PRTA

SEC source: 0001567619-22-018291 · doc1.xml · nonDerivative · entry 1

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,076

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-22-035562 · form4.xml · derivative · entry 3

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Ordinary Shares · 25,000 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately four months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

F2 · derivative.expiration_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately four months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

SEC source: 0001140361-22-035562 · form4.xml · nonDerivative · entry 2

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,219

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001140361-22-035562 · form4.xml · nonDerivative · entry 1

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,219

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-22-035561 · form4.xml · derivative · entry 3

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,334

Underlying: Ordinary Shares · 31,666 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The shares underlying the option are fully vested exercisable as of the date hereof.

SEC source: 0001140361-22-035561 · form4.xml · nonDerivative · entry 2

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 243

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001140361-22-035561 · form4.xml · nonDerivative · entry 1

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,909

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-22-035563 · form4.xml · derivative · entry 3

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Ordinary Shares · 10,000 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately four months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

F2 · derivative.expiration_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately four months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

SEC source: 0001140361-22-035563 · form4.xml · nonDerivative · entry 2

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001140361-22-035563 · form4.xml · nonDerivative · entry 1

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-22-035564 · form4.xml · derivative · entry 12

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 16,412 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F9 · derivative.exercise_date: The option was granted on January 29, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately four months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

F10 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 2,004,700 shares at exercise prices ranging from $12.15 to $32.45, of which 1,507,303 are currently exercisable, and 497,397 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award.

SEC source: 0001140361-22-035564 · form4.xml · nonDerivative · entry 11

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,793

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001140361-22-035564 · form4.xml · nonDerivative · entry 10

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,922

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F8 · price: The transaction was executed in multiple trades in prices ranging from $57.37 to $58.08, inclusive.

SEC source: 0001140361-22-035564 · form4.xml · nonDerivative · entry 9

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,165

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F7 · price: The transaction was executed in multiple trades in prices ranging from $56.115 to $56.34, inclusive.

SEC source: 0001140361-22-035564 · form4.xml · nonDerivative · entry 8

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,205

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F6 · price: The transaction was executed in multiple trades in prices ranging from $54.995 to $55.94, inclusive.

SEC source: 0001140361-22-035564 · form4.xml · nonDerivative · entry 7

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,547

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F5 · price: The transaction was executed in multiple trades in prices ranging from $53.96 to $54.91, inclusive.

SEC source: 0001140361-22-035564 · form4.xml · nonDerivative · entry 6

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,295

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $52.96 to $53.92, inclusive.

SEC source: 0001140361-22-035564 · form4.xml · nonDerivative · entry 5

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,147

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $51.95 to $52.93, inclusive.

SEC source: 0001140361-22-035564 · form4.xml · nonDerivative · entry 4

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,480

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $50.84 to $51.785, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in footnotes 2 through 8 of this Form 4.

SEC source: 0001140361-22-035564 · form4.xml · nonDerivative · entry 3

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,032

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001140361-22-035564 · form4.xml · nonDerivative · entry 2

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,160

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001140361-22-035564 · form4.xml · nonDerivative · entry 1

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,205

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-22-034587 · form4.xml · derivative · entry 3

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Ordinary Shares · 10,000 shares

Expires 2023-03-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option was granted on April 1, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately six months and be forfeited to the extent it is not exercised on or prior to March 31, 2023.

F4 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 913,837 shares at exercise prices ranging from $6.73 to $32.45, of which 725,087 are currently exercisable, and 188,750 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award. Certain of these options are subject to the Court Order.

SEC source: 0001140361-22-034587 · form4.xml · nonDerivative · entry 2

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,200

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and proposed order regarding the separation of assets ("Court Order") in anticipation of a potential divorce settlement agreement.

F2 · price: The transaction was executed in multiple trades in prices ranging from $30.47 to $30.875, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001140361-22-034587 · form4.xml · nonDerivative · entry 1

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,200

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-22-034588 · form4.xml · derivative · entry 3

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,412

Underlying: Ordinary Shares · 2,720 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option was granted on January 29, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately four months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

F4 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 2,021,112 shares at exercise prices ranging from $6.41 to $32.45, of which 1,509,237 are currently exercisable, and 511,875 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award.

SEC source: 0001140361-22-034588 · form4.xml · nonDerivative · entry 2

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,793

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $32.00 to $32.11, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001140361-22-034588 · form4.xml · nonDerivative · entry 1

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,513

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-017567 · doc1.xml · derivative · entry 3

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 234,000

Underlying: Ordinary Shares · 4,000 shares

Expires 2031-04-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on April 5, 2022 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001567619-22-017567 · doc1.xml · nonDerivative · entry 2

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001567619-22-017567 · doc1.xml · nonDerivative · entry 1

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-017016 · doc1.xml · derivative · entry 1

Kim Helen Susan · CIK 0001422772 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Ordinary Shares · 30,000 shares

Expires 2032-08-31

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 33 and 1/3% of the total number of shares subject to the option on the first anniversary of the grant date, 33 and 1/3% on the second anniversary of the grant date, and the remaining 33 and 1/3% on the earlier of the third anniversary of the grant date or the day of the annual general meeting in 2025 of the Issuer's shareholders, assuming continuous services as a director until each such vesting date.

SEC source: 0001567619-22-016737 · doc1.xml · derivative · entry 3

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Ordinary Shares · 10,000 shares

Expires 2023-03-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option was granted on April 1, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately seven months and be forfeited to the extent it is not exercised on or prior to March 31, 2023.

F4 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 923,837 shares at exercise prices ranging from $6.73 to $32.45, of which 733,107 are currently exercisable, and 190,730 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award. Certain of these options are subject to the Court Order.

SEC source: 0001567619-22-016737 · doc1.xml · nonDerivative · entry 2

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,200

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and proposed order regarding the separation of assets ("Court Order") in anticipation of a potential divorce settlement agreement.

F2 · price: The transaction was executed in multiple trades in prices ranging from $29.71 to $30.70, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-22-016737 · doc1.xml · nonDerivative · entry 1

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,200

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-016512 · doc1.xml · derivative · entry 3

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,132

Underlying: Ordinary Shares · 2,181 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option was granted on January 29, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately six months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

F4 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 2,023,832 shares at exercise prices ranging from $6.41 to $32.45, of which 1,497,476 are currently exercisable, and 526,356 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award.

SEC source: 0001567619-22-016512 · doc1.xml · nonDerivative · entry 2

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,793

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $32.00 to $32.09, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-22-016512 · doc1.xml · nonDerivative · entry 1

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,974

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-22-029517 · form4.xml · derivative · entry 9

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,313

Underlying: Ordinary Shares · 20,284 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The option was granted on January 29, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately six months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

F6 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 2,026,013 shares at exercises prices ranging from $6.41 to $32.45, of which 1,499,657 are currently exercisable, and 526,356 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award.

SEC source: 0001140361-22-029517 · form4.xml · nonDerivative · entry 6

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,793

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $32.00 to $32.35, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001140361-22-029517 · form4.xml · nonDerivative · entry 5

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,077

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-22-029517 · form4.xml · derivative · entry 8

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,597

Underlying: Ordinary Shares · 13,650 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The option was granted on January 29, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately six months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

SEC source: 0001140361-22-029517 · form4.xml · nonDerivative · entry 4

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,793

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $32.00 to $32.325, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001140361-22-029517 · form4.xml · nonDerivative · entry 3

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,443

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-22-029517 · form4.xml · derivative · entry 7

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,247

Underlying: Ordinary Shares · 991 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The option was granted on January 29, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately six months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

SEC source: 0001140361-22-029517 · form4.xml · nonDerivative · entry 2

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,793

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $32.00 to $32.06, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001140361-22-029517 · form4.xml · nonDerivative · entry 1

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,784

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-015086 · doc1.xml · derivative · entry 7

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,238

Underlying: Ordinary Shares · 21,506 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option was granted on January 29, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately six months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

F6 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 2,060,938 shares at exercises prices ranging from $6.41 to $32.45, of which 1,529,478 are currently exercisable, and 531,460 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award.

SEC source: 0001567619-22-015086 · doc1.xml · nonDerivative · entry 5

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,793

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F5 · price: The transaction was executed in multiple trades in prices ranging from $33.00 to $33.14, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-22-015086 · doc1.xml · nonDerivative · entry 4

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,466

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $32.00 to $32.99, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.