PTCT

SEC source: 0001808968-26-000011 · form4-03132026_050301.xml · nonDerivative · entry 1

Klein Matthew B. · CIK 0001808968 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 399,582

F1 · shares: Represents the number of shares of the Issuer's common stock underlying restricted stock units ("RSUs") earned upon the vesting of performance-based restricted stock units ("PSUs") granted in December 2024. The Issuer's compensation committee of the board of directors certified the Issuer's achievement of a pre-established milestone set forth in the PSUs, as of March 11, 2026, which resulted in the reported RSUs being earned. Each earned RSU represents the contingent right to receive one share of the Issuer's common stock upon vesting. The earned RSUs immediately vested as to 6,500 shares on March 11, 2026 in connection with being earned and are scheduled to vest with respect to the remaining 6,500 shares on March 11, 2027.

SEC source: 0001742616-26-000006 · form4-03122026_050301.xml · derivative · entry 6

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 14,000 shares

Expires 2028-12-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 24, 2025.

F2 · derivative.exercise_date: Currently exercisable.

SEC source: 0001742616-26-000006 · form4-03122026_050301.xml · derivative · entry 5

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,167 shares

Expires 2028-12-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 24, 2025.

F2 · derivative.exercise_date: Currently exercisable.

SEC source: 0001742616-26-000006 · form4-03122026_050301.xml · nonDerivative · entry 4

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,000

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 24, 2025.

SEC source: 0001742616-26-000006 · form4-03122026_050301.xml · nonDerivative · entry 3

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 24, 2025.

SEC source: 0001742616-26-000006 · form4-03122026_050301.xml · nonDerivative · entry 2

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,000

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 24, 2025.

SEC source: 0001742616-26-000006 · form4-03122026_050301.xml · nonDerivative · entry 1

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,167

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 24, 2025.

SEC source: 0001742616-26-000004 · form4-03092026_050305.xml · nonDerivative · entry 1

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,000

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 24, 2025.

SEC source: 0001686217-26-000010 · form4-03092026_050303.xml · nonDerivative · entry 1

Golden Lee Scott · CIK 0001686217 · EVP & CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 79,944

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 4, 2025.

SEC source: 0001578850-26-000010 · form4-03092026_050301.xml · nonDerivative · entry 2

Almstead Neil Gregory · CIK 0001578850 · CHIEF TECHNICAL OPS OFFICER

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 2,737

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on November 26, 2025.

SEC source: 0001578852-26-000010 · form4-02232026_050201.xml · nonDerivative · entry 4

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,212

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

F3 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $69.52 to $70.18 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001578852-26-000010 · form4-02232026_050201.xml · nonDerivative · entry 3

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,802

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

F2 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $67.99 to $68.93 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001578852-26-000010 · form4-02232026_050201.xml · nonDerivative · entry 2

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 106,014

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

F3 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $69.52 to $70.18 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001578852-26-000010 · form4-02232026_050201.xml · nonDerivative · entry 1

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 107,643

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

F2 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $67.99 to $68.93 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001578852-26-000008 · form4-02192026_050201.xml · nonDerivative · entry 4

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 108,231

F3 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 4,500 RSUs from a February 15, 2024 grant of 18,000 RSUs and the vesting of 1,600 RSUs from a February 15, 2024 grant of 3,200 RSUs.

SEC source: 0001707685-26-000008 · form4-02202026_050211.xml · nonDerivative · entry 1

Utter Christine Marie · CIK 0001707685 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 70,199

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 3,500 RSUs from a February 15, 2024 grant of 14,000 RSUs and the vesting of 1,450 RSUs from a February 15, 2024 grant of 2,900 RSUs.

SEC source: 0001984065-26-000006 · form4-02202026_050209.xml · nonDerivative · entry 1

Gravier Pierre · CIK 0001984065 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 87,318

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 4,750 RSUs from a February 15, 2024 grant of 19,000 RSUs and the vesting of 1,550 RSUs from a February 15, 2024 grant of 3,100 RSUs.

SEC source: 0001323212-26-000008 · form4-02202026_050207.xml · nonDerivative · entry 1

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 77,122

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 5,500 RSUs from a February 15, 2024 grant of 22,000 RSUs and the vesting of 1,150 RSUs from a February 15, 2024 grant of 2,300 RSUs.

SEC source: 0001808968-26-000009 · form4-02202026_050205.xml · nonDerivative · entry 1

Klein Matthew B. · CIK 0001808968 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 387,082

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 17,500 RSUs from a February 15, 2025 grant of 70,000 RSUs.

SEC source: 0001686217-26-000008 · form4-02202026_050203.xml · nonDerivative · entry 1

Golden Lee Scott · CIK 0001686217 · EVP & CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 89,944

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 5,000 RSUs from a February 15, 2024 grant of 20,000 RSUs and the vesting of 1,300 RSUs from a February 15, 2024 grant of 2,600 RSUs.

SEC source: 0001578850-26-000008 · form4-02202026_050201.xml · nonDerivative · entry 2

Almstead Neil Gregory · CIK 0001578850 · CHIEF TECHNICAL OPS OFFICER

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 6,726

F2 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 217 RSUs from a February 15, 2024 grant of 870 RSUs.

SEC source: 0001578850-26-000008 · form4-02202026_050201.xml · nonDerivative · entry 1

Almstead Neil Gregory · CIK 0001578850 · CHIEF TECHNICAL OPS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 112,140

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 4,750 RSUs from a February 15, 2024 grant of 19,000 RSUs and the vesting of 3,000 RSUs from a February 15, 2024 grant of 6,000 RSUs.

SEC source: 0001578852-26-000008 · form4-02192026_050201.xml · derivative · entry 5

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,501

Underlying: Common Stock · 2,813 shares

Expires 2034-02-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

F4 · derivative.exercise_date: Currently exercisable.

SEC source: 0001578852-26-000008 · form4-02192026_050201.xml · nonDerivative · entry 3

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 111,312

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

SEC source: 0001578852-26-000008 · form4-02192026_050201.xml · nonDerivative · entry 2

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 111,314

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

F2 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $68.84 to $69.80 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001578852-26-000008 · form4-02192026_050201.xml · nonDerivative · entry 1

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 114,125

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

SEC source: 0001323212-26-000006 · form4-01122026_050109.xml · nonDerivative · entry 5

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 80,141

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2025.

F6 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $78.16 to $79.01 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001323212-26-000006 · form4-01122026_050109.xml · nonDerivative · entry 4

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 81,165

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2025.

F5 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $77.10 to $77.77 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001578852-26-000006 · form4-01122026_050103.xml · nonDerivative · entry 6

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 111,312

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

F7 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $79.35 to $79.60 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001578852-26-000006 · form4-01122026_050103.xml · nonDerivative · entry 5

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 111,419

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

F6 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $78.23 to $79.21 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001578852-26-000006 · form4-01122026_050103.xml · nonDerivative · entry 4

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 112,105

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

F5 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $77.12 to $78.08 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001707685-26-000006 · form4-01122026_050111.xml · nonDerivative · entry 1

Utter Christine Marie · CIK 0001707685 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,693

F1 · shares: Represents shares automatically sold pursuant to irrevocable sell to cover elections entered into upon acceptance of the respective grants to satisfy tax withholding obligations in connection with the vesting of 2,900 RSUs from a January 7, 2022 grant of 11,600 RSUs.

SEC source: 0001323212-26-000006 · form4-01122026_050109.xml · nonDerivative · entry 3

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 82,887

F4 · shares: Represents shares automatically sold pursuant to irrevocable sell to cover elections entered into upon acceptance of the respective grants to satisfy tax withholding obligations in connection with the vesting of 4,200 RSUs from a January 7, 2022 grant of 16,800 RSUs.

SEC source: 0001323212-26-000006 · form4-01122026_050109.xml · nonDerivative · entry 2

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 84,341

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2025.

F3 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $76.91 to $77.13 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001323212-26-000006 · form4-01122026_050109.xml · nonDerivative · entry 1

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 84,928

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 15, 2025.

F2 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $75.89 to $76.88 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001808968-26-000007 · form4-01122026_050107.xml · nonDerivative · entry 1

Klein Matthew B. · CIK 0001808968 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 394,453

F1 · shares: Represents shares automatically sold pursuant to irrevocable sell to cover elections entered into upon acceptance of the respective grants to satisfy tax withholding obligations in connection with the vesting of 5,250 RSUs from a January 7, 2022 grant of 21,000 RSUs.

SEC source: 0001686217-26-000006 · form4-01122026_050105.xml · nonDerivative · entry 1

Golden Lee Scott · CIK 0001686217 · EVP & CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 92,428

F1 · shares: Represents shares automatically sold pursuant to irrevocable sell to cover elections entered into upon acceptance of the respective grants to satisfy tax withholding obligations in connection with the vesting of 3,539 RSUs from January 7, 2022 grants totaling 14,155 RSUs.

SEC source: 0001578852-26-000006 · form4-01122026_050103.xml · nonDerivative · entry 3

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 113,626

F4 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election to satisfy tax withholding obligations in connection with the vesting of 3,600 RSUs from a January 7, 2022 grant of 14,400 RSUs.

SEC source: 0001578852-26-000006 · form4-01122026_050103.xml · nonDerivative · entry 2

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 114,912

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

F3 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $76.99 to $77.23 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001578852-26-000006 · form4-01122026_050103.xml · nonDerivative · entry 1

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,177

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

F2 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $75.95 to $76.92 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001578850-26-000006 · form4-01122026_050101.xml · nonDerivative · entry 2

Almstead Neil Gregory · CIK 0001578850 · CHIEF TECHNICAL OPS OFFICER

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 6,791

F2 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election to satisfy tax withholding obligations in connection with the vesting of 195 RSUs from a January 7, 2022 grant of 780 RSUs.

SEC source: 0001578850-26-000006 · form4-01122026_050101.xml · nonDerivative · entry 1

Almstead Neil Gregory · CIK 0001578850 · CHIEF TECHNICAL OPS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,196

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election to satisfy tax withholding obligations in connection with the vesting of 3,600 RSUs from a January 7, 2022 grant of 14,400 RSUs.

SEC source: 0001707685-26-000004 · form4-01082026_050123.xml · nonDerivative · entry 2

Utter Christine Marie · CIK 0001707685 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 73,727

F2 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 3,500 RSUs from a January 5, 2023 grant of 14,000 RSUs.

SEC source: 0001323212-26-000004 · form4-01082026_050119.xml · nonDerivative · entry 2

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 87,489

F2 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 4,500 RSUs from a January 5, 2023 grant of 18,000 RSUs.

SEC source: 0001808968-26-000005 · form4-01082026_050118.xml · nonDerivative · entry 2

Klein Matthew B. · CIK 0001808968 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 396,967

F2 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 6,500 RSUs from a January 5, 2023 grant of 26,000 RSUs.

SEC source: 0001686217-26-000004 · form4-01082026_050106.xml · nonDerivative · entry 2

Golden Lee Scott · CIK 0001686217 · EVP & CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 93,294

F2 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 2,666 RSUs from a January 5, 2023 grant of 10,640 RSUs.

SEC source: 0001578852-26-000004 · form4-01082026_050104.xml · derivative · entry 12

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 751 shares

Expires 2032-01-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

F8 · derivative.exercise_date: Currently exercisable.

SEC source: 0001578852-26-000004 · form4-01082026_050104.xml · derivative · entry 11

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 751

Underlying: Common Stock · 2,627 shares

Expires 2032-01-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

F8 · derivative.exercise_date: Currently exercisable.

SEC source: 0001578852-26-000004 · form4-01082026_050104.xml · nonDerivative · entry 10

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 117,659

F3 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

SEC source: 0001578852-26-000004 · form4-01082026_050104.xml · nonDerivative · entry 9

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 117,670

F3 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 4, 2024.

F7 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $77.54 to $78.47 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.