MANE

SEC source: 0001628280-26-005907 · wk-form4_1770336262.xml · derivative · entry 10

Coric Vlad · CIK 0001704317 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 33,706 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · price: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · derivative.exercise_date: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · derivative.expiration_date: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F2 · ownership.nature: Shares held by Vladimir Coric Family Trust 2013.

SEC source: 0001628280-26-005907 · wk-form4_1770336262.xml · nonDerivative · entry 9

Coric Vlad · CIK 0001704317 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 319,398

F3 · ownership.nature: Shares held by Vladimir Coric Marital Trust 2013.

SEC source: 0001628280-26-005907 · wk-form4_1770336262.xml · nonDerivative · entry 8

Coric Vlad · CIK 0001704317 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 319,398

F2 · ownership.nature: Shares held by Vladimir Coric Family Trust 2013.

SEC source: 0001628280-26-005907 · wk-form4_1770336262.xml · nonDerivative · entry 7

Coric Vlad · CIK 0001704317 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 129,939

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · kind: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F5 · price: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

SEC source: 0001628280-26-005907 · wk-form4_1770336262.xml · nonDerivative · entry 6

Coric Vlad · CIK 0001704317 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 260,575

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · kind: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F5 · price: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F3 · ownership.nature: Shares held by Vladimir Coric Marital Trust 2013.

SEC source: 0001628280-26-005907 · wk-form4_1770336262.xml · nonDerivative · entry 5

Coric Vlad · CIK 0001704317 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 260,575

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · kind: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F5 · price: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F2 · ownership.nature: Shares held by Vladimir Coric Family Trust 2013.

SEC source: 0001628280-26-005907 · wk-form4_1770336262.xml · nonDerivative · entry 4

Coric Vlad · CIK 0001704317 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 182,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · kind: On February 5, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F4 · price: On February 5, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F3 · ownership.nature: Shares held by Vladimir Coric Marital Trust 2013.

SEC source: 0001628280-26-005907 · wk-form4_1770336262.xml · nonDerivative · entry 3

Coric Vlad · CIK 0001704317 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 182,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · kind: On February 5, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F4 · price: On February 5, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F2 · ownership.nature: Shares held by Vladimir Coric Family Trust 2013.

SEC source: 0001628280-26-005907 · wk-form4_1770336262.xml · nonDerivative · entry 2

Coric Vlad · CIK 0001704317 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 33,706

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · price: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F3 · ownership.nature: Shares held by Vladimir Coric Marital Trust 2013.

SEC source: 0001628280-26-005907 · wk-form4_1770336262.xml · nonDerivative · entry 1

Coric Vlad · CIK 0001704317 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 33,706

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · price: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F2 · ownership.nature: Shares held by Vladimir Coric Family Trust 2013.

SEC source: 0001628280-26-005910 · wk-form4_1770336315.xml · derivative · entry 2

Grant-Kels Jane M. · CIK 0002108622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,455 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share, on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · price: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share, on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · derivative.exercise_date: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share, on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · derivative.expiration_date: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share, on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

SEC source: 0001628280-26-005910 · wk-form4_1770336315.xml · nonDerivative · entry 1

Grant-Kels Jane M. · CIK 0002108622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,455

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share, on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · price: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share, on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

SEC source: 0001628280-26-005905 · wk-form4_1770336213.xml · derivative · entry 8

Longitude Capital Partners V, LLC · CIK 0002018312 · 10% owner

Longitude 103.8 East Partners, LLC · CIK 0002094273 · 10% owner

Longitude 103.8 East, L.P. · CIK 0002094269 · 10% owner

Longitude Venture Partners V, L.P. · CIK 0001935964 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 1,171,121 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F3 · price: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F3 · derivative.exercise_date: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F3 · derivative.expiration_date: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F4 · ownership.nature: These shares are held by Longitude 103.8 East, L.P. ("L103"). Longitude 103.8 East Partners, LLC ("L103P") is the general partner of L103 and may be deemed to have voting, investment and dispositive power with respect to these shares. Juliet Tammenoms Bakker and Patrick Enright, a member of the board of directors of the Issuer, are the managing members of L103P, and may each be deemed to share voting, investment and dispositive power with respect to these shares. Each of L103P, Ms. Tammenoms Bakker and Patrick Enright disclaims beneficial ownership of such shares except to the extent of their respective pecuniary interests therein.

SEC source: 0001628280-26-005905 · wk-form4_1770336213.xml · derivative · entry 7

Longitude Capital Partners V, LLC · CIK 0002018312 · 10% owner

Longitude 103.8 East Partners, LLC · CIK 0002094273 · 10% owner

Longitude 103.8 East, L.P. · CIK 0002094269 · 10% owner

Longitude Venture Partners V, L.P. · CIK 0001935964 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 1,171,121 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F3 · price: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F3 · derivative.exercise_date: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F3 · derivative.expiration_date: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners V, L.P. ("LVPV"). Longitude Capital Partners V, LLC ("LCPV"), is the general partner of LVPV and may be deemed to have voting, investment and dispositive power with respect to these shares. Juliet Tammenoms Bakker and Patrick Enright, a member of the board of directors of the Issuer, are the managing members of LCPV, and may each be deemed to share voting, investment and dispositive power with respect to these shares. Each of LCPV, Ms. Tammenoms Bakker and Patrick Enright disclaims beneficial ownership of such shares except to the extent of their respective pecuniary interests therein.

SEC source: 0001628280-26-005905 · wk-form4_1770336213.xml · derivative · entry 6

Longitude Capital Partners V, LLC · CIK 0002018312 · 10% owner

Longitude 103.8 East Partners, LLC · CIK 0002094273 · 10% owner

Longitude 103.8 East, L.P. · CIK 0002094269 · 10% owner

Longitude Venture Partners V, L.P. · CIK 0001935964 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 1,236,631 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On February 5, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · price: On February 5, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · derivative.exercise_date: On February 5, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · derivative.expiration_date: On February 5, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners V, L.P. ("LVPV"). Longitude Capital Partners V, LLC ("LCPV"), is the general partner of LVPV and may be deemed to have voting, investment and dispositive power with respect to these shares. Juliet Tammenoms Bakker and Patrick Enright, a member of the board of directors of the Issuer, are the managing members of LCPV, and may each be deemed to share voting, investment and dispositive power with respect to these shares. Each of LCPV, Ms. Tammenoms Bakker and Patrick Enright disclaims beneficial ownership of such shares except to the extent of their respective pecuniary interests therein.

SEC source: 0001628280-26-005905 · wk-form4_1770336213.xml · nonDerivative · entry 5

Longitude Capital Partners V, LLC · CIK 0002018312 · 10% owner

Longitude 103.8 East Partners, LLC · CIK 0002094273 · 10% owner

Longitude 103.8 East, L.P. · CIK 0002094269 · 10% owner

Longitude Venture Partners V, L.P. · CIK 0001935964 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 2,053,474

F4 · ownership.nature: These shares are held by Longitude 103.8 East, L.P. ("L103"). Longitude 103.8 East Partners, LLC ("L103P") is the general partner of L103 and may be deemed to have voting, investment and dispositive power with respect to these shares. Juliet Tammenoms Bakker and Patrick Enright, a member of the board of directors of the Issuer, are the managing members of L103P, and may each be deemed to share voting, investment and dispositive power with respect to these shares. Each of L103P, Ms. Tammenoms Bakker and Patrick Enright disclaims beneficial ownership of such shares except to the extent of their respective pecuniary interests therein.

SEC source: 0001628280-26-005905 · wk-form4_1770336213.xml · nonDerivative · entry 4

Longitude Capital Partners V, LLC · CIK 0002018312 · 10% owner

Longitude 103.8 East Partners, LLC · CIK 0002094273 · 10% owner

Longitude 103.8 East, L.P. · CIK 0002094269 · 10% owner

Longitude Venture Partners V, L.P. · CIK 0001935964 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 2,600,399

F2 · ownership.nature: These shares are held by Longitude Venture Partners V, L.P. ("LVPV"). Longitude Capital Partners V, LLC ("LCPV"), is the general partner of LVPV and may be deemed to have voting, investment and dispositive power with respect to these shares. Juliet Tammenoms Bakker and Patrick Enright, a member of the board of directors of the Issuer, are the managing members of LCPV, and may each be deemed to share voting, investment and dispositive power with respect to these shares. Each of LCPV, Ms. Tammenoms Bakker and Patrick Enright disclaims beneficial ownership of such shares except to the extent of their respective pecuniary interests therein.

SEC source: 0001628280-26-005905 · wk-form4_1770336213.xml · nonDerivative · entry 3

Longitude Capital Partners V, LLC · CIK 0002018312 · 10% owner

Longitude 103.8 East Partners, LLC · CIK 0002094273 · 10% owner

Longitude 103.8 East, L.P. · CIK 0002094269 · 10% owner

Longitude Venture Partners V, L.P. · CIK 0001935964 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 1,171,121

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F3 · price: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F4 · ownership.nature: These shares are held by Longitude 103.8 East, L.P. ("L103"). Longitude 103.8 East Partners, LLC ("L103P") is the general partner of L103 and may be deemed to have voting, investment and dispositive power with respect to these shares. Juliet Tammenoms Bakker and Patrick Enright, a member of the board of directors of the Issuer, are the managing members of L103P, and may each be deemed to share voting, investment and dispositive power with respect to these shares. Each of L103P, Ms. Tammenoms Bakker and Patrick Enright disclaims beneficial ownership of such shares except to the extent of their respective pecuniary interests therein.

SEC source: 0001628280-26-005905 · wk-form4_1770336213.xml · nonDerivative · entry 2

Longitude Capital Partners V, LLC · CIK 0002018312 · 10% owner

Longitude 103.8 East Partners, LLC · CIK 0002094273 · 10% owner

Longitude 103.8 East, L.P. · CIK 0002094269 · 10% owner

Longitude Venture Partners V, L.P. · CIK 0001935964 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 2,407,752

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F3 · price: On February 5, 2026, the shares of Series C Convertible Preferred Stock automatically converted into shares of Common Stock on a on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners V, L.P. ("LVPV"). Longitude Capital Partners V, LLC ("LCPV"), is the general partner of LVPV and may be deemed to have voting, investment and dispositive power with respect to these shares. Juliet Tammenoms Bakker and Patrick Enright, a member of the board of directors of the Issuer, are the managing members of LCPV, and may each be deemed to share voting, investment and dispositive power with respect to these shares. Each of LCPV, Ms. Tammenoms Bakker and Patrick Enright disclaims beneficial ownership of such shares except to the extent of their respective pecuniary interests therein.

SEC source: 0001628280-26-005905 · wk-form4_1770336213.xml · nonDerivative · entry 1

Longitude Capital Partners V, LLC · CIK 0002018312 · 10% owner

Longitude 103.8 East Partners, LLC · CIK 0002094273 · 10% owner

Longitude 103.8 East, L.P. · CIK 0002094269 · 10% owner

Longitude Venture Partners V, L.P. · CIK 0001935964 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 1,236,631

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On February 5, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · price: On February 5, 2026, the shares of Series B Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F2 · ownership.nature: These shares are held by Longitude Venture Partners V, L.P. ("LVPV"). Longitude Capital Partners V, LLC ("LCPV"), is the general partner of LVPV and may be deemed to have voting, investment and dispositive power with respect to these shares. Juliet Tammenoms Bakker and Patrick Enright, a member of the board of directors of the Issuer, are the managing members of LCPV, and may each be deemed to share voting, investment and dispositive power with respect to these shares. Each of LCPV, Ms. Tammenoms Bakker and Patrick Enright disclaims beneficial ownership of such shares except to the extent of their respective pecuniary interests therein.

SEC source: 0001628280-26-005898 · wk-form4_1770336047.xml · derivative · entry 3

Durso Timothy August · CIK 0002107508 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,473 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share (the "Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · price: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share (the "Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · derivative.exercise_date: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share (the "Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · derivative.expiration_date: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share (the "Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

SEC source: 0001628280-26-005898 · wk-form4_1770336047.xml · nonDerivative · entry 1

Durso Timothy August · CIK 0002107508 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 118,190

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share (the "Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · price: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share (the "Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

SEC source: 0001628280-26-005897 · wk-form4_1770336007.xml · derivative · entry 2

Waldman Reid Alexander · CIK 0002107415 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,437 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · price: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · derivative.exercise_date: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · derivative.expiration_date: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

SEC source: 0001628280-26-005897 · wk-form4_1770336007.xml · nonDerivative · entry 1

Waldman Reid Alexander · CIK 0002107415 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 234,872

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

F1 · price: On February 5, 2026, the shares of Series A Convertible Preferred Stock automatically converted into shares of the Issuer's common stock, par value $0.00001 per share ("Common Stock"), on a 10.067-for-1 basis without payment of further consideration immediately prior to the closing of the Issuer's initial public offering. The shares have no expiration date.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 17

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 489,932

F18 · shares: Notes are included on Exhibit 99.1.

F18 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F18 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 16

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 473,369

F17 · shares: Notes are included on Exhibit 99.1.

F17 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F17 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 15

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 455,534

F16 · shares: Notes are included on Exhibit 99.1.

F16 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F16 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 14

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 416,763

F15 · shares: Notes are included on Exhibit 99.1.

F15 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F15 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 13

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 397,564

F14 · shares: Notes are included on Exhibit 99.1.

F14 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F14 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0001027035-26-000004 · wk-form4a_1772228643.xml · nonDerivative · entry 1

CHILDS JOHN W · CIK 0001027035 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 294,117

F1 · shares: This amendment is being filed to correct the nature of the indirect ownership reported in the Form 4 filed on February 5, 2026 (Original Form 4). The Original Form 4 inadvertently misstated that 294,117 shares of Common Stock were indirectly acquired by the Reporting Person through J.W. Childs Associates (FL), L.P. However, as reflected in this amendment, 294,117 shares of Common Stock were indirectly acquired by the Reporting Person through the John W. Childs 2013 Revocable Trust, and no shares of Common Stock were indirectly acquired by the Reporting Person through J.W. Childs Associates (FL), L.P.

F1 · balance_after: This amendment is being filed to correct the nature of the indirect ownership reported in the Form 4 filed on February 5, 2026 (Original Form 4). The Original Form 4 inadvertently misstated that 294,117 shares of Common Stock were indirectly acquired by the Reporting Person through J.W. Childs Associates (FL), L.P. However, as reflected in this amendment, 294,117 shares of Common Stock were indirectly acquired by the Reporting Person through the John W. Childs 2013 Revocable Trust, and no shares of Common Stock were indirectly acquired by the Reporting Person through J.W. Childs Associates (FL), L.P.

F1 · ownership.nature: This amendment is being filed to correct the nature of the indirect ownership reported in the Form 4 filed on February 5, 2026 (Original Form 4). The Original Form 4 inadvertently misstated that 294,117 shares of Common Stock were indirectly acquired by the Reporting Person through J.W. Childs Associates (FL), L.P. However, as reflected in this amendment, 294,117 shares of Common Stock were indirectly acquired by the Reporting Person through the John W. Childs 2013 Revocable Trust, and no shares of Common Stock were indirectly acquired by the Reporting Person through J.W. Childs Associates (FL), L.P.

F2 · ownership.nature: Shares held by the John W. Childs 2013 Revocable Trust. The Reporting Person is Trustee of the John W. Childs 2013 Revocable Trust and may be deemed to hold voting and dispositive power with respect to these securities.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 12

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 393,732

F13 · shares: Notes are included on Exhibit 99.1.

F13 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F13 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 11

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 390,554

F12 · shares: Notes are included on Exhibit 99.1.

F12 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F12 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 10

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 386,101

F11 · shares: Notes are included on Exhibit 99.1.

F11 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F11 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 9

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 376,933

F10 · shares: Notes are included on Exhibit 99.1.

F10 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F10 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 8

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 374,414

F9 · shares: Notes are included on Exhibit 99.1.

F9 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F9 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 7

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 372,579

F8 · shares: Notes are included on Exhibit 99.1.

F8 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F8 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 6

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,648,538

F7 · shares: Notes are included on Exhibit 99.1.

F7 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F7 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 5

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,630,049

F6 · shares: Notes are included on Exhibit 99.1.

F6 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F6 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 4

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,604,141

F5 · shares: Notes are included on Exhibit 99.1.

F5 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F5 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 3

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,550,797

F4 · shares: Notes are included on Exhibit 99.1.

F4 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F4 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 2

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,536,138

F3 · shares: Notes are included on Exhibit 99.1.

F3 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F3 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0000899140-26-000140 · form4.xml · nonDerivative · entry 1

SUVRETTA CAPITAL MANAGEMENT, LLC · CIK 0001569064 · Director · 10% owner

Cowen Aaron · CIK 0001869640 · 10% owner

Averill Master Fund, Ltd. · CIK 0001939329 · Director · 10% owner

Averill Madison Master Fund, Ltd. · CIK 0002021243 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 3,525,462

F2 · shares: Notes are included on Exhibit 99.1.

F2 · price: Notes are included on Exhibit 99.1.

F1 · ownership.direct: Notes are included on Exhibit 99.1.

F1 · ownership.nature: Notes are included on Exhibit 99.1.

F2 · ownership.nature: Notes are included on Exhibit 99.1.

SEC source: 0001628280-26-005906 · wk-form4_1770336237.xml · derivative · entry 8

CHILDS JOHN W · CIK 0001027035 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,525

Underlying: Common Stock · 51,525 shares

Expires 2036-02-03

F5 · derivative.exercise_date: This option shall be fully vested and exercisable on February 3, 2027, the first anniversary of the vesting commencement date.

SEC source: 0001628280-26-005903 · wk-form4_1770336145.xml · derivative · entry 1

Greco Michael V. · CIK 0001786766 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 144,401

Underlying: Common Stock · 144,401 shares

Expires 2036-02-03

F1 · derivative.exercise_date: The option vests as to 25% of the underlying shares of the Issuer's common stock, par value $0.00001 per share, on February 3, 2027, the first anniversary of the vesting commencement date, and as to the remaining shares, in equal monthly installments over 36 months thereafter, subject to continued service.

SEC source: 0001628280-26-005904 · wk-form4_1770336183.xml · derivative · entry 9

ENRIGHT PATRICK G · CIK 0001253886 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,131

Underlying: Common Stock · 45,131 shares

Expires 2036-02-03

F5 · derivative.exercise_date: This option shall be fully vested and exercisable on February 3, 2027, the first anniversary of the vesting commencement date.

SEC source: 0001628280-26-005907 · wk-form4_1770336262.xml · derivative · entry 17

Coric Vlad · CIK 0001704317 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,525

Underlying: Common Stock · 51,525 shares

Expires 2036-02-03

F6 · derivative.exercise_date: This option shall be fully vested and exercisable on February 3, 2027, the first anniversary of the vesting commencement date.

SEC source: 0001628280-26-005900 · wk-form4_1770336117.xml · derivative · entry 1

Neumann Mark · CIK 0001756211 · Chief Commercial Officer · Strategy Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,885

Underlying: Common Stock · 102,885 shares

Expires 2036-02-03

F1 · derivative.exercise_date: The option vests as to 25% of the underlying shares of the Issuer's common stock, par value $0.00001 per share, on February 3, 2027, the first anniversary of the vesting commencement date, and as to the remaining shares, in equal monthly installments over 36 months thereafter, subject to continued service.

SEC source: 0001628280-26-005910 · wk-form4_1770336315.xml · derivative · entry 3

Grant-Kels Jane M. · CIK 0002108622 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 51,525

Underlying: Common Stock · 51,525 shares

Expires 2036-02-03

F2 · derivative.exercise_date: This option shall be fully vested and exercisable on February 3, 2027, the first anniversary of the vesting commencement date.

SEC source: 0001193125-26-039876 · ownership.xml · derivative · entry 1

Pance Katarina · CIK 0002105096 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,000

Underlying: Common Stock · 43,000 shares

Expires 2036-02-03

F1 · derivative.exercise_date: This option shall be fully vested and exercisable on February 3, 2027, the first anniversary of the vesting commencement date.

SEC source: 0001628280-26-005909 · wk-form4_1770336291.xml · derivative · entry 1

Friedman David Matthew · CIK 0002108980 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,000

Underlying: Common Stock · 43,000 shares

Expires 2036-02-03

F1 · shares: Consists of options to purchase shares of the Issuer's common stock awarded to Mr. Friedman in connection with his role as a member of the Issuer's Board of Directors. Mr. Friedman, as an employee of Suvretta Capital Management, LLC ("Suvretta Capital"), the investment manager of Averill Master Fund, Ltd. and Averill Madison Master Fund, Ltd (the "Funds"), is holding such options for the benefit of the Funds, and as such Mr. Friedman disclaims beneficial ownership of such options. The Funds, and Suvretta Capital may be deemed to have an indirect pecuniary interest in such options because Suvretta Capital has rights to receive the benefit of director compensation provided in respect of Mr. Friedman's board service.

F2 · derivative.exercise_date: This option shall be fully vested and exercisable on February 3, 2027, the first anniversary of the vesting commencement date.