MRNA

SEC source: 0001127602-23-023856 · form4.xml · nonDerivative · entry 1

Garay Arpa · CIK 0001916360 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,687

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001127602-23-023779 · form4.xml · derivative · entry 3

Klinger Shannon Thyme · CIK 0001866132 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,326

Underlying: Common Stock · 233 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F3 · derivative.exercise_date: 25% of the shares subject to this restricted stock unit award vested on March 1, 2023 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

F3 · derivative.expiration_date: 25% of the shares subject to this restricted stock unit award vested on March 1, 2023 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

SEC source: 0001127602-23-023779 · form4.xml · nonDerivative · entry 1

Klinger Shannon Thyme · CIK 0001866132 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,749

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0001127602-23-023774 · form4.xml · derivative · entry 5

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,516

Underlying: Common Stock · 652 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: 25% of the shares subject to this restricted stock unit award vested on March 1, 2023 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

F4 · derivative.expiration_date: 25% of the shares subject to this restricted stock unit award vested on March 1, 2023 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

SEC source: 0001127602-23-023774 · form4.xml · nonDerivative · entry 1

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,589,507

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0000950170-23-046131 · ownership.xml · nonDerivative · entry 4

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,997,209

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

SEC source: 0000950170-23-046131 · ownership.xml · nonDerivative · entry 3

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,997,309

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $116.15 to $117.05, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-046131 · ownership.xml · nonDerivative · entry 2

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,001,645

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $115.08 to $115.97, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-046131 · ownership.xml · nonDerivative · entry 1

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,006,362

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $114.06 to $115.05, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001127602-23-023416 · form4.xml · nonDerivative · entry 4

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,588,855

F3 · kind: Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of RSUs. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.

SEC source: 0001127602-23-023416 · form4.xml · derivative · entry 5

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,822

Underlying: Common Stock · 2,411 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: 50% of the shares subject to this restricted stock unit award vested on February 28, 2022 with the remainder vesting in eight (8) equal quarterly installments thereafter.

F4 · derivative.expiration_date: 50% of the shares subject to this restricted stock unit award vested on February 28, 2022 with the remainder vesting in eight (8) equal quarterly installments thereafter.

SEC source: 0001127602-23-023416 · form4.xml · nonDerivative · entry 3

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,589,990

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F2 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0000950170-23-044660 · ownership.xml · nonDerivative · entry 5

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,012,209

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $116.43 to $116.48, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-044660 · ownership.xml · nonDerivative · entry 4

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,012,509

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $115.41 to $116.37, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-044660 · ownership.xml · nonDerivative · entry 3

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,022,387

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $114.41 to $115.40, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-044660 · ownership.xml · nonDerivative · entry 2

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,026,044

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $113.33 to $114.31, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-044660 · ownership.xml · nonDerivative · entry 1

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,026,898

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $112.20 to $112.81, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001127602-23-022963 · form4.xml · nonDerivative · entry 1

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,587,579

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted on March 15, 2023.

SEC source: 0000950170-23-043536 · ownership.xml · nonDerivative · entry 5

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,027,209

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $99.35 to $99.62 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-043536 · ownership.xml · nonDerivative · entry 4

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,027,509

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $98.32 to $99.25 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-043536 · ownership.xml · nonDerivative · entry 3

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,031,509

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $97.32 to $98.31 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-043536 · ownership.xml · nonDerivative · entry 2

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,032,709

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $96.03 to $96.97 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-043536 · ownership.xml · nonDerivative · entry 1

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,035,609

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $95.02 to $95.99 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001127602-23-022369 · form4.xml · nonDerivative · entry 4

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,602,579

F3 · kind: Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of RSUs. These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of a tax withholding obligation to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person.

SEC source: 0001127602-23-022369 · form4.xml · derivative · entry 5

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,134

Underlying: Common Stock · 523 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F4 · derivative.exercise_date: 25% of the shares subject to this restricted stock unit award vested on February 9, 2022 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

F4 · derivative.expiration_date: 25% of the shares subject to this restricted stock unit award vested on February 9, 2022 with the remainder vesting in twelve (12) equal quarterly installments thereafter.

SEC source: 0001127602-23-022369 · form4.xml · nonDerivative · entry 3

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,602,826

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: Restricted stock units convert into common stock on a one-for-one basis.

F2 · price: Restricted stock units convert into common stock on a one-for-one basis.

SEC source: 0000950170-23-038677 · ownership.xml · nonDerivative · entry 4

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,037,209

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $113.32 to $114.03, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-038677 · ownership.xml · nonDerivative · entry 3

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,037,409

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $112.22 to $112.83, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-038677 · ownership.xml · nonDerivative · entry 2

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,038,309

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $111.16 to $112.14, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-038677 · ownership.xml · nonDerivative · entry 1

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,042,484

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $110.14 to $111.13 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-035618 · ownership.xml · nonDerivative · entry 3

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,052,209

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $121.07 to $121.42, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-035618 · ownership.xml · nonDerivative · entry 2

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,053,310

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $120.06 to $121.02, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-035618 · ownership.xml · nonDerivative · entry 1

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,064,809

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $119.06 to $120.05 inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-033879 · ownership.xml · nonDerivative · entry 3

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,067,209

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $125.73 to $126.55, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-033879 · ownership.xml · nonDerivative · entry 2

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,072,358

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $124.72 to $125.71, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-033879 · ownership.xml · nonDerivative · entry 1

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,081,362

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $123.55 to $124.50, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0001127602-23-020950 · form4.xml · nonDerivative · entry 1

Hoge Stephen · CIK 0001760669 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,602,303

F1 · kind: The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted on March 15, 2023.

SEC source: 0000950170-23-033076 · ownership.xml · nonDerivative · entry 4

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,082,209

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $127.05 to $127.28, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-033076 · ownership.xml · nonDerivative · entry 3

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,082,509

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $126.04 to $126.77, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-033076 · ownership.xml · nonDerivative · entry 2

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,089,354

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $125.01 to $126.00, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-033076 · ownership.xml · nonDerivative · entry 1

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,095,219

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $124.01 to $124.97, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-017283 · doc4.xml · nonDerivative · entry 6

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,097,209

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F7 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $128.13 to $128.20, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-017283 · doc4.xml · nonDerivative · entry 5

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,097,379

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F6 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $127.09 to $128.05, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-017283 · doc4.xml · nonDerivative · entry 4

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,098,928

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $125.98 to $126.97, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-017283 · doc4.xml · nonDerivative · entry 3

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,099,940

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $124.83 to $125.60, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-017283 · doc4.xml · nonDerivative · entry 2

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,102,579

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $123.77 to $124.75, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000899243-23-017283 · doc4.xml · nonDerivative · entry 1

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,108,676

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $122.77 to $123.69, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-031214 · ownership.xml · nonDerivative · entry 4

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,112,209

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $122.32 to $123.19, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-031214 · ownership.xml · nonDerivative · entry 3

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,114,305

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $121.30 to $122.29, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

SEC source: 0000950170-23-031214 · ownership.xml · nonDerivative · entry 2

AFEYAN NOUBAR · CIK 0001222012 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,122,378

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2023.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $120.26 to $121.19, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.