QTRX

SEC source: 0001562180-22-000232 · primarydocument.xml · nonDerivative · entry 5

CRANDELL KEITH · CIK 0001219039 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F3 · ownership.nature: These shares are directly held by ARCH Venture Fund VIII Overage, L.P. ("ARCH Overage"). ARCH Venture Partners VIII, LLC ("ARCH VIII LLC") the sole general partner of ARCH Overage, may be deemed to beneficially own the shares held by ARCH Overage. The Reporting Person is a managing director of the ARCH VIII LLC and shares voting and investment control with respect to these shares. The Reporting Person may be deemed to beneficially own the shares held by ARCH Overage. The Reporting Person disclaims beneficial ownership of the securities reported herein, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001562180-22-000232 · primarydocument.xml · nonDerivative · entry 4

CRANDELL KEITH · CIK 0001219039 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F2 · ownership.nature: These shares are directly held by ARCH Venture Fund VI, L.P. ("ARCH VI"). ARCH Venture Partners VI, L.P. ("GPLP"), the sole general partner of ARCH VI, may be deemed to beneficially own the shares held by ARCH VI. ARCH Venture Partners VI, LLC ("GPLLC"), as the sole general partner of GPLP, may be deemed to beneficially own the shares held by ARCH VI. The Reporting Person is a managing director of the GPLLC and shares voting and investment control with respect to these shares. The Reporting Person may be deemed to beneficially own the shares held by ARCH VI. The Reporting Person disclaims beneficial ownership of the securities reported herein, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001562180-22-000232 · primarydocument.xml · nonDerivative · entry 3

CRANDELL KEITH · CIK 0001219039 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,964

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F4 · kind: Change from indirect to direct ownership of shares previously reported as beneficially owned by the Reporting Person.

SEC source: 0001562180-22-000232 · primarydocument.xml · nonDerivative · entry 2

CRANDELL KEITH · CIK 0001219039 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 113,003

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F3 · ownership.nature: These shares are directly held by ARCH Venture Fund VIII Overage, L.P. ("ARCH Overage"). ARCH Venture Partners VIII, LLC ("ARCH VIII LLC") the sole general partner of ARCH Overage, may be deemed to beneficially own the shares held by ARCH Overage. The Reporting Person is a managing director of the ARCH VIII LLC and shares voting and investment control with respect to these shares. The Reporting Person may be deemed to beneficially own the shares held by ARCH Overage. The Reporting Person disclaims beneficial ownership of the securities reported herein, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001562180-22-000232 · primarydocument.xml · nonDerivative · entry 1

CRANDELL KEITH · CIK 0001219039 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 177,247

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F2 · ownership.nature: These shares are directly held by ARCH Venture Fund VI, L.P. ("ARCH VI"). ARCH Venture Partners VI, L.P. ("GPLP"), the sole general partner of ARCH VI, may be deemed to beneficially own the shares held by ARCH VI. ARCH Venture Partners VI, LLC ("GPLLC"), as the sole general partner of GPLP, may be deemed to beneficially own the shares held by ARCH VI. The Reporting Person is a managing director of the GPLLC and shares voting and investment control with respect to these shares. The Reporting Person may be deemed to beneficially own the shares held by ARCH VI. The Reporting Person disclaims beneficial ownership of the securities reported herein, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001562180-21-006965 · primarydocument.xml · nonDerivative · entry 3

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 897,811

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F5 · price: This transaction was executed in multiple trades at prices ranging from $55.93 to $56.015. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 65,504 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-006965 · primarydocument.xml · nonDerivative · entry 2

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 898,211

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F4 · price: This transaction was executed in multiple trades at prices ranging from $54.76 to $55.755. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 65,504 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-006965 · primarydocument.xml · nonDerivative · entry 1

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 901,911

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $53.73 to $54.44. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 65,504 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-006883 · primarydocument.xml · derivative · entry 5

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,557

Underlying: Common Stock · 10,718 shares

Expires 2028-05-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The option vests as to 25% of the shares on May 10, 2019 and vests as to an additional 2.083% of the shares per month for 36 months thereafter.

SEC source: 0001562180-21-006883 · primarydocument.xml · nonDerivative · entry 4

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,697

F1 · kind: The sale of shares was effected pursuant to a Rule 10b5-1 trading plan adopted on March 15, 2021.

F4 · price: This transaction was executed in multiple trades at prices ranging from $58.35 to $58.435.The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · balance_after: Includes 13,966 restricted stock units.

SEC source: 0001562180-21-006883 · primarydocument.xml · nonDerivative · entry 3

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,897

F1 · kind: The sale of shares was effected pursuant to a Rule 10b5-1 trading plan adopted on March 15, 2021.

F3 · price: This transaction was executed in multiple trades at prices ranging from $57.00 to $57.975. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · balance_after: Includes 13,966 restricted stock units.

SEC source: 0001562180-21-006883 · primarydocument.xml · nonDerivative · entry 2

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,232

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · balance_after: Includes 13,966 restricted stock units.

SEC source: 0001562180-21-006883 · primarydocument.xml · nonDerivative · entry 1

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,514

F1 · kind: The sale of shares was effected pursuant to a Rule 10b5-1 trading plan adopted on March 15, 2021.

SEC source: 0001562180-21-006833 · primarydocument.xml · nonDerivative · entry 2

Fry John J · CIK 0001419544 · General Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,678

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 700 RSUs.

F4 · price: This transaction was executed in multiple trades at prices ranging from $52.96 to $53.78.The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001562180-21-006833 · primarydocument.xml · nonDerivative · entry 1

Fry John J · CIK 0001419544 · General Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,770

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 700 RSUs.

F2 · price: This transaction was executed in multiple trades at prices ranging from $51.86 to $52.85. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 18,870 restricted stock units.

SEC source: 0001562180-21-006834 · primarydocument.xml · nonDerivative · entry 2

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 902,811

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 7,935 RSUs.

F4 · price: This transaction was executed in multiple trades at prices ranging from $52.96 to $53.78.The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 65,504 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-006834 · primarydocument.xml · nonDerivative · entry 1

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 903,790

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 7,935 RSUs.

F2 · price: This transaction was executed in multiple trades at prices ranging from $51.86 to $52.85. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 65,504 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-006836 · primarydocument.xml · nonDerivative · entry 2

Roskey Mark T. · CIK 0001724565 · SVP, Strategic Partnerships

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,416

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 472 RSUs.

F4 · price: This transaction was executed in multiple trades at prices ranging from $52.96 to $53.78.The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 11,405 restricted stock units.

SEC source: 0001562180-21-006836 · primarydocument.xml · nonDerivative · entry 1

Roskey Mark T. · CIK 0001724565 · SVP, Strategic Partnerships

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,455

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 472 RSUs.

F2 · price: This transaction was executed in multiple trades at prices ranging from $51.86 to $52.85. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 11,405 restricted stock units.

SEC source: 0001562180-21-006835 · primarydocument.xml · nonDerivative · entry 2

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,515

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 750 RSUs.

F4 · price: This transaction was executed in multiple trades at prices ranging from $52.96 to $53.78.The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001562180-21-006835 · primarydocument.xml · nonDerivative · entry 1

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,608

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 750 RSUs.

F2 · price: This transaction was executed in multiple trades at prices ranging from $51.86 to $52.85. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 13,966 restricted stock units.

SEC source: 0001562180-21-006622 · primarydocument.xml · nonDerivative · entry 3

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 906,316

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F3 · balance_after: Includes 73,439 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-006622 · primarydocument.xml · nonDerivative · entry 2

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 906,416

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F4 · price: This transaction was executed in multiple trades at prices ranging from $50.63 to $51.50. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 73,439 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-006622 · primarydocument.xml · nonDerivative · entry 1

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 909,416

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F2 · price: This transaction was executed in multiple trades at prices ranging from $49.56 to $50.54. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 73,439 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-006543 · primarydocument.xml · nonDerivative · entry 1

Duffy David C. · CIK 0001724566 · SVP R&D and CTO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,616

F1 · shares: The sale of shares reported on this Form 4 was made pursuant to a Rule 10b5-1 trading plan adopted on March 8, 2021.

F2 · balance_after: Includes 9,117 restricted stock units.

SEC source: 0001562180-21-006230 · primarydocument.xml · nonDerivative · entry 3

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 911,316

F4 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 7,935 RSUs.

F5 · balance_after: Includes 73,439 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-006296 · primarydocument.xml · nonDerivative · entry 1

MEISTER PAUL M · CIK 0001033876 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,930

F1 · shares: Consists of stock granted in lieu of cash fees for service on the Company's Board of Directors and committees thereof for the third quarter of 2021.

F2 · price: Closing price of the Company's common stock on the Nasdaq Global Market on October 1, 2021.

F3 · balance_after: Includes 2,270 restricted stock units.

SEC source: 0001562180-21-006298 · primarydocument.xml · nonDerivative · entry 1

Hlavinka Sarah E. · CIK 0001433554 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,892

F1 · shares: Consists of stock granted in lieu of cash fees for service on the Company's Board of Directors and committees thereof for the third quarter of 2021.

F2 · price: Closing price of the Company's common stock on the Nasdaq Global Market on October 1, 2021.

F3 · balance_after: Includes 5,297 restricted stock units.

SEC source: 0001562180-21-006301 · primarydocument.xml · nonDerivative · entry 1

Fry John J · CIK 0001419544 · General Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,009

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 700 RSUs.

F2 · balance_after: Includes 19,570 restricted stock units.

SEC source: 0001562180-21-006297 · primarydocument.xml · nonDerivative · entry 1

Madaus Martin D · CIK 0001310268 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,348

F1 · shares: Consists of stock granted in lieu of cash fees for service on the Company's Board of Directors and committees thereof for the third quarter of 2021.

F2 · price: Closing price of the Company's common stock on the Nasdaq Global Market on October 1, 2021.

F3 · balance_after: Includes 2,270 restricted stock units.

SEC source: 0001562180-21-006302 · primarydocument.xml · nonDerivative · entry 7

CRANDELL KEITH · CIK 0001219039 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,012

F5 · shares: Consists of stock granted in lieu of cash fees for service on the Company's Board of Directors and committees thereof for the third quarter of 2021.

F6 · price: Closing price of the Company's common stock on the Nasdaq Global Market on October 1, 2021.

F7 · balance_after: Includes 2,270 restricted stock units.

SEC source: 0001562180-21-006300 · primarydocument.xml · nonDerivative · entry 1

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,848

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 750 RSUs.

F2 · balance_after: Includes 14,716 restricted stock units.

SEC source: 0001562180-21-006299 · primarydocument.xml · nonDerivative · entry 1

Roskey Mark T. · CIK 0001724565 · SVP, Strategic Partnerships

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,555

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 472 RSUs.

F2 · balance_after: Includes 11,877 restricted stock units.

SEC source: 0001562180-21-006230 · primarydocument.xml · nonDerivative · entry 2

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 914,910

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F3 · price: This transaction was executed in multiple trades at prices ranging from $48.74 to $49.59. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · balance_after: Includes 81,374 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-006230 · primarydocument.xml · nonDerivative · entry 1

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 919,510

F1 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F2 · balance_after: Includes 81,374 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-006231 · primarydocument.xml · nonDerivative · entry 1

Duffy David C. · CIK 0001724566 · SVP R&D and CTO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,283

F1 · shares: The sale of shares reported on this Form 4 was made pursuant to a Rule 10b5-1 trading plan adopted on March 8, 2021.

F2 · balance_after: Includes 9,117 restricted stock units.

SEC source: 0001562180-21-005792 · primarydocument.xml · nonDerivative · entry 4

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 919,910

F5 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F3 · balance_after: Includes 81,374 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-005792 · primarydocument.xml · nonDerivative · entry 3

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 919,914

F5 · shares: The sale of shares was effected pursuant to a 10b5-1 trading plan adopted on December 14, 2020.

F6 · price: This transaction was executed in multiple trades at prices ranging from $49.21 to $50.18. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 81,374 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-005794 · primarydocument.xml · nonDerivative · entry 2

Fry John J · CIK 0001419544 · General Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,349

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 700 RSUs.

F4 · price: This transaction was executed in multiple trades at prices ranging from $50.39 to $51.21. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 20,270 restricted stock units.

SEC source: 0001562180-21-005794 · primarydocument.xml · nonDerivative · entry 1

Fry John J · CIK 0001419544 · General Counsel & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,399

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 700 RSUs.

F2 · price: This transaction was executed in multiple trades at prices ranging from $49.32 to $50.22. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 20,270 restricted stock units.

SEC source: 0001562180-21-005792 · primarydocument.xml · nonDerivative · entry 2

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 924,910

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 7,935 RSUs.

F4 · price: This transaction was executed in multiple trades at prices ranging from $50.39 to $51.21. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 81,374 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-005792 · primarydocument.xml · nonDerivative · entry 1

HRUSOVSKY E KEVIN · CIK 0001252546 · Director · Chairman, President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 925,444

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 7,935 RSUs.

F2 · price: This transaction was executed in multiple trades at prices ranging from $49.32 to $50.22. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 81,374 restricted stock units and 39,815 shares of common stock that are subject to performance based vesting.

SEC source: 0001562180-21-005795 · primarydocument.xml · nonDerivative · entry 2

Roskey Mark T. · CIK 0001724565 · SVP, Strategic Partnerships

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,698

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 472 RSUs.

F4 · price: This transaction was executed in multiple trades at prices ranging from $50.39 to $51.21. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 12,349 restricted stock units.

SEC source: 0001562180-21-005795 · primarydocument.xml · nonDerivative · entry 1

Roskey Mark T. · CIK 0001724565 · SVP, Strategic Partnerships

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,719

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 472 RSUs.

F2 · price: This transaction was executed in multiple trades at prices ranging from $49.32 to $50.22. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 12,349 restricted stock units.

SEC source: 0001562180-21-005793 · primarydocument.xml · nonDerivative · entry 2

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,190

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 750 RSUs.

F4 · price: This transaction was executed in multiple trades at prices ranging from $50.39 to $51.21. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 15,466 restricted stock units.

SEC source: 0001562180-21-005793 · primarydocument.xml · nonDerivative · entry 1

Mattoon Dawn · CIK 0001731785 · Sr. VP, Diagnostics

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,241

F1 · shares: The sales of shares reported on this Form 4 were made solely to cover tax obligations upon the vesting of 750 RSUs.

F2 · price: This transaction was executed in multiple trades at prices ranging from $49.32 to $50.22. The price reported reflects the weighted average sale price. The reporting person undertakes to provide upon request to the SEC staff, the issuer or any security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F3 · balance_after: Includes 15,466 restricted stock units.

SEC source: 0001562180-21-005490 · primarydocument.xml · nonDerivative · entry 1

Duffy David C. · CIK 0001724566 · SVP R&D and CTO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,950

F1 · shares: The sale of shares reported on this Form 4 was made pursuant to a Rule 10b5-1 trading plan adopted on March 8, 2021.

F2 · balance_after: Includes 9,483 restricted stock units.

SEC source: 0001562180-21-006302 · primarydocument.xml · nonDerivative · entry 6

CRANDELL KEITH · CIK 0001219039 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 95,758

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F4 · kind: Change from indirect to direct ownership of shares previously reported as beneficially owned by the Reporting Person.

SEC source: 0001562180-21-006302 · primarydocument.xml · nonDerivative · entry 5

CRANDELL KEITH · CIK 0001219039 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 233,692

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F3 · ownership.nature: These shares are directly held by ARCH Venture Fund VIII Overage, L.P. ("ARCH Overage"). ARCH Venture Partners VIII, LLC ("ARCH VIII LLC") the sole general partner of ARCH Overage, may be deemed to beneficially own the shares held by ARCH Overage. The Reporting Person is a managing director of the ARCH VIII LLC and shares voting and investment control with respect to these shares. The Reporting Person may be deemed to beneficially own the shares held by ARCH Overage. The Reporting Person disclaims beneficial ownership of the securities reported herein, except to the extent of his pecuniary interest therein, if any.

SEC source: 0001562180-21-006302 · primarydocument.xml · nonDerivative · entry 4

CRANDELL KEITH · CIK 0001219039 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 366,558

F1 · kind: Distribution of Common Stock held by a limited partnership to its partners for no consideration.

F2 · ownership.nature: These shares are directly held by ARCH Venture Fund VI, L.P. ("ARCH VI"). ARCH Venture Partners VI, L.P. ("GPLP"), the sole general partner of ARCH VI, may be deemed to beneficially own the shares held by ARCH VI. ARCH Venture Partners VI, LLC ("GPLLC"), as the sole general partner of GPLP, may be deemed to beneficially own the shares held by ARCH VI. The Reporting Person is a managing director of the GPLLC and shares voting and investment control with respect to these shares. The Reporting Person may be deemed to beneficially own the shares held by ARCH VI. The Reporting Person disclaims beneficial ownership of the securities reported herein, except to the extent of his pecuniary interest therein, if any.