PTCT

SEC source: 0001415889-24-000913 · form4-01102024_090125.xml · nonDerivative · entry 2

Golden Lee Scott · CIK 0001686217 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 37,914

F3 · shares: Represents shares automatically sold pursuant to irrevocable sell to cover elections entered into upon acceptance of the respective grants to satisfy tax withholding obligations in connection with the vesting of 990 RSUs from a January 6, 2021 grant of 3,960 RSUs and the vesting of 3,539 RSUs from January 7, 2022 grants totaling14,155 RSUs.

SEC source: 0001415889-24-000910 · form4-01102024_090136.xml · nonDerivative · entry 2

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,983

F2 · shares: Represents shares automatically sold pursuant to irrevocable sell to cover elections entered into upon acceptance of the respective grants to satisfy tax withholding obligations in connection with the vesting of 2,550 RSUs from a January 6, 2021 grant of 10,200 RSUs and the vesting of 3,600 RSUs from a January 7, 2022 grant of 14,400 RSUs.

SEC source: 0001415889-24-000908 · form4-01102024_090133.xml · nonDerivative · entry 4

Almstead Neil Gregory · CIK 0001578850 · CHIEF TECHNICAL OPS OFFICER

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 3,734

F6 · shares: Represents shares automatically sold pursuant to irrevocable sell to cover elections entered into upon acceptance of the respective grants to satisfy tax withholding obligations in connection with the vesting of 150 RSUs from a January 6, 2021 grant of 600 RSUs and the vesting of 195 RSUs from a January 7, 2022 grant of 780 RSUs.

SEC source: 0001415889-24-000908 · form4-01102024_090133.xml · nonDerivative · entry 3

Almstead Neil Gregory · CIK 0001578850 · CHIEF TECHNICAL OPS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 61,820

F5 · shares: Represents shares automatically sold pursuant to irrevocable sell to cover elections entered into upon acceptance of the respective grants to satisfy tax withholding obligations in connection with the vesting of 2,550 RSUs from a January 6, 2021 grant of 10,200 RSUs and the vesting of 3,600 RSUs from a January 7, 2022 grant of 14,400 RSUs.

SEC source: 0001415889-24-000921 · form4-01102024_090117.xml · nonDerivative · entry 1

Utter Christine Marie · CIK 0001707685 · SVP, FINANCE & CAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 37,499

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 3,500 RSUs from a January 5, 2023 grant of 14,000 RSUs.

F2 · balance_after: Includes 327 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ending June 30, 2023 and 301 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ending December 31, 2023.

SEC source: 0001415889-24-000919 · form4-01102024_090117.xml · nonDerivative · entry 1

SCHMERTZLER MICHAEL · CIK 0001288952 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,266

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023, to satisfy tax obligations in connection with the vesting of 4,664 restricted stock units from a January 5, 2023 grant of 8,000 restricted stock units.

SEC source: 0001415889-24-000917 · form4-01102024_090157.xml · nonDerivative · entry 1

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 46,612

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 4,500 RSUs from a January 5, 2023 grant of 18,000 RSUs.

F2 · balance_after: Includes 327 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ending June 30, 2023 and 301 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ending December 31, 2023.

SEC source: 0001415889-24-000915 · form4-01102024_090152.xml · nonDerivative · entry 1

Klein Matthew B. · CIK 0001808968 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 165,918

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 6,500 RSUs from a January 5, 2023 grant of 26,000 RSUs.

SEC source: 0001415889-24-000913 · form4-01102024_090125.xml · nonDerivative · entry 1

Golden Lee Scott · CIK 0001686217 · CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 39,139

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 2,666 RSUs from a January 5, 2023 grant of 10,640 RSUs.

F2 · balance_after: Includes 327 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ending June 30, 2023 and 301 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ending December 31, 2023.

SEC source: 0001415889-24-000910 · form4-01102024_090136.xml · nonDerivative · entry 1

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 73,921

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 4,250 RSUs from a January 5, 2023 grant of 17,000 RSUs.

SEC source: 0001415889-24-000908 · form4-01102024_090133.xml · nonDerivative · entry 2

Almstead Neil Gregory · CIK 0001578850 · CHIEF TECHNICAL OPS OFFICER

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 3,834

F3 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 177 RSUs from a January 5, 2023 grant of 710 RSUs.

F4 · balance_after: Includes 327 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ending June 30, 2023 and 301 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ending December 31, 2023.

SEC source: 0001415889-24-000908 · form4-01102024_090133.xml · nonDerivative · entry 1

Almstead Neil Gregory · CIK 0001578850 · CHIEF TECHNICAL OPS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 63,341

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 4,250 RSUs from a January 5, 2023 grant of 17,000 RSUs.

F2 · balance_after: Includes 327 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ending June 30, 2023 and 301 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ending December 31, 2023.

SEC source: 0001415889-24-000854 · form4-01092024_090130.xml · nonDerivative · entry 1

Klein Matthew B. · CIK 0001808968 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 168,155

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 18,750 RSUs from a December 28, 2023 grant of 75,000 RSUs.

F2 · balance_after: Includes 301 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ending December 31, 2023.

SEC source: 0001415889-23-016992 · form4-12282023_101229.xml · nonDerivative · entry 1

Klein Matthew B. · CIK 0001808968 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 177,961

F1 · shares: Restricted stock unit granted on December 28, 2023 that vests in four equal installments over four years, commencing on December 29, 2023.

F2 · balance_after: Includes 316 shares of common stock acquired under the Issuer's employee stock purchase plan for the period ending June 30, 2023.

SEC source: 0001415889-23-016478 · form4-12142023_091224.xml · nonDerivative · entry 1

Gravier Pierre · CIK 0001984065 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,700

F1 · price: This price represents the weighted average price of purchase transactions that were executed in multiple trades at prices ranging from $25.77 to $25.82 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-23-013116 · form4-09082023_080934.xml · derivative · entry 6

Young Alethia · CIK 0001918147 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,334

Underlying: Common Stock · 4,666 shares

Expires 2032-06-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: This option was granted on June 9, 2022 and vests over thirty-six approximately equal monthly installments, commencing on July 8, 2022

SEC source: 0001415889-23-013116 · form4-09082023_080934.xml · derivative · entry 5

Young Alethia · CIK 0001918147 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,000 shares

Expires 2032-06-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Currently exercisable.

SEC source: 0001415889-23-013116 · form4-09082023_080934.xml · nonDerivative · entry 4

Young Alethia · CIK 0001918147 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,067

F1 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $39.77 to $39.88 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-23-013116 · form4-09082023_080934.xml · nonDerivative · entry 3

Young Alethia · CIK 0001918147 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,733

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-23-013116 · form4-09082023_080934.xml · nonDerivative · entry 2

Young Alethia · CIK 0001918147 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,067

SEC source: 0001415889-23-013116 · form4-09082023_080934.xml · nonDerivative · entry 1

Young Alethia · CIK 0001918147 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,067

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-23-011167 · form4-07172023_080747.xml · derivative · entry 2

Gravier Pierre · CIK 0001984065 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Stock · 65,000 shares

Expires 2033-07-12

F2 · derivative.exercise_date: This option was granted on July 13, 2023, and vests over four years, with 25% of the shares underlying the option vesting on July 13, 2024, and an additional 6.25% of the original number of shares underlying the option vesting at the end of each successive three-month period thereafter, beginning on October 13, 2024.

SEC source: 0001415889-23-011167 · form4-07172023_080747.xml · nonDerivative · entry 1

Gravier Pierre · CIK 0001984065 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,000

F1 · shares: Restricted stock units granted on July 13, 2023 that vest in four equal installments over four years, commencing on July 13, 2024.

SEC source: 0001415889-23-009501 · form4-06092023_080626.xml · nonDerivative · entry 1

SCHMERTZLER MICHAEL · CIK 0001288952 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 116,766

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023, to satisfy tax obligations in connection with the vesting of 3,334 restricted stock units from a January 5, 2023 grant of 8,000 restricted stock units.

SEC source: 0001415889-23-009356 · form4-06072023_080617.xml · derivative · entry 4

Bell William F. Jr. · CIK 0001980122 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,834

Underlying: Common Stock · 5,834 shares

Expires 2033-06-05

F4 · derivative.exercise_date: This option was granted on June 6, 2023 and vests over seven approximately equal monthly installments, commencing on July 5, 2023.

SEC source: 0001415889-23-009356 · form4-06072023_080617.xml · derivative · entry 3

Bell William F. Jr. · CIK 0001980122 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2033-06-05

F3 · derivative.exercise_date: This option was granted on June 6, 2023 and vests over thirty-six approximately equal monthly installments, commencing on July 6, 2023.

SEC source: 0001415889-23-009356 · form4-06072023_080617.xml · nonDerivative · entry 2

Bell William F. Jr. · CIK 0001980122 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,333

F2 · shares: Restricted stock units granted on June 6, 2023 that vest on January 5, 2024.

SEC source: 0001415889-23-009356 · form4-06072023_080617.xml · nonDerivative · entry 1

Bell William F. Jr. · CIK 0001980122 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,000

F1 · shares: Restricted stock units granted on June 6, 2023 that vest in three equal installments over three years, commencing on June 6, 2024.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · derivative · entry 18

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,650

Underlying: Common Stock · 1,402 shares

Expires 2028-12-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

F8 · derivative.exercise_date: Currently exercisable.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · derivative · entry 17

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,912

Underlying: Common Stock · 1,093 shares

Expires 2029-01-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

F8 · derivative.exercise_date: Currently exercisable.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · derivative · entry 16

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 837

Underlying: Common Stock · 157 shares

Expires 2028-12-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

F8 · derivative.exercise_date: Currently exercisable.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · nonDerivative · entry 12

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,200

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

F7 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $59.50 to $59.71 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · nonDerivative · entry 11

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,602

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · nonDerivative · entry 10

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,200

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

F6 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $59.50 to $59.70 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · nonDerivative · entry 9

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,293

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · nonDerivative · entry 8

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,200

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

F5 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $59.50 to $59.62 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · nonDerivative · entry 7

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,357

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

SEC source: 0001415889-23-008568 · form4-05232023_080529.xml · nonDerivative · entry 3

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 47,553

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 13, 2022.

SEC source: 0001415889-23-008568 · form4-05232023_080529.xml · nonDerivative · entry 2

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 47,653

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 13, 2022.

F3 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $58.61 to $59.52 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · derivative · entry 15

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,052

Underlying: Common Stock · 3,948 shares

Expires 2028-12-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

F8 · derivative.exercise_date: Currently exercisable.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · derivative · entry 14

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,005

Underlying: Common Stock · 2,995 shares

Expires 2029-01-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

F8 · derivative.exercise_date: Currently exercisable.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · derivative · entry 13

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 994

Underlying: Common Stock · 173 shares

Expires 2028-12-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

F8 · derivative.exercise_date: Currently exercisable.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · nonDerivative · entry 6

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,200

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

F4 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $59.50 to $59.73 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · nonDerivative · entry 5

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,148

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · nonDerivative · entry 4

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,200

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

F3 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $59.50 to $59.73 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · nonDerivative · entry 3

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,195

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · nonDerivative · entry 2

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,200

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

F2 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $59.50 to $59.57 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-23-008704 · form4-05242023_080557.xml · nonDerivative · entry 1

Reeve Emma · CIK 0001680329 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,373

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on February 24, 2023.

SEC source: 0001415889-23-008568 · form4-05232023_080529.xml · nonDerivative · entry 1

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 49,566

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 13, 2022.

F2 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $58.50 to $59.42 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-23-008390 · form4-05192023_080525.xml · nonDerivative · entry 3

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,969

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on September 13, 2022.

F3 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $58.50 to $59.16 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.