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Nasdaq · USD

QURE

uniQure N.V.

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4162
SEC CIK
0001590560
Parsed reports
431

Last 12 months

Inside the activity.

0 purchase rows · 57 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202505
Dec 202500
Jan 202604
Feb 202602
Mar 202608
Apr 202600
May 202602
Jun 2026033
Jul 202603
Aug 202600
Sep 202600
Oct 202600

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
January 28, 2020 Filed Jan 30, 2020 21:11 UTC
van Deventer SanderEVP, Research & Product Dev.
SaleOrdinary Shares 1,304 $61.27 $79,896.08
Disclosure

SEC source: 0000904454-20-000114 · edgar.xml · nonDerivative · entry 1

van Deventer Sander · CIK 0001543084 · EVP, Research & Product Dev.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,050

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $60.85 to $61.83. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
January 28, 2020 Filed Jan 31, 2020 02:23 UTC SaleOrdinary Shares 807 $62.20 $50,195.40
Disclosure

SEC source: 0000904454-20-000118 · edgar.xml · nonDerivative · entry 1

Balachandran Madhavan · CIK 0001555508 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,005

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

Read SEC document
January 28, 2020 Filed Jan 31, 2020 01:54 UTC SaleOrdinary Shares 718 $62.20 $44,659.60
Disclosure

SEC source: 0000904454-20-000106 · edgar.xml · nonDerivative · entry 2

Meek David D. · CIK 0001555337 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,508

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $62.20 to $62.21. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
January 28, 2020 Filed Jan 31, 2020 01:54 UTC SaleOrdinary Shares 4 $60.94 $243.76
Disclosure

SEC source: 0000904454-20-000106 · edgar.xml · nonDerivative · entry 1

Meek David D. · CIK 0001555337 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,226

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

Read SEC document
January 28, 2020 Filed Jan 31, 2020 01:57 UTC SaleOrdinary Shares 803 $62.20 $49,946.60
Disclosure

SEC source: 0000904454-20-000108 · edgar.xml · nonDerivative · entry 2

Springhorn Jeremy P. · CIK 0001717852 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,005

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

Read SEC document
January 28, 2020 Filed Jan 31, 2020 01:57 UTC SaleOrdinary Shares 4 $60.94 $243.76
Disclosure

SEC source: 0000904454-20-000108 · edgar.xml · nonDerivative · entry 1

Springhorn Jeremy P. · CIK 0001717852 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,808

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

Read SEC document
January 28, 2020 Filed Jan 31, 2020 02:02 UTC
KLEMT CHRISTIANChief Accounting Officer
SaleOrdinary Shares 3,033 $62.02 $188,106.66
Disclosure

SEC source: 0000904454-20-000110 · edgar.xml · nonDerivative · entry 2

KLEMT CHRISTIAN · CIK 0001711885 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,564

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $61.84 to $62.20. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
January 28, 2020 Filed Jan 31, 2020 02:02 UTC
KLEMT CHRISTIANChief Accounting Officer
SaleOrdinary Shares 8,942 $61.28 $547,965.76
Disclosure

SEC source: 0000904454-20-000110 · edgar.xml · nonDerivative · entry 1

KLEMT CHRISTIAN · CIK 0001711885 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,597

F1 · kind: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F1 · shares: As required by the relevant Restricted Share Unit Agreement, the Reporting Person sold the Ordinary Shares and remitted the proceeds therefrom to the Issuer to satisfy estimated tax withholding obligations triggered by the vesting of restricted share units.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $60.83 to $61.62. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
January 27, 2020 Filed Jan 29, 2020 16:24 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 600 $62.44 $37,464.00
Disclosure

SEC source: 0000904454-20-000084 · edgar.xml · nonDerivative · entry 4

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 339,162

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F5 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $62.39 to $62.49. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
January 27, 2020 Filed Jan 29, 2020 16:24 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 13,106 $61.86 $810,737.16
Disclosure

SEC source: 0000904454-20-000084 · edgar.xml · nonDerivative · entry 3

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 339,762

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $61.38 to $62.37. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
January 27, 2020 Filed Jan 29, 2020 16:24 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 13,207 $69.94 $923,697.58
Disclosure

SEC source: 0000904454-20-000084 · edgar.xml · nonDerivative · entry 2

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 352,868

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $60.37 to $61.36. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
January 27, 2020 Filed Jan 29, 2020 16:24 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 1,376 $59.87 $82,381.12
Disclosure

SEC source: 0000904454-20-000084 · edgar.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 366,075

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $59.25 to $60.23. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
January 27, 2020 Filed Jan 29, 2020 23:02 UTC
Gut RobertChief Medical Officer
SaleOrdinary Shares 6,897 $60.01 $413,888.97
Disclosure

SEC source: 0000904454-20-000090 · edgar.xml · nonDerivative · entry 1

Gut Robert · CIK 0001716268 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,481

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

Read SEC document
January 15, 2020 Filed Jan 17, 2020 14:39 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
Exercise / conversionStock Option (Right to Buy) · Derivative 4,000 $0.00 Strike: $5.31 $0.00
Disclosure

SEC source: 0000904454-20-000041 · edgar.xml · derivative · entry 3

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,000

Underlying: Ordinary Shares · 4,000 shares

Expires 2027-01-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The Stock Option vested 25% on January 23, 2018 (the first anniversary of the date of grant), and vests 6.25% quarterly thereafter until fully vested, subject to the Reporting Person's continued relationship with the Issuer through such dates.

Read SEC document
January 15, 2020 Filed Jan 17, 2020 14:39 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
SaleOrdinary Shares 4,000 $68.97 $275,880.00
Disclosure

SEC source: 0000904454-20-000041 · edgar.xml · nonDerivative · entry 2

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,578

F2 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $68.61 to $69.35. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
January 15, 2020 Filed Jan 17, 2020 14:39 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
Exercise / conversionOrdinary Shares 4,000 $5.31 $21,240.00
Disclosure

SEC source: 0000904454-20-000041 · edgar.xml · nonDerivative · entry 1

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,578

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 07, 2020 Filed Jan 8, 2020 18:48 UTC SaleOrdinary Shares 3,000 $72.18 $216,540.00
Disclosure

SEC source: 0000904454-20-000011 · edgar.xml · nonDerivative · entry 1

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,352

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $71.79 to $72.62. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
December 18, 2019 Filed Dec 20, 2019 21:13 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
Exercise / conversionStock Option (Right to Buy) · Derivative 7,339 $0.00 Strike: $7.53 $0.00
Disclosure

SEC source: 0000904454-19-000754 · edgar.xml · derivative · entry 5

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 92,661

Underlying: Ordinary Shares · 7,339 shares

Expires 2026-09-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The Stock Option vested 25% on September 29, 2017 (the first anniversary of the date of grant), and vests 6.25% quarterly thereafter until fully vested, subject to the Reporting Person's continued relationship with the Issuer through such dates.

Read SEC document
December 18, 2019 Filed Dec 20, 2019 21:13 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 276 $71.70 $19,789.20
Disclosure

SEC source: 0000904454-19-000754 · edgar.xml · nonDerivative · entry 4

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 367,451

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $71.685 to $71.750. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
December 18, 2019 Filed Dec 20, 2019 21:13 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 1,110 $70.55 $78,310.50
Disclosure

SEC source: 0000904454-19-000754 · edgar.xml · nonDerivative · entry 3

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 367,727

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $70.325 to $71.100. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
December 18, 2019 Filed Dec 20, 2019 21:13 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 6,154 $69.94 $430,410.76
Disclosure

SEC source: 0000904454-19-000754 · edgar.xml · nonDerivative · entry 2

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 368,837

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $69.325 to $70.320. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
December 18, 2019 Filed Dec 20, 2019 21:13 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
Exercise / conversionOrdinary Shares 7,339 $7.53 $55,262.67
Disclosure

SEC source: 0000904454-19-000754 · edgar.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 374,991

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 16, 2019 Filed Dec 17, 2019 21:09 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
Exercise / conversionStock Option (Right to Buy) · Derivative 4,000 $0.00 Strike: $5.31 $0.00
Disclosure

SEC source: 0000904454-19-000751 · edgar.xml · derivative · entry 4

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,000

Underlying: Ordinary Shares · 4,000 shares

Expires 2027-01-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The Stock Option vested 25% on January 23, 2018 (the first anniversary of the date of grant), and vests 6.25% quarterly thereafter until fully vested, subject to the Reporting Person's continued relationship with the Issuer through such dates.

Read SEC document
December 16, 2019 Filed Dec 17, 2019 21:09 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
SaleOrdinary Shares 724 $75.58 $54,719.92
Disclosure

SEC source: 0000904454-19-000751 · edgar.xml · nonDerivative · entry 3

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,578

F2 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $75.05 to $75.60. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
December 16, 2019 Filed Dec 17, 2019 21:09 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
SaleOrdinary Shares 3,276 $74.37 $243,636.12
Disclosure

SEC source: 0000904454-19-000751 · edgar.xml · nonDerivative · entry 2

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,302

F2 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $74.00 to $74.73. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
December 16, 2019 Filed Dec 17, 2019 21:09 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
Exercise / conversionOrdinary Shares 4,000 $5.31 $21,240.00
Disclosure

SEC source: 0000904454-19-000751 · edgar.xml · nonDerivative · entry 1

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,578

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 13, 2019 Filed Dec 17, 2019 21:06 UTC Exercise / conversionStock Option (Right to Buy) · Derivative 2,000 $0.00 Strike: $5.37 $0.00
Disclosure

SEC source: 0000904454-19-000749 · edgar.xml · derivative · entry 3

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,000

Underlying: Ordinary Shares · 2,000 shares

Expires 2027-01-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The Stock Option vested on January 27, 2018, the first anniversary of the grant date.

Read SEC document
December 13, 2019 Filed Dec 17, 2019 21:06 UTC SaleOrdinary Shares 2,000 $70.50 $141,000.00
Disclosure

SEC source: 0000904454-19-000749 · edgar.xml · nonDerivative · entry 2

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,352

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $70.50 to $70.51. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
December 13, 2019 Filed Dec 17, 2019 21:06 UTC Exercise / conversionOrdinary Shares 2,000 $5.37 $10,740.00
Disclosure

SEC source: 0000904454-19-000749 · edgar.xml · nonDerivative · entry 1

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,352

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

Read SEC document
December 09, 2019 Filed Dec 9, 2019 23:30 UTC SaleOrdinary Shares 2,500 $67.50 $168,750.00
Disclosure

SEC source: 0000904454-19-000737 · edgar.xml · nonDerivative · entry 3

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,352

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

Read SEC document
December 06, 2019 Filed Dec 9, 2019 23:30 UTC SaleOrdinary Shares 7,382 $64.39 $475,326.98
Disclosure

SEC source: 0000904454-19-000737 · edgar.xml · nonDerivative · entry 2

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,852

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $64.32 to $64.50. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
December 06, 2019 Filed Dec 9, 2019 23:30 UTC SaleOrdinary Shares 1,700 $63.69 $108,273.00
Disclosure

SEC source: 0000904454-19-000737 · edgar.xml · nonDerivative · entry 1

Soteropoulos Paula · CIK 0001692444 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,234

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $63.20 to $64.03. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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November 20, 2019 Filed Nov 22, 2019 15:12 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 1,200 $54.67 $65,604.00
Disclosure

SEC source: 0000904454-19-000732 · edgar.xml · nonDerivative · entry 3

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 367,652

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $54.49 to $54.82. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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November 20, 2019 Filed Nov 22, 2019 15:12 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 3,500 $54.09 $189,315.00
Disclosure

SEC source: 0000904454-19-000732 · edgar.xml · nonDerivative · entry 2

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 368,852

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $53.49 to $54.47. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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November 20, 2019 Filed Nov 22, 2019 15:12 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 3,300 $53.04 $175,032.00
Disclosure

SEC source: 0000904454-19-000732 · edgar.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 372,352

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $52.46 to $53.40. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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November 15, 2019 Filed Nov 19, 2019 13:51 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
Exercise / conversionStock Option (Right to Buy) · Derivative 4,000 $0.00 Strike: $5.31 $0.00
Disclosure

SEC source: 0000904454-19-000730 · edgar.xml · derivative · entry 4

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 106,000

Underlying: Ordinary Shares · 4,000 shares

Expires 2027-01-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The Stock Option vested 25% on January 23, 2018 (the first anniversary of the date of grant), and vests 6.25% quarterly thereafter until fully vested, subject to the Reporting Person's continued relationship with the Issuer through such dates.

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November 15, 2019 Filed Nov 19, 2019 13:51 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
SaleOrdinary Shares 500 $52.69 $26,345.00
Disclosure

SEC source: 0000904454-19-000730 · edgar.xml · nonDerivative · entry 3

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,578

F2 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

Read SEC document
November 15, 2019 Filed Nov 19, 2019 13:51 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
SaleOrdinary Shares 3,500 $51.99 $181,965.00
Disclosure

SEC source: 0000904454-19-000730 · edgar.xml · nonDerivative · entry 2

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,078

F2 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $51.63 to $52.43. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
November 15, 2019 Filed Nov 19, 2019 13:51 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
Exercise / conversionOrdinary Shares 4,000 $5.31 $21,240.00
Disclosure

SEC source: 0000904454-19-000730 · edgar.xml · nonDerivative · entry 1

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,578

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 23, 2019 Filed Oct 25, 2019 12:38 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 3,184 $43.65 $138,981.60
Disclosure

SEC source: 0000904454-19-000689 · edgar.xml · nonDerivative · entry 2

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 375,652

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $43.43 to $43.98. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
October 23, 2019 Filed Oct 25, 2019 12:38 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 4,816 $42.94 $206,799.04
Disclosure

SEC source: 0000904454-19-000689 · edgar.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 378,836

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $42.43 to $43.42. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
October 15, 2019 Filed Oct 17, 2019 17:21 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
Exercise / conversionStock Option (Right to Buy) · Derivative 4,000 $0.00 Strike: $5.31 $0.00
Disclosure

SEC source: 0000904454-19-000687 · edgar.xml · derivative · entry 3

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 110,000

Underlying: Ordinary Shares · 4,000 shares

Expires 2027-01-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The Stock Option vested 25% on January 23, 2018 (the first anniversary of the date of grant), and vests 6.25% quarterly thereafter until fully vested, subject to the Reporting Person's continued relationship with the Issuer through such dates.

Read SEC document
October 15, 2019 Filed Oct 17, 2019 17:21 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
SaleOrdinary Shares 4,000 $42.35 $169,400.00
Disclosure

SEC source: 0000904454-19-000687 · edgar.xml · nonDerivative · entry 2

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,578

F2 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $41.93 to $42.71. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
October 15, 2019 Filed Oct 17, 2019 17:21 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
Exercise / conversionOrdinary Shares 4,000 $5.31 $21,240.00
Disclosure

SEC source: 0000904454-19-000687 · edgar.xml · nonDerivative · entry 1

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,578

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
September 19, 2019 Filed Sep 20, 2019 18:00 UTC
Gut RobertChief Medical Officer
SaleOrdinary Shares 4,769 $47.16 $224,906.04
Disclosure

SEC source: 0000904454-19-000646 · edgar.xml · nonDerivative · entry 1

Gut Robert · CIK 0001716268 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,378

F1 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $46.91 to $ 47.50. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
September 18, 2019 Filed Sep 20, 2019 17:49 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 77 $48.38 $3,725.26
Disclosure

SEC source: 0000904454-19-000644 · edgar.xml · nonDerivative · entry 4

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 383,652

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

Read SEC document
September 18, 2019 Filed Sep 20, 2019 17:49 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 1,841 $47.58 $87,594.78
Disclosure

SEC source: 0000904454-19-000644 · edgar.xml · nonDerivative · entry 3

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 383,729

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $47.27 to $48.22. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
September 18, 2019 Filed Sep 20, 2019 17:49 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 3,008 $46.69 $140,443.52
Disclosure

SEC source: 0000904454-19-000644 · edgar.xml · nonDerivative · entry 2

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 385,570

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $46.25 to $47.22. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
September 18, 2019 Filed Sep 20, 2019 17:49 UTC
Kapusta Matthew CDirector · CEO, CFO, Managing Director
SaleOrdinary Shares 3,074 $47.73 $146,722.02
Disclosure

SEC source: 0000904454-19-000644 · edgar.xml · nonDerivative · entry 1

Kapusta Matthew C · CIK 0001536290 · Director · CEO, CFO, Managing Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 388,578

F1 · kind: The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $45.20 to $45.95. The Reporting Person undertakes to provide to the Issuer, any shareholder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F5 · balance_after: Includes 114 shares acquired under the Issuer's Employee Stock Purchase Plan on August 31, 2019 and 308 shares acquired under the Issuer's Employee Stock Purchase Plan on May 31, 2019.

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September 17, 2019 Filed Sep 18, 2019 17:25 UTC
Kuta Alexander Edward IIIExecutive VP, Operations
GrantOrdinary Shares 15,000 $0.00 $0.00
Disclosure

SEC source: 0000904454-19-000640 · edgar.xml · nonDerivative · entry 3

Kuta Alexander Edward III · CIK 0001696698 · Executive VP, Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,578

F4 · shares: Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest in equal annual installments of 1/3 each, beginning on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such dates.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.