PTCT

SEC source: 0001415889-25-008452 · form4-03182025_050301.xml · nonDerivative · entry 4

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,940

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 13, 2024.

F5 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $57.30 to $58.26 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-25-008452 · form4-03182025_050301.xml · nonDerivative · entry 3

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 76,280

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 13, 2024.

F4 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $56.20 to $57.14 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-25-008452 · form4-03182025_050301.xml · nonDerivative · entry 2

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 77,365

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 13, 2024.

F3 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $55.00 to $55.98 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-25-008452 · form4-03182025_050301.xml · nonDerivative · entry 1

Pauwels Eric · CIK 0001323212 · CHIEF BUSINESS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 79,402

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 13, 2024.

F2 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $55.00 to $55.49 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-25-008235 · form4-03172025_050301.xml · nonDerivative · entry 1

Okey Stephanie · CIK 0001742616 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,867

SEC source: 0001415889-25-008141 · form4-03142025_050301.xml · derivative · entry 6

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,395 shares

Expires 2029-01-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 5, 2024.

F4 · derivative.exercise_date: Currently exercisable.

SEC source: 0001415889-25-008141 · form4-03142025_050301.xml · derivative · entry 5

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 13,126 shares

Expires 2029-01-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 5, 2024.

F4 · derivative.exercise_date: Currently exercisable.

SEC source: 0001415889-25-008141 · form4-03142025_050301.xml · nonDerivative · entry 4

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 103,901

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 5, 2024.

F3 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $53.00 to 53.68 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-25-008141 · form4-03142025_050301.xml · nonDerivative · entry 3

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 106,296

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 5, 2024.

SEC source: 0001415889-25-008141 · form4-03142025_050301.xml · nonDerivative · entry 2

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 103,901

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 5, 2024.

F2 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $53.00 to 53.71 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-25-008141 · form4-03142025_050301.xml · nonDerivative · entry 1

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 117,027

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the Reporting Person on December 5, 2024.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · derivative · entry 16

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,395

Underlying: Common Stock · 1,719 shares

Expires 2029-01-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

F8 · derivative.exercise_date: Currently exercisable.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · derivative · entry 15

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,126

Underlying: Common Stock · 5,662 shares

Expires 2029-01-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

F8 · derivative.exercise_date: Currently exercisable.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · nonDerivative · entry 11

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 103,901

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

F7 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $37.30 to $38.20 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · nonDerivative · entry 10

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,620

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · nonDerivative · entry 9

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 103,901

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

F6 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $53.00 to $53.14 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · nonDerivative · entry 8

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 109,563

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · derivative · entry 14

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,751

Underlying: Common Stock · 11,249 shares

Expires 2034-02-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

F9 · derivative.exercise_date: This option was granted on February 15, 2024, and vests over four years, with 25% of the shares underlying the option vesting on February 15, 2025, and an additional 6.25% of the original number of shares underlying the option vesting at the end of each successive three-month period thereafter, beginning on May 15, 2025.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · derivative · entry 13

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,114

Underlying: Common Stock · 11,398 shares

Expires 2029-01-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

F8 · derivative.exercise_date: Currently exercisable.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · derivative · entry 12

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,788

Underlying: Common Stock · 45,392 shares

Expires 2029-01-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

F8 · derivative.exercise_date: Currently exercisable.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · nonDerivative · entry 7

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 103,901

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

F5 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $52.74 to $53.57 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · nonDerivative · entry 6

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 111,663

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

F4 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $51.73 to $52.71 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · nonDerivative · entry 5

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,150

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · nonDerivative · entry 4

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 103,901

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

F3 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $53.00 to $53.57 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · nonDerivative · entry 3

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,299

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · nonDerivative · entry 2

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 103,901

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

F2 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $53.00 to $53.82 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-25-007856 · form4-03122025_050301.xml · nonDerivative · entry 1

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 149,293

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a written Rule 10b5-1 plan adopted by the reporting person on December 5, 2024.

SEC source: 0001415889-25-007250 · form4-03062025_050301.xml · nonDerivative · entry 1

Jacobson Allan Steven · CIK 0001579003 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,118

F1 · price: This price represents the weighted average price of sale transactions that were executed in multiple trades at prices ranging from $51.50 to $51.54 per share. The Reporting Person hereby undertakes, upon request by the SEC staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price.

SEC source: 0001415889-25-005139 · form4-02212025_050215.xml · nonDerivative · entry 2

Utter Christine Marie · CIK 0001707685 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 62,564

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 3,500 RSUs from a February 15, 2024 grant of 14,000 RSUs and the vesting of 1,450 RSUs from a February 15, 2024 grant of 2,900 RSUs.

SEC source: 0001415889-25-005137 · form4-02212025_050211.xml · nonDerivative · entry 2

Pauwels Eric · CIK 0001323212 · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 83,860

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 5,500 RSUs from a February 15, 2024 grant of 22,000 RSUs and the vesting of 1,150 RSUs from a February 15, 2024 grant of 2,300 RSUs.

SEC source: 0001415889-25-005138 · form4-02212025_050213.xml · nonDerivative · entry 2

Gravier Pierre · CIK 0001984065 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 74,436

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 4,750 RSUs from a February 15, 2024 grant of 19,000 RSUs and the vesting of 1,550 RSUs from a February 15, 2024 grant of 3,100 RSUs.

SEC source: 0001415889-25-005136 · form4-02212025_050208.xml · nonDerivative · entry 2

Klein Matthew B. · CIK 0001808968 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 276,038

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 17,500 RSUs from a February 15, 2025 grant of 70,000 RSUs.

SEC source: 0001415889-25-005135 · form4-02212025_050206.xml · nonDerivative · entry 2

Golden Lee Scott · CIK 0001686217 · EVP & CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 76,894

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 5,000 RSUs from a February 15, 2024 grant of 20,000 RSUs and the vesting of 1,300 RSUs from a February 15, 2024 grant of 2,600 RSUs.

SEC source: 0001415889-25-005134 · form4-02212025_050204.xml · nonDerivative · entry 2

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 103,901

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 4,500 RSUs from a February 15, 2024 grant of 18,000 RSUs and the vesting of 1,600 RSUs from a February 15, 2024 grant of 3,200 RSUs.

SEC source: 0001415889-25-005133 · form4-02212025_050201.xml · nonDerivative · entry 4

Almstead Neil Gregory · CIK 0001578850 · CHIEF TECHNICAL OPS OFFICER

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 5,907

F2 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 217 RSUs from a February 15, 2024 grant of 870 RSUs.

SEC source: 0001415889-25-005133 · form4-02212025_050201.xml · nonDerivative · entry 3

Almstead Neil Gregory · CIK 0001578850 · CHIEF TECHNICAL OPS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 100,353

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 4,750 RSUs from a February 15, 2024 grant of 19,000 RSUs and the vesting of 3,000 RSUs from a February 15, 2024 grant of 6,000 RSUs.

SEC source: 0001415889-25-005139 · form4-02212025_050215.xml · nonDerivative · entry 1

Utter Christine Marie · CIK 0001707685 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 63,442

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 3,500 RSUs from a February 15, 2024 grant of 14,000 RSUs and the vesting of 1,450 RSUs from a February 15, 2024 grant of 2,900 RSUs.

SEC source: 0001415889-25-005137 · form4-02212025_050211.xml · nonDerivative · entry 1

Pauwels Eric · CIK 0001323212 · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 85,427

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 5,500 RSUs from a February 15, 2024 grant of 22,000 RSUs and the vesting of 1,150 RSUs from a February 15, 2024 grant of 2,300 RSUs.

SEC source: 0001415889-25-005138 · form4-02212025_050213.xml · nonDerivative · entry 1

Gravier Pierre · CIK 0001984065 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 75,603

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 4,750 RSUs from a February 15, 2024 grant of 19,000 RSUs and the vesting of 1,550 RSUs from a February 15, 2024 grant of 3,100 RSUs.

SEC source: 0001415889-25-005136 · form4-02212025_050208.xml · nonDerivative · entry 1

Klein Matthew B. · CIK 0001808968 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 279,933

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 17,500 RSUs from a February 15, 2025 grant of 70,000 RSUs.

SEC source: 0001415889-25-005135 · form4-02212025_050206.xml · nonDerivative · entry 1

Golden Lee Scott · CIK 0001686217 · EVP & CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 77,856

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 5,000 RSUs from a February 15, 2024 grant of 20,000 RSUs and the vesting of 1,300 RSUs from a February 15, 2024 grant of 2,600 RSUs.

SEC source: 0001415889-25-005134 · form4-02212025_050204.xml · nonDerivative · entry 1

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,515

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 4,500 RSUs from a February 15, 2024 grant of 18,000 RSUs and the vesting of 1,600 RSUs from a February 15, 2024 grant of 3,200 RSUs.

SEC source: 0001415889-25-005133 · form4-02212025_050201.xml · nonDerivative · entry 2

Almstead Neil Gregory · CIK 0001578850 · CHIEF TECHNICAL OPS OFFICER

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 5,941

F2 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 217 RSUs from a February 15, 2024 grant of 870 RSUs.

SEC source: 0001415889-25-005133 · form4-02212025_050201.xml · nonDerivative · entry 1

Almstead Neil Gregory · CIK 0001578850 · CHIEF TECHNICAL OPS OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 101,931

F1 · shares: Represents shares automatically sold pursuant to an irrevocable sell to cover election entered into upon acceptance of the grant to satisfy tax withholding obligations in connection with the vesting of 4,750 RSUs from a February 15, 2024 grant of 19,000 RSUs and the vesting of 3,000 RSUs from a February 15, 2024 grant of 6,000 RSUs.

SEC source: 0001415889-25-001295 · form4-01102025_050111.xml · nonDerivative · entry 2

Utter Christine Marie · CIK 0001707685 · SVP, CHIEF ACCOUNTING OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 64,321

F2 · shares: Represents shares automatically sold pursuant to irrevocable sell to cover elections entered into upon acceptance of the respective grants to satisfy tax withholding obligations in connection with the vesting of 2,175 RSUs from January 6, 2021 grants totaling 8,700 RSUs and the vesting of 2,900 RSUs from a January 7, 2022 grant of 11,600 RSUs.

SEC source: 0001415889-25-001294 · form4-01102025_050109.xml · nonDerivative · entry 2

Pauwels Eric · CIK 0001323212 · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 86,805

F2 · shares: Represents shares automatically sold pursuant to irrevocable sell to cover elections entered into upon acceptance of the respective grants to satisfy tax withholding obligations in connection with the vesting of 2,550 RSUs from a January 6, 2021 grant of 10,200 RSUs and the vesting of 4,200 RSUs from a January 7, 2022 grant of 16,800 RSUs.

SEC source: 0001415889-25-001293 · form4-01102025_050107.xml · nonDerivative · entry 2

Klein Matthew B. · CIK 0001808968 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 283,830

F2 · shares: Represents shares automatically sold pursuant to irrevocable sell to cover elections entered into upon acceptance of the respective grants to satisfy tax withholding obligations in connection with the vesting of 2,250 RSUs from a January 6, 2021 grant of 9,000 RSUs and the vesting of 15,250 RSUs from January 7, 2022 grants totaling 41,000 RSUs.

SEC source: 0001415889-25-001292 · form4-01102025_050105.xml · nonDerivative · entry 2

Golden Lee Scott · CIK 0001686217 · EVP & CHIEF MEDICAL OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 78,651

F2 · shares: Represents shares automatically sold pursuant to irrevocable sell to cover elections entered into upon acceptance of the respective grants to satisfy tax withholding obligations in connection with the vesting of 990 RSUs from a January 6, 2021 grant of 3,960 RSUs and the vesting of 3,539 RSUs from January 7, 2022 grants totaling 14,155 RSUs.

SEC source: 0001415889-25-001291 · form4-01102025_050103.xml · nonDerivative · entry 2

Boulding Mark Elliott · CIK 0001578852 · EXEC. VP AND CLO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 106,848

F2 · shares: Represents shares automatically sold pursuant to irrevocable sell to cover elections entered into upon acceptance of the respective grants to satisfy tax withholding obligations in connection with the vesting of 2,550 RSUs from a January 6, 2021 grant of 10,200 RSUs and the vesting of 3,600 RSUs from a January 7, 2022 grant of 14,400 RSUs.

SEC source: 0001415889-25-001290 · form4-01102025_050101.xml · nonDerivative · entry 4

Almstead Neil Gregory · CIK 0001578850 · CHIEF TECHNICAL OPS OFFICER

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 5,975

F4 · shares: Represents shares automatically sold pursuant to irrevocable sell to cover elections entered into upon acceptance of the respective grants to satisfy tax withholding obligations in connection with the vesting of 150 RSUs from a January 6, 2021 grant of 600 RSUs and the vesting of 195 RSUs from a January 7, 2022 grant of 780 RSUs.