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Nasdaq · USD

PVLA

PALVELLA THERAPEUTICS, INC.

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Tapewire entity
4452
SEC CIK
0001583648
Parsed reports
217

Last 12 months

Inside the activity.

3 purchase rows · 60 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202502
Dec 202501
Jan 202602
Feb 202622
Mar 202613
Apr 202605
May 202603
Jun 202603
Jul 202604
Aug 202605
Sep 2026013
Oct 2026017

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
June 25, 2021 Filed Jun 29, 2021 17:30 UTC GrantStock Option (right to buy) · Derivative 40,000 $0.00 Strike: $4.00 $0.00
Disclosure

SEC source: 0001562180-21-004561 · primarydocument.xml · derivative · entry 1

KIRITSY CHRISTOPHER P · CIK 0001261156 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2031-06-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on the date of the Company's 2022 annual stockholders meeting, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
June 25, 2021 Filed Jun 29, 2021 21:23 UTC GrantStock Option (right to buy) · Derivative 45,000 $0.00 Strike: $4.00 $0.00
Disclosure

SEC source: 0001562180-21-004559 · primarydocument.xml · derivative · entry 1

GERAGHTY JAMES A · CIK 0001239746 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2031-06-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on the date of the Company's 2022 annual stockholders meeting, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
June 25, 2021 Filed Jun 29, 2021 17:26 UTC GrantStock Option (right to buy) · Derivative 40,000 $0.00 Strike: $4.00 $0.00
Disclosure

SEC source: 0001562180-21-004560 · primarydocument.xml · derivative · entry 1

Kiener Peter A · CIK 0001328146 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2031-06-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on the date of the Company's 2022 annual stockholders meeting, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
June 25, 2021 Filed Jun 29, 2021 17:33 UTC GrantStock Option (right to buy) · Derivative 40,000 $0.00 Strike: $4.00 $0.00
Disclosure

SEC source: 0001562180-21-004562 · primarydocument.xml · derivative · entry 1

Richman Michael · CIK 0001366265 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2031-06-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on the date of the Company's 2022 annual stockholders meeting, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
June 25, 2021 Filed Jun 29, 2021 21:36 UTC
Said Maya R.Director
GrantStock Option (right to buy) · Derivative 40,000 $0.00 Strike: $4.00 $0.00
Disclosure

SEC source: 0001562180-21-004563 · primarydocument.xml · derivative · entry 1

Said Maya R. · CIK 0001783701 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2031-06-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on the date of the Company's 2022 annual stockholders meeting, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
March 04, 2021 Filed Mar 8, 2021 21:08 UTC
Bures ThomasVice President, Finance
GrantStock Options (Right to buy) · Derivative 150,000 $0.00 Strike: $2.50 $0.00
Disclosure

SEC source: 0001562180-21-002058 · primarydocument.xml · derivative · entry 1

Bures Thomas · CIK 0001787029 · Vice President, Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2031-03-04

F1 · derivative.exercise_date: The option vests as to 25% of the option shares on March 4, 2022 and as to an additional 6.25% of the option shares at the end of each successive three-month period thereafter.

Read SEC document
March 04, 2021 Filed Mar 8, 2021 21:07 UTC
Yoder Stephen S.Director · Chief Executive Officer
GrantStock Options (Right to buy) · Derivative 530,000 $0.00 Strike: $2.50 $0.00
Disclosure

SEC source: 0001562180-21-002056 · primarydocument.xml · derivative · entry 1

Yoder Stephen S. · CIK 0001645577 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 530,000

Underlying: Common Stock · 530,000 shares

Expires 2031-03-04

F1 · derivative.exercise_date: The option vests as to 25% of the option shares on March 4, 2022 and as to an additional 6.25% of the option shares at the end of each successive three-month period thereafter.

Read SEC document
March 04, 2021 Filed Mar 8, 2021 21:08 UTC
Kaufmann HittoSVP, Chief Scientific Officer
GrantStock Options (Right to buy) · Derivative 220,000 $0.00 Strike: $2.50 $0.00
Disclosure

SEC source: 0001562180-21-002057 · primarydocument.xml · derivative · entry 1

Kaufmann Hitto · CIK 0001787104 · SVP, Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 220,000

Underlying: Common Stock · 220,000 shares

Expires 2031-03-04

F1 · derivative.exercise_date: The option vests as to 25% of the option shares on March 4, 2022 and as to an additional 6.25% of the option shares at the end of each successive three-month period thereafter.

Read SEC document
July 21, 2020 Filed Jul 22, 2020 22:15 UTC SaleCommon Stock, $0.001 par value 1,900,000 $2.95 $5,605,000.00
Disclosure

SEC source: 0001591986-20-000011 · primary_doc.xml · nonDerivative · entry 1

Aquilo Capital Management, LLC · CIK 0001591986 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 3,675,530

F1 · security: The reporting persons are Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of investment funds that hold these securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of those funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of Aquilo and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

F1 · ownership.nature: The reporting persons are Aquilo Capital Management, LLC ("Aquilo") and Marc R. Schneidman. Aquilo is the general partner and investment adviser of investment funds that hold these securities directly for the benefit of their investors. Aquilo may be deemed to beneficially own such securities indirectly as the investment adviser and general partner of those funds, and Mr. Schneidman may be deemed to beneficially own them indirectly as the control person of Aquilo. Each of Aquilo and Mr. Schneidman disclaims beneficial ownership of such securities except to the extent of his or its pecuniary interest therein.

Read SEC document
June 25, 2020 Filed Jun 25, 2020 20:46 UTC
Said Maya R.Director
GrantStock Option (right to buy) · Derivative 40,000 $0.00 Strike: $3.27 $0.00
Disclosure

SEC source: 0001562180-20-004693 · primarydocument.xml · derivative · entry 1

Said Maya R. · CIK 0001783701 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2030-01-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on June 23, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
June 23, 2020 Filed Jun 25, 2020 16:44 UTC
Barbier AnnDirector
GrantStock Options (Right to buy) · Derivative 40,000 $0.00 Strike: $3.27 $0.00
Disclosure

SEC source: 0001562180-20-004686 · primarydocument.xml · derivative · entry 1

Barbier Ann · CIK 0001737596 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2030-06-23

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on June 23, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
June 23, 2020 Filed Jun 25, 2020 16:46 UTC GrantStock Option (right to buy) · Derivative 40,000 $0.00 Strike: $3.27 $0.00
Disclosure

SEC source: 0001562180-20-004692 · primarydocument.xml · derivative · entry 1

Sherman Matthew L · CIK 0001325710 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2030-06-23

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on June 23, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
June 23, 2020 Filed Jun 25, 2020 17:05 UTC Amendment GrantStock Option (right to buy) · Derivative 40,000 $0.00 Strike: $3.27 $0.00
Disclosure

SEC source: 0001562180-20-004696 · primarydocument.xml · derivative · entry 1

KIRITSY CHRISTOPHER P · CIK 0001261156 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2030-06-23

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on June 23, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
June 23, 2020 Filed Jun 25, 2020 16:45 UTC GrantStock Option (right to buy) · Derivative 40,000 $0.00 Strike: $3.27 $0.00
Disclosure

SEC source: 0001562180-20-004689 · primarydocument.xml · derivative · entry 1

KIRITSY CHRISTOPHER P · CIK 0001261156 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2030-01-23

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on June 23, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
June 23, 2020 Filed Jun 25, 2020 20:45 UTC GrantStock Option (right to buy) · Derivative 45,000 $0.00 Strike: $3.27 $0.00
Disclosure

SEC source: 0001562180-20-004687 · primarydocument.xml · derivative · entry 1

GERAGHTY JAMES A · CIK 0001239746 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2030-06-23

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on June 23, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
June 23, 2020 Filed Jun 25, 2020 16:45 UTC GrantStock Options (Right to buy) · Derivative 40,000 $0.00 Strike: $3.27 $0.00
Disclosure

SEC source: 0001562180-20-004688 · primarydocument.xml · derivative · entry 1

Kiener Peter A · CIK 0001328146 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2030-06-23

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on June 23, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
June 23, 2020 Filed Jun 25, 2020 16:45 UTC GrantStock Option (right to buy) · Derivative 40,000 $0.00 Strike: $3.27 $0.00
Disclosure

SEC source: 0001562180-20-004691 · primarydocument.xml · derivative · entry 1

Richman Michael · CIK 0001366265 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2030-06-23

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on June 23, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
June 23, 2020 Filed Jun 25, 2020 20:59 UTC Amendment
Said Maya R.Director
GrantStock Option (right to buy) · Derivative 40,000 $0.00 Strike: $3.27 $0.00
Disclosure

SEC source: 0001562180-20-004695 · primarydocument.xml · derivative · entry 1

Said Maya R. · CIK 0001783701 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2030-06-23

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on June 23, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
February 27, 2020 Filed Mar 2, 2020 21:03 UTC
Bures ThomasVice President, Finance
GrantStock Option (Right to Buy) · Derivative 80,000 $0.00 Strike: $3.15 $0.00
Disclosure

SEC source: 0001562180-20-001866 · primarydocument.xml · derivative · entry 1

Bures Thomas · CIK 0001787029 · Vice President, Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2030-02-27

F1 · derivative.exercise_date: The option vests as to 25% of the option shares on February 27, 2021 and as to an additional 6.25% of the option shares at the end of each successive three-month period thereafter.

Read SEC document
February 27, 2020 Filed Mar 2, 2020 21:02 UTC
Kaufmann HittoSVP, Chief Scientific Officer
GrantStock Option (Right to Buy) · Derivative 45,000 $0.00 Strike: $3.15 $0.00
Disclosure

SEC source: 0001562180-20-001865 · primarydocument.xml · derivative · entry 1

Kaufmann Hitto · CIK 0001787104 · SVP, Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2030-02-27

F1 · derivative.exercise_date: The option vests as to 25% of the option shares on February 27, 2021 and as to an additional 6.25% of the option shares at the end of each successive three-month period thereafter.

Read SEC document
February 27, 2020 Filed Mar 2, 2020 21:02 UTC
Yoder Stephen S.Director · Chief Executive Officer
GrantStock Option (Right to Buy) · Derivative 420,000 $0.00 Strike: $3.15 $0.00
Disclosure

SEC source: 0001562180-20-001864 · primarydocument.xml · derivative · entry 1

Yoder Stephen S. · CIK 0001645577 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 420,000

Underlying: Common Stock · 420,000 shares

Expires 2030-02-27

F1 · derivative.exercise_date: The option vests as to 25% of the option shares on February 27, 2021 and as to an additional 6.25% of the option shares at the end of each successive three-month period thereafter.

Read SEC document
January 25, 2020 Filed Jan 28, 2020 16:21 UTC
Barbier AnnDirector
GrantStock Option (right to buy) · Derivative 20,000 $0.00 Strike: $3.23 $0.00
Disclosure

SEC source: 0001562180-20-000622 · primarydocument.xml · derivative · entry 1

Barbier Ann · CIK 0001737596 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2030-01-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on January 25, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
January 25, 2020 Filed Jan 28, 2020 16:22 UTC GrantStock Option (right to buy) · Derivative 20,000 $0.00 Strike: $3.23 $0.00
Disclosure

SEC source: 0001562180-20-000625 · primarydocument.xml · derivative · entry 1

Sherman Matthew L · CIK 0001325710 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2030-01-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on January 25, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
January 25, 2020 Filed Jan 28, 2020 16:20 UTC GrantStock Option (right to buy) · Derivative 20,000 $0.00 Strike: $3.23 $0.00
Disclosure

SEC source: 0001562180-20-000621 · primarydocument.xml · derivative · entry 1

KIRITSY CHRISTOPHER P · CIK 0001261156 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2030-01-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on January 25, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
January 25, 2020 Filed Jan 28, 2020 21:18 UTC GrantStock Option (right to buy) · Derivative 22,500 $0.00 Strike: $3.23 $0.00
Disclosure

SEC source: 0001562180-20-000617 · primarydocument.xml · derivative · entry 1

GERAGHTY JAMES A · CIK 0001239746 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,500

Underlying: Common Stock · 22,500 shares

Expires 2030-01-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on January 25, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
January 25, 2020 Filed Jan 28, 2020 16:22 UTC GrantStock Option (right to buy) · Derivative 20,000 $0.00 Strike: $3.23 $0.00
Disclosure

SEC source: 0001562180-20-000623 · primarydocument.xml · derivative · entry 1

Kiener Peter A · CIK 0001328146 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2030-01-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on January 25, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
January 25, 2020 Filed Jan 28, 2020 16:18 UTC GrantStock Option (right to buy) · Derivative 20,000 $0.00 Strike: $3.23 $0.00
Disclosure

SEC source: 0001562180-20-000619 · primarydocument.xml · derivative · entry 2

Richman Michael · CIK 0001366265 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2030-01-25

F2 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on January 25, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
January 25, 2020 Filed Jan 28, 2020 16:18 UTC GrantStock Option (right to buy) · Derivative 5,431 $2.11 Strike: $3.23 $11,443.12
Disclosure

SEC source: 0001562180-20-000619 · primarydocument.xml · derivative · entry 1

Richman Michael · CIK 0001366265 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,431

Underlying: Common Stock · 5,431 shares

Expires 2030-01-25

F1 · price: The stock option was issued to the Reporting Person, who elected to take stock options in lieu of $11,445.56 in cash compensation for services as a director and committee member, which compensation is payable to the Reporting Person quarterly in arrears pursuant to the Issuer's non-employee director compensation policy.

Read SEC document
January 25, 2020 Filed Jan 28, 2020 21:22 UTC
Said Maya R.Director
GrantStock Option (right to buy) · Derivative 20,000 $0.00 Strike: $3.23 $0.00
Disclosure

SEC source: 0001562180-20-000624 · primarydocument.xml · derivative · entry 1

Said Maya R. · CIK 0001783701 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2030-01-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on January 25, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
January 25, 2020 Filed Jan 28, 2020 21:19 UTC GrantStock Option (right to buy) · Derivative 20,000 $0.00 Strike: $3.23 $0.00
Disclosure

SEC source: 0001562180-20-000620 · primarydocument.xml · derivative · entry 1

BIZZARI JEAN-PIERRE · CIK 0001630914 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2030-01-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on January 25, 2021, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
October 25, 2019 Filed Oct 28, 2019 16:38 UTC GrantStock Options (right to buy) · Derivative 5,165 $2.12 Strike: $3.24 $10,939.47
Disclosure

SEC source: 0001562180-19-005263 · primarydocument.xml · derivative · entry 1

Richman Michael · CIK 0001366265 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,165

Underlying: Common Stock · 5,165 shares

Expires 2029-10-25

F1 · price: The stock option was issued to the Reporting Person, who elected to take stock options in lieu of $10,937.50 in cash compensation for services as a director and committee member, which compensation is payable to the Reporting Person quarterly in arrears pursuant to the Issuer's non-employee director compensation policy.

Read SEC document
September 06, 2019 Filed Sep 10, 2019 22:00 UTC
BIOTECHNOLOGY VALUE FUND L PSee Explanation of Responses
BIOTECHNOLOGY VALUE FUND II LPSee Explanation of Responses
Biotechnology Value Trading Fund OS LPSee Explanation of Responses
BVF Partners OS Ltd.See Explanation of Responses
BVF INC/IL10% owner
SaleCommon Stock, $0.001 par value 1,128 $4.50 $5,075.32
Disclosure

SEC source: 0000921895-19-002391 · form407422010_09102019.xml · nonDerivative · entry 3

BVF PARTNERS L P/IL · CIK 0001055947 · 10% owner

BIOTECHNOLOGY VALUE FUND L P · CIK 0000918923 · See Explanation of Responses

BIOTECHNOLOGY VALUE FUND II LP · CIK 0001102444 · See Explanation of Responses

Biotechnology Value Trading Fund OS LP · CIK 0001660683 · See Explanation of Responses

BVF Partners OS Ltd. · CIK 0001660684 · See Explanation of Responses

BVF INC/IL · CIK 0001056807 · 10% owner

LAMPERT MARK N · CIK 0001233840 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 314,139

F1 · security: This Form 4 is filed jointly by Biotechnology Value Fund, L.P. ("BVF"), Biotechnology Value Fund II, L.P. ("BVF2"), Biotechnology Value Trading Fund OS LP ("Trading Fund OS"), BVF Partners OS Ltd. ("Partners OS"), BVF Partners L.P. ("Partners"), BVF Inc. and Mark N. Lampert (collectively, the "Reporting Persons"). Each of the Reporting Persons is a member of a Section 13(d) group that previously owned in the aggregate more than 10% of the Issuer's outstanding shares of Common Stock. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein except to the extent of his or its pecuniary interest therein.

F4 · ownership.direct: Securities owned directly by Trading Fund OS. As the general partner of Trading Fund OS, Partners OS may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment manager of Trading Fund OS and the sole member of Partners OS, Partners may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by Trading Fund OS. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by Trading Fund OS.

Read SEC document
September 06, 2019 Filed Sep 10, 2019 22:00 UTC
BIOTECHNOLOGY VALUE FUND L PSee Explanation of Responses
BIOTECHNOLOGY VALUE FUND II LPSee Explanation of Responses
Biotechnology Value Trading Fund OS LPSee Explanation of Responses
BVF Partners OS Ltd.See Explanation of Responses
BVF INC/IL10% owner
SaleCommon Stock, $0.001 par value 25,720 $4.50 $115,724.57
Disclosure

SEC source: 0000921895-19-002391 · form407422010_09102019.xml · nonDerivative · entry 2

BVF PARTNERS L P/IL · CIK 0001055947 · 10% owner

BIOTECHNOLOGY VALUE FUND L P · CIK 0000918923 · See Explanation of Responses

BIOTECHNOLOGY VALUE FUND II LP · CIK 0001102444 · See Explanation of Responses

Biotechnology Value Trading Fund OS LP · CIK 0001660683 · See Explanation of Responses

BVF Partners OS Ltd. · CIK 0001660684 · See Explanation of Responses

BVF INC/IL · CIK 0001056807 · 10% owner

LAMPERT MARK N · CIK 0001233840 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,233,074

F1 · security: This Form 4 is filed jointly by Biotechnology Value Fund, L.P. ("BVF"), Biotechnology Value Fund II, L.P. ("BVF2"), Biotechnology Value Trading Fund OS LP ("Trading Fund OS"), BVF Partners OS Ltd. ("Partners OS"), BVF Partners L.P. ("Partners"), BVF Inc. and Mark N. Lampert (collectively, the "Reporting Persons"). Each of the Reporting Persons is a member of a Section 13(d) group that previously owned in the aggregate more than 10% of the Issuer's outstanding shares of Common Stock. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein except to the extent of his or its pecuniary interest therein.

F3 · ownership.direct: Securities owned directly by BVF2. As the general partner of BVF2, Partners may be deemed to beneficially own the securities owned directly by BVF2. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF2. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF2.

Read SEC document
September 06, 2019 Filed Sep 10, 2019 22:00 UTC
BIOTECHNOLOGY VALUE FUND L PSee Explanation of Responses
BIOTECHNOLOGY VALUE FUND II LPSee Explanation of Responses
Biotechnology Value Trading Fund OS LPSee Explanation of Responses
BVF Partners OS Ltd.See Explanation of Responses
BVF INC/IL10% owner
SaleCommon Stock, $0.001 par value 23,152 $4.50 $104,170.11
Disclosure

SEC source: 0000921895-19-002391 · form407422010_09102019.xml · nonDerivative · entry 1

BVF PARTNERS L P/IL · CIK 0001055947 · 10% owner

BIOTECHNOLOGY VALUE FUND L P · CIK 0000918923 · See Explanation of Responses

BIOTECHNOLOGY VALUE FUND II LP · CIK 0001102444 · See Explanation of Responses

Biotechnology Value Trading Fund OS LP · CIK 0001660683 · See Explanation of Responses

BVF Partners OS Ltd. · CIK 0001660684 · See Explanation of Responses

BVF INC/IL · CIK 0001056807 · 10% owner

LAMPERT MARK N · CIK 0001233840 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,385,055

F1 · security: This Form 4 is filed jointly by Biotechnology Value Fund, L.P. ("BVF"), Biotechnology Value Fund II, L.P. ("BVF2"), Biotechnology Value Trading Fund OS LP ("Trading Fund OS"), BVF Partners OS Ltd. ("Partners OS"), BVF Partners L.P. ("Partners"), BVF Inc. and Mark N. Lampert (collectively, the "Reporting Persons"). Each of the Reporting Persons is a member of a Section 13(d) group that previously owned in the aggregate more than 10% of the Issuer's outstanding shares of Common Stock. Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein except to the extent of his or its pecuniary interest therein.

F2 · ownership.direct: Securities owned directly by BVF. As the general partner of BVF, Partners may be deemed to beneficially own the securities owned directly by BVF. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF.

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August 30, 2019 Filed Sep 3, 2019 21:49 UTC
Kaufmann HittoSVP, Chief Scientific Officer
GrantStock Option (right to buy) · Derivative 300,000 $0.00 Strike: $4.65 $0.00
Disclosure

SEC source: 0001562180-19-004585 · primarydocument.xml · derivative · entry 1

Kaufmann Hitto · CIK 0001787104 · SVP, Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2029-08-30

F1 · derivative.exercise_date: The option vests as to 25% of the option shares on August 30, 2020 and vests as to an additional 6.25% of the option shares at the end of each successive calendar quarter thereafter beginning on December 31, 2020.

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July 31, 2019 Filed Aug 1, 2019 22:22 UTC
Said Maya R.Director
GrantStock Option (right to buy) · Derivative 30,000 $0.00 Strike: $5.50 $0.00
Disclosure

SEC source: 0001562180-19-004130 · primarydocument.xml · derivative · entry 1

Said Maya R. · CIK 0001783701 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2029-07-31

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on July 31, 2020, subject to the Reporting Person's continued service as a director through the vesting date.

Read SEC document
July 25, 2019 Filed Jul 26, 2019 16:13 UTC GrantStock Option (right to buy) · Derivative 3,789 $2.89 Strike: $4.40 $10,950.21
Disclosure

SEC source: 0001562180-19-004075 · primarydocument.xml · derivative · entry 1

Richman Michael · CIK 0001366265 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,789

Underlying: Common Stock · 3,789 shares

Expires 2029-07-25

F1 · price: The stock option was issued to the Reporting Person, who elected to take stock options in lieu of $10,937.50 in cash compensation for services as a director and committee member, which compensation is payable to the Reporting Person quarterly in arrears pursuant to the Issuer's non-employee director compensation policy.

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April 25, 2019 Filed Apr 30, 2019 17:36 UTC GrantStock Option (right to buy) · Derivative 5,640 $1.94 Strike: $2.94 $10,941.60
Disclosure

SEC source: 0001562180-19-002447 · primarydocument.xml · derivative · entry 1

Richman Michael · CIK 0001366265 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,640

Underlying: Common Stock · 5,640 shares

Expires 2029-04-25

F1 · price: The stock option was issued to the Reporting Person, who elected to take stock options in lieu of $10,937.50 in cash compensation for services as a director and committee member, which compensation is payable to the Reporting Person quarterly in arrears, pursuant to the Issuer's non-employee director compensation policy.

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February 26, 2019 Filed Feb 28, 2019 22:24 UTC
Reine AllanChief Financial Officer
GrantStock Options (Right to Buy) · Derivative 162,500 $0.00 Strike: $3.09 $0.00
Disclosure

SEC source: 0001562180-19-001487 · primarydocument.xml · derivative · entry 1

Reine Allan · CIK 0001714023 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 162,500

Underlying: Common Stock · 162,500 shares

Expires 2029-02-26

F1 · derivative.exercise_date: The option vests as to 25% of the option shares on February 26, 2020 and vests as to an additional 6.25% of the option shares at the end of each successive three-month period thereafter.

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February 26, 2019 Filed Feb 28, 2019 22:25 UTC
Matis LouisChief Development Officer
GrantStock Option (Right to Buy) · Derivative 96,500 $0.00 Strike: $3.09 $0.00
Disclosure

SEC source: 0001562180-19-001488 · primarydocument.xml · derivative · entry 1

Matis Louis · CIK 0001650991 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,500

Underlying: Common Stock · 96,500 shares

Expires 2029-02-26

F1 · derivative.exercise_date: The option vests as to 25% of the option shares on February 26, 2020 and vests as to an additional 6.25% of the option shares at the end of each successive three-month period thereafter.

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February 26, 2019 Filed Feb 28, 2019 22:23 UTC
Yoder Stephen S.Director · Chief Executive Officer
GrantStock Options (Right to Buy) · Derivative 380,000 $0.00 Strike: $3.09 $0.00
Disclosure

SEC source: 0001562180-19-001486 · primarydocument.xml · derivative · entry 1

Yoder Stephen S. · CIK 0001645577 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 380,000

Underlying: Common Stock · 380,000 shares

Expires 2029-02-26

F1 · derivative.exercise_date: The option vests as to 25% of the option shares on February 26, 2020 and vests as to an additional 6.25% of the option shares at the end of each successive three-month period thereafter.

Read SEC document
January 30, 2019 Filed Feb 1, 2019 16:57 UTC
BIOTECHNOLOGY VALUE FUND L PSee Explanation of Responses
BIOTECHNOLOGY VALUE FUND II LPSee Explanation of Responses
Biotechnology Value Trading Fund OS LPSee Explanation of Responses
BVF Partners OS Ltd.See Explanation of Responses
BVF INC/IL10% owner
OtherSeries B Convertible Preferred Stock, $0.001 par value · Derivative 284 Not disclosed Not disclosed
Disclosure

SEC source: 0000921895-19-000178 · form407422010_01312019.xml · derivative · entry 6

BVF PARTNERS L P/IL · CIK 0001055947 · 10% owner

BIOTECHNOLOGY VALUE FUND L P · CIK 0000918923 · See Explanation of Responses

BIOTECHNOLOGY VALUE FUND II LP · CIK 0001102444 · See Explanation of Responses

Biotechnology Value Trading Fund OS LP · CIK 0001660683 · See Explanation of Responses

BVF Partners OS Ltd. · CIK 0001660684 · See Explanation of Responses

BVF INC/IL · CIK 0001056807 · 10% owner

LAMPERT MARK N · CIK 0001233840 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 284

Underlying: Common Stock, $0.001 par value · 284,000 shares

Expires not disclosed

F6 · derivative.exercise_price: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F9 · kind: Pursuant to a letter agreement between the Issuer and certain of the Reporting Persons, the Reporting Persons agreed to exchange an aggregate of 5,000,000 shares of Common Stock in consideration for a total of 5,000 shares of Series B Preferred Stock.

F6 · price: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F6 · derivative.exercise_date: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F6 · derivative.expiration_date: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F4 · ownership.direct: Securities owned directly by Trading Fund OS. As the general partner of Trading Fund OS, Partners OS may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment manager of Trading Fund OS and the sole member of Partners OS, Partners may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by Trading Fund OS. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by Trading Fund OS.

Read SEC document
January 30, 2019 Filed Feb 1, 2019 16:57 UTC
BIOTECHNOLOGY VALUE FUND L PSee Explanation of Responses
BIOTECHNOLOGY VALUE FUND II LPSee Explanation of Responses
Biotechnology Value Trading Fund OS LPSee Explanation of Responses
BVF Partners OS Ltd.See Explanation of Responses
BVF INC/IL10% owner
OtherSeries B Convertible Preferred Stock, $0.001 par value · Derivative 2,143 Not disclosed Not disclosed
Disclosure

SEC source: 0000921895-19-000178 · form407422010_01312019.xml · derivative · entry 5

BVF PARTNERS L P/IL · CIK 0001055947 · 10% owner

BIOTECHNOLOGY VALUE FUND L P · CIK 0000918923 · See Explanation of Responses

BIOTECHNOLOGY VALUE FUND II LP · CIK 0001102444 · See Explanation of Responses

Biotechnology Value Trading Fund OS LP · CIK 0001660683 · See Explanation of Responses

BVF Partners OS Ltd. · CIK 0001660684 · See Explanation of Responses

BVF INC/IL · CIK 0001056807 · 10% owner

LAMPERT MARK N · CIK 0001233840 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,143

Underlying: Common Stock, $0.001 par value · 2,143,000 shares

Expires not disclosed

F6 · derivative.exercise_price: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F9 · kind: Pursuant to a letter agreement between the Issuer and certain of the Reporting Persons, the Reporting Persons agreed to exchange an aggregate of 5,000,000 shares of Common Stock in consideration for a total of 5,000 shares of Series B Preferred Stock.

F6 · price: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F6 · derivative.exercise_date: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F6 · derivative.expiration_date: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F3 · ownership.direct: Securities owned directly by BVF2. As the general partner of BVF2, Partners may be deemed to beneficially own the securities owned directly by BVF2. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF2. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF2.

Read SEC document
January 30, 2019 Filed Feb 1, 2019 16:57 UTC
BIOTECHNOLOGY VALUE FUND L PSee Explanation of Responses
BIOTECHNOLOGY VALUE FUND II LPSee Explanation of Responses
Biotechnology Value Trading Fund OS LPSee Explanation of Responses
BVF Partners OS Ltd.See Explanation of Responses
BVF INC/IL10% owner
OtherSeries B Convertible Preferred Stock, $0.001 par value · Derivative 2,573 Not disclosed Not disclosed
Disclosure

SEC source: 0000921895-19-000178 · form407422010_01312019.xml · derivative · entry 4

BVF PARTNERS L P/IL · CIK 0001055947 · 10% owner

BIOTECHNOLOGY VALUE FUND L P · CIK 0000918923 · See Explanation of Responses

BIOTECHNOLOGY VALUE FUND II LP · CIK 0001102444 · See Explanation of Responses

Biotechnology Value Trading Fund OS LP · CIK 0001660683 · See Explanation of Responses

BVF Partners OS Ltd. · CIK 0001660684 · See Explanation of Responses

BVF INC/IL · CIK 0001056807 · 10% owner

LAMPERT MARK N · CIK 0001233840 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,573

Underlying: Common Stock, $0.001 par value · 2,573,000 shares

Expires not disclosed

F6 · derivative.exercise_price: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F9 · kind: Pursuant to a letter agreement between the Issuer and certain of the Reporting Persons, the Reporting Persons agreed to exchange an aggregate of 5,000,000 shares of Common Stock in consideration for a total of 5,000 shares of Series B Preferred Stock.

F6 · price: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F6 · derivative.exercise_date: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F6 · derivative.expiration_date: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F2 · ownership.direct: Securities owned directly by BVF. As the general partner of BVF, Partners may be deemed to beneficially own the securities owned directly by BVF. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF.

Read SEC document
January 30, 2019 Filed Feb 1, 2019 16:57 UTC
BIOTECHNOLOGY VALUE FUND L PSee Explanation of Responses
BIOTECHNOLOGY VALUE FUND II LPSee Explanation of Responses
Biotechnology Value Trading Fund OS LPSee Explanation of Responses
BVF Partners OS Ltd.See Explanation of Responses
BVF INC/IL10% owner
OtherCommon Stock, $0.001 par value 284,000 Not disclosed Not disclosed
Disclosure

SEC source: 0000921895-19-000178 · form407422010_01312019.xml · nonDerivative · entry 3

BVF PARTNERS L P/IL · CIK 0001055947 · 10% owner

BIOTECHNOLOGY VALUE FUND L P · CIK 0000918923 · See Explanation of Responses

BIOTECHNOLOGY VALUE FUND II LP · CIK 0001102444 · See Explanation of Responses

Biotechnology Value Trading Fund OS LP · CIK 0001660683 · See Explanation of Responses

BVF Partners OS Ltd. · CIK 0001660684 · See Explanation of Responses

BVF INC/IL · CIK 0001056807 · 10% owner

LAMPERT MARK N · CIK 0001233840 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 141,346

F1 · security: This Form 4 is filed jointly by Biotechnology Value Fund, L.P. ("BVF"), Biotechnology Value Fund II, L.P. ("BVF2"), Biotechnology Value Trading Fund OS LP ("Trading Fund OS"), BVF Partners OS Ltd. ("Partners OS"), BVF Partners L.P. ("Partners"), BVF Inc. and Mark N. Lampert (collectively, the "Reporting Persons"). Each of the Reporting Persons is a member of a Section 13(d) group that previously owned in the aggregate more than 10% of the Issuer's outstanding shares of Common Stock. Each of the Reporting Persons disclaims beneficial ownership of the shares of the Common Stock reported herein except to the extent of his or its pecuniary interest therein.

F9 · kind: Pursuant to a letter agreement between the Issuer and certain of the Reporting Persons, the Reporting Persons agreed to exchange an aggregate of 5,000,000 shares of Common Stock in consideration for a total of 5,000 shares of Series B Preferred Stock.

F6 · price: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F4 · ownership.direct: Securities owned directly by Trading Fund OS. As the general partner of Trading Fund OS, Partners OS may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment manager of Trading Fund OS and the sole member of Partners OS, Partners may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by Trading Fund OS. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by Trading Fund OS.

Read SEC document
January 30, 2019 Filed Feb 1, 2019 16:57 UTC
BIOTECHNOLOGY VALUE FUND L PSee Explanation of Responses
BIOTECHNOLOGY VALUE FUND II LPSee Explanation of Responses
Biotechnology Value Trading Fund OS LPSee Explanation of Responses
BVF Partners OS Ltd.See Explanation of Responses
BVF INC/IL10% owner
OtherCommon Stock, $0.001 par value 2,143,000 Not disclosed Not disclosed
Disclosure

SEC source: 0000921895-19-000178 · form407422010_01312019.xml · nonDerivative · entry 2

BVF PARTNERS L P/IL · CIK 0001055947 · 10% owner

BIOTECHNOLOGY VALUE FUND L P · CIK 0000918923 · See Explanation of Responses

BIOTECHNOLOGY VALUE FUND II LP · CIK 0001102444 · See Explanation of Responses

Biotechnology Value Trading Fund OS LP · CIK 0001660683 · See Explanation of Responses

BVF Partners OS Ltd. · CIK 0001660684 · See Explanation of Responses

BVF INC/IL · CIK 0001056807 · 10% owner

LAMPERT MARK N · CIK 0001233840 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 772,324

F1 · security: This Form 4 is filed jointly by Biotechnology Value Fund, L.P. ("BVF"), Biotechnology Value Fund II, L.P. ("BVF2"), Biotechnology Value Trading Fund OS LP ("Trading Fund OS"), BVF Partners OS Ltd. ("Partners OS"), BVF Partners L.P. ("Partners"), BVF Inc. and Mark N. Lampert (collectively, the "Reporting Persons"). Each of the Reporting Persons is a member of a Section 13(d) group that previously owned in the aggregate more than 10% of the Issuer's outstanding shares of Common Stock. Each of the Reporting Persons disclaims beneficial ownership of the shares of the Common Stock reported herein except to the extent of his or its pecuniary interest therein.

F9 · kind: Pursuant to a letter agreement between the Issuer and certain of the Reporting Persons, the Reporting Persons agreed to exchange an aggregate of 5,000,000 shares of Common Stock in consideration for a total of 5,000 shares of Series B Preferred Stock.

F6 · price: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F3 · ownership.direct: Securities owned directly by BVF2. As the general partner of BVF2, Partners may be deemed to beneficially own the securities owned directly by BVF2. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF2. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF2.

Read SEC document
January 30, 2019 Filed Feb 1, 2019 16:57 UTC
BIOTECHNOLOGY VALUE FUND L PSee Explanation of Responses
BIOTECHNOLOGY VALUE FUND II LPSee Explanation of Responses
Biotechnology Value Trading Fund OS LPSee Explanation of Responses
BVF Partners OS Ltd.See Explanation of Responses
BVF INC/IL10% owner
OtherCommon Stock, $0.001 par value 2,573,000 Not disclosed Not disclosed
Disclosure

SEC source: 0000921895-19-000178 · form407422010_01312019.xml · nonDerivative · entry 1

BVF PARTNERS L P/IL · CIK 0001055947 · 10% owner

BIOTECHNOLOGY VALUE FUND L P · CIK 0000918923 · See Explanation of Responses

BIOTECHNOLOGY VALUE FUND II LP · CIK 0001102444 · See Explanation of Responses

Biotechnology Value Trading Fund OS LP · CIK 0001660683 · See Explanation of Responses

BVF Partners OS Ltd. · CIK 0001660684 · See Explanation of Responses

BVF INC/IL · CIK 0001056807 · 10% owner

LAMPERT MARK N · CIK 0001233840 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 978,200

F1 · security: This Form 4 is filed jointly by Biotechnology Value Fund, L.P. ("BVF"), Biotechnology Value Fund II, L.P. ("BVF2"), Biotechnology Value Trading Fund OS LP ("Trading Fund OS"), BVF Partners OS Ltd. ("Partners OS"), BVF Partners L.P. ("Partners"), BVF Inc. and Mark N. Lampert (collectively, the "Reporting Persons"). Each of the Reporting Persons is a member of a Section 13(d) group that previously owned in the aggregate more than 10% of the Issuer's outstanding shares of Common Stock. Each of the Reporting Persons disclaims beneficial ownership of the shares of the Common Stock reported herein except to the extent of his or its pecuniary interest therein.

F9 · kind: Pursuant to a letter agreement between the Issuer and certain of the Reporting Persons, the Reporting Persons agreed to exchange an aggregate of 5,000,000 shares of Common Stock in consideration for a total of 5,000 shares of Series B Preferred Stock.

F6 · price: The Reporting Persons hold 5,000 shares of Series B Convertible Preferred Stock, (the "Series B Preferred Stock") convertible for an aggregate of 5,000,000 shares of Common Stock. Each share of Series B Preferred Stock is convertible into 1,000 shares of Common Stock. The Series B Preferred Stock is convertible at any time, at the holder's election, except that the Series B Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Exchange Act, more than 9.99% of the number of shares of Common Stock then issued and outstanding.

F2 · ownership.direct: Securities owned directly by BVF. As the general partner of BVF, Partners may be deemed to beneficially own the securities owned directly by BVF. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF.

Read SEC document
January 25, 2019 Filed Jan 29, 2019 17:35 UTC
Barbier AnnDirector
GrantStock Option (right to buy) · Derivative 20,000 $0.00 Strike: $2.74 $0.00
Disclosure

SEC source: 0001562180-19-000570 · primarydocument.xml · derivative · entry 1

Barbier Ann · CIK 0001737596 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2029-01-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on January 25, 2020, subject to the Reporting Person's continued service as a director through the vesting date.

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January 25, 2019 Filed Jan 29, 2019 17:46 UTC GrantStock Option (right to buy) · Derivative 20,000 $0.00 Strike: $2.74 $0.00
Disclosure

SEC source: 0001562180-19-000580 · primarydocument.xml · derivative · entry 1

Sherman Matthew L · CIK 0001325710 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2029-01-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on January 25, 2020, subject to the Reporting Person's continued service as a director through the vesting date.

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January 25, 2019 Filed Jan 29, 2019 17:40 UTC GrantStock Option (right to buy) · Derivative 20,000 $0.00 Strike: $2.74 $0.00
Disclosure

SEC source: 0001562180-19-000577 · primarydocument.xml · derivative · entry 1

KIRITSY CHRISTOPHER P · CIK 0001261156 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2029-01-25

F1 · derivative.exercise_date: The stock option will vest as to 100% of the underlying shares on January 25, 2020, subject to the Reporting Person's continued service as a director through the vesting date.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.