OKUR

SEC source: 0001415889-24-024913 · form4-10082024_111039.xml · derivative · entry 1

GREY MICHAEL G · CIK 0001240122 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,300

Underlying: Class A Common Stock · 15,300 shares

Expires 2034-10-03

F1 · derivative.exercise_date: 1/36th of the shares subject to the option shall vest on November 4, 2024 and each month thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0000950170-24-113604 · ownership.xml · derivative · entry 1

Mathers Edward T · CIK 0001328625 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,300

Underlying: Class A Common Stock · 15,300 shares

Expires 2034-10-03

F1 · derivative.exercise_date: 1/36th of the shares subject to the option shall vest on November 4, 2024 and each month thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001415889-24-024921 · form4-10082024_111041.xml · derivative · entry 6

Saccomano Nicholas A · CIK 0001609284 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 542,232

Underlying: Class A Common Stock · 542,232 shares

Expires 2034-10-03

F7 · derivative.exercise_date: 1/36th of the shares subject to the option shall vest on November 4, 2024 and each month thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001415889-24-024921 · form4-10082024_111041.xml · derivative · entry 5

Saccomano Nicholas A · CIK 0001609284 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,449

Underlying: Class A Common Stock · 8,449 shares

Expires 2033-10-14

F4 · price: Each OnKure stock option that was outstanding immediately prior to the effective time of the Merger was assumed by Reneo and became an option to acquire, on the same terms and conditions as were applicable to such OnKure stock option immediately prior to the effective time of the Merger, a number of shares of Reneo Class A common stock equal to the number of shares of OnKure common stock subject to the unexercised portion of the OnKure stock option immediately prior to the effective time of the Merger, multiplied by a designated exchange ratio (rounded down to the nearest whole share). The exercise price per share for the options is equal to the exercise price per share of such OnKure stock option immediately prior to the effective time of the Merger divided by the exchange ratio (rounded up to the nearest whole cent).

F6 · derivative.exercise_date: All of the shares subject to this option are fully vested and exercisable as of the date hereof.

SEC source: 0001415889-24-024921 · form4-10082024_111041.xml · derivative · entry 4

Saccomano Nicholas A · CIK 0001609284 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,898

Underlying: Class A Common Stock · 16,898 shares

Expires 2033-10-14

F4 · price: Each OnKure stock option that was outstanding immediately prior to the effective time of the Merger was assumed by Reneo and became an option to acquire, on the same terms and conditions as were applicable to such OnKure stock option immediately prior to the effective time of the Merger, a number of shares of Reneo Class A common stock equal to the number of shares of OnKure common stock subject to the unexercised portion of the OnKure stock option immediately prior to the effective time of the Merger, multiplied by a designated exchange ratio (rounded down to the nearest whole share). The exercise price per share for the options is equal to the exercise price per share of such OnKure stock option immediately prior to the effective time of the Merger divided by the exchange ratio (rounded up to the nearest whole cent).

F6 · derivative.exercise_date: All of the shares subject to this option are fully vested and exercisable as of the date hereof.

SEC source: 0001415889-24-024921 · form4-10082024_111041.xml · derivative · entry 3

Saccomano Nicholas A · CIK 0001609284 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,485

Underlying: Class A Common Stock · 1,485 shares

Expires 2033-08-29

F4 · price: Each OnKure stock option that was outstanding immediately prior to the effective time of the Merger was assumed by Reneo and became an option to acquire, on the same terms and conditions as were applicable to such OnKure stock option immediately prior to the effective time of the Merger, a number of shares of Reneo Class A common stock equal to the number of shares of OnKure common stock subject to the unexercised portion of the OnKure stock option immediately prior to the effective time of the Merger, multiplied by a designated exchange ratio (rounded down to the nearest whole share). The exercise price per share for the options is equal to the exercise price per share of such OnKure stock option immediately prior to the effective time of the Merger divided by the exchange ratio (rounded up to the nearest whole cent).

F5 · derivative.exercise_date: 1/48th of the shares subject to the option vested on May 1, 2023 and 1/48th of the shares subject to the option vest monthly thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001415889-24-024921 · form4-10082024_111041.xml · derivative · entry 2

Saccomano Nicholas A · CIK 0001609284 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,359

Underlying: Class A Common Stock · 2,359 shares

Expires 2032-01-10

F4 · price: Each OnKure stock option that was outstanding immediately prior to the effective time of the Merger was assumed by Reneo and became an option to acquire, on the same terms and conditions as were applicable to such OnKure stock option immediately prior to the effective time of the Merger, a number of shares of Reneo Class A common stock equal to the number of shares of OnKure common stock subject to the unexercised portion of the OnKure stock option immediately prior to the effective time of the Merger, multiplied by a designated exchange ratio (rounded down to the nearest whole share). The exercise price per share for the options is equal to the exercise price per share of such OnKure stock option immediately prior to the effective time of the Merger divided by the exchange ratio (rounded up to the nearest whole cent).

F3 · derivative.exercise_date: 1/12th of the shares subject to the option vested on March 31, 2022 and 1/12th of the shares subject to the option vest on the last day of each quarter thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001415889-24-024921 · form4-10082024_111041.xml · nonDerivative · entry 1

Saccomano Nicholas A · CIK 0001609284 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,556

F1 · shares: These securities are restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Class A Common Stock upon the meeting of both a "Service-Based Requirement" and a "Liquidity Event Plus Service Requirement." 1/16th of the RSUs met the "Service-Based" requirement on June 20, 2023 and 1/16th of the RSUs are scheduled to meet the Service-Based Requirement on each three-month anniversary thereafter, subject to the Reporting Person continuing as a service provider through each such date. The Liquidity Event Plus Service Requirement will be satisfied on the 181st day following the closing of the Merger (as defined below), subject to the Reporting Person continuing as a service provider through such date. On October 4, 2024, the effective time of the Merger, each RSU of OnKure (as defined below) (footnote continued in footnote (2))

F2 · shares: (continued from footnote (1)) was assumed by, and converted into an RSU award of, Reneo (as defined below) covering such number of shares of Reneo Class A Common Stock determined by multiplying the number of shares of OnKure preferred stock subject to the RSU award by a designated exchange ratio (rounded down to the nearest whole share). The Agreement and Plan of Merger, dated as of May 10, 2024 (the "Merger Agreement"), by and among Reneo Pharmaceuticals, Inc. ("Reneo"), Radiate Merger Sub I, a wholly owned subsidiary of Reneo ("Merger Sub I"), and OnKure, Inc. ("OnKure"), provided for the merger of Merger Sub I with and into OnKure, with OnKure surviving the merger as a wholly-owned subsidiary of Reneo (the "Merger"). After completion of the Merger, the combined company was renamed "OnKure Therapeutics, Inc." and the Class A Common Stock of the combined company trades on The Nasdaq Stock Market under the symbol "OKUR."

F1 · price: These securities are restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Class A Common Stock upon the meeting of both a "Service-Based Requirement" and a "Liquidity Event Plus Service Requirement." 1/16th of the RSUs met the "Service-Based" requirement on June 20, 2023 and 1/16th of the RSUs are scheduled to meet the Service-Based Requirement on each three-month anniversary thereafter, subject to the Reporting Person continuing as a service provider through each such date. The Liquidity Event Plus Service Requirement will be satisfied on the 181st day following the closing of the Merger (as defined below), subject to the Reporting Person continuing as a service provider through such date. On October 4, 2024, the effective time of the Merger, each RSU of OnKure (as defined below) (footnote continued in footnote (2))

F2 · price: (continued from footnote (1)) was assumed by, and converted into an RSU award of, Reneo (as defined below) covering such number of shares of Reneo Class A Common Stock determined by multiplying the number of shares of OnKure preferred stock subject to the RSU award by a designated exchange ratio (rounded down to the nearest whole share). The Agreement and Plan of Merger, dated as of May 10, 2024 (the "Merger Agreement"), by and among Reneo Pharmaceuticals, Inc. ("Reneo"), Radiate Merger Sub I, a wholly owned subsidiary of Reneo ("Merger Sub I"), and OnKure, Inc. ("OnKure"), provided for the merger of Merger Sub I with and into OnKure, with OnKure surviving the merger as a wholly-owned subsidiary of Reneo (the "Merger"). After completion of the Merger, the combined company was renamed "OnKure Therapeutics, Inc." and the Class A Common Stock of the combined company trades on The Nasdaq Stock Market under the symbol "OKUR."

SEC source: 0001415889-24-024920 · form4-10082024_111029.xml · derivative · entry 1

Phillips Andrew John · CIK 0001921956 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,300

Underlying: Class A Common Stock · 15,300 shares

Expires 2034-10-03

F1 · derivative.exercise_date: 1/36th of the shares subject to the option shall vest on November 4, 2024 and each month thereafter, subject to the Reporting Person continuing as a service provider through each such date.

SEC source: 0001373604-24-000098 · form4.xml · nonDerivative · entry 2

Leonard Braden Michael · CIK 0001373603 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P.

Disclosed balance after: 3,457,395

F3 · price: Purchased in multiple transactions with a weighted average price of $1.4964. The reporting person will provide, upon request by the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares purchased at each separate price.

F1 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001373604-24-000098 · form4.xml · nonDerivative · entry 1

Leonard Braden Michael · CIK 0001373603 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P.

Disclosed balance after: 3,388,649

F2 · price: Purchased in multiple transactions with a weighted average price of $1.4144. The reporting person will provide, upon request by the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares purchased at each separate price.

F1 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001373604-24-000094 · form4.xml · nonDerivative · entry 2

Leonard Braden Michael · CIK 0001373603 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P.

Disclosed balance after: 3,359,049

F3 · price: Purchased in multiple transactions with a weighted average price of $1.40. The reporting person will provide, upon request by the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares purchased at each separate price.

F1 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001373604-24-000094 · form4.xml · nonDerivative · entry 1

Leonard Braden Michael · CIK 0001373603 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P.

Disclosed balance after: 3,358,243

F2 · price: Purchased in multiple transactions with a weighted average price of $1.3582. The reporting person will provide, upon request by the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares purchased at each separate price.

F1 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001373604-24-000090 · form4.xml · nonDerivative · entry 3

Leonard Braden Michael · CIK 0001373603 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P.

Disclosed balance after: 3,302,943

F4 · price: Purchased in multiple transactions with a weighted average price of $1.3712. The reporting person will provide, upon request by the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares purchased at each separate price.

F1 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001373604-24-000090 · form4.xml · nonDerivative · entry 2

Leonard Braden Michael · CIK 0001373603 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P.

Disclosed balance after: 3,130,196

F3 · price: Purchased in multiple transactions with a weighted average price of $1.313. The reporting person will provide, upon request by the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares purchased at each separate price.

F1 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001373604-24-000090 · form4.xml · nonDerivative · entry 1

Leonard Braden Michael · CIK 0001373603 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P.

Disclosed balance after: 2,980,196

F2 · price: Purchased in multiple transactions with a weighted average price of $1.3966. The reporting person will provide, upon request by the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares purchased at each separate price.

F1 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001373604-24-000071 · form4.xml · nonDerivative · entry 2

Leonard Braden Michael · CIK 0001373603 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P.

Disclosed balance after: 2,944,020

F3 · price: Purchased in multiple transactions with a weighted average price of $1.4132. The reporting person will provide, upon request by the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range.

F1 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001373604-24-000071 · form4.xml · nonDerivative · entry 1

Leonard Braden Michael · CIK 0001373603 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P.

Disclosed balance after: 2,843,533

F2 · price: Purchased in multiple transactions with a weighted average price of $1.3925. The reporting person will provide, upon request by the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range.

F1 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001373604-24-000028 · form4.xml · nonDerivative · entry 2

Leonard Braden Michael · CIK 0001373603 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P.

Disclosed balance after: 2,672,194

F3 · price: Purchased in multiple transactions with a weighted average price of $1.54. The reporting person will provide, upon request by the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range.

F1 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001373604-24-000028 · form4.xml · nonDerivative · entry 1

Leonard Braden Michael · CIK 0001373603 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · Holding of BML Investment Partners, L.P.

Disclosed balance after: 2,337,194

F2 · price: Purchased in multiple transactions with a weighted average price of $1.56. The reporting person will provide, upon request by the SEC staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range.

F1 · ownership.nature: BML Capital Management, LLC ("BML Capital") serves as the general partner of BML Investment Partners, L.P., a Delaware limited partnership (the "Fund"), which is the direct owner of the subject shares. Mr. Leonard is the managing member of BML Capital, and exercises investment and voting control over the subject shares. Accordingly, shares owned directly by the Fund may be regarded as being beneficially owned by Mr. Leonard. Notwithstanding, Mr. Leonard disclaims beneficial ownership of such shares, except to the extent of his pecuniary interest therein.

SEC source: 0001209191-23-047626 · doc4.xml · derivative · entry 3

Hall Ashley · CIK 0001801842 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 109,375

Underlying: Common Stock · 15,625 shares

Expires 2032-12-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The shares vest in a series of 16 equal quarterly installments measured from December 9, 2022 subject to Reporting Person's Continuous Service (as defined in the Issuer's 2021 Equity Incentive Plan) as of each such vesting date.

SEC source: 0001209191-23-047626 · doc4.xml · nonDerivative · entry 2

Hall Ashley · CIK 0001801842 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,600

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $6.24 to $6.44, inclusive. The reporting person undertakes to provide any security holder of Reneo Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth herein.

SEC source: 0001209191-23-047626 · doc4.xml · nonDerivative · entry 1

Hall Ashley · CIK 0001801842 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,225

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 4,000 shares acquired under the Issuer's 2021 Employee Stock Purchase Plan (the "Plan") on June 8, 2023.

SEC source: 0001209191-23-043558 · doc4.xml · nonDerivative · entry 1

GREY MICHAEL G · CIK 0001240122 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · shares: On July 26, 2023, the Reporting Person transferred 50,000 shares of Issuer common stock to The Grey Family Trust dated November 12, 1999 ("The Grey Family Trust"). The Reporting Person is trustee of The Grey Family Trust of which members of the Reporting Person's immediate family are the beneficiaries.

SEC source: 0001209191-23-039541 · doc4.xml · nonDerivative · entry 1

Novo Holdings A/S · CIK 0001388325 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,330,337

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.93 to $7.50, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-23-035564 · doc4.xml · derivative · entry 1

Hoelscher Paul W. · CIK 0001611468 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The shares subject to the option vest on the earlier of June 6, 2024 or the day prior to the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-035565 · doc4.xml · derivative · entry 1

GREY MICHAEL G · CIK 0001240122 · Director · Executive Chairman

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The shares subject to the option vest on the earlier of June 6, 2024 or the day prior to the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-035585 · doc4.xml · derivative · entry 1

Mathers Edward T · CIK 0001328625 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The shares subject to the option vest on the earlier of June 6, 2024 or the day prior to the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-035566 · doc4.xml · derivative · entry 1

Blunt Roshawn A. · CIK 0001787773 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,815

Underlying: Common Stock · 14,815 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The shares subject to the option vest on the earlier of June 6, 2024 or the day prior to the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-035563 · doc4.xml · derivative · entry 1

Muralidhar Bali · CIK 0001784138 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The shares subject to the option vest on the earlier of June 6, 2024 or the day prior to the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-035562 · doc4.xml · derivative · entry 1

O'Donnell Niall · CIK 0001780235 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The shares subject to the option vest on the earlier of June 6, 2024 or the day prior to the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-035557 · doc4.xml · derivative · entry 1

Dube Eric M · CIK 0001763494 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The shares subject to the option vest on the earlier of June 6, 2024 or the day prior to the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-035560 · doc4.xml · derivative · entry 1

Seltzer Stacey Denenberg · CIK 0001648895 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2033-06-05

F1 · derivative.exercise_date: The shares subject to the option vest on the earlier of June 6, 2024 or the day prior to the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-028533 · doc4.xml · nonDerivative · entry 1

O'Donnell Niall · CIK 0001780235 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By RiverVest Venture Fund IV, L.P.

Disclosed balance after: 2,188,713

F1 · kind: The shares were purchased in the Issuer's public offering.

F2 · ownership.nature: The shares held by RiverVest Venture Fund IV, L.P. ("RiverVest Fund IV") are indirectly held by RiverVest Venture Partners IV, L.P., its general partner ("RiverVest Partners IV"). RiverVest Venture Partners IV, LLC is the general partner of RiverVest Partners IV. The individual managers of RiverVest Ventures Partners IV, LLC are Jay Schmelter, John P. McKearn, Ph.D. and the Reporting Person. RiverVest Partners IV, RiverVest Venture Partners IV, LLC and each of the individual managers (including the Reporting Person) share voting and dispositive power with regard to the Company's securities directly held by RiverVest Fund IV.

SEC source: 0001209191-22-061044 · doc4.xml · derivative · entry 2

Lam Jennifer · CIK 0001919598 · VP of Finance & Administration

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 90,000

Underlying: Common Stock · 90,000 shares

Expires 2032-12-08

F2 · derivative.exercise_date: The shares vest in a series of equal quarterly installments measured from December 9, 2022 subject to Reporting Person's Continuous Service (as defined in the Issuer's 2021 Equity Incentive Plan) as of each such vesting date.

SEC source: 0001209191-22-061031 · doc4.xml · derivative · entry 3

Cruse Michael · CIK 0001854179 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2032-12-08

F3 · derivative.exercise_date: The shares vest in a series of 16 successive equal quarterly installments measured from December 9, 2022 subject to Reporting Person's Continuous Service (as defined in the Issuer's 2021 Equity Incentive Plan) as of each such vesting date.

SEC source: 0001209191-22-061038 · doc4.xml · derivative · entry 2

Hall Ashley · CIK 0001801842 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2032-12-08

F2 · derivative.exercise_date: The shares vest in a series of 16 equal quarterly installments measured from December 9, 2022 subject to Reporting Person's Continuous Service (as defined in the Issuer's 2021 Equity Incentive Plan) as of each such vesting date.

SEC source: 0001209191-22-061032 · doc4.xml · derivative · entry 2

Dorenbaum Alejandro · CIK 0001606083 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

Underlying: Common Stock · 125,000 shares

Expires 2032-12-08

F1 · derivative.exercise_date: The shares vest in a series of 16 successive equal quarterly installments measured from December 9, 2022 subject to Reporting Person's Continuous Service (as defined in the Issuer's 2021 Equity Incentive Plan) as of each such vesting date.

SEC source: 0001209191-22-061034 · doc4.xml · derivative · entry 2

FLESHER GREGORY J. · CIK 0001705287 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2032-12-08

F2 · derivative.exercise_date: The shares vest in a series of 16 equal quarterly installments measured from December 9, 2022 subject to Reporting Person's Continuous Service (as defined in the Issuer's 2021 Equity Incentive Plan) as of each such vesting date.

SEC source: 0001209191-22-048534 · doc4.xml · nonDerivative · entry 1

Cruse Michael · CIK 0001854179 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · by Trust

Disclosed balance after: 13,697

F1 · price: The weighted average purchase price for the transaction was $3.393. The shares were purchased at a range of prices between $3.36 and $3.48. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided.

F2 · ownership.nature: By Michael P. Cruse and Thu Anh Thuy Cruse, Trustees of The Cruse Family Revocable Living Trust.

SEC source: 0001209191-22-048167 · doc4.xml · nonDerivative · entry 5

Cruse Michael · CIK 0001854179 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · by Trust

Disclosed balance after: 6,197

F5 · price: The weighted average purchase price for the transaction was $3.209. The shares were purchased at a range of prices between $3.19 and $3.29. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided.

F2 · ownership.nature: By Michael P. Cruse and Thu Anh Thuy Cruse, Trustees of The Cruse Family Revocable Living Trust.

SEC source: 0001209191-22-048532 · doc4.xml · derivative · entry 4

GREY MICHAEL G · CIK 0001240122 · Director · Executive Chairman

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,406

Underlying: Common Stock · 50,000 shares

Expires 2028-04-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-048532 · doc4.xml · nonDerivative · entry 1

GREY MICHAEL G · CIK 0001240122 · Director · Executive Chairman

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-22-048167 · doc4.xml · nonDerivative · entry 4

Cruse Michael · CIK 0001854179 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · by Trust

Disclosed balance after: 2,985

F4 · price: The weighted average purchase price for the transaction was $3.1938. The shares were purchased at a range of prices between $3.16 and $3.25. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided.

F2 · ownership.nature: By Michael P. Cruse and Thu Anh Thuy Cruse, Trustees of The Cruse Family Revocable Living Trust.

SEC source: 0001209191-22-048167 · doc4.xml · nonDerivative · entry 3

Cruse Michael · CIK 0001854179 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,758

F3 · price: The weighted average purchase price for the transaction was $3.16. The shares were purchased at a range of prices between $3.11 and $3.19. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided.

SEC source: 0001209191-22-048167 · doc4.xml · nonDerivative · entry 2

Cruse Michael · CIK 0001854179 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · by Trust

Disclosed balance after: 1,140

F2 · ownership.nature: By Michael P. Cruse and Thu Anh Thuy Cruse, Trustees of The Cruse Family Revocable Living Trust.

SEC source: 0001209191-22-048167 · doc4.xml · nonDerivative · entry 1

Cruse Michael · CIK 0001854179 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,783

F1 · balance_after: Includes 1,600 shares acquired under the Issuer's 2021 Employee Stock Purchase Plan on June 8, 2022.

SEC source: 0001209191-22-061032 · doc4.xml · nonDerivative · entry 1

Dorenbaum Alejandro · CIK 0001606083 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

SEC source: 0001209191-22-043994 · doc4.xml · derivative · entry 1

Blunt Roshawn A. · CIK 0001787773 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Stock · 35,000 shares

Expires 2032-08-01

F1 · derivative.exercise_date: The shares subject to the stock option vest and become exercisable in equal monthly installments over a three-year period.

SEC source: 0001209191-22-034178 · doc4.xml · derivative · entry 1

Hoelscher Paul W. · CIK 0001611468 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,376

Underlying: Common Stock · 6,376 shares

Expires 2032-05-31

F1 · derivative.exercise_date: The shares subject to the option vest on the earlier of June 1, 2023 or the day prior to the date of the Issuer's 2023 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.