NRIX

SEC source: 0001209191-21-050977 · doc4.xml · nonDerivative · entry 2

Ring Christine · CIK 0001817199 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 805

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · price: Represents the weighted average sale price. The lowest price at which shares were sold was $29.37 and the highest price at which shares were sold was $30.33. The reporting person undertakes to provide upon request to the staff of the Securities and Exchange Commission, the issuer or its stockholders, full information regarding the total number of shares sold at each separate price within the ranges set forth herein.

SEC source: 0001209191-21-050977 · doc4.xml · nonDerivative · entry 1

Ring Christine · CIK 0001817199 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,005

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0001209191-21-049420 · doc4.xml · derivative · entry 3

Hansen Gwenn · CIK 0001817160 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,466

Underlying: Common Stock · 400 shares

Expires 2030-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · derivative.exercise_date: The stock option vests as to 1/48 of the total shares monthly beginning February 18, 2020 until the option is fully vested on January 18, 2024, subject to the Reporting Person's provision of service to the Issuer on each vesting date. The option contains an early-exercise provision and is exercisable as to unvested shares, subject to the Issuer's right of repurchase.

SEC source: 0001209191-21-049420 · doc4.xml · nonDerivative · entry 2

Hansen Gwenn · CIK 0001817160 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,804

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0001209191-21-049420 · doc4.xml · nonDerivative · entry 1

Hansen Gwenn · CIK 0001817160 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,204

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0001209191-21-047612 · doc4.xml · derivative · entry 3

Ring Christine · CIK 0001817199 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 112,066

Underlying: Common Stock · 1,200 shares

Expires 2029-09-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · derivative.exercise_date: The option vests as to 1/4 of the total shares on September 9, 2020, and then 1/48 of the total shares will vest monthly thereafter until the option is fully vested on August 9, 2023, subject to the Reporting Person's provision of service to the Issuer on each vesting date. The option contains an early-exercise provision and is exercisable as to unvested shares, subject to the Issuer's right of repurchase.

SEC source: 0001209191-21-047612 · doc4.xml · nonDerivative · entry 2

Ring Christine · CIK 0001817199 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 805

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0001209191-21-047612 · doc4.xml · nonDerivative · entry 1

Ring Christine · CIK 0001817199 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,005

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0001209191-21-046362 · doc4.xml · derivative · entry 5

Beaurang Pierre · CIK 0001817226 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,062

Underlying: Common Stock · 7,500 shares

Expires 2027-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F5 · derivative.exercise_date: The option is fully vested.

SEC source: 0001209191-21-046362 · doc4.xml · nonDerivative · entry 3

Beaurang Pierre · CIK 0001817226 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,330

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F3 · price: Represents the weighted average sale price. The lowest price at which shares were sold was $24.65 and the highest price at which shares were sold was $24.79.

SEC source: 0001209191-21-046362 · doc4.xml · nonDerivative · entry 2

Beaurang Pierre · CIK 0001817226 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,730

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · price: Represents the weighted average sale price. The lowest price at which shares were sold was $23.62 and the highest price at which shares were sold was $24.40. The reporting person undertakes to provide upon request to the staff of the Securities and Exchange Commission, the issuer or its stockholders, full information regarding the total number of shares sold at each separate price within the ranges set forth in footnotes (2) and (3) to this Form 4.

SEC source: 0001209191-21-046362 · doc4.xml · nonDerivative · entry 1

Beaurang Pierre · CIK 0001817226 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,830

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0001209191-21-044868 · doc4.xml · derivative · entry 3

Hansen Gwenn · CIK 0001817160 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,866

Underlying: Common Stock · 400 shares

Expires 2030-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · derivative.exercise_date: The stock option vests as to 1/48 of the total shares monthly beginning February 18, 2020 until the option is fully vested on January 18, 2024, subject to the Reporting Person's provision of service to the Issuer on each vesting date. The option contains an early-exercise provision and is exercisable as to unvested shares, subject to the Issuer's right of repurchase.

SEC source: 0001209191-21-044868 · doc4.xml · nonDerivative · entry 2

Hansen Gwenn · CIK 0001817160 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,804

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0001209191-21-044868 · doc4.xml · nonDerivative · entry 1

Hansen Gwenn · CIK 0001817160 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,204

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0001209191-21-039813 · doc4.xml · derivative · entry 4

Ring Christine · CIK 0001817199 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 113,266

Underlying: Common Stock · 1,200 shares

Expires 2029-09-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F4 · derivative.exercise_date: The option vests as to 1/4 of the total shares on September 9, 2020, and then 1/48 of the total shares will vest monthly thereafter until the option is fully vested on August 9, 2023, subject to the Reporting Person's provision of service to the Issuer on each vesting date. The option contains an early-exercise provision and is exercisable as to unvested shares, subject to the Issuer's right of repurchase.

SEC source: 0001209191-21-039813 · doc4.xml · nonDerivative · entry 3

Ring Christine · CIK 0001817199 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 805

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F3 · price: Represents the weighted average sale price. The lowest price at which shares were sold was $30.08 and the highest price at which shares were sold was $30.95.

SEC source: 0001209191-21-039813 · doc4.xml · nonDerivative · entry 2

Ring Christine · CIK 0001817199 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,005

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · price: Represents the weighted average sale price. The lowest price at which shares were sold was $28.77 and the highest price at which shares were sold was $29.47. The reporting person undertakes to provide upon request to the staff of the Securities Exchange Commission, the issuer or its stockholders, full information regarding the total number of shares sold at each separate price within the ranges set forth in footnotes 2 and 3 to this Form 4.

SEC source: 0001209191-21-039813 · doc4.xml · nonDerivative · entry 1

Ring Christine · CIK 0001817199 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,005

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0001209191-21-039810 · doc4.xml · derivative · entry 6

Beaurang Pierre · CIK 0001817226 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,562

Underlying: Common Stock · 7,500 shares

Expires 2027-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F6 · derivative.exercise_date: The option is fully vested.

SEC source: 0001209191-21-039810 · doc4.xml · nonDerivative · entry 4

Beaurang Pierre · CIK 0001817226 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,330

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F4 · price: Represents the weighted average sale price. The lowest price at which shares were sold was $30.765 and the highest price at which shares were sold was $30.95.

SEC source: 0001209191-21-039810 · doc4.xml · nonDerivative · entry 3

Beaurang Pierre · CIK 0001817226 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,730

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F3 · price: Represents the weighted average sale price. The lowest price at which shares were sold was $29.67 and the highest price at which shares were sold was $30.57.

SEC source: 0001209191-21-039810 · doc4.xml · nonDerivative · entry 2

Beaurang Pierre · CIK 0001817226 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,830

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · price: Represents the weighted average sale price. The lowest price at which shares were sold was $28.64 and the highest price at which shares were sold was $29.62. The reporting person undertakes to provide upon request to the staff of the Securities and Exchange Commission, the issuer or its stockholders, full information regarding the total number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (4) to this Form 4.

SEC source: 0001209191-21-039810 · doc4.xml · nonDerivative · entry 1

Beaurang Pierre · CIK 0001817226 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,830

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0001209191-21-037263 · doc4.xml · derivative · entry 3

Hansen Gwenn · CIK 0001817160 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,266

Underlying: Common Stock · 400 shares

Expires 2030-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · derivative.exercise_date: The stock option vests as to 1/48 of the total shares monthly beginning February 18, 2020 until the option is fully vested on January 18, 2024, subject to the Reporting Person's provision of service to the Issuer on each vesting date. The option contains an early-exercise provision and is exercisable as to unvested shares, subject to the Issuer's right of repurchase.

SEC source: 0001209191-21-037263 · doc4.xml · nonDerivative · entry 2

Hansen Gwenn · CIK 0001817160 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,804

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0001209191-21-037263 · doc4.xml · nonDerivative · entry 1

Hansen Gwenn · CIK 0001817160 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,204

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0001209191-21-036823 · doc4.xml · derivative · entry 1

SIEGALL CLAY B · CIK 0001167496 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Stock · 35,000 shares

Expires 2031-05-27

F1 · derivative.exercise_date: The stock option vests as to 1/36 of the total shares monthly beginning June 28, 2021 until the option is fully vested on May 28, 2024, subject to the Reporting Person's provision of service to the Issuer on each vesting date.

SEC source: 0001209191-21-031895 · doc4.xml · derivative · entry 3

Ring Christine · CIK 0001817199 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 114,466

Underlying: Common Stock · 1,200 shares

Expires 2029-09-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · derivative.exercise_date: The option vests as to 1/4 of the total shares on September 9, 2020, and then 1/48 of the total shares will vest monthly thereafter until the option is fully vested on August 9, 2023, subject to the Reporting Person's provision of service to the Issuer on each vesting date. The option contains an early-exercise provision and is exercisable as to unvested shares, subject to the Issuer's right of repurchase.

SEC source: 0001209191-21-031895 · doc4.xml · nonDerivative · entry 2

Ring Christine · CIK 0001817199 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 805

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0001209191-21-031895 · doc4.xml · nonDerivative · entry 1

Ring Christine · CIK 0001817199 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,005

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0001209191-21-031891 · doc4.xml · derivative · entry 6

Beaurang Pierre · CIK 0001817226 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,062

Underlying: Common Stock · 7,500 shares

Expires 2027-02-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F6 · derivative.exercise_date: The option is fully vested.

SEC source: 0001209191-21-031891 · doc4.xml · nonDerivative · entry 4

Beaurang Pierre · CIK 0001817226 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,330

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F4 · price: Represents the weighted average sale price. The lowest price at which shares were sold was $27.42 and the highest price at which shares were sold was $27.95.

SEC source: 0001209191-21-031891 · doc4.xml · nonDerivative · entry 3

Beaurang Pierre · CIK 0001817226 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,030

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F3 · price: Represents the weighted average sale price. The lowest price at which shares were sold was $26.41 and the highest price at which shares were sold was $27.32.

SEC source: 0001209191-21-031891 · doc4.xml · nonDerivative · entry 2

Beaurang Pierre · CIK 0001817226 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,531

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

F2 · price: Represents the weighted average sale price. The lowest price at which shares were sold was $25.40 and the highest price at which shares were sold was $26.39. The reporting person undertakes to provide upon request to the staff of the Securities and Exchange Commission, the issuer or its stockholders, full information regarding the total number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (4) to this Form 4.

SEC source: 0001209191-21-031891 · doc4.xml · nonDerivative · entry 1

Beaurang Pierre · CIK 0001817226 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,830

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person.

SEC source: 0000899243-21-018932 · doc4.xml · nonDerivative · entry 1

Third Rock Ventures III, L.P. · CIK 0001569705 · 10% owner

Third Rock Ventures GP III, L.P. · CIK 0001637300 · 10% owner

TRV GP III, LLC · CIK 0001637299 · 10% owner

STARR KEVIN P · CIK 0001192603 · 10% owner

TEPPER ROBERT I · CIK 0001192595 · 10% owner

LEVIN MARK J · CIK 0001180428 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,422,549

F1 · kind: Pursuant to a 10b5-1 trading plan adopted on October 29, 2020 by Third Rock Ventures III, L.P. ("TRV III"), TRV III distributed for no consideration, 1,085,784 shares of Common Stock of the Issuer (the "Shares") on May 6, 2021 to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP III"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended.

F1 · price: Pursuant to a 10b5-1 trading plan adopted on October 29, 2020 by Third Rock Ventures III, L.P. ("TRV III"), TRV III distributed for no consideration, 1,085,784 shares of Common Stock of the Issuer (the "Shares") on May 6, 2021 to its limited partners and to Third Rock Ventures GP III, L.P. ("TRV GP III"), the general partner of TRV III, representing each such partner's pro rata interest in such Shares. On the same date, TRV GP III distributed, for no consideration, the Shares it received in the distribution by TRV III to its partners, representing each such partner's pro rata interest in such Shares. All of the aforementioned distributions were made in accordance with the exemptions afforded by Rules 16a-13 and 16a-9 of the Securities Exchange Act of 1934, as amended.

F2 · ownership.direct: These shares are directly held by TRV III. The general partner of TRV III is TRV GP III. The general partner of TRV GP III is TRV GP III, LLC ("TRV GP III LLC"). The individual managers of TRV GP III LLC are Mark Levin ("Levin"), Kevin Starr ("Starr") and Dr. Robert Tepper ("Tepper"). Each of TRV GP III, TRV GP III LLC, Levin, Starr and Tepper disclaims beneficial ownership of the shares except to the extent of its or his pecuniary interest therein, if any, and this report shall not be deemed an admission that it or he is the beneficial owner of such shares.

SEC source: 0001209191-21-035540 · doc4.xml · derivative · entry 1

Tong Jeffrey K · CIK 0001479701 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2031-05-05

F1 · derivative.exercise_date: The stock option vests as to 100% of the award on the earlier of (a) the date of the next annual meeting of the Issuer's stockholders and (b) May 6, 2022, in each case, subject to the Reporting Person's provision of service to the Issuer on such vesting date.

SEC source: 0001209191-21-035536 · doc4.xml · derivative · entry 1

GREGORY JULIA P · CIK 0001226675 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2031-05-05

F1 · derivative.exercise_date: The stock option vests as to 100% of the award on the earlier of (a) the date of the next annual meeting of the Issuer's stockholders and (b) May 6, 2022, in each case, subject to the Reporting Person's provision of service to the Issuer on such vesting date.

SEC source: 0001209191-21-035538 · doc4.xml · derivative · entry 1

Kunkel Lori Anne · CIK 0001536368 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2031-05-05

F1 · derivative.exercise_date: The stock option vests as to 100% of the award on the earlier of (a) the date of the next annual meeting of the Issuer's stockholders and (b) May 6, 2022, in each case, subject to the Reporting Person's provision of service to the Issuer on such vesting date.

SEC source: 0001209191-21-035539 · doc4.xml · derivative · entry 1

Lacey David L. · CIK 0001734422 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2031-05-05

F1 · derivative.exercise_date: The stock option vests as to 100% of the award on the earlier of (a) the date of the next annual meeting of the Issuer's stockholders and (b) May 6, 2022, in each case, subject to the Reporting Person's provision of service to the Issuer on such vesting date.

SEC source: 0001209191-21-035535 · doc4.xml · derivative · entry 1

Chen Leon · CIK 0001752432 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,500

Underlying: Common Stock · 17,500 shares

Expires 2031-05-05

F1 · derivative.exercise_date: The stock option vests as to 100% of the award on the earlier of (a) the date of the next annual meeting of the Issuer's stockholders and (b) May 6, 2022, in each case, subject to the Reporting Person's provision of service to the Issuer on such vesting date.

F2 · ownership.direct: The Reporting Person is a partner of The Column Group which invests through The Column Group II, LP ("TCG II LP"), Ponoi Capital, LP ("Ponoi LP") and Ponoi Capital II, LP ("Ponoi II LP," and together with TCG II LP and Ponoi LP, the "Funds"), among other entities. Under the partnership agreements of the Funds, the Reporting Person is deemed to hold the stock option for the economic benefit of the Funds. The Funds may be deemed indirect beneficial owners of the stock option. The Reporting Person disclaims beneficial ownership of the stock option except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-018761 · doc4.xml · nonDerivative · entry 15

COLUMN GROUP L P · CIK 0001347769 · 10% owner

COLUMN GROUP GP, LP · CIK 0001614627 · 10% owner

COLUMN GROUP II, LP · CIK 0001600420 · 10% owner

Column Group II GP, LP · CIK 0001645333 · 10% owner · General Partner

PONOI CAPITAL, LP · CIK 0001707230 · 10% owner

Ponoi Management, LLC · CIK 0001720702 · 10% owner

Ponoi II Management, LLC · CIK 0001746488 · 10% owner

Ponoi Capital II, LP · CIK 0001732601 · 10% owner

Kutzkey Tim · CIK 0001614186 · 10% owner

GOEDDEL DAVID V · CIK 0001182464 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 48,406

F22 · kind: Represents a change in the form of ownership of Tim Kutzkey by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG II GP.

F10 · ownership.nature: The securities are directly held by Tim Kutzkey.

SEC source: 0000899243-21-018761 · doc4.xml · nonDerivative · entry 14

COLUMN GROUP L P · CIK 0001347769 · 10% owner

COLUMN GROUP GP, LP · CIK 0001614627 · 10% owner

COLUMN GROUP II, LP · CIK 0001600420 · 10% owner

Column Group II GP, LP · CIK 0001645333 · 10% owner · General Partner

PONOI CAPITAL, LP · CIK 0001707230 · 10% owner

Ponoi Management, LLC · CIK 0001720702 · 10% owner

Ponoi II Management, LLC · CIK 0001746488 · 10% owner

Ponoi Capital II, LP · CIK 0001732601 · 10% owner

Kutzkey Tim · CIK 0001614186 · 10% owner

GOEDDEL DAVID V · CIK 0001182464 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 139,383

F21 · kind: Represents a change in the form of ownership of David Goeddel by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG II GP.

F8 · ownership.nature: The securities are directly held by David Goeddel.

SEC source: 0000899243-21-018761 · doc4.xml · nonDerivative · entry 13

COLUMN GROUP L P · CIK 0001347769 · 10% owner

COLUMN GROUP GP, LP · CIK 0001614627 · 10% owner

COLUMN GROUP II, LP · CIK 0001600420 · 10% owner

Column Group II GP, LP · CIK 0001645333 · 10% owner · General Partner

PONOI CAPITAL, LP · CIK 0001707230 · 10% owner

Ponoi Management, LLC · CIK 0001720702 · 10% owner

Ponoi II Management, LLC · CIK 0001746488 · 10% owner

Ponoi Capital II, LP · CIK 0001732601 · 10% owner

Kutzkey Tim · CIK 0001614186 · 10% owner

GOEDDEL DAVID V · CIK 0001182464 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 134,010

F20 · kind: Represents a change in the form of ownership of Peter Svennilson by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG II GP.

F6 · ownership.nature: The securities are directly held by Peter Svennilson

SEC source: 0000899243-21-018761 · doc4.xml · nonDerivative · entry 12

COLUMN GROUP L P · CIK 0001347769 · 10% owner

COLUMN GROUP GP, LP · CIK 0001614627 · 10% owner

COLUMN GROUP II, LP · CIK 0001600420 · 10% owner

Column Group II GP, LP · CIK 0001645333 · 10% owner · General Partner

PONOI CAPITAL, LP · CIK 0001707230 · 10% owner

Ponoi Management, LLC · CIK 0001720702 · 10% owner

Ponoi II Management, LLC · CIK 0001746488 · 10% owner

Ponoi Capital II, LP · CIK 0001732601 · 10% owner

Kutzkey Tim · CIK 0001614186 · 10% owner

GOEDDEL DAVID V · CIK 0001182464 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F19 · kind: Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by TCG II GP to its general and limited partners.

F18 · ownership.nature: The securities are directly held by TCG II GP. The Managing Partners may be deemed to share voting and investment power with respect to such shares. Each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-018761 · doc4.xml · nonDerivative · entry 11

COLUMN GROUP L P · CIK 0001347769 · 10% owner

COLUMN GROUP GP, LP · CIK 0001614627 · 10% owner

COLUMN GROUP II, LP · CIK 0001600420 · 10% owner

Column Group II GP, LP · CIK 0001645333 · 10% owner · General Partner

PONOI CAPITAL, LP · CIK 0001707230 · 10% owner

Ponoi Management, LLC · CIK 0001720702 · 10% owner

Ponoi II Management, LLC · CIK 0001746488 · 10% owner

Ponoi Capital II, LP · CIK 0001732601 · 10% owner

Kutzkey Tim · CIK 0001614186 · 10% owner

GOEDDEL DAVID V · CIK 0001182464 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 49,689

F17 · kind: Represents a change in the form of ownership of TCG II GP by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG II LP.

F18 · ownership.nature: The securities are directly held by TCG II GP. The Managing Partners may be deemed to share voting and investment power with respect to such shares. Each of the Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.

SEC source: 0000899243-21-018761 · doc4.xml · nonDerivative · entry 10

COLUMN GROUP L P · CIK 0001347769 · 10% owner

COLUMN GROUP GP, LP · CIK 0001614627 · 10% owner

COLUMN GROUP II, LP · CIK 0001600420 · 10% owner

Column Group II GP, LP · CIK 0001645333 · 10% owner · General Partner

PONOI CAPITAL, LP · CIK 0001707230 · 10% owner

Ponoi Management, LLC · CIK 0001720702 · 10% owner

Ponoi II Management, LLC · CIK 0001746488 · 10% owner

Ponoi Capital II, LP · CIK 0001732601 · 10% owner

Kutzkey Tim · CIK 0001614186 · 10% owner

GOEDDEL DAVID V · CIK 0001182464 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 989,000

F15 · kind: Represents a pro-rata distribution, and not a purchase or sale, without additional consideration by The Column Group II, LP ("TCG II LP") to its general and limited partners.

F16 · ownership.nature: The securities are directly held by TCG II LP, and indirectly held by The Column Group II GP, LP ("TCG II GP"), the general partner of TCG II LP. The managing partners of TCG II GP are the Managing Partners. The Managing Partners may be deemed to have voting and investment power with respect to such shares. Each individual Managing Partner disclaims beneficial ownership of these shares, except to the extent of his pecuniary interest in such shares.

SEC source: 0000899243-21-018761 · doc4.xml · nonDerivative · entry 9

COLUMN GROUP L P · CIK 0001347769 · 10% owner

COLUMN GROUP GP, LP · CIK 0001614627 · 10% owner

COLUMN GROUP II, LP · CIK 0001600420 · 10% owner

Column Group II GP, LP · CIK 0001645333 · 10% owner · General Partner

PONOI CAPITAL, LP · CIK 0001707230 · 10% owner

Ponoi Management, LLC · CIK 0001720702 · 10% owner

Ponoi II Management, LLC · CIK 0001746488 · 10% owner

Ponoi Capital II, LP · CIK 0001732601 · 10% owner

Kutzkey Tim · CIK 0001614186 · 10% owner

GOEDDEL DAVID V · CIK 0001182464 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 40,654

F14 · kind: Represents a change in the form of ownership of Tim Kutzkey by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG GP.

F10 · ownership.nature: The securities are directly held by Tim Kutzkey.

SEC source: 0000899243-21-018761 · doc4.xml · nonDerivative · entry 8

COLUMN GROUP L P · CIK 0001347769 · 10% owner

COLUMN GROUP GP, LP · CIK 0001614627 · 10% owner

COLUMN GROUP II, LP · CIK 0001600420 · 10% owner

Column Group II GP, LP · CIK 0001645333 · 10% owner · General Partner

PONOI CAPITAL, LP · CIK 0001707230 · 10% owner

Ponoi Management, LLC · CIK 0001720702 · 10% owner

Ponoi II Management, LLC · CIK 0001746488 · 10% owner

Ponoi Capital II, LP · CIK 0001732601 · 10% owner

Kutzkey Tim · CIK 0001614186 · 10% owner

GOEDDEL DAVID V · CIK 0001182464 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 121,554

F13 · kind: Represents a change in the form of ownership of David Goeddel by virtue of the receipt of shares as a result of the pro-rata in-kind distribution of common stock of the Issuer for no consideration by TCG GP.

F8 · ownership.nature: The securities are directly held by David Goeddel.