

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

Read SEC document
July 02, 2021 Filed Aug 19, 2021 20:05 UTC GiftCommon Stock 373 $0.00 $0.00
Disclosure

SEC source: 0001708138-21-000062 · edgardoc.xml · nonDerivative · entry 5

VAGELOS P ROY · CIK 0001013064 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by CLAT

Disclosed balance after: 141,977

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC
McCourt MarionEVP Commercial
Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 1,000 $0.00 Strike: $342.93 $0.00
Disclosure

SEC source: 0001708138-21-000034 · edgardoc.xml · derivative · entry 4

McCourt Marion · CIK 0001663758 · EVP Commercial

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 1,000 shares

Expires 2028-02-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F2 · derivative.exercise_date: The stock option award vests in four equal annual installments, commencing one year after the date of grant.

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC
McCourt MarionEVP Commercial
SaleCommon Stock 1,000 $556.60 $556,600.00
Disclosure

SEC source: 0001708138-21-000034 · edgardoc.xml · nonDerivative · entry 2

McCourt Marion · CIK 0001663758 · EVP Commercial

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,038

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC
McCourt MarionEVP Commercial
Exercise / conversionCommon Stock 1,000 $342.93 $342,930.00
Disclosure

SEC source: 0001708138-21-000034 · edgardoc.xml · nonDerivative · entry 1

McCourt Marion · CIK 0001663758 · EVP Commercial

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,038

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC SaleCommon Stock 13 $568.43 $7,389.59
Disclosure

SEC source: 0001708138-21-000033 · edgardoc.xml · nonDerivative · entry 13

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,491

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F11 · price: Represents volume-weighted average price of sales of 13 shares of Company stock on July 1, 2021 at prices ranging from $568.10 to $568.68. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 1, 2021 at each separate price.

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC SaleCommon Stock 13 $567.56 $7,378.28
Disclosure

SEC source: 0001708138-21-000033 · edgardoc.xml · nonDerivative · entry 12

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,504

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F10 · price: Represents volume-weighted average price of sales of 13 shares of Company stock on July 1, 2021 at prices ranging from $567.15 to $567.88. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 1, 2021 at each separate price.

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC SaleCommon Stock 12 $566.42 $6,797.04
Disclosure

SEC source: 0001708138-21-000033 · edgardoc.xml · nonDerivative · entry 11

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,517

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F9 · price: Represents volume-weighted average price of sales of 12 shares of Company stock on July 1, 2021 at prices ranging from $566.09 to $566.96. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 1, 2021 at each separate price.

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC SaleCommon Stock 13 $565.44 $7,350.72
Disclosure

SEC source: 0001708138-21-000033 · edgardoc.xml · nonDerivative · entry 10

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,529

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F8 · price: Represents volume-weighted average price of sales of 13 shares of Company stock on July 1, 2021 at prices ranging from $565.00 to $565.83. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 1, 2021 at each separate price.

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC SaleCommon Stock 6 $564.71 $3,388.26
Disclosure

SEC source: 0001708138-21-000033 · edgardoc.xml · nonDerivative · entry 9

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,542

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F7 · price: Represents volume-weighted average price of sales of 6 shares of Company stock on July 1, 2021 at prices ranging from $564.26 to $564.86. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 1, 2021 at each separate price.

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC SaleCommon Stock 16 $563.40 $9,014.40
Disclosure

SEC source: 0001708138-21-000033 · edgardoc.xml · nonDerivative · entry 8

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,548

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F6 · price: Represents volume-weighted average price of sales of 16 shares of Company stock on July 1, 2021 at prices ranging from $563.03 to $563.91. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 1, 2021 at each separate price.

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC SaleCommon Stock 10 $562.48 $5,624.80
Disclosure

SEC source: 0001708138-21-000033 · edgardoc.xml · nonDerivative · entry 7

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,564

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F5 · price: Represents volume-weighted average price of sales of 10 shares of Company stock on July 1, 2021 at prices ranging from $562.00 to $562.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 1, 2021 at each separate price.

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC SaleCommon Stock 6 $561.80 $3,370.80
Disclosure

SEC source: 0001708138-21-000033 · edgardoc.xml · nonDerivative · entry 6

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,574

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F4 · price: Represents volume-weighted average price of sales of 6 shares of Company stock on July 1, 2021 at prices ranging from $561.57 to $561.89. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 1, 2021 at each separate price.

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC SaleCommon Stock 2 $560.62 $1,121.24
Disclosure

SEC source: 0001708138-21-000033 · edgardoc.xml · nonDerivative · entry 5

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,580

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F3 · price: Represents volume-weighted average price of sales of 2 shares of Company stock on July 1, 2021 at prices ranging from $560.43 to $560.81. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 1, 2021 at each separate price.

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC SaleCommon Stock 2 $559.78 $1,119.56
Disclosure

SEC source: 0001708138-21-000033 · edgardoc.xml · nonDerivative · entry 4

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,582

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC SaleCommon Stock 1 $557.75 $557.75
Disclosure

SEC source: 0001708138-21-000033 · edgardoc.xml · nonDerivative · entry 3

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,584

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC SaleCommon Stock 4 $556.71 $2,226.84
Disclosure

SEC source: 0001708138-21-000033 · edgardoc.xml · nonDerivative · entry 2

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,585

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F2 · price: Represents volume-weighted average price of sales of 4 shares of Company stock on July 1, 2021 at prices ranging from $556.60 to $556.81. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on July 1, 2021 at each separate price.

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:02 UTC SaleCommon Stock 2 $555.47 $1,110.94
Disclosure

SEC source: 0001708138-21-000033 · edgardoc.xml · nonDerivative · entry 1

RYAN ARTHUR F · CIK 0001187443 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,589

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:01 UTC Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 2,558 $0.00 Strike: $391.92 $0.00
Disclosure

SEC source: 0001708138-21-000032 · edgardoc.xml · derivative · entry 3

Bassler Bonnie L · CIK 0001683607 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,677

Underlying: Common Stock · 2,558 shares

Expires 2026-09-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F2 · derivative.exercise_date: The stock option becomes exercisable in three equal annual installments, commencing one year after the date of grant.

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:01 UTC SaleCommon Stock 2,558 $575.00 $1,470,850.00
Disclosure

SEC source: 0001708138-21-000032 · edgardoc.xml · nonDerivative · entry 2

Bassler Bonnie L · CIK 0001683607 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 891

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

Read SEC document
July 01, 2021 Filed Jul 2, 2021 20:01 UTC Exercise / conversionCommon Stock 2,558 $391.92 $1,002,531.36
Disclosure

SEC source: 0001708138-21-000032 · edgardoc.xml · nonDerivative · entry 1

Bassler Bonnie L · CIK 0001683607 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,449

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

Read SEC document
June 25, 2021 Filed Jun 28, 2021 20:01 UTC Exercise / conversionNon-Qualified Stock Option (right to buy) · Derivative 2,084 $0.00 Strike: $371.40 $0.00
Disclosure

SEC source: 0001708138-21-000028 · edgardoc.xml · derivative · entry 5

BROWN MICHAEL S · CIK 0001174475 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,084 shares

Expires 2029-01-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F3 · derivative.exercise_date: On the date of the Issuer's first annual meeting of shareholders following the date of grant, a portion of these stock options equal to the portion of one year that had passed from the date of grant became exercisable, and the remainder became exercisable on the first anniversary of the date of grant.

Read SEC document
June 25, 2021 Filed Jun 28, 2021 20:01 UTC SaleCommon Stock 2,084 $549.00 $1,144,116.00
Disclosure

SEC source: 0001708138-21-000028 · edgardoc.xml · nonDerivative · entry 2

BROWN MICHAEL S · CIK 0001174475 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 891

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

Read SEC document
June 25, 2021 Filed Jun 28, 2021 20:01 UTC Exercise / conversionCommon Stock 2,084 $371.40 $773,997.60
Disclosure

SEC source: 0001708138-21-000028 · edgardoc.xml · nonDerivative · entry 1

BROWN MICHAEL S · CIK 0001174475 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,975

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

Read SEC document
June 24, 2021 Filed Aug 6, 2021 20:03 UTC
YANCOPOULOS GEORGEDirector · President and Chief Scientific
GiftCommon Stock 211,585 $0.00 $0.00
Disclosure

SEC source: 0001708138-21-000044 · edgardoc.xml · nonDerivative · entry 3

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific

10b5-1 filing: Not disclosed

Ownership: Indirect · by 2019 GRAT

Disclosed balance after: 0

Read SEC document
June 24, 2021 Filed Aug 6, 2021 20:03 UTC
YANCOPOULOS GEORGEDirector · President and Chief Scientific
GiftCommon Stock 211,585 $0.00 $0.00
Disclosure

SEC source: 0001708138-21-000044 · edgardoc.xml · nonDerivative · entry 2

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific

10b5-1 filing: Not disclosed

Ownership: Indirect · By Trust for Chldn.

Disclosed balance after: 213,693

F3 · ownership.nature: As investment trustee of trusts for the benefit of the reporting person's children.

Read SEC document
June 21, 2021 Filed Jun 23, 2021 20:02 UTC
YANCOPOULOS GEORGEDirector · President and Chief Scientific
SaleCommon Stock 2,276 $543.13 $1,236,163.88
Disclosure

SEC source: 0001708138-21-000026 · edgardoc.xml · nonDerivative · entry 13

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific

10b5-1 filing: Not disclosed

Ownership: Indirect · By Trust for Chldn.

Disclosed balance after: 2,108

F2 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F14 · price: Represents volume-weighted average price of sales of 2,276 shares of Company stock on June 21, 2021 at prices ranging from $543.01 to $543.46. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on June 21, 2021 at each separate price.

F1 · ownership.nature: As investment trustee of trusts for the benefit of the reporting person's children.

Read SEC document
June 21, 2021 Filed Jun 23, 2021 20:02 UTC
YANCOPOULOS GEORGEDirector · President and Chief Scientific
SaleCommon Stock 10,514 $542.43 $5,703,109.02
Disclosure

SEC source: 0001708138-21-000026 · edgardoc.xml · nonDerivative · entry 12

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific

10b5-1 filing: Not disclosed

Ownership: Indirect · By Trust for Chldn.

Disclosed balance after: 4,384

F2 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F13 · price: Represents volume-weighted average price of sales of 10,514 shares of Company stock on June 21, 2021 at prices ranging from $542.00 to $542.98. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on June 21, 2021 at each separate price.

F1 · ownership.nature: As investment trustee of trusts for the benefit of the reporting person's children.

Read SEC document
June 21, 2021 Filed Jun 23, 2021 20:02 UTC
YANCOPOULOS GEORGEDirector · President and Chief Scientific
SaleCommon Stock 19,911 $541.44 $10,780,611.84
Disclosure

SEC source: 0001708138-21-000026 · edgardoc.xml · nonDerivative · entry 11

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific

10b5-1 filing: Not disclosed

Ownership: Indirect · By Trust for Chldn.

Disclosed balance after: 14,898

F2 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F12 · price: Represents volume-weighted average price of sales of 19,911 shares of Company stock on June 21, 2021 at prices ranging from $541.00 to $541.97. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on June 21, 2021 at each separate price.

F1 · ownership.nature: As investment trustee of trusts for the benefit of the reporting person's children.

Read SEC document
June 21, 2021 Filed Jun 23, 2021 20:02 UTC
YANCOPOULOS GEORGEDirector · President and Chief Scientific
SaleCommon Stock 8,099 $540.61 $4,378,400.39
Disclosure

SEC source: 0001708138-21-000026 · edgardoc.xml · nonDerivative · entry 10

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific

10b5-1 filing: Not disclosed

Ownership: Indirect · By Trust for Chldn.

Disclosed balance after: 34,809

F2 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F11 · price: Represents volume-weighted average price of sales of 8,099 shares of Company stock on June 21, 2021 at prices ranging from $540.00 to $540.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on June 21, 2021 at each separate price.

F1 · ownership.nature: As investment trustee of trusts for the benefit of the reporting person's children.

Read SEC document
June 21, 2021 Filed Jun 23, 2021 20:02 UTC
YANCOPOULOS GEORGEDirector · President and Chief Scientific
SaleCommon Stock 3,306 $539.66 $1,784,115.96
Disclosure

SEC source: 0001708138-21-000026 · edgardoc.xml · nonDerivative · entry 9

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific

10b5-1 filing: Not disclosed

Ownership: Indirect · By Trust for Chldn.

Disclosed balance after: 42,908

F2 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F10 · price: Represents volume-weighted average price of sales of 3,306 shares of Company stock on June 21, 2021 at prices ranging from $539.14 to $539.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on June 21, 2021 at each separate price.

F1 · ownership.nature: As investment trustee of trusts for the benefit of the reporting person's children.

Read SEC document
June 21, 2021 Filed Jun 23, 2021 20:02 UTC
YANCOPOULOS GEORGEDirector · President and Chief Scientific
SaleCommon Stock 4,868 $538.54 $2,621,612.72
Disclosure

SEC source: 0001708138-21-000026 · edgardoc.xml · nonDerivative · entry 8

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific

10b5-1 filing: Not disclosed

Ownership: Indirect · By Trust for Chldn.

Disclosed balance after: 46,214

F2 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F9 · price: Represents volume-weighted average price of sales of 4,868 shares of Company stock on June 21, 2021 at prices ranging from $538.01 to $538.97. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on June 21, 2021 at each separate price.

F1 · ownership.nature: As investment trustee of trusts for the benefit of the reporting person's children.

Read SEC document
June 21, 2021 Filed Jun 23, 2021 20:02 UTC
YANCOPOULOS GEORGEDirector · President and Chief Scientific
SaleCommon Stock 6,636 $537.61 $3,567,579.96
Disclosure

SEC source: 0001708138-21-000026 · edgardoc.xml · nonDerivative · entry 7

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific

10b5-1 filing: Not disclosed

Ownership: Indirect · By Trust for Chldn.

Disclosed balance after: 51,082

F2 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F8 · price: Represents volume-weighted average price of sales of 6,636 shares of Company stock on June 21, 2021 at prices ranging from $537.05 to $537.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on June 21, 2021 at each separate price.

F1 · ownership.nature: As investment trustee of trusts for the benefit of the reporting person's children.

Read SEC document
June 21, 2021 Filed Jun 23, 2021 20:02 UTC
YANCOPOULOS GEORGEDirector · President and Chief Scientific
SaleCommon Stock 3,768 $536.37 $2,021,042.16
Disclosure

SEC source: 0001708138-21-000026 · edgardoc.xml · nonDerivative · entry 6

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific

10b5-1 filing: Not disclosed

Ownership: Indirect · By Trust for Chldn.

Disclosed balance after: 57,718

F2 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F7 · price: Represents volume-weighted average price of sales of 3,768 shares of Company stock on June 21, 2021 at prices ranging from $536.02 to $536.99. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on June 21, 2021 at each separate price.

F1 · ownership.nature: As investment trustee of trusts for the benefit of the reporting person's children.

Read SEC document
June 21, 2021 Filed Jun 23, 2021 20:02 UTC
YANCOPOULOS GEORGEDirector · President and Chief Scientific
SaleCommon Stock 4,154 $535.63 $2,225,007.02
Disclosure

SEC source: 0001708138-21-000026 · edgardoc.xml · nonDerivative · entry 5

YANCOPOULOS GEORGE · CIK 0001226690 · Director · President and Chief Scientific

10b5-1 filing: Not disclosed

Ownership: Indirect · By Trust for Chldn.

Disclosed balance after: 61,486

F2 · kind: Disposition/acquisition made pursuant to a plan intended to comply with Rule 10b5-1(c).

F6 · price: Represents volume-weighted average price of sales of 4,154 shares of Company stock on June 21, 2021 at prices ranging from $535.05 to $535.87. Upon request by the Commission staff, the Company, or a security holder of the Company, the reporting person will provide full information regarding the number of shares sold by the reporting person on June 21, 2021 at each separate price.

F1 · ownership.nature: As investment trustee of trusts for the benefit of the reporting person's children.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.