OKUR

SEC source: 0001209191-21-026823 · doc4.xml · nonDerivative · entry 2

Muralidhar Bali · CIK 0001784138 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Abingworth Bioventures 8 LP

Disclosed balance after: 1,858,226

F3 · kind: The shares were purchased in the Issuer's initial public offering.

F2 · ownership.nature: See Exhibit 99.1

SEC source: 0001209191-21-026823 · doc4.xml · nonDerivative · entry 1

Muralidhar Bali · CIK 0001784138 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Abingworth Bioventures 8 LP

Disclosed balance after: 1,658,226

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: All outstanding shares of Preferred Stock automatically converted into shares of Common Stock immediately prior to the closing of the Issuer's initial public offering, for no additional consideration at a rate of 1 share of Common Stock for each 4.4748 shares of Preferred Stock. The Preferred Stock had no expiration date.

F2 · ownership.nature: See Exhibit 99.1

SEC source: 0000899243-21-015634 · doc4.xml · derivative · entry 5

RiverVest Venture Fund III, L.P. · CIK 0001601559 · 10% owner

RiverVest Venture Fund III (Ohio), L.P. · CIK 0001636686 · 10% owner

RiverVest Venture Fund IV, L.P. · CIK 0001725443 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 829,113 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into 1 share of the Issuer's common stock for each 4.4748 shares of Preferred Stock upon the closing of the Issuer's initial public offering on April 9, 2021. The shares have no expiration date.

F1 · derivative.exercise_date: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into 1 share of the Issuer's common stock for each 4.4748 shares of Preferred Stock upon the closing of the Issuer's initial public offering on April 9, 2021. The shares have no expiration date.

F1 · derivative.expiration_date: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into 1 share of the Issuer's common stock for each 4.4748 shares of Preferred Stock upon the closing of the Issuer's initial public offering on April 9, 2021. The shares have no expiration date.

F5 · ownership.nature: Consists of shares held of record by RiverVest IV.

F6 · ownership.nature: The shares held by RiverVest IV are indirectly held by RiverVest Venture Partners IV, L.P., its general partner ("RiverVest Partners IV"). RiverVest Venture Partners IV, LLC is the general partner of RiverVest Partners IV. The individual managers of RiverVest Ventures Partners IV, LLC are Jay Schmelter, John P. McKearn, Ph.D. and Niall O'Donnell, a member of the Issuer's board of directors. RiverVest Partners IV, RiverVest Venture Partners IV, LLC and each of the individual managers share voting and dispositive power with regard to the Company's securities directly held by RiverVest IV.

SEC source: 0000899243-21-015634 · doc4.xml · derivative · entry 4

RiverVest Venture Fund III, L.P. · CIK 0001601559 · 10% owner

RiverVest Venture Fund III (Ohio), L.P. · CIK 0001636686 · 10% owner

RiverVest Venture Fund IV, L.P. · CIK 0001725443 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Common Stock · 1,100,765 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into 1 share of the Issuer's common stock for each 4.4748 shares of Preferred Stock upon the closing of the Issuer's initial public offering on April 9, 2021. The shares have no expiration date.

F1 · derivative.exercise_date: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into 1 share of the Issuer's common stock for each 4.4748 shares of Preferred Stock upon the closing of the Issuer's initial public offering on April 9, 2021. The shares have no expiration date.

F1 · derivative.expiration_date: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into 1 share of the Issuer's common stock for each 4.4748 shares of Preferred Stock upon the closing of the Issuer's initial public offering on April 9, 2021. The shares have no expiration date.

F2 · ownership.nature: Consists of shares held of record by (i) RiverVest Venture Fund III, L.P. ("RiverVest III"), (ii) RiverVest Venture Fund III (Ohio), L.P. ("RiverVest (Ohio) III"), and (iii) RiverVest Venture Fund IV, L.P ("RiverVest IV").

F3 · ownership.nature: The shares held by RiverVest III are indirectly held by RiverVest Venture Partners III, L.P. ("RiverVest Partners III"), which is the general partner of RiverVest III. The shares held by RiverVest (Ohio) III are indirectly held by RiverVest Venture Partners III (Ohio), LLC ("RiverVest Partners (Ohio) III"), which is the general partner of RiverVest (Ohio) III. RiverVest Partners III is the sole member of RiverVest Partners (Ohio) III. RiverVest Venture Partners III, LLC is the general partner of RiverVest Partners III.

F4 · ownership.nature: The individual managers of RiverVest Ventures Partners III, LLC are Thomas C. Melzer, Jay Schmelter and John P. McKearn, Ph.D. RiverVest Partners III, RiverVest Partners (Ohio) III, RiverVest Venture Partners III, LLC and each of the individual managers share voting and dispositive power with regard to the Issuer's securities directly held by RiverVest Venture Fund III, L.P. and RiverVest Venture Fund III (Ohio), L.P.

F5 · ownership.nature: Consists of shares held of record by RiverVest IV.

F6 · ownership.nature: The shares held by RiverVest IV are indirectly held by RiverVest Venture Partners IV, L.P., its general partner ("RiverVest Partners IV"). RiverVest Venture Partners IV, LLC is the general partner of RiverVest Partners IV. The individual managers of RiverVest Ventures Partners IV, LLC are Jay Schmelter, John P. McKearn, Ph.D. and Niall O'Donnell, a member of the Issuer's board of directors. RiverVest Partners IV, RiverVest Venture Partners IV, LLC and each of the individual managers share voting and dispositive power with regard to the Company's securities directly held by RiverVest IV.

SEC source: 0000899243-21-015634 · doc4.xml · nonDerivative · entry 3

RiverVest Venture Fund III, L.P. · CIK 0001601559 · 10% owner

RiverVest Venture Fund III (Ohio), L.P. · CIK 0001636686 · 10% owner

RiverVest Venture Fund IV, L.P. · CIK 0001725443 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,409,220

F7 · kind: RiverVest IV purchased the shares in the Issuer's initial public offering.

F7 · shares: RiverVest IV purchased the shares in the Issuer's initial public offering.

F8 · ownership.nature: The 2,409,220 shares consists of (i) 328,094 shares held of record by RiverVest III, (ii) 17,413 shares held of record by RiverVest (Ohio) III, and (iii) 2,063,713 shares held of record by RiverVest IV.

SEC source: 0000899243-21-015634 · doc4.xml · nonDerivative · entry 2

RiverVest Venture Fund III, L.P. · CIK 0001601559 · 10% owner

RiverVest Venture Fund III (Ohio), L.P. · CIK 0001636686 · 10% owner

RiverVest Venture Fund IV, L.P. · CIK 0001725443 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,209,220

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into 1 share of the Issuer's common stock for each 4.4748 shares of Preferred Stock upon the closing of the Issuer's initial public offering on April 9, 2021. The shares have no expiration date.

F5 · ownership.nature: Consists of shares held of record by RiverVest IV.

F6 · ownership.nature: The shares held by RiverVest IV are indirectly held by RiverVest Venture Partners IV, L.P., its general partner ("RiverVest Partners IV"). RiverVest Venture Partners IV, LLC is the general partner of RiverVest Partners IV. The individual managers of RiverVest Ventures Partners IV, LLC are Jay Schmelter, John P. McKearn, Ph.D. and Niall O'Donnell, a member of the Issuer's board of directors. RiverVest Partners IV, RiverVest Venture Partners IV, LLC and each of the individual managers share voting and dispositive power with regard to the Company's securities directly held by RiverVest IV.

SEC source: 0000899243-21-015634 · doc4.xml · nonDerivative · entry 1

RiverVest Venture Fund III, L.P. · CIK 0001601559 · 10% owner

RiverVest Venture Fund III (Ohio), L.P. · CIK 0001636686 · 10% owner

RiverVest Venture Fund IV, L.P. · CIK 0001725443 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 1,380,107

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into 1 share of the Issuer's common stock for each 4.4748 shares of Preferred Stock upon the closing of the Issuer's initial public offering on April 9, 2021. The shares have no expiration date.

F2 · ownership.nature: Consists of shares held of record by (i) RiverVest Venture Fund III, L.P. ("RiverVest III"), (ii) RiverVest Venture Fund III (Ohio), L.P. ("RiverVest (Ohio) III"), and (iii) RiverVest Venture Fund IV, L.P ("RiverVest IV").

F3 · ownership.nature: The shares held by RiverVest III are indirectly held by RiverVest Venture Partners III, L.P. ("RiverVest Partners III"), which is the general partner of RiverVest III. The shares held by RiverVest (Ohio) III are indirectly held by RiverVest Venture Partners III (Ohio), LLC ("RiverVest Partners (Ohio) III"), which is the general partner of RiverVest (Ohio) III. RiverVest Partners III is the sole member of RiverVest Partners (Ohio) III. RiverVest Venture Partners III, LLC is the general partner of RiverVest Partners III.

F4 · ownership.nature: The individual managers of RiverVest Ventures Partners III, LLC are Thomas C. Melzer, Jay Schmelter and John P. McKearn, Ph.D. RiverVest Partners III, RiverVest Partners (Ohio) III, RiverVest Venture Partners III, LLC and each of the individual managers share voting and dispositive power with regard to the Issuer's securities directly held by RiverVest Venture Fund III, L.P. and RiverVest Venture Fund III (Ohio), L.P.

F5 · ownership.nature: Consists of shares held of record by RiverVest IV.

F6 · ownership.nature: The shares held by RiverVest IV are indirectly held by RiverVest Venture Partners IV, L.P., its general partner ("RiverVest Partners IV"). RiverVest Venture Partners IV, LLC is the general partner of RiverVest Partners IV. The individual managers of RiverVest Ventures Partners IV, LLC are Jay Schmelter, John P. McKearn, Ph.D. and Niall O'Donnell, a member of the Issuer's board of directors. RiverVest Partners IV, RiverVest Venture Partners IV, LLC and each of the individual managers share voting and dispositive power with regard to the Company's securities directly held by RiverVest IV.

SEC source: 0001209191-21-026335 · doc4.xml · derivative · entry 1

Cardon Lon · CIK 0001854337 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Common Stock · 14,000 shares

Expires 2031-04-07

F1 · derivative.exercise_date: The shares subject to the option vest on April 8, 2022.

SEC source: 0001209191-21-026339 · doc4.xml · derivative · entry 1

Harrison Kenneth Ph.D. · CIK 0001852977 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Common Stock · 14,000 shares

Expires 2031-04-07

F1 · derivative.exercise_date: The shares subject to the option vest on April 8, 2022.

SEC source: 0001209191-21-026337 · doc4.xml · derivative · entry 1

GREY MICHAEL G · CIK 0001240122 · Director · Executive Chairman

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Common Stock · 14,000 shares

Expires 2031-04-07

F1 · derivative.exercise_date: The shares subject to the option vest on April 8, 2022.

SEC source: 0001209191-21-026343 · doc4.xml · derivative · entry 1

Mathers Edward T · CIK 0001328625 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Common Stock · 14,000 shares

Expires 2031-04-07

F1 · derivative.exercise_date: The shares subject to the option vest on April 8, 2022.

SEC source: 0001209191-21-026340 · doc4.xml · derivative · entry 1

O'Donnell Niall · CIK 0001780235 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Common Stock · 14,000 shares

Expires 2031-04-07

F1 · derivative.exercise_date: The shares subject to the option vest on April 8, 2022.

SEC source: 0001209191-21-026338 · doc4.xml · derivative · entry 1

Seltzer Stacey Denenberg · CIK 0001648895 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Common Stock · 14,000 shares

Expires 2031-04-07

F1 · derivative.exercise_date: The shares subject to the option vest on April 8, 2022.

SEC source: 0001209191-21-026336 · doc4.xml · derivative · entry 1

Muralidhar Bali · CIK 0001784138 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Common Stock · 14,000 shares

Expires 2031-04-07

F1 · derivative.exercise_date: The shares subject to the option vest on April 8, 2022.