MIRM

SEC source: 0001415889-25-008558 · form4-03182025_090306.xml · nonDerivative · entry 2

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,647

F2 · kind: Shares sold to cover tax withholding obligations associated with the vesting of the performance restricted stock units.

SEC source: 0001415889-25-008557 · form4-03182025_090304.xml · nonDerivative · entry 2

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,672

F2 · kind: Shares sold to cover tax withholding obligations associated with the vesting of the performance restricted stock units.

SEC source: 0001415889-25-008556 · form4-03182025_090301.xml · nonDerivative · entry 2

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 138,641

F2 · kind: Shares sold to cover tax withholding obligations associated with the vesting of the performance restricted stock units.

SEC source: 0001415889-25-008439 · form4-03182025_090327.xml · nonDerivative · entry 2

Heron Patrick J · CIK 0001365617 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Frazier Life Sciences X, L.P.

Disclosed balance after: 168,672

F3 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $43.925 to $43.945, inclusive.

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. The Reporting Person is one of two managing members of FHMLS X, L.L.C. The Reporting Person disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.

SEC source: 0001415889-25-008558 · form4-03182025_090306.xml · derivative · entry 7

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,658

Underlying: Common Stock · 5,315 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each performance restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F7 · derivative.exercise_date: The shares vest as follows: 2/3 of the shares vest on March 15, 2025 and 1/3 of the shares vest on March 15, 2026.

F7 · derivative.expiration_date: The shares vest as follows: 2/3 of the shares vest on March 15, 2025 and 1/3 of the shares vest on March 15, 2026.

SEC source: 0001415889-25-008558 · form4-03182025_090306.xml · nonDerivative · entry 1

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,547

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each performance restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-008557 · form4-03182025_090304.xml · derivative · entry 3

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,220

Underlying: Common Stock · 14,440 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each performance restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: The shares vest as follows: 2/3 of the shares vest on March 15, 2025 and 1/3 of the shares vest on March 15, 2026.

F3 · derivative.expiration_date: The shares vest as follows: 2/3 of the shares vest on March 15, 2025 and 1/3 of the shares vest on March 15, 2026.

SEC source: 0001415889-25-008557 · form4-03182025_090304.xml · nonDerivative · entry 1

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,551

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each performance restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-008556 · form4-03182025_090301.xml · derivative · entry 4

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 50,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each performance restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: The shares vest as follows: 2/3 of the shares vest on March 15, 2025 and 1/3 of the shares vest on March 15, 2026.

F3 · derivative.expiration_date: The shares vest as follows: 2/3 of the shares vest on March 15, 2025 and 1/3 of the shares vest on March 15, 2026.

SEC source: 0001415889-25-008556 · form4-03182025_090301.xml · nonDerivative · entry 1

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 165,920

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each performance restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-008439 · form4-03182025_090327.xml · nonDerivative · entry 1

Heron Patrick J · CIK 0001365617 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Frazier Life Sciences X, L.P.

Disclosed balance after: 168,651

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $44.00 to $44.15, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnotes (1) and (3) to this Form 4.

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. The Reporting Person is one of two managing members of FHMLS X, L.L.C. The Reporting Person disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.

SEC source: 0001415889-25-007828 · form4-03122025_080317.xml · nonDerivative · entry 3

Heron Patrick J · CIK 0001365617 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Frazier Life Sciences X, L.P.

Disclosed balance after: 168,123

F4 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $43.405 to $44, inclusive.

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. The Reporting Person is one of two managing members of FHMLS X, L.L.C. The Reporting Person disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.

SEC source: 0001415889-25-007828 · form4-03122025_080317.xml · nonDerivative · entry 2

Heron Patrick J · CIK 0001365617 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Frazier Life Sciences X, L.P.

Disclosed balance after: 167,160

F3 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $43.20 to $43.50, inclusive.

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. The Reporting Person is one of two managing members of FHMLS X, L.L.C. The Reporting Person disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.

SEC source: 0001415889-25-007828 · form4-03122025_080317.xml · nonDerivative · entry 1

Heron Patrick J · CIK 0001365617 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Frazier Life Sciences X, L.P.

Disclosed balance after: 166,583

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $43.42 to $43, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnotes (1), (3) and (4) to this Form 4.

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. The Reporting Person is one of two managing members of FHMLS X, L.L.C. The Reporting Person disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.

SEC source: 0001415889-25-007540 · form4-03102025_090354.xml · nonDerivative · entry 2

Heron Patrick J · CIK 0001365617 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Frazier Life Sciences X, L.P.

Disclosed balance after: 165,825

F3 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $42.79 to $43.42, inclusive.

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. The Reporting Person is one of two managing members of FHMLS X, L.L.C. The Reporting Person disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.

SEC source: 0001415889-25-007540 · form4-03102025_090354.xml · nonDerivative · entry 1

Heron Patrick J · CIK 0001365617 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Frazier Life Sciences X, L.P.

Disclosed balance after: 165,245

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $43.42 to $44.25, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnotes (1) and (3) to this Form 4.

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. The Reporting Person is one of two managing members of FHMLS X, L.L.C. The Reporting Person disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.

SEC source: 0001415889-25-007260 · form4-03062025_100339.xml · nonDerivative · entry 3

Heron Patrick J · CIK 0001365617 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Frazier Life Sciences X, L.P.

Disclosed balance after: 163,910

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. The Reporting Person is one of two managing members of FHMLS X, L.L.C. The Reporting Person disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.

SEC source: 0001415889-25-006955 · form4-03052025_090314.xml · nonDerivative · entry 2

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,111

SEC source: 0001415889-25-006955 · form4-03052025_090314.xml · nonDerivative · entry 1

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,280

F1 · price: The weighted average sale price for the transaction reported was $45.571143, and the range of prices were between $45.50 and $45.88. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided.

SEC source: 0001415889-25-007260 · form4-03062025_100339.xml · nonDerivative · entry 2

Heron Patrick J · CIK 0001365617 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Frazier Life Sciences X, L.P.

Disclosed balance after: 163,643

F3 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $45.935 to $45.99, inclusive.

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. The Reporting Person is one of two managing members of FHMLS X, L.L.C. The Reporting Person disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.

SEC source: 0001415889-25-007260 · form4-03062025_100339.xml · nonDerivative · entry 1

Heron Patrick J · CIK 0001365617 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Frazier Life Sciences X, L.P.

Disclosed balance after: 163,587

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $44.935 to $45.92, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnotes (1) and (3) to this Form 4.

F2 · ownership.nature: The shares are held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. The Reporting Person is one of two managing members of FHMLS X, L.L.C. The Reporting Person disclaims beneficial ownership of such securities except to the extent of his pecuniary interest therein.

SEC source: 0001415889-25-006524 · form4-03042025_090312.xml · derivative · entry 5

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 238,487

Underlying: Common Stock · 40,000 shares

Expires 2029-03-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The stock option is fully vested.

SEC source: 0001415889-25-006524 · form4-03042025_090312.xml · nonDerivative · entry 3

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,920

F1 · kind: Reported transaction occurred pursuant to a Rule 10b5-1 Plan adopted by the reporting person on November 22, 2024.

F3 · price: The weighted average sale price for the transaction reported was $47.19, and the range of prices were between $46.82 and $47.78. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided.

SEC source: 0001415889-25-006524 · form4-03042025_090312.xml · nonDerivative · entry 2

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 136,528

F1 · kind: Reported transaction occurred pursuant to a Rule 10b5-1 Plan adopted by the reporting person on November 22, 2024.

F2 · price: The weighted average sale price for the transaction reported was $46.61, and the range of prices were between $45.82 and $46.81. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided.

SEC source: 0001415889-25-006524 · form4-03042025_090312.xml · nonDerivative · entry 1

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 155,920

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-25-002980 · form4-02042025_050201.xml · nonDerivative · entry 2

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,232

F2 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-25-002982 · form4-02042025_050206.xml · nonDerivative · entry 1

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,961

F1 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-25-002981 · form4-02042025_050204.xml · nonDerivative · entry 1

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,920

F1 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-25-002980 · form4-02042025_050201.xml · derivative · entry 3

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,771

Underlying: Common Stock · 1,772 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock (or its cash equivalent, at the discretion of the Issuer).

F3 · derivative.exercise_date: The restricted stock units vest in a series of three successive equal annual installments beginning January 31, 2024. 1,772 shares vested on January 31, 2024 ; 1,772 shares vested January 31, 2025 and the remaining 1,771 shares will vest on January 31, 2026.

F3 · derivative.expiration_date: The restricted stock units vest in a series of three successive equal annual installments beginning January 31, 2024. 1,772 shares vested on January 31, 2024 ; 1,772 shares vested January 31, 2025 and the remaining 1,771 shares will vest on January 31, 2026.

SEC source: 0001415889-25-002980 · form4-02042025_050201.xml · nonDerivative · entry 1

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,296

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock (or its cash equivalent, at the discretion of the Issuer).

SEC source: 0001415889-25-002135 · form4-01272025_090147.xml · nonDerivative · entry 2

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,524

F2 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-25-002137 · form4-01272025_090133.xml · nonDerivative · entry 2

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,588

F2 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-25-002134 · form4-01272025_090100.xml · nonDerivative · entry 2

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,022

F2 · kind: Shares sold to cover tax withholding obligations associated with the vesting of restricted stock units.

SEC source: 0001415889-25-002135 · form4-01272025_090147.xml · derivative · entry 3

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,000

Underlying: Common Stock · 1,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock (or its cash equivalent, at the discretion of the Issuer).

F3 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

SEC source: 0001415889-25-002135 · form4-01272025_090147.xml · nonDerivative · entry 1

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,426

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock (or its cash equivalent, at the discretion of the Issuer).

SEC source: 0001415889-25-002137 · form4-01272025_090133.xml · derivative · entry 3

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,500

Underlying: Common Stock · 5,750 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock (or its cash equivalent, at the discretion of the Issuer).

F3 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

SEC source: 0001415889-25-002137 · form4-01272025_090133.xml · nonDerivative · entry 1

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,765

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock (or its cash equivalent, at the discretion of the Issuer).

SEC source: 0001415889-25-002136 · form4-01272025_090146.xml · derivative · entry 2

BJERKHOLT ERIC · CIK 0001197350 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,333

Underlying: Common Stock · 2,667 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock (or its cash equivalent, at the discretion of the Issuer).

F2 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F2 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

SEC source: 0001415889-25-002136 · form4-01272025_090146.xml · nonDerivative · entry 1

BJERKHOLT ERIC · CIK 0001197350 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,946

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock (or its cash equivalent, at the discretion of the Issuer).

SEC source: 0001415889-25-002134 · form4-01272025_090100.xml · derivative · entry 4

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 12,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 23, 2024 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

SEC source: 0001415889-25-002134 · form4-01272025_090100.xml · nonDerivative · entry 1

Peetz Christopher · CIK 0001614740 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 131,859

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001415889-25-001955 · form4-01232025_100106.xml · derivative · entry 3

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,973

Underlying: Common Stock · 7,973 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F4 · derivative.exercise_date: On January 31, 2023, the reporting person was granted performance restricted stock units ("PSUs") which vest upon satisfaction of certain performance criteria. On January 21, 2025, performance criteria were determined to have been met. The shares subject to the PSUs vest as follows: 2/3 of the shares vest on March 15, 2025 and 1/3 of the shares vest on March 15, 2026.

F4 · derivative.expiration_date: On January 31, 2023, the reporting person was granted performance restricted stock units ("PSUs") which vest upon satisfaction of certain performance criteria. On January 21, 2025, performance criteria were determined to have been met. The shares subject to the PSUs vest as follows: 2/3 of the shares vest on March 15, 2025 and 1/3 of the shares vest on March 15, 2026.

SEC source: 0001415889-25-001955 · form4-01232025_100106.xml · derivative · entry 2

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,625

Underlying: Common Stock · 4,625 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 21, 2025 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 21, 2025 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

SEC source: 0001415889-25-001955 · form4-01232025_100106.xml · derivative · entry 1

Howe Jolanda · CIK 0001974200 · SVP, GLOBAL CONTROLLER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,500

Underlying: Common Stock · 18,500 shares

Expires 2035-01-20

F1 · derivative.exercise_date: 1/4th of the shares vest one year after January 21, 2025 (the "Vesting Commencement Date") and the balance of the shares vest in a series of 36 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date.

SEC source: 0001415889-25-001953 · form4-01232025_100126.xml · derivative · entry 2

BJERKHOLT ERIC · CIK 0001197350 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 21, 2025 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 21, 2025 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

SEC source: 0001415889-25-001953 · form4-01232025_100126.xml · derivative · entry 1

BJERKHOLT ERIC · CIK 0001197350 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2035-01-20

F1 · derivative.exercise_date: 1/4th of the shares vest one year after January 21, 2025 (the "Vesting Commencement Date") and the balance of the shares vest in a series of 36 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date.

SEC source: 0001415889-25-001954 · form4-01232025_100156.xml · derivative · entry 2

Quan Joanne · CIK 0001670138 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 21, 2025 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 21, 2025 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

SEC source: 0001415889-25-001954 · form4-01232025_100156.xml · derivative · entry 1

Quan Joanne · CIK 0001670138 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2035-01-20

F1 · derivative.exercise_date: 1/4th of the shares vest one year after January 21, 2025 (the "Vesting Commencement Date") and the balance of the shares vest in a series of 36 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date.

SEC source: 0001415889-25-001952 · form4-01232025_100138.xml · derivative · entry 3

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,660

Underlying: Common Stock · 21,660 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F4 · derivative.exercise_date: On January 31, 2023, the reporting person was granted performance restricted stock units ("PSUs") which vest upon satisfaction of certain performance criteria. On January 21, 2025, performance criteria were determined to have been met. The shares subject to the PSUs vest as follows: 2/3 of the shares vest on March 15, 2025 and 1/3 of the shares vest on March 15, 2026.

F4 · derivative.expiration_date: On January 31, 2023, the reporting person was granted performance restricted stock units ("PSUs") which vest upon satisfaction of certain performance criteria. On January 21, 2025, performance criteria were determined to have been met. The shares subject to the PSUs vest as follows: 2/3 of the shares vest on March 15, 2025 and 1/3 of the shares vest on March 15, 2026.

SEC source: 0001415889-25-001952 · form4-01232025_100138.xml · derivative · entry 2

Radovich Peter · CIK 0001650131 · PRESIDENT AND COO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 21, 2025 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.

F3 · derivative.expiration_date: 1/3rd of the shares subject to the restricted stock units shall vest on each anniversary of January 21, 2025 (the "Vesting Commencement Date"), such that the entire award will be vested on the three-year anniversary of the Vesting Commencement Date.