MIST

SEC source: 0001209191-19-049211 · doc4.xml · derivative · entry 1

Maness Timothy · CIK 0001774294 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Shares · 20,000 shares

Expires 2029-09-09

F1 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vest on September 9, 2020 and one forty-eighth (1/48th) of the shares subject to the option vest on each one month anniversary thereafter, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-19-049210 · doc4.xml · derivative · entry 1

Hasija Amit · CIK 0001787700 · CFO & EVP of Corp. Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 147,000

Underlying: Common Shares · 147,000 shares

Expires 2029-09-09

F1 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to the option vest on September 9, 2020 and one forty-eighth (1/48th) of the shares subject to the option vest on each one month anniversary thereafter, subject to the Reporting Person continuing to provide service through each such date.

SEC source: 0001209191-19-029660 · doc4.xml · derivative · entry 5

Novo Holdings A/S · CIK 0001388325 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: COMMON SHARES · 964,089 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Class C Preferred share and Class D Preferred share automatically converted into one Common share upon the completion of the initial public offering.

F1 · derivative.exercise_date: Each Class C Preferred share and Class D Preferred share automatically converted into one Common share upon the completion of the initial public offering.

F1 · derivative.expiration_date: Each Class C Preferred share and Class D Preferred share automatically converted into one Common share upon the completion of the initial public offering.

SEC source: 0001209191-19-029660 · doc4.xml · derivative · entry 4

Novo Holdings A/S · CIK 0001388325 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: COMMON SHARES · 1,377,048 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Class C Preferred share and Class D Preferred share automatically converted into one Common share upon the completion of the initial public offering.

F1 · derivative.exercise_date: Each Class C Preferred share and Class D Preferred share automatically converted into one Common share upon the completion of the initial public offering.

F1 · derivative.expiration_date: Each Class C Preferred share and Class D Preferred share automatically converted into one Common share upon the completion of the initial public offering.

SEC source: 0001209191-19-029660 · doc4.xml · nonDerivative · entry 3

Novo Holdings A/S · CIK 0001388325 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,674,470

SEC source: 0001209191-19-029660 · doc4.xml · nonDerivative · entry 2

Novo Holdings A/S · CIK 0001388325 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,341,137

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-19-029660 · doc4.xml · nonDerivative · entry 1

Novo Holdings A/S · CIK 0001388325 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,377,048

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-19-029668 · doc4.xml · derivative · entry 2

Douville Philippe · CIK 0001771205 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 4,124 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Class A-1 Preferred was convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, had no expiration date and converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · derivative.exercise_date: Each share of Class A-1 Preferred was convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, had no expiration date and converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · derivative.expiration_date: Each share of Class A-1 Preferred was convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, had no expiration date and converted into Common Shares upon the closing of the Issuer's initial public offering.

SEC source: 0001209191-19-029668 · doc4.xml · nonDerivative · entry 1

Douville Philippe · CIK 0001771205 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,392

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Class A-1 Preferred was convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, had no expiration date and converted into Common Shares upon the closing of the Issuer's initial public offering.

SEC source: 0000950142-19-001098 · es1900658_4-fonds.xml · derivative · entry 11

FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC · CIK 0000903337 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 306,092 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · derivative.exercise_date: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · derivative.expiration_date: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

SEC source: 0000950142-19-001098 · es1900658_4-fonds.xml · derivative · entry 10

FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC · CIK 0000903337 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 437,203 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · derivative.exercise_date: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · derivative.expiration_date: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

SEC source: 0000950142-19-001098 · es1900658_4-fonds.xml · derivative · entry 9

FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC · CIK 0000903337 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 574,292 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · derivative.exercise_date: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · derivative.expiration_date: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

SEC source: 0000950142-19-001098 · es1900658_4-fonds.xml · derivative · entry 8

FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC · CIK 0000903337 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 798,974 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · derivative.exercise_date: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · derivative.expiration_date: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

SEC source: 0000950142-19-001098 · es1900658_4-fonds.xml · derivative · entry 7

FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC · CIK 0000903337 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Shares · 139,849 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · derivative.exercise_date: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

F1 · derivative.expiration_date: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

SEC source: 0000950142-19-001098 · es1900658_4-fonds.xml · nonDerivative · entry 6

FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC · CIK 0000903337 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,720,310

SEC source: 0000950142-19-001098 · es1900658_4-fonds.xml · nonDerivative · entry 5

FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC · CIK 0000903337 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,286,977

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

SEC source: 0000950142-19-001098 · es1900658_4-fonds.xml · nonDerivative · entry 4

FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC · CIK 0000903337 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,980,885

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

SEC source: 0000950142-19-001098 · es1900658_4-fonds.xml · nonDerivative · entry 3

FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC · CIK 0000903337 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,543,682

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

SEC source: 0000950142-19-001098 · es1900658_4-fonds.xml · nonDerivative · entry 2

FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC · CIK 0000903337 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 969,390

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

SEC source: 0000950142-19-001098 · es1900658_4-fonds.xml · nonDerivative · entry 1

FONDS DE SOLIDARITE DES TRAVAILLEURS DU QUEBEC · CIK 0000903337 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 170,416

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Class A-1 Preferred, Class A-2 Preferred, Class B Preferred, Class C Preferred and Class D-1 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and has converted into Common Shares upon the closing of the Issuer's initial public offering.

SEC source: 0001493152-19-006679 · ownership.xml · derivative · entry 5

RTW INVESTMENTS, LP · CIK 0001493215 · 10% owner

WONG RODERICK · CIK 0001493280 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By RTW

Disclosed balance after: 0

Underlying: Common Shares · 203,942 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Class D-1 Preferred and Class D-2 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and will convert into Common Shares upon the closing of the Issuer's initial public offering, which occurred on May 9, 2019.

F1 · price: Each share of Class D-1 Preferred and Class D-2 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and will convert into Common Shares upon the closing of the Issuer's initial public offering, which occurred on May 9, 2019.

F1 · derivative.exercise_date: Each share of Class D-1 Preferred and Class D-2 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and will convert into Common Shares upon the closing of the Issuer's initial public offering, which occurred on May 9, 2019.

F1 · derivative.expiration_date: Each share of Class D-1 Preferred and Class D-2 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and will convert into Common Shares upon the closing of the Issuer's initial public offering, which occurred on May 9, 2019.

F2 · ownership.nature: The securities reported herein may be deemed beneficially owned by each of: (i) RTW Investments, LP ("RTW"), which is deemed the beneficial owner of shares held by RTW Master Fund, Ltd. and RTW Innovation Master Fund, Ltd. (the "Funds"), which are investment funds managed by RTW, and (ii) Roderick Wong, M.D who serves as the Managing Partner and Chief Investment Officer of RTW. Dr. Wong exercises voting and dispositive control over the securities held by RTW and is therefore deemed to be a beneficial owner of securities owned or controlled by RTW. Each of RTW and Dr. Wong disclaim beneficial ownership of the reported securities held by the Funds, except to the extent of its or his pecuniary interest therein.

SEC source: 0001493152-19-006679 · ownership.xml · derivative · entry 4

RTW INVESTMENTS, LP · CIK 0001493215 · 10% owner

WONG RODERICK · CIK 0001493280 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By RTW

Disclosed balance after: 0

Underlying: Common Shares · 2,651,247 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Class D-1 Preferred and Class D-2 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and will convert into Common Shares upon the closing of the Issuer's initial public offering, which occurred on May 9, 2019.

F1 · price: Each share of Class D-1 Preferred and Class D-2 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and will convert into Common Shares upon the closing of the Issuer's initial public offering, which occurred on May 9, 2019.

F1 · derivative.exercise_date: Each share of Class D-1 Preferred and Class D-2 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and will convert into Common Shares upon the closing of the Issuer's initial public offering, which occurred on May 9, 2019.

F1 · derivative.expiration_date: Each share of Class D-1 Preferred and Class D-2 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and will convert into Common Shares upon the closing of the Issuer's initial public offering, which occurred on May 9, 2019.

F2 · ownership.nature: The securities reported herein may be deemed beneficially owned by each of: (i) RTW Investments, LP ("RTW"), which is deemed the beneficial owner of shares held by RTW Master Fund, Ltd. and RTW Innovation Master Fund, Ltd. (the "Funds"), which are investment funds managed by RTW, and (ii) Roderick Wong, M.D who serves as the Managing Partner and Chief Investment Officer of RTW. Dr. Wong exercises voting and dispositive control over the securities held by RTW and is therefore deemed to be a beneficial owner of securities owned or controlled by RTW. Each of RTW and Dr. Wong disclaim beneficial ownership of the reported securities held by the Funds, except to the extent of its or his pecuniary interest therein.

SEC source: 0001493152-19-006679 · ownership.xml · nonDerivative · entry 3

RTW INVESTMENTS, LP · CIK 0001493215 · 10% owner

WONG RODERICK · CIK 0001493280 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By RTW

Disclosed balance after: 3,521,856

F3 · balance_after: Consists of 2,708,386 shares held directly by RTW Master Fund, Ltd. and 813,470 shares held by RTW Innovation Master Fund, Ltd.

F2 · ownership.nature: The securities reported herein may be deemed beneficially owned by each of: (i) RTW Investments, LP ("RTW"), which is deemed the beneficial owner of shares held by RTW Master Fund, Ltd. and RTW Innovation Master Fund, Ltd. (the "Funds"), which are investment funds managed by RTW, and (ii) Roderick Wong, M.D who serves as the Managing Partner and Chief Investment Officer of RTW. Dr. Wong exercises voting and dispositive control over the securities held by RTW and is therefore deemed to be a beneficial owner of securities owned or controlled by RTW. Each of RTW and Dr. Wong disclaim beneficial ownership of the reported securities held by the Funds, except to the extent of its or his pecuniary interest therein.

SEC source: 0001493152-19-006679 · ownership.xml · nonDerivative · entry 2

RTW INVESTMENTS, LP · CIK 0001493215 · 10% owner

WONG RODERICK · CIK 0001493280 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By RTW

Disclosed balance after: 2,855,189

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Class D-1 Preferred and Class D-2 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and will convert into Common Shares upon the closing of the Issuer's initial public offering, which occurred on May 9, 2019.

F2 · ownership.nature: The securities reported herein may be deemed beneficially owned by each of: (i) RTW Investments, LP ("RTW"), which is deemed the beneficial owner of shares held by RTW Master Fund, Ltd. and RTW Innovation Master Fund, Ltd. (the "Funds"), which are investment funds managed by RTW, and (ii) Roderick Wong, M.D who serves as the Managing Partner and Chief Investment Officer of RTW. Dr. Wong exercises voting and dispositive control over the securities held by RTW and is therefore deemed to be a beneficial owner of securities owned or controlled by RTW. Each of RTW and Dr. Wong disclaim beneficial ownership of the reported securities held by the Funds, except to the extent of its or his pecuniary interest therein.

SEC source: 0001493152-19-006679 · ownership.xml · nonDerivative · entry 1

RTW INVESTMENTS, LP · CIK 0001493215 · 10% owner

WONG RODERICK · CIK 0001493280 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By RTW

Disclosed balance after: 2,651,247

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Class D-1 Preferred and Class D-2 Preferred is convertible at any time, at the option of the holder, into Common Shares, on a one-for-one basis, has no expiration date and will convert into Common Shares upon the closing of the Issuer's initial public offering, which occurred on May 9, 2019.

F2 · ownership.nature: The securities reported herein may be deemed beneficially owned by each of: (i) RTW Investments, LP ("RTW"), which is deemed the beneficial owner of shares held by RTW Master Fund, Ltd. and RTW Innovation Master Fund, Ltd. (the "Funds"), which are investment funds managed by RTW, and (ii) Roderick Wong, M.D who serves as the Managing Partner and Chief Investment Officer of RTW. Dr. Wong exercises voting and dispositive control over the securities held by RTW and is therefore deemed to be a beneficial owner of securities owned or controlled by RTW. Each of RTW and Dr. Wong disclaim beneficial ownership of the reported securities held by the Funds, except to the extent of its or his pecuniary interest therein.

SEC source: 0000930413-19-001627 · ownership.xml · nonDerivative · entry 1

BDC CAPITAL INC. · CIK 0001430885 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,388,088

F1 · balance_after: Consists of the purchase of shares reported hereunder and upon the closing of the Issuer's IPO of 1,094,011 shares held by BDC Capital, Inc., or BDC Capital, and 1,094,011 shares held by GO Capital, s.e.c., a fund for which BDC Capital is the general partner and investment manager. BDC Capital has the power to vote and the power to direct the disposition of all such shares held by itself and Go Capital, s.e.c. BDC Capital's investment in our company is managed by Amplitude Ventures Capital Management Inc., or Amplitude, of which Dion Madsen and Jean-Francois Pariseau serve as partners. Go Capital, s.e.c. is managed by Dominique Belanger, Managing Partner, Co-Investments at BDC Capital. BDC Capital retains the right to approve of certain investment, voting or divestiture decisions proposed by Amplitude, such decisions being approved, depending on their quantum and potential impact, by either senior management at BDC Capital or by BDC Capital's investment committee.

F2 · balance_after: The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by GO Capital, s.e.c., in which the Reporting Person has no pecuniary interest.

SEC source: 0001209191-19-028517 · doc4.xml · derivative · entry 1

Maness Timothy · CIK 0001774294 · Vice President, Finance

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,998

Underlying: Common Shares · 46,998 shares

Expires 2029-05-08

F1 · derivative.exercise_date: One-fourth (1/4th) of the share subject to the option vest on April 11, 2020 and one forty-eighth (1/48th) of the shares subject to the option vest on each one month anniversary thereafter, subject to the Reporting Person continuing to provide service through each such date.