PRPO

SEC source: 0001140361-17-027006 · doc1.xml · derivative · entry 8

KIRK RANDAL J · CIK 0001091823 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · by Senior Staff 2008

Disclosed balance after: 141,052

Underlying: Common Stock · 141,052 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: In connection with the merger between Transgenomic, Inc. and Precipio Diagnostics, LLC, effective June 29, 2017 (the "Merger"), the Convertible Promissory Notes (the "Notes") held by Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010") and Third Security Incentive 2010 LLC ("Incentive 2010"), in the principal amount of $7.243 million, plus $1.026 million of accrued interest, became convertible and were converted into 352,630 shares of common stock of the issuer and 802,925 shares of Series A Senior Convertible Preferred Stock ("New Preferred Stock") of the issuer, with each entity receiving the respective number of shares set forth in Table II. The maturity date of the Notes was November 1, 2017.

F1 · price: In connection with the merger between Transgenomic, Inc. and Precipio Diagnostics, LLC, effective June 29, 2017 (the "Merger"), the Convertible Promissory Notes (the "Notes") held by Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010") and Third Security Incentive 2010 LLC ("Incentive 2010"), in the principal amount of $7.243 million, plus $1.026 million of accrued interest, became convertible and were converted into 352,630 shares of common stock of the issuer and 802,925 shares of Series A Senior Convertible Preferred Stock ("New Preferred Stock") of the issuer, with each entity receiving the respective number of shares set forth in Table II. The maturity date of the Notes was November 1, 2017.

F1 · derivative.exercise_date: In connection with the merger between Transgenomic, Inc. and Precipio Diagnostics, LLC, effective June 29, 2017 (the "Merger"), the Convertible Promissory Notes (the "Notes") held by Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010") and Third Security Incentive 2010 LLC ("Incentive 2010"), in the principal amount of $7.243 million, plus $1.026 million of accrued interest, became convertible and were converted into 352,630 shares of common stock of the issuer and 802,925 shares of Series A Senior Convertible Preferred Stock ("New Preferred Stock") of the issuer, with each entity receiving the respective number of shares set forth in Table II. The maturity date of the Notes was November 1, 2017.

F1 · derivative.expiration_date: In connection with the merger between Transgenomic, Inc. and Precipio Diagnostics, LLC, effective June 29, 2017 (the "Merger"), the Convertible Promissory Notes (the "Notes") held by Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010") and Third Security Incentive 2010 LLC ("Incentive 2010"), in the principal amount of $7.243 million, plus $1.026 million of accrued interest, became convertible and were converted into 352,630 shares of common stock of the issuer and 802,925 shares of Series A Senior Convertible Preferred Stock ("New Preferred Stock") of the issuer, with each entity receiving the respective number of shares set forth in Table II. The maturity date of the Notes was November 1, 2017.

F1 · derivative.underlying_shares: In connection with the merger between Transgenomic, Inc. and Precipio Diagnostics, LLC, effective June 29, 2017 (the "Merger"), the Convertible Promissory Notes (the "Notes") held by Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010") and Third Security Incentive 2010 LLC ("Incentive 2010"), in the principal amount of $7.243 million, plus $1.026 million of accrued interest, became convertible and were converted into 352,630 shares of common stock of the issuer and 802,925 shares of Series A Senior Convertible Preferred Stock ("New Preferred Stock") of the issuer, with each entity receiving the respective number of shares set forth in Table II. The maturity date of the Notes was November 1, 2017.

F1 · balance_after: In connection with the merger between Transgenomic, Inc. and Precipio Diagnostics, LLC, effective June 29, 2017 (the "Merger"), the Convertible Promissory Notes (the "Notes") held by Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010") and Third Security Incentive 2010 LLC ("Incentive 2010"), in the principal amount of $7.243 million, plus $1.026 million of accrued interest, became convertible and were converted into 352,630 shares of common stock of the issuer and 802,925 shares of Series A Senior Convertible Preferred Stock ("New Preferred Stock") of the issuer, with each entity receiving the respective number of shares set forth in Table II. The maturity date of the Notes was November 1, 2017.

F5 · ownership.nature: Randal J. Kirk controls each of Senior Staff 2008, Staff 2010, Incentive 2010 and Staff 2014. Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001140361-17-027006 · doc1.xml · nonDerivative · entry 7

KIRK RANDAL J · CIK 0001091823 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · by Staff 2014

Disclosed balance after: 27,651

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: In connection with the Merger, the indicated shares represent the number of shares received upon conversion of the issuer's Series A-1 Convertible Preferred Stock into shares of common stock, on a 1-for-1 basis. The Shares of Series A-1 Convertible Preferred Stock were immediately exercisable and had no expiration date.

F4 · balance_after: The indicated number of common shares is reflective of a 1-for-30 reverse stock split effected by the issuer on June 13, 2017.

F5 · ownership.nature: Randal J. Kirk controls each of Senior Staff 2008, Staff 2010, Incentive 2010 and Staff 2014. Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001140361-17-027006 · doc1.xml · nonDerivative · entry 6

KIRK RANDAL J · CIK 0001091823 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · by Incentive 2010

Disclosed balance after: 109,128

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: In connection with the Merger, the indicated shares represent the number of shares received upon conversion of the issuer's Series A-1 Convertible Preferred Stock into shares of common stock, on a 1-for-1 basis. The Shares of Series A-1 Convertible Preferred Stock were immediately exercisable and had no expiration date.

F5 · ownership.nature: Randal J. Kirk controls each of Senior Staff 2008, Staff 2010, Incentive 2010 and Staff 2014. Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001140361-17-027006 · doc1.xml · nonDerivative · entry 5

KIRK RANDAL J · CIK 0001091823 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · by Incentive 2010

Disclosed balance after: 107,697

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: In connection with the merger between Transgenomic, Inc. and Precipio Diagnostics, LLC, effective June 29, 2017 (the "Merger"), the Convertible Promissory Notes (the "Notes") held by Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010") and Third Security Incentive 2010 LLC ("Incentive 2010"), in the principal amount of $7.243 million, plus $1.026 million of accrued interest, became convertible and were converted into 352,630 shares of common stock of the issuer and 802,925 shares of Series A Senior Convertible Preferred Stock ("New Preferred Stock") of the issuer, with each entity receiving the respective number of shares set forth in Table II. The maturity date of the Notes was November 1, 2017.

F4 · balance_after: The indicated number of common shares is reflective of a 1-for-30 reverse stock split effected by the issuer on June 13, 2017.

F5 · ownership.nature: Randal J. Kirk controls each of Senior Staff 2008, Staff 2010, Incentive 2010 and Staff 2014. Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001140361-17-027006 · doc1.xml · nonDerivative · entry 4

KIRK RANDAL J · CIK 0001091823 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · by Staff 2010

Disclosed balance after: 190,604

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: In connection with the Merger, the indicated shares represent the number of shares received upon conversion of the issuer's Series A-1 Convertible Preferred Stock into shares of common stock, on a 1-for-1 basis. The Shares of Series A-1 Convertible Preferred Stock were immediately exercisable and had no expiration date.

F5 · ownership.nature: Randal J. Kirk controls each of Senior Staff 2008, Staff 2010, Incentive 2010 and Staff 2014. Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001140361-17-027006 · doc1.xml · nonDerivative · entry 3

KIRK RANDAL J · CIK 0001091823 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · by Staff 2010

Disclosed balance after: 189,173

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: In connection with the merger between Transgenomic, Inc. and Precipio Diagnostics, LLC, effective June 29, 2017 (the "Merger"), the Convertible Promissory Notes (the "Notes") held by Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010") and Third Security Incentive 2010 LLC ("Incentive 2010"), in the principal amount of $7.243 million, plus $1.026 million of accrued interest, became convertible and were converted into 352,630 shares of common stock of the issuer and 802,925 shares of Series A Senior Convertible Preferred Stock ("New Preferred Stock") of the issuer, with each entity receiving the respective number of shares set forth in Table II. The maturity date of the Notes was November 1, 2017.

F4 · balance_after: The indicated number of common shares is reflective of a 1-for-30 reverse stock split effected by the issuer on June 13, 2017.

F5 · ownership.nature: Randal J. Kirk controls each of Senior Staff 2008, Staff 2010, Incentive 2010 and Staff 2014. Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001140361-17-027006 · doc1.xml · nonDerivative · entry 2

KIRK RANDAL J · CIK 0001091823 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · by Senior Staff 2008

Disclosed balance after: 218,256

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: In connection with the Merger, the indicated shares represent the number of shares received upon conversion of the issuer's Series A-1 Convertible Preferred Stock into shares of common stock, on a 1-for-1 basis. The Shares of Series A-1 Convertible Preferred Stock were immediately exercisable and had no expiration date.

F5 · ownership.nature: Randal J. Kirk controls each of Senior Staff 2008, Staff 2010, Incentive 2010 and Staff 2014. Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001140361-17-027006 · doc1.xml · nonDerivative · entry 1

KIRK RANDAL J · CIK 0001091823 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · by Senior Staff 2008

Disclosed balance after: 215,394

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: In connection with the merger between Transgenomic, Inc. and Precipio Diagnostics, LLC, effective June 29, 2017 (the "Merger"), the Convertible Promissory Notes (the "Notes") held by Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010") and Third Security Incentive 2010 LLC ("Incentive 2010"), in the principal amount of $7.243 million, plus $1.026 million of accrued interest, became convertible and were converted into 352,630 shares of common stock of the issuer and 802,925 shares of Series A Senior Convertible Preferred Stock ("New Preferred Stock") of the issuer, with each entity receiving the respective number of shares set forth in Table II. The maturity date of the Notes was November 1, 2017.

F4 · balance_after: The indicated number of common shares is reflective of a 1-for-30 reverse stock split effected by the issuer on June 13, 2017.

F5 · ownership.nature: Randal J. Kirk controls each of Senior Staff 2008, Staff 2010, Incentive 2010 and Staff 2014. Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001144204-17-035508 · v470281_4.xml · derivative · entry 10

Rimer Mark · CIK 0001709016 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Kuzven Precipio Investor LLC

Disclosed balance after: 263,332

Underlying: Common Stock · 263,332 shares

Expires 2017-12-31

F10 · derivative.exercise_price: Kuzven Precipio Investor LLC has the right to buy 263,332 shares of the Issuer's Common Stock for an aggregate purchase price of $1.00.

F6 · ownership.nature: The Reporting Person is a managing member of Kuzven Precipio Investor LLC.

SEC source: 0001144204-17-035508 · v470281_4.xml · derivative · entry 9

Rimer Mark · CIK 0001709016 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Chenies Investor LLC

Disclosed balance after: 2,500

Underlying: Common Stock · 2,500 shares

Expires 2022-06-29

F9 · derivative.exercise_price: If the Issuer completes a Qualified Financing (as defined in the Warrant to Purchase Common Stock), the exercise price will become the lower of (i) $7.50 or (ii) 110% of the per share offering price in such Qualified Financing, but in no event lower than $1.50 per share.

F1 · ownership.nature: The Reporting Person is a managing member of Chenies Investor LLC.

SEC source: 0001144204-17-035508 · v470281_4.xml · derivative · entry 8

Rimer Mark · CIK 0001709016 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Chenies Investor LLC

Disclosed balance after: 20,073

Underlying: Common Stock or Series A Senior Convertible Preferred Stock · 20,073 shares

Expires not disclosed

F8 · shares: The 8% Convertible Promissory Note (the "Chenies Note") was issued to Chenies Investor LLC on June 29, 2017 in the principal amount of $75,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Chenies Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Chenies Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Chenies Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Chenies Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock.

F8 · price: The 8% Convertible Promissory Note (the "Chenies Note") was issued to Chenies Investor LLC on June 29, 2017 in the principal amount of $75,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Chenies Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Chenies Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Chenies Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Chenies Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock.

F8 · derivative.exercise_date: The 8% Convertible Promissory Note (the "Chenies Note") was issued to Chenies Investor LLC on June 29, 2017 in the principal amount of $75,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Chenies Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Chenies Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Chenies Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Chenies Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock.

F8 · derivative.expiration_date: The 8% Convertible Promissory Note (the "Chenies Note") was issued to Chenies Investor LLC on June 29, 2017 in the principal amount of $75,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Chenies Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Chenies Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Chenies Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Chenies Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock.

F8 · derivative.underlying: The 8% Convertible Promissory Note (the "Chenies Note") was issued to Chenies Investor LLC on June 29, 2017 in the principal amount of $75,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Chenies Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Chenies Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Chenies Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Chenies Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock.

F8 · derivative.underlying_shares: The 8% Convertible Promissory Note (the "Chenies Note") was issued to Chenies Investor LLC on June 29, 2017 in the principal amount of $75,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Chenies Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Chenies Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Chenies Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Chenies Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock.

F8 · balance_after: The 8% Convertible Promissory Note (the "Chenies Note") was issued to Chenies Investor LLC on June 29, 2017 in the principal amount of $75,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Chenies Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Chenies Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Chenies Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Chenies Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock.

F1 · ownership.nature: The Reporting Person is a managing member of Chenies Investor LLC.

SEC source: 0001144204-17-035508 · v470281_4.xml · derivative · entry 7

Rimer Mark · CIK 0001709016 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Dominion Capital LLC

Disclosed balance after: 214,113

Underlying: Common Stock or Series A Senior Convertible Preferred Stock · 214,113 shares

Expires not disclosed

F7 · security: The 8% Convertible Promissory Note (the "Dominion Note") was issued to Dominion Capital LLC on June 29, 2017 in the principal amount of $800,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Dominion Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Dominion Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Dominion Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Dominion Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock. Kuzven Precipio Investor LLC has a call option on the Dominion Note.

F7 · shares: The 8% Convertible Promissory Note (the "Dominion Note") was issued to Dominion Capital LLC on June 29, 2017 in the principal amount of $800,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Dominion Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Dominion Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Dominion Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Dominion Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock. Kuzven Precipio Investor LLC has a call option on the Dominion Note.

F7 · price: The 8% Convertible Promissory Note (the "Dominion Note") was issued to Dominion Capital LLC on June 29, 2017 in the principal amount of $800,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Dominion Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Dominion Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Dominion Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Dominion Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock. Kuzven Precipio Investor LLC has a call option on the Dominion Note.

F7 · derivative.exercise_date: The 8% Convertible Promissory Note (the "Dominion Note") was issued to Dominion Capital LLC on June 29, 2017 in the principal amount of $800,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Dominion Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Dominion Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Dominion Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Dominion Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock. Kuzven Precipio Investor LLC has a call option on the Dominion Note.

F7 · derivative.expiration_date: The 8% Convertible Promissory Note (the "Dominion Note") was issued to Dominion Capital LLC on June 29, 2017 in the principal amount of $800,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Dominion Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Dominion Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Dominion Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Dominion Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock. Kuzven Precipio Investor LLC has a call option on the Dominion Note.

F7 · derivative.underlying: The 8% Convertible Promissory Note (the "Dominion Note") was issued to Dominion Capital LLC on June 29, 2017 in the principal amount of $800,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Dominion Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Dominion Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Dominion Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Dominion Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock. Kuzven Precipio Investor LLC has a call option on the Dominion Note.

F7 · derivative.underlying_shares: The 8% Convertible Promissory Note (the "Dominion Note") was issued to Dominion Capital LLC on June 29, 2017 in the principal amount of $800,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Dominion Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Dominion Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Dominion Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Dominion Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock. Kuzven Precipio Investor LLC has a call option on the Dominion Note.

F7 · balance_after: The 8% Convertible Promissory Note (the "Dominion Note") was issued to Dominion Capital LLC on June 29, 2017 in the principal amount of $800,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Dominion Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Dominion Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Dominion Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Dominion Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock. Kuzven Precipio Investor LLC has a call option on the Dominion Note.

F7 · ownership.nature: The 8% Convertible Promissory Note (the "Dominion Note") was issued to Dominion Capital LLC on June 29, 2017 in the principal amount of $800,000 and is payable upon the earlier to occur of (i) October 1, 2017 or (ii) the closing of a Qualified Offering (as defined in the Dominion Note) (such date, the "Maturity Date"). At any time after the Maturity Date, the Dominion Note together with any accrued interest is convertible into shares of Common Stock of the Issuer. If the Issuer does not complete a Qualified Financing by October 1, 2017, the holder may convert the outstanding principal and interest of the Dominion Note into shares of the Issuer's Series A Senior Convertible Preferred Stock. Upon the closing of a Qualified Financing, the outstanding principal and interest of the Dominion Note will automatically be converted into shares of the Issuer's Series A Senior Convertible Preferred Stock. Kuzven Precipio Investor LLC has a call option on the Dominion Note.

SEC source: 0001144204-17-035508 · v470281_4.xml · derivative · entry 6

Rimer Mark · CIK 0001709016 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Kuzven Precipio Investor LLC

Disclosed balance after: 91,420

Underlying: Common Stock · 91,420 shares

Expires 2022-06-29

F5 · shares: The Warrant to Purchase Common Stock is exercisable as to 22,857 shares of Common Stock of the Issuer upon grant and as to 68,572 shares of Common Stock of the Issuer upon Kuzven Precipio Investor LLC's performance of certain obligations as set forth in the Warrant to Purchase Common Stock.

F5 · derivative.exercise_date: The Warrant to Purchase Common Stock is exercisable as to 22,857 shares of Common Stock of the Issuer upon grant and as to 68,572 shares of Common Stock of the Issuer upon Kuzven Precipio Investor LLC's performance of certain obligations as set forth in the Warrant to Purchase Common Stock.

F5 · derivative.underlying_shares: The Warrant to Purchase Common Stock is exercisable as to 22,857 shares of Common Stock of the Issuer upon grant and as to 68,572 shares of Common Stock of the Issuer upon Kuzven Precipio Investor LLC's performance of certain obligations as set forth in the Warrant to Purchase Common Stock.

F5 · balance_after: The Warrant to Purchase Common Stock is exercisable as to 22,857 shares of Common Stock of the Issuer upon grant and as to 68,572 shares of Common Stock of the Issuer upon Kuzven Precipio Investor LLC's performance of certain obligations as set forth in the Warrant to Purchase Common Stock.

F6 · ownership.nature: The Reporting Person is a managing member of Kuzven Precipio Investor LLC.

SEC source: 0001144204-17-035508 · v470281_4.xml · derivative · entry 5

Rimer Mark · CIK 0001709016 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Chenies Management LLC

Disclosed balance after: 59,082

Underlying: Common Stock · 59,082 shares

Expires not disclosed

F4 · derivative.exercise_price: Each share of Series A Senior Convertible Preferred Stock is convertible into one share of Common Stock of the Issuer at any time and has no expiration date.

F4 · derivative.exercise_date: Each share of Series A Senior Convertible Preferred Stock is convertible into one share of Common Stock of the Issuer at any time and has no expiration date.

F4 · derivative.expiration_date: Each share of Series A Senior Convertible Preferred Stock is convertible into one share of Common Stock of the Issuer at any time and has no expiration date.

F2 · ownership.nature: The Reporting Person is a managing member of Chenies Management LLC.

SEC source: 0001144204-17-035508 · v470281_4.xml · derivative · entry 4

Rimer Mark · CIK 0001709016 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Chenies Investor LLC

Disclosed balance after: 174,829

Underlying: Common Stock · 174,829 shares

Expires not disclosed

F4 · derivative.exercise_price: Each share of Series A Senior Convertible Preferred Stock is convertible into one share of Common Stock of the Issuer at any time and has no expiration date.

F4 · derivative.exercise_date: Each share of Series A Senior Convertible Preferred Stock is convertible into one share of Common Stock of the Issuer at any time and has no expiration date.

F4 · derivative.expiration_date: Each share of Series A Senior Convertible Preferred Stock is convertible into one share of Common Stock of the Issuer at any time and has no expiration date.

F1 · ownership.nature: The Reporting Person is a managing member of Chenies Investor LLC.

SEC source: 0001144204-17-035508 · v470281_4.xml · nonDerivative · entry 3

Rimer Mark · CIK 0001709016 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Precipio Employee Holdings, LLC

Disclosed balance after: 4,179

F3 · ownership.nature: The Reporting Person holds units of Precipio Employee Holdings, LLC.

SEC source: 0001144204-17-035508 · v470281_4.xml · nonDerivative · entry 2

Rimer Mark · CIK 0001709016 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Chenies Management LLC

Disclosed balance after: 281,055

F2 · ownership.nature: The Reporting Person is a managing member of Chenies Management LLC.

SEC source: 0001144204-17-035508 · v470281_4.xml · nonDerivative · entry 1

Rimer Mark · CIK 0001709016 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Chenies Investor LLC

Disclosed balance after: 424,270

F1 · ownership.nature: The Reporting Person is a managing member of Chenies Investor LLC.

SEC source: 0001144204-17-035438 · v470243_4.xml · nonDerivative · entry 1

DANIELI ILAN · CIK 0001433130 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · By IDP Holdings LLC

Disclosed balance after: 169,714

F1 · ownership.nature: The Reporting Person is a manager and member of IDP Holdings, LLC.

SEC source: 0001140361-17-024726 · doc1.xml · nonDerivative · entry 4

KIRK RANDAL J · CIK 0001091823 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · by Staff 2014

Disclosed balance after: 786,613

F1 · kind: On April 7, 2017, Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010"), Third Security Incentive 2010 LLC ("Incentive 2010") and Third Security Staff 2014 LLC ("Staff 2014" and together with Senior Staff 2008, Staff 2010 and Incentive 2010, the "Investors") entered into a Call Option Agreement with BV Advisory Partners, LLC ("BVAP") (the "Agreement"). On June 8, 2017, BVAP exercised its option by payment of a $1.00 exercise price upon agreement by the Investors and BVAP that the conditions related to the transfer of an initial tranche of an aggregate of 1,975,000 shares of the issuer pursuant to the Agreement were satisfied.

F1 · price: On April 7, 2017, Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010"), Third Security Incentive 2010 LLC ("Incentive 2010") and Third Security Staff 2014 LLC ("Staff 2014" and together with Senior Staff 2008, Staff 2010 and Incentive 2010, the "Investors") entered into a Call Option Agreement with BV Advisory Partners, LLC ("BVAP") (the "Agreement"). On June 8, 2017, BVAP exercised its option by payment of a $1.00 exercise price upon agreement by the Investors and BVAP that the conditions related to the transfer of an initial tranche of an aggregate of 1,975,000 shares of the issuer pursuant to the Agreement were satisfied.

F2 · ownership.nature: Randal J. Kirk controls Third Security, LLC, which is the manager of each of Senior Staff 2008, Staff 2010, Incentive 2010 and Staff 2014. Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001140361-17-024726 · doc1.xml · nonDerivative · entry 3

KIRK RANDAL J · CIK 0001091823 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · by Incentive 2010

Disclosed balance after: 1,115,135

F1 · kind: On April 7, 2017, Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010"), Third Security Incentive 2010 LLC ("Incentive 2010") and Third Security Staff 2014 LLC ("Staff 2014" and together with Senior Staff 2008, Staff 2010 and Incentive 2010, the "Investors") entered into a Call Option Agreement with BV Advisory Partners, LLC ("BVAP") (the "Agreement"). On June 8, 2017, BVAP exercised its option by payment of a $1.00 exercise price upon agreement by the Investors and BVAP that the conditions related to the transfer of an initial tranche of an aggregate of 1,975,000 shares of the issuer pursuant to the Agreement were satisfied.

F1 · price: On April 7, 2017, Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010"), Third Security Incentive 2010 LLC ("Incentive 2010") and Third Security Staff 2014 LLC ("Staff 2014" and together with Senior Staff 2008, Staff 2010 and Incentive 2010, the "Investors") entered into a Call Option Agreement with BV Advisory Partners, LLC ("BVAP") (the "Agreement"). On June 8, 2017, BVAP exercised its option by payment of a $1.00 exercise price upon agreement by the Investors and BVAP that the conditions related to the transfer of an initial tranche of an aggregate of 1,975,000 shares of the issuer pursuant to the Agreement were satisfied.

F2 · ownership.nature: Randal J. Kirk controls Third Security, LLC, which is the manager of each of Senior Staff 2008, Staff 2010, Incentive 2010 and Staff 2014. Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001140361-17-024726 · doc1.xml · nonDerivative · entry 2

KIRK RANDAL J · CIK 0001091823 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · by Staff 2010

Disclosed balance after: 1,443,654

F1 · kind: On April 7, 2017, Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010"), Third Security Incentive 2010 LLC ("Incentive 2010") and Third Security Staff 2014 LLC ("Staff 2014" and together with Senior Staff 2008, Staff 2010 and Incentive 2010, the "Investors") entered into a Call Option Agreement with BV Advisory Partners, LLC ("BVAP") (the "Agreement"). On June 8, 2017, BVAP exercised its option by payment of a $1.00 exercise price upon agreement by the Investors and BVAP that the conditions related to the transfer of an initial tranche of an aggregate of 1,975,000 shares of the issuer pursuant to the Agreement were satisfied.

F1 · price: On April 7, 2017, Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010"), Third Security Incentive 2010 LLC ("Incentive 2010") and Third Security Staff 2014 LLC ("Staff 2014" and together with Senior Staff 2008, Staff 2010 and Incentive 2010, the "Investors") entered into a Call Option Agreement with BV Advisory Partners, LLC ("BVAP") (the "Agreement"). On June 8, 2017, BVAP exercised its option by payment of a $1.00 exercise price upon agreement by the Investors and BVAP that the conditions related to the transfer of an initial tranche of an aggregate of 1,975,000 shares of the issuer pursuant to the Agreement were satisfied.

F2 · ownership.nature: Randal J. Kirk controls Third Security, LLC, which is the manager of each of Senior Staff 2008, Staff 2010, Incentive 2010 and Staff 2014. Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001140361-17-024726 · doc1.xml · nonDerivative · entry 1

KIRK RANDAL J · CIK 0001091823 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · by Senior Staff 2008

Disclosed balance after: 2,230,267

F1 · kind: On April 7, 2017, Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010"), Third Security Incentive 2010 LLC ("Incentive 2010") and Third Security Staff 2014 LLC ("Staff 2014" and together with Senior Staff 2008, Staff 2010 and Incentive 2010, the "Investors") entered into a Call Option Agreement with BV Advisory Partners, LLC ("BVAP") (the "Agreement"). On June 8, 2017, BVAP exercised its option by payment of a $1.00 exercise price upon agreement by the Investors and BVAP that the conditions related to the transfer of an initial tranche of an aggregate of 1,975,000 shares of the issuer pursuant to the Agreement were satisfied.

F1 · price: On April 7, 2017, Third Security Senior Staff 2008 LLC ("Senior Staff 2008"), Third Security Staff 2010 LLC ("Staff 2010"), Third Security Incentive 2010 LLC ("Incentive 2010") and Third Security Staff 2014 LLC ("Staff 2014" and together with Senior Staff 2008, Staff 2010 and Incentive 2010, the "Investors") entered into a Call Option Agreement with BV Advisory Partners, LLC ("BVAP") (the "Agreement"). On June 8, 2017, BVAP exercised its option by payment of a $1.00 exercise price upon agreement by the Investors and BVAP that the conditions related to the transfer of an initial tranche of an aggregate of 1,975,000 shares of the issuer pursuant to the Agreement were satisfied.

F2 · ownership.nature: Randal J. Kirk controls Third Security, LLC, which is the manager of each of Senior Staff 2008, Staff 2010, Incentive 2010 and Staff 2014. Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

SEC source: 0001144204-16-139751 · v455081_form4a.xml · derivative · entry 1

Thomae Mya · CIK 0001644663 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2026-12-13

SEC source: 0001140361-16-089870 · doc1.xml · derivative · entry 1

Koppler Doit II · CIK 0001509511 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2026-12-13

F1 · security: This stock option was originally granted pursuant to the Company's 2006 Equity Incentive Plan, as amended (the "2006 Plan") on October 6, 2016 (the "Grant"). On December 13, 2016, the Board of Directors of the Company (the "Board") approved the 2016 Stock Option and Incentive Plan (the "2016 Plan") and recommended the 2016 Plan for approval by the Company's stockholders. The 2016 Plan is intended to serve as a successor to and replacement for the 2006 Plan. Also on December 13, 2016, the Board re-issued the Grant pursuant to the 2016 Plan, subject to the approval of the 2016 Plan by the Company's stockholders. This amended Form 4 reflects this re-issuance.

SEC source: 0001144204-16-139752 · v455082_form4a.xml · derivative · entry 1

Patzig Robert · CIK 0001509558 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,000

Underlying: Common Stock · 105,000 shares

Expires 2026-12-13

SEC source: 0001144204-16-139750 · v455080_form4-a.xml · derivative · entry 1

Luther Michael A · CIK 0001590078 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,000

Underlying: Common Stock · 5,000 shares

Expires 2016-12-13

SEC source: 0001144204-16-127744 · v450356_4.xml · derivative · entry 1

Luther Michael A · CIK 0001590078 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2026-10-06

SEC source: 0001144204-16-127752 · v450359_4.xml · derivative · entry 1

Patzig Robert · CIK 0001509558 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 105,000

Underlying: Common Stock · 105,000 shares

Expires 2026-10-06

SEC source: 0001144204-16-127745 · v450358_4.xml · derivative · entry 1

Thomae Mya · CIK 0001644663 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2026-10-06

SEC source: 0001140361-16-082480 · doc1.xml · derivative · entry 1

Koppler Doit II · CIK 0001509511 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires 2026-10-06