PRTA

SEC source: 0001567619-22-019408 · doc1.xml · nonDerivative · entry 2

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,733

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $54.29 to $55.195, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 4 of this Form 4.

SEC source: 0001567619-22-019408 · doc1.xml · nonDerivative · entry 1

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,219

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-22-039910 · form4.xml · derivative · entry 4

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 226,000

Underlying: Ordinary Shares · 4,000 shares

Expires 2031-04-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on April 5, 2022, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-22-039910 · form4.xml · nonDerivative · entry 3

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $62.22 to $62.59, inclusive.

SEC source: 0001140361-22-039910 · form4.xml · nonDerivative · entry 2

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 511

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $61.21 to $62.20, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnotes 2 through 3 of this Form 4.

SEC source: 0001140361-22-039910 · form4.xml · nonDerivative · entry 1

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-22-039911 · form4.xml · derivative · entry 6

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,668

Underlying: Ordinary Shares · 15,833 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately three months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

SEC source: 0001140361-22-039911 · form4.xml · nonDerivative · entry 5

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 243

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F5 · price: The transaction was executed in multiple trades in prices ranging from $64.86 to $65.16, inclusive.

SEC source: 0001140361-22-039911 · form4.xml · nonDerivative · entry 4

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,904

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $63.83 to $64.815, inclusive.

SEC source: 0001140361-22-039911 · form4.xml · nonDerivative · entry 3

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,216

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $62.57 to $63.27, inclusive.

SEC source: 0001140361-22-039911 · form4.xml · nonDerivative · entry 2

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,933

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $61.56 to $62.54, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnotes 2 through 5 of this Form 4.

SEC source: 0001140361-22-039911 · form4.xml · nonDerivative · entry 1

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,076

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-018925 · doc1.xml · derivative · entry 8

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 145,000

Underlying: Ordinary Shares · 20,000 shares

Expires 2029-07-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on July 1, 2020, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001567619-22-018925 · doc1.xml · nonDerivative · entry 6

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F5 · price: The transaction was executed in multiple trades in prices ranging from $62.00 to $62.06, inclusive.

SEC source: 0001567619-22-018925 · doc1.xml · nonDerivative · entry 5

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-018925 · doc1.xml · derivative · entry 7

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 165,000

Underlying: Ordinary Shares · 65,000 shares

Expires 2029-07-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on July 1, 2020, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001567619-22-018925 · doc1.xml · nonDerivative · entry 4

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $60.815 to $61.49, inclusive.

SEC source: 0001567619-22-018925 · doc1.xml · nonDerivative · entry 3

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,720

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $59.785 to $60.775, inclusive.

SEC source: 0001567619-22-018925 · doc1.xml · nonDerivative · entry 2

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,292

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $58.785 to $59.78, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnotes 2 through 5 of this Form 4.

SEC source: 0001567619-22-018925 · doc1.xml · nonDerivative · entry 1

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-018818 · doc1.xml · derivative · entry 6

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 65,481

Underlying: Ordinary Shares · 20,000 shares

Expires 2028-06-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on June 21, 2019, and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001567619-22-018818 · doc1.xml · nonDerivative · entry 5

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F5 · price: The transaction was executed in multiple trades in prices ranging from $58.88 to $59.085, inclusive.

SEC source: 0001567619-22-018818 · doc1.xml · nonDerivative · entry 4

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,164

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $57.865 to $58.81, inclusive.

SEC source: 0001567619-22-018818 · doc1.xml · nonDerivative · entry 3

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,949

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $56.86 to $57.85, inclusive.

SEC source: 0001567619-22-018818 · doc1.xml · nonDerivative · entry 2

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,093

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $55.855 to $56.73, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnotes 2 through 5 of this Form 4.

SEC source: 0001567619-22-018818 · doc1.xml · nonDerivative · entry 1

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-018716 · doc1.xml · derivative · entry 6

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Ordinary Shares · 10,000 shares

Expires 2023-03-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option was granted on April 1, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately five months and be forfeited to the extent it is not exercised on or prior to March 31, 2023.

F7 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 903,837 shares at exercise prices ranging from $6.73 to $32.45, of which 721,003 are currently exercisable, and 182,834 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award. Certain of these options are subject to the Court Order.

SEC source: 0001567619-22-018716 · doc1.xml · nonDerivative · entry 5

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,200

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and proposed order regarding the separation of assets ("Court Order") in anticipation of a potential divorce settlement agreement.

F5 · price: The transaction was executed in multiple trades in prices ranging from $58.05 to $58.20, inclusive.

SEC source: 0001567619-22-018716 · doc1.xml · nonDerivative · entry 4

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,371

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and proposed order regarding the separation of assets ("Court Order") in anticipation of a potential divorce settlement agreement.

F4 · price: The transaction was executed in multiple trades in prices ranging from $56.84 to $57.72, inclusive.

SEC source: 0001567619-22-018716 · doc1.xml · nonDerivative · entry 3

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,912

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and proposed order regarding the separation of assets ("Court Order") in anticipation of a potential divorce settlement agreement.

F3 · price: The transaction was executed in multiple trades in prices ranging from $55.805 to $56.77, inclusive.

SEC source: 0001567619-22-018716 · doc1.xml · nonDerivative · entry 2

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,432

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and proposed order regarding the separation of assets ("Court Order") in anticipation of a potential divorce settlement agreement.

F2 · price: The transaction was executed in multiple trades in prices ranging from $54.78 to $55.765, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnotes 2 through 5 of this Form 4.

SEC source: 0001567619-22-018716 · doc1.xml · nonDerivative · entry 1

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,200

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-018466 · doc1.xml · derivative · entry 4

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 5,000 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately four months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

F4 · derivative.expiration_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately four months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

SEC source: 0001567619-22-018466 · doc1.xml · nonDerivative · entry 3

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $56.01 to $56.96, inclusive.

SEC source: 0001567619-22-018466 · doc1.xml · nonDerivative · entry 2

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,676

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $54.855 to $55.85, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 and 3 of this Form 4.

SEC source: 0001567619-22-018466 · doc1.xml · nonDerivative · entry 1

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-018377 · doc1.xml · derivative · entry 6

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 5,000 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately four months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

F6 · derivative.expiration_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately four months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

SEC source: 0001567619-22-018377 · doc1.xml · nonDerivative · entry 5

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,219

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F5 · price: The transaction was executed in multiple trades in prices ranging from $59.90 to $60.00, inclusive.

SEC source: 0001567619-22-018377 · doc1.xml · nonDerivative · entry 4

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,573

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $58.585 to $59.30, inclusive.

SEC source: 0001567619-22-018377 · doc1.xml · nonDerivative · entry 3

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,925

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $57.53 to $58.48, inclusive.

SEC source: 0001567619-22-018377 · doc1.xml · nonDerivative · entry 2

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,329

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $56.37 to $56.87, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 5 of this Form 4.

SEC source: 0001567619-22-018377 · doc1.xml · nonDerivative · entry 1

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,219

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-018292 · doc1.xml · derivative · entry 3

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 230,000

Underlying: Ordinary Shares · 4,000 shares

Expires 2031-04-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on April 5, 2022 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001567619-22-018292 · doc1.xml · nonDerivative · entry 2

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001567619-22-018292 · doc1.xml · nonDerivative · entry 1

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-018291 · doc1.xml · derivative · entry 6

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,501

Underlying: Ordinary Shares · 15,833 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately four months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

SEC source: 0001567619-22-018291 · doc1.xml · nonDerivative · entry 5

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 243

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F5 · price: The transaction was executed in multiple trades in prices ranging from $62.66 to $63.47, inclusive.

SEC source: 0001567619-22-018291 · doc1.xml · nonDerivative · entry 4

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,936

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $61.61 to $62.47, inclusive.

SEC source: 0001567619-22-018291 · doc1.xml · nonDerivative · entry 3

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,291

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $60.60 to $61.59, inclusive.

SEC source: 0001567619-22-018291 · doc1.xml · nonDerivative · entry 2

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,568

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $59.60 to $60.59, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnotes 2 through 5 of this Form 4.