QTRX

SEC source: 0001562180-21-004150 · primarydocument.xml · nonDerivative · entry 6

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,580

F2 · kind: The sale of shares was effected pursuant to a Rule 10b5-1 trading plan adopted on March 15, 2021.

F1 · balance_after: Includes 17,716 restricted stock units.

SEC source: 0001562180-21-004150 · primarydocument.xml · nonDerivative · entry 5

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,246

F2 · kind: The sale of shares was effected pursuant to a Rule 10b5-1 trading plan adopted on March 15, 2021.

F1 · balance_after: Includes 17,716 restricted stock units.

SEC source: 0001562180-21-004150 · primarydocument.xml · nonDerivative · entry 4

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,129

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 17,716 restricted stock units.

SEC source: 0001562180-21-004150 · primarydocument.xml · nonDerivative · entry 3

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,223

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 17,716 restricted stock units.

SEC source: 0001562180-21-004150 · primarydocument.xml · nonDerivative · entry 2

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,099

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 17,716 restricted stock units.

SEC source: 0001562180-21-004150 · primarydocument.xml · nonDerivative · entry 1

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,763

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 17,716 restricted stock units.

SEC source: 0001562180-21-004128 · primarydocument.xml · derivative · entry 8

DEKKERS MARIJN E · CIK 0001216068 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,732

Underlying: Common Stock · 3,168 shares

Expires 2030-01-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001562180-21-004128 · primarydocument.xml · derivative · entry 7

DEKKERS MARIJN E · CIK 0001216068 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,951 shares

Expires 2027-03-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option vests as to 25% of the shares on March 13, 2018 and vests as to an additional 2.083% of the shares per month thereafter until February 28, 2021.

SEC source: 0001562180-21-004128 · primarydocument.xml · nonDerivative · entry 3

DEKKERS MARIJN E · CIK 0001216068 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,589

F2 · kind: The sale of shares was effected pursuant to a Rule 10b5-1 trading plan adopted on March 12, 2021.

F3 · price: This transaction was executed in multiple trades at prices ranging from $55.00 to $55.11. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F1 · balance_after: Includes 2,270 restricted stock units.

SEC source: 0001562180-21-004128 · primarydocument.xml · nonDerivative · entry 2

DEKKERS MARIJN E · CIK 0001216068 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,199

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 2,270 restricted stock units.

SEC source: 0001562180-21-004128 · primarydocument.xml · nonDerivative · entry 1

DEKKERS MARIJN E · CIK 0001216068 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,031

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 2,270 restricted stock units.

SEC source: 0001562180-21-003922 · primarydocument.xml · nonDerivative · entry 3

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 955,925

F4 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F6 · price: This transaction was executed in multiple trades at prices ranging from $49.305 to $49.71. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 105,179 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-003922 · primarydocument.xml · nonDerivative · entry 2

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 958,425

F4 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $48.30 to $49.29. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 105,179 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-003919 · primarydocument.xml · nonDerivative · entry 1

Fry John J · CIK 0001419544 · General Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,389

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 700 RSUs.

F2 · price: This transaction was executed in multiple trades at prices ranging from $48.00 to $48.75. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 22,370 restricted stock units.

SEC source: 0001562180-21-003922 · primarydocument.xml · nonDerivative · entry 1

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 960,925

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 7,935 RSUs.

F2 · price: This transaction was executed in multiple trades at prices ranging from $48.00 to $48.75. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 105,179 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-003921 · primarydocument.xml · nonDerivative · entry 1

Roskey Mark T. · CIK 0001724565 · SVP, Strategic Partnerships

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,136

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 472 RSUs.

F2 · price: This transaction was executed in multiple trades at prices ranging from $48.00 to $48.75. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 13,765 restricted stock units.

SEC source: 0001562180-21-003920 · primarydocument.xml · nonDerivative · entry 1

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,733

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 750 RSUs.

F2 · price: This transaction was executed in multiple trades at prices ranging from $48.00 to $48.75. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 17,716 restricted stock units.

SEC source: 0001562180-21-003918 · primarydocument.xml · nonDerivative · entry 1

Duffy David C. · CIK 0001724566 · SVP R&D and CTO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,951

F1 · shares: The sale of shares reported on this Form 4 was made pursuant to a Rule 10b5-1 trading plan adopted on March 8, 2021.

F2 · balance_after: Includes 10,581 restricted stock units.

SEC source: 0001104659-21-089485 · tm2121524-2_4seq1.xml · nonDerivative · entry 9

CRANDELL KEITH · CIK 0001219039 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,634

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F4 · kind: Change from indirect to direct ownership of shares previously reported as beneficially owned by the Reporting Person.

F1 · price: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

SEC source: 0001104659-21-089485 · tm2121524-2_4seq1.xml · nonDerivative · entry 8

CRANDELL KEITH · CIK 0001219039 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 475,070

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F1 · price: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F3 · ownership.nature: These shares are directly held by ARCH Venture Fund VIII Overage, L.P. ("ARCH Overage"). ARCH Venture Partners VIII, LLC ("ARCH VIII LLC") the sole general partner of ARCH Overage, may be deemed to beneficially own the shares held by ARCH Overage. The Reporting Person is a managing director of the ARCH VIII LLC and shares voting and investment control with respect to these shares. The Reporting Person may be deemed to beneficially own the shares held by ARCH Overage. The Reporting Person disclaims beneficial ownership of the securities reported herein, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001104659-21-089485 · tm2121524-2_4seq1.xml · nonDerivative · entry 7

CRANDELL KEITH · CIK 0001219039 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 745,180

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F1 · price: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F2 · ownership.nature: These shares are directly held by ARCH Venture Fund VI, L.P. ("ARCH VI"). ARCH Venture Partners VI, L.P. ("GPLP"), the sole general partner of ARCH VI, may be deemed to beneficially own the shares held by ARCH VI. ARCH Venture Partners VI, LLC ("GPLLC"), as the sole general partner of GPLP, may be deemed to beneficially own the shares held by ARCH VI. The Reporting Person is a managing director of the GPLLC and shares voting and investment control with respect to these shares. The Reporting Person may be deemed to beneficially own the shares held by ARCH VI. The Reporting Person disclaims beneficial ownership of the securities reported herein, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001104659-21-089485 · tm2121524-2_4seq1.xml · nonDerivative · entry 6

CRANDELL KEITH · CIK 0001219039 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 64,398

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F4 · kind: Change from indirect to direct ownership of shares previously reported as beneficially owned by the Reporting Person.

F1 · price: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

SEC source: 0001104659-21-089485 · tm2121524-2_4seq1.xml · nonDerivative · entry 5

CRANDELL KEITH · CIK 0001219039 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 611,330

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F1 · price: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F3 · ownership.nature: These shares are directly held by ARCH Venture Fund VIII Overage, L.P. ("ARCH Overage"). ARCH Venture Partners VIII, LLC ("ARCH VIII LLC") the sole general partner of ARCH Overage, may be deemed to beneficially own the shares held by ARCH Overage. The Reporting Person is a managing director of the ARCH VIII LLC and shares voting and investment control with respect to these shares. The Reporting Person may be deemed to beneficially own the shares held by ARCH Overage. The Reporting Person disclaims beneficial ownership of the securities reported herein, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001104659-21-089485 · tm2121524-2_4seq1.xml · nonDerivative · entry 4

CRANDELL KEITH · CIK 0001219039 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 958,920

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F1 · price: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F2 · ownership.nature: These shares are directly held by ARCH Venture Fund VI, L.P. ("ARCH VI"). ARCH Venture Partners VI, L.P. ("GPLP"), the sole general partner of ARCH VI, may be deemed to beneficially own the shares held by ARCH VI. ARCH Venture Partners VI, LLC ("GPLLC"), as the sole general partner of GPLP, may be deemed to beneficially own the shares held by ARCH VI. The Reporting Person is a managing director of the GPLLC and shares voting and investment control with respect to these shares. The Reporting Person may be deemed to beneficially own the shares held by ARCH VI. The Reporting Person disclaims beneficial ownership of the securities reported herein, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001562180-21-003494 · primarydocument.xml · nonDerivative · entry 3

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 964,779

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $47.10 to $47.34. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 113,114 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-003494 · primarydocument.xml · nonDerivative · entry 2

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 966,178

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F4 · price: This transaction was executed in multiple trades at prices ranging from $46.00 to $46.97. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 113,114 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-003494 · primarydocument.xml · nonDerivative · entry 1

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 967,908

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $45.00 to $45.985. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 113,114 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001104659-21-089485 · tm2121524-2_4seq1.xml · nonDerivative · entry 3

CRANDELL KEITH · CIK 0001219039 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,161

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F4 · kind: Change from indirect to direct ownership of shares previously reported as beneficially owned by the Reporting Person.

F1 · price: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

SEC source: 0001104659-21-089485 · tm2121524-2_4seq1.xml · nonDerivative · entry 2

CRANDELL KEITH · CIK 0001219039 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 747,590

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F1 · price: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F3 · ownership.nature: These shares are directly held by ARCH Venture Fund VIII Overage, L.P. ("ARCH Overage"). ARCH Venture Partners VIII, LLC ("ARCH VIII LLC") the sole general partner of ARCH Overage, may be deemed to beneficially own the shares held by ARCH Overage. The Reporting Person is a managing director of the ARCH VIII LLC and shares voting and investment control with respect to these shares. The Reporting Person may be deemed to beneficially own the shares held by ARCH Overage. The Reporting Person disclaims beneficial ownership of the securities reported herein, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001104659-21-089485 · tm2121524-2_4seq1.xml · nonDerivative · entry 1

CRANDELL KEITH · CIK 0001219039 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,172,660

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F1 · price: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F2 · ownership.nature: These shares are directly held by ARCH Venture Fund VI, L.P. ("ARCH VI"). ARCH Venture Partners VI, L.P. ("GPLP"), the sole general partner of ARCH VI, may be deemed to beneficially own the shares held by ARCH VI. ARCH Venture Partners VI, LLC ("GPLLC"), as the sole general partner of GPLP, may be deemed to beneficially own the shares held by ARCH VI. The Reporting Person is a managing director of the GPLLC and shares voting and investment control with respect to these shares. The Reporting Person may be deemed to beneficially own the shares held by ARCH VI. The Reporting Person disclaims beneficial ownership of the securities reported herein, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001562180-21-003464 · primarydocument.xml · derivative · entry 2

Stetson Shawn · CIK 0001862161 · Interim CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,321

Underlying: Common Stock · 3,321 shares

Expires 2031-05-11

F3 · derivative.exercise_date: The option vests as to 25% of the shares on May 11, 2022, and the remaining 75% vests in 36 equal monthly installments at the end of each month beginning on May 31, 2022.

SEC source: 0001562180-21-003464 · primarydocument.xml · nonDerivative · entry 1

Stetson Shawn · CIK 0001862161 · Interim CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,712

F1 · shares: Represents shares of stock issuable on vesting of restricted stock units. The restricted stock units vest as to 25% of the shares on May 11, 2022, and the remaining 75% vest in 36 equal monthly installments at the end of each month beginning on May 31, 2022.

F2 · balance_after: Includes 3,644 restricted stock units.

SEC source: 0001562180-21-003284 · primarydocument.xml · nonDerivative · entry 4

Fry John J · CIK 0001419544 · General Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,615

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 700 RSUs.

F3 · balance_after: Includes 23,070 restricted stock units.

SEC source: 0001562180-21-003284 · primarydocument.xml · nonDerivative · entry 3

Fry John J · CIK 0001419544 · General Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,623

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 700 RSUs.

F5 · price: This transaction was executed in multiple trades at prices ranging from $57.67 to $58.64. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 23,070 restricted stock units.

SEC source: 0001562180-21-003284 · primarydocument.xml · nonDerivative · entry 2

Fry John J · CIK 0001419544 · General Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,636

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 700 RSUs.

F4 · price: This transaction was executed in multiple trades at prices ranging from $58.75 to $59.45. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 23,070 restricted stock units.

SEC source: 0001562180-21-003284 · primarydocument.xml · nonDerivative · entry 1

Fry John J · CIK 0001419544 · General Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,722

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 700 RSUs.

F2 · price: This transaction was executed in multiple trades at prices ranging from $56.67 to $57.63. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 23,070 restricted stock units.

SEC source: 0001562180-21-003287 · primarydocument.xml · nonDerivative · entry 9

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 969,779

F8 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 7,935 RSUs.

F3 · balance_after: Includes 113,114 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-003287 · primarydocument.xml · nonDerivative · entry 8

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 969,807

F8 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 7,935 RSUs.

F11 · price: This transaction was executed in multiple trades at prices ranging from $57.67 to $58.64. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 113,114 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-003287 · primarydocument.xml · nonDerivative · entry 7

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 969,855

F8 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 7,935 RSUs.

F10 · price: This transaction was executed in multiple trades at prices ranging from $58.75 to $59.45. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 113,114 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-003287 · primarydocument.xml · nonDerivative · entry 6

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 970,168

F8 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 7,935 RSUs.

F9 · price: This transaction was executed in multiple trades at prices ranging from $56.67 to $57.63. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 113,114 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-003287 · primarydocument.xml · nonDerivative · entry 5

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 970,568

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F7 · price: This transaction was executed in multiple trades at prices ranging from $61.10 to $61.26. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 113,114 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-003287 · primarydocument.xml · nonDerivative · entry 4

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 970,668

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F6 · price: This transaction was executed in multiple trades at prices ranging from $60.03 to $60.98. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 113,114 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-003287 · primarydocument.xml · nonDerivative · entry 3

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 971,368

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $58.95 to $59.51. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 113,114 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-003287 · primarydocument.xml · nonDerivative · entry 2

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 971,868

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F4 · price: This transaction was executed in multiple trades at prices ranging from $57.94 to $58.64. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 113,114 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-003287 · primarydocument.xml · nonDerivative · entry 1

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 972,919

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $56.93 to $57.78. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 113,114 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-003286 · primarydocument.xml · nonDerivative · entry 4

Roskey Mark T. · CIK 0001724565 · SVP, Strategic Partnerships

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,289

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 472 RSUs.

F3 · balance_after: Includes 14,237 restricted stock units.

SEC source: 0001562180-21-003286 · primarydocument.xml · nonDerivative · entry 3

Roskey Mark T. · CIK 0001724565 · SVP, Strategic Partnerships

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,294

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 472 RSUs.

F5 · price: This transaction was executed in multiple trades at prices ranging from $57.67 to $58.64. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 14,237 restricted stock units.

SEC source: 0001562180-21-003286 · primarydocument.xml · nonDerivative · entry 2

Roskey Mark T. · CIK 0001724565 · SVP, Strategic Partnerships

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,303

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 472 RSUs.

F4 · price: This transaction was executed in multiple trades at prices ranging from $58.75 to $59.45. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 14,237 restricted stock units.

SEC source: 0001562180-21-003286 · primarydocument.xml · nonDerivative · entry 1

Roskey Mark T. · CIK 0001724565 · SVP, Strategic Partnerships

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,361

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 472 RSUs.

F2 · price: This transaction was executed in multiple trades at prices ranging from $56.67 to $57.63. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 14,237 restricted stock units.

SEC source: 0001562180-21-003285 · primarydocument.xml · nonDerivative · entry 4

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,976

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 750 RSUs.

F3 · balance_after: Includes 18,466 restricted stock units.