MRKR

SEC source: 0001209191-21-039629 · doc4.xml · nonDerivative · entry 1

Wilson John Robert · CIK 0001755569 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,812,008

F1 · shares: Represents the portion of the annual board retainer for each non-employee director payable in immediately vested common stock under the Company's 2020 Equity Incentive Plan and based on the closing price of $3.16 per share, on the day immediately preceding the date of the Company's 2021 annual meeting.

SEC source: 0001209191-21-034427 · doc4.xml · nonDerivative · entry 1

Wasserman Frederick Gerald · CIK 0001384383 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,565

SEC source: 0001209191-23-035617 · doc4.xml · nonDerivative · entry 4

Eansor Norman David · CIK 0001270905 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Scott Eansor 2020 Exempt Trust

Disclosed balance after: 7,142

F1 · shares: Reflects a 10-1 reverse stock split which became effective on January 16, 2023.

F1 · balance_after: Reflects a 10-1 reverse stock split which became effective on January 16, 2023.

F2 · balance_after: The Reporting Person transferred these shares to a trust of which the Reporting Person is the trustee. The Reporting Person's immediate family is the sole beneficiary of the trust.

SEC source: 0001209191-23-035617 · doc4.xml · nonDerivative · entry 3

Eansor Norman David · CIK 0001270905 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By the John R. Eansor 2020 Exempt Trust

Disclosed balance after: 7,142

F1 · shares: Reflects a 10-1 reverse stock split which became effective on January 16, 2023.

F1 · balance_after: Reflects a 10-1 reverse stock split which became effective on January 16, 2023.

F2 · balance_after: The Reporting Person transferred these shares to a trust of which the Reporting Person is the trustee. The Reporting Person's immediate family is the sole beneficiary of the trust.

SEC source: 0001209191-23-035617 · doc4.xml · nonDerivative · entry 2

Eansor Norman David · CIK 0001270905 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,428

F1 · shares: Reflects a 10-1 reverse stock split which became effective on January 16, 2023.

F2 · shares: The Reporting Person transferred these shares to a trust of which the Reporting Person is the trustee. The Reporting Person's immediate family is the sole beneficiary of the trust.

F1 · balance_after: Reflects a 10-1 reverse stock split which became effective on January 16, 2023.

SEC source: 0001209191-21-021818 · doc4.xml · nonDerivative · entry 1

Walker Paul Edward · CIK 0001553150 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 10,714,285

F1 · ownership.nature: The Reporting Person is a manager of NEA 16 GP, LLC, which is the sole general partner of NEA Partners 16, L.P. ("NEA Partners 16"). NEA Partners 16 is the sole general partner of New Enterprise Associates 16, L.P. ("NEA 16"), which is the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the shares held by NEA 16 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-21-021817 · doc4.xml · nonDerivative · entry 1

Sonsini Peter W. · CIK 0001559807 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 10,714,285

F1 · ownership.nature: The Reporting Person is a manager of NEA 16 GP, LLC, which is the sole general partner of NEA Partners 16, L.P. ("NEA Partners 16"). NEA Partners 16 is the sole general partner of New Enterprise Associates 16, L.P. ("NEA 16"), which is the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the shares held by NEA 16 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-21-021816 · doc4.xml · nonDerivative · entry 1

SANDELL SCOTT D · CIK 0001237289 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 10,714,285

F1 · ownership.nature: The Reporting Person is a manager of NEA 16 GP, LLC, which is the sole general partner of NEA Partners 16, L.P. ("NEA Partners 16"). NEA Partners 16 is the sole general partner of New Enterprise Associates 16, L.P. ("NEA 16"), which is the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the shares held by NEA 16 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-21-021815 · doc4.xml · nonDerivative · entry 1

MAKOWER JOSHUA · CIK 0001235952 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 10,714,285

F1 · ownership.nature: The Reporting Person is a manager of NEA 16 GP, LLC, which is the sole general partner of NEA Partners 16, L.P. ("NEA Partners 16"). NEA Partners 16 is the sole general partner of New Enterprise Associates 16, L.P. ("NEA 16"), which is the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the shares held by NEA 16 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-21-021813 · doc4.xml · nonDerivative · entry 1

Florence Anthony A. Jr. · CIK 0001559827 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 10,714,285

F1 · ownership.nature: The Reporting Person is a manager of NEA 16 GP, LLC, which is the sole general partner of NEA Partners 16, L.P. ("NEA Partners 16"). NEA Partners 16 is the sole general partner of New Enterprise Associates 16, L.P. ("NEA 16"), which is the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the shares held by NEA 16 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-21-021814 · doc4.xml · nonDerivative · entry 1

Makhzoumi Mohamad · CIK 0001630226 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 10,714,285

F1 · ownership.nature: The Reporting Person is a manager of NEA 16 GP, LLC, which is the sole general partner of NEA Partners 16, L.P. ("NEA Partners 16"). NEA Partners 16 is the sole general partner of New Enterprise Associates 16, L.P. ("NEA 16"), which is the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the shares held by NEA 16 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-21-021812 · doc4.xml · nonDerivative · entry 1

Chang Carmen · CIK 0001746342 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 10,714,285

F1 · ownership.nature: The Reporting Person is a manager of NEA 16 GP, LLC, which is the sole general partner of NEA Partners 16, L.P. ("NEA Partners 16"). NEA Partners 16 is the sole general partner of New Enterprise Associates 16, L.P. ("NEA 16"), which is the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the shares held by NEA 16 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-21-021810 · doc4.xml · nonDerivative · entry 1

BASKETT FOREST · CIK 0001277631 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 10,714,285

F1 · ownership.nature: The Reporting Person is a manager of NEA 16 GP, LLC, which is the sole general partner of NEA Partners 16, L.P. ("NEA Partners 16"). NEA Partners 16 is the sole general partner of New Enterprise Associates 16, L.P. ("NEA 16"), which is the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the shares held by NEA 16 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-21-021811 · doc4.xml · nonDerivative · entry 1

Behbahani Ali · CIK 0001613867 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note 1

Disclosed balance after: 10,714,285

F1 · ownership.nature: The Reporting Person is a manager of NEA 16 GP, LLC, which is the sole general partner of NEA Partners 16, L.P. ("NEA Partners 16"). NEA Partners 16 is the sole general partner of New Enterprise Associates 16, L.P. ("NEA 16"), which is the direct beneficial owner of the shares. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the shares held by NEA 16 in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-21-021809 · doc4.xml · nonDerivative · entry 1

New Enterprise Associates 16, L.P. · CIK 0001694560 · 10% owner

NEA Partners 16, L.P. · CIK 0001712881 · 10% owner

NEA 16 GP, LLC · CIK 0001712882 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,714,285

F1 · ownership.direct: The shares are directly held by New Enterprise Associates 16, L.P. ("NEA 16"), and indirectly held by NEA Partners 16, L.P. ("NEA Partners"), the sole general partner of NEA 16, NEA 16 GP, LLC ("NEA 16 GP"), the sole general partner of NEA Partners 16, and the individual managers of NEA 16 GP (NEA Partners 16, NEA 16 GP and the individual managers of NEA 16 GP, together, the "Indirect Reporting Persons").The individual managers of NEA 16 GP are Forest Baskett, Ali Behbahani, Carmen Chang, Anthony A. Florence, Jr., Mohamad Makhzoumi, Josh Makower, Scott D. Sandell, Peter W. Sonsini and Paul Walker. The Indirect Reporting Persons disclaim beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the shares of the Issuer held by NEA 16 in which the Indirect Reporting Persons have no pecuniary interest.

SEC source: 0001209191-21-021775 · doc4.xml · nonDerivative · entry 1

Wilson John Robert · CIK 0001755569 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,799,350

SEC source: 0001209191-21-021773 · doc4.xml · nonDerivative · entry 1

Vera Juan · CIK 0001755495 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,564,487

SEC source: 0001209191-21-021771 · doc4.xml · nonDerivative · entry 1

Hoang Peter L. · CIK 0001626893 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 332,568

SEC source: 0001209191-21-021769 · doc4.xml · nonDerivative · entry 1

ELMS STEVE · CIK 0001250195 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 3,142,857

F1 · ownership.nature: The reportable securities are directly owned by Aisling Capital IV, LP ("Aisling"), and which may be deemed to be beneficially owned by Aisling Capital Partners IV, LP ("Aisling GP"), as general partner of Aisling, Aisling Capital Partners IV LLC ("Aisling Partners"), as general partner of Aisling GP, and each of the individual managing members and partners (collectively, the "Managers") of Aisling GP and Aisling Partners. The Managers of Aisling Partners are Dr. Andrew Schiff and Steve Elms, who have shared voting and dispositive power over the shares. Mr. Elms, the Reporting Person, disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein, and the inclusion of these securities herein shall not be deemed an admission of beneficial ownership for purposes of Section 16 or for any other purpose.

SEC source: 0001209191-23-035617 · doc4.xml · nonDerivative · entry 1

Eansor Norman David · CIK 0001270905 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,713

F1 · shares: Reflects a 10-1 reverse stock split which became effective on January 16, 2023.

F1 · price: Reflects a 10-1 reverse stock split which became effective on January 16, 2023.

F1 · balance_after: Reflects a 10-1 reverse stock split which became effective on January 16, 2023.

SEC source: 0001209191-21-010267 · doc4.xml · derivative · entry 1

Hoang Peter L. · CIK 0001626893 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 430,000

Underlying: Common Stock · 430,000 shares

Expires 2031-02-11

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 11, 2021 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-21-010306 · doc4.xml · derivative · entry 1

Szymanska Anna · CIK 0001804499 · Vice President, Quality

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2031-02-10

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 10, 2021 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-21-010262 · doc4.xml · derivative · entry 1

Garrett Gerald · CIK 0001804510 · Vice President, Clinical Ops.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2031-02-10

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 10, 2021 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-21-010312 · doc4.xml · derivative · entry 1

Vera Juan · CIK 0001755495 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,000

Underlying: Common Stock · 140,000 shares

Expires 2031-02-10

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 10, 2021 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-21-010302 · doc4.xml · derivative · entry 1

Loiacono Michael · CIK 0001679119 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,000

Underlying: Common Stock · 140,000 shares

Expires 2031-02-10

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 10, 2021 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-21-010297 · doc4.xml · derivative · entry 1

Koneru Mythili · CIK 0001776659 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,000

Underlying: Common Stock · 140,000 shares

Expires 2031-02-10

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 10, 2021 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-21-010285 · doc4.xml · derivative · entry 1

Kim Anthony H. · CIK 0001759782 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 160,000

Underlying: Common Stock · 160,000 shares

Expires 2031-02-10

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 10, 2021 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-21-010278 · doc4.xml · derivative · entry 1

Hoang Tsvetelina P · CIK 0001763023 · VP, Research and Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2031-02-10

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 10, 2021 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-21-010256 · doc4.xml · derivative · entry 1

Agopyan Nadia · CIK 0001784758 · VP, Regulatory Affairs

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2031-02-10

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on March 10, 2021 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001408408-20-000029 · ownership.xml · derivative · entry 1

Eastern Capital LTD · CIK 0001408408 · 10% owner

Portfolio Services Ltd. · CIK 0001488856 · 10% owner

DART KENNETH BRYAN · CIK 0001331271 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 0 shares

Expires 2020-06-16

F1 · security: The Series E-1 Warrant to purchase 416,667 shares of Common Stock of the Issuer at the exercise price of $15.00 per share with an expiration date of June 16, 2020, was not exercised by the Reporting Persons before such expiration.

F1 · date: The Series E-1 Warrant to purchase 416,667 shares of Common Stock of the Issuer at the exercise price of $15.00 per share with an expiration date of June 16, 2020, was not exercised by the Reporting Persons before such expiration.

F1 · shares: The Series E-1 Warrant to purchase 416,667 shares of Common Stock of the Issuer at the exercise price of $15.00 per share with an expiration date of June 16, 2020, was not exercised by the Reporting Persons before such expiration.

F1 · price: The Series E-1 Warrant to purchase 416,667 shares of Common Stock of the Issuer at the exercise price of $15.00 per share with an expiration date of June 16, 2020, was not exercised by the Reporting Persons before such expiration.

F1 · derivative.expiration_date: The Series E-1 Warrant to purchase 416,667 shares of Common Stock of the Issuer at the exercise price of $15.00 per share with an expiration date of June 16, 2020, was not exercised by the Reporting Persons before such expiration.

F1 · derivative.underlying: The Series E-1 Warrant to purchase 416,667 shares of Common Stock of the Issuer at the exercise price of $15.00 per share with an expiration date of June 16, 2020, was not exercised by the Reporting Persons before such expiration.

F1 · derivative.underlying_shares: The Series E-1 Warrant to purchase 416,667 shares of Common Stock of the Issuer at the exercise price of $15.00 per share with an expiration date of June 16, 2020, was not exercised by the Reporting Persons before such expiration.

SEC source: 0001209191-21-010250 · doc5.xml · nonDerivative · entry 1

Wilson John Robert · CIK 0001755569 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,085,065

F1 · shares: Represents the portion of the annual board retainer for each non-employee director payable in immediately vested common stock under the Company's 2014 Omnibus Stock Ownership Plan, as amended and based on the closing price of $2.35 per share, on the day immediately preceding the date of the Company's 2019 annual meeting.

SEC source: 0001209191-21-010241 · doc5.xml · nonDerivative · entry 1

Wasserman Frederick Gerald · CIK 0001384383 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,565

F1 · shares: Represents the portion of the annual board retainer for each non-employee director payable in immediately vested common stock under the Company's 2014 Omnibus Stock Ownership Plan, as amended and based on the closing price of $2.35 per share, on the day immediately preceding the date of the Company's 2019 annual meeting.

SEC source: 0001209191-21-010231 · doc5.xml · nonDerivative · entry 1

Laskow-Pooley David · CIK 0001638533 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,565

F1 · shares: Represents the portion of the annual board retainer for each non-employee director payable in immediately vested common stock under the Company's 2014 Omnibus Stock Ownership Plan, as amended and based on the closing price of $2.35 per share, on the day immediately preceding the date of the Company's 2019 annual meeting.

SEC source: 0001209191-21-010226 · doc5.xml · nonDerivative · entry 1

ELMS STEVE · CIK 0001250195 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,022

F1 · shares: Represents the portion of the annual board retainer for each non-employee director payable in immediately vested common stock under the Company's 2014 Omnibus Stock Ownership Plan, as amended and based on the closing price of $2.35 per share, on the day immediately preceding the date of the Company's 2019 annual meeting.

SEC source: 0001209191-21-010224 · doc5.xml · nonDerivative · entry 1

Eansor Norman David · CIK 0001270905 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,282

F1 · shares: Represents the portion of the annual board retainer for each non-employee director payable in immediately vested common stock under the Company's 2014 Omnibus Stock Ownership Plan, as amended and based on the closing price of $2.35 per share, on the day immediately preceding the date of the Company's 2019 annual meeting.

SEC source: 0001209191-20-018543 · doc4.xml · derivative · entry 2

Szymanska Anna · CIK 0001804499 · Vice President, Quality

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,500

Underlying: Common Stock · 32,500 shares

Expires 2030-03-10

F2 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-20-018543 · doc4.xml · derivative · entry 1

Szymanska Anna · CIK 0001804499 · Vice President, Quality

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires 2030-03-10

F1 · derivative.exercise_date: Represents a bonus for 2019 performance granted under the Company's 2014 Omnibus Stock Ownership Plan. This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-20-018528 · doc4.xml · derivative · entry 2

Garrett Gerald · CIK 0001804510 · Vice President, Clinical Ops.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,300

Underlying: Common Stock · 38,300 shares

Expires 2030-03-10

F2 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-20-018528 · doc4.xml · derivative · entry 1

Garrett Gerald · CIK 0001804510 · Vice President, Clinical Ops.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,700

Underlying: Common Stock · 1,700 shares

Expires 2030-03-10

F1 · derivative.exercise_date: Represents a bonus for 2019 performance granted under the Company's 2014 Omnibus Stock Ownership Plan. This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-20-018548 · doc4.xml · derivative · entry 2

Vera Juan · CIK 0001755495 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 113,400

Underlying: Common Stock · 113,400 shares

Expires 2030-03-10

F2 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-20-018548 · doc4.xml · derivative · entry 1

Vera Juan · CIK 0001755495 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,600

Underlying: Common Stock · 26,600 shares

Expires 2030-03-10

F1 · derivative.exercise_date: Represents a bonus for 2019 performance granted under the Company's 2014 Omnibus Stock Ownership Plan. This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-20-018556 · doc4.xml · derivative · entry 2

Hoang Peter L. · CIK 0001626893 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 388,800

Underlying: Common Stock · 388,800 shares

Expires 2030-03-10

F2 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-20-018556 · doc4.xml · derivative · entry 1

Hoang Peter L. · CIK 0001626893 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 41,200

Underlying: Common Stock · 41,200 shares

Expires 2030-03-10

F1 · derivative.exercise_date: Represents a bonus for 2019 performance granted under the Company's 2014 Omnibus Stock Ownership Plan. This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-20-018539 · doc4.xml · derivative · entry 2

Loiacono Michael · CIK 0001679119 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 119,100

Underlying: Common Stock · 119,100 shares

Expires 2030-03-10

F2 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-20-018539 · doc4.xml · derivative · entry 1

Loiacono Michael · CIK 0001679119 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,900

Underlying: Common Stock · 20,900 shares

Expires 2030-03-10

F1 · derivative.exercise_date: Represents a bonus for 2019 performance granted under the Company's 2014 Omnibus Stock Ownership Plan. This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-20-018535 · doc4.xml · derivative · entry 2

Koneru Mythili · CIK 0001776659 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 116,100

Underlying: Common Stock · 116,100 shares

Expires 2030-03-10

F2 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-20-018535 · doc4.xml · derivative · entry 1

Koneru Mythili · CIK 0001776659 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,900

Underlying: Common Stock · 23,900 shares

Expires 2030-03-10

F1 · derivative.exercise_date: Represents a bonus for 2019 performance granted under the Company's 2014 Omnibus Stock Ownership Plan. This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-20-018534 · doc4.xml · derivative · entry 2

Kim Anthony H. · CIK 0001759782 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 127,500

Underlying: Common Stock · 127,500 shares

Expires 2030-03-10

F2 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-20-018534 · doc4.xml · derivative · entry 1

Kim Anthony H. · CIK 0001759782 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,500

Underlying: Common Stock · 32,500 shares

Expires 2030-03-10

F1 · derivative.exercise_date: Represents a bonus for 2019 performance granted under the Company's 2014 Omnibus Stock Ownership Plan. This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.

SEC source: 0001209191-20-018531 · doc4.xml · derivative · entry 2

Hoang Tsvetelina P · CIK 0001763023 · VP, Research and Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,400

Underlying: Common Stock · 25,400 shares

Expires 2030-03-10

F2 · derivative.exercise_date: This option vests in equal monthly installments over a four year period commencing on April 10, 2020 subject to the continued service by the Reporting Person to the Issuer as of the applicable vesting date.