LXRX

SEC source: 0001127602-24-015076 · form4.xml · derivative · entry 2

Amouyal Philippe · CIK 0001376854 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,810

Underlying: Common Stock · 36,810 shares

Expires not disclosed

F2 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F3 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-015076 · form4.xml · derivative · entry 1

Amouyal Philippe · CIK 0001376854 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,906

Underlying: Common Stock · 44,906 shares

Expires 2034-05-13

F1 · derivative.exercise_date: Option vests with respect to one third of the shares subject to the option on each of the first three anniversaries of the grant date.

SEC source: 0000950170-24-059789 · ownership.xml · derivative · entry 5

Artal International S.C.A. · CIK 0001218180 · Director · 10% owner

Wittouck Amaury · CIK 0001841311 · Director · 10% owner

Artal International Management S.A. · CIK 0001522131 · Director · 10% owner

Artal Group S.A. · CIK 0001053906 · Director · 10% owner

Westend S.A. · CIK 0001283968 · Director · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · Director · 10% owner

Invus Public Equities, L.P. · CIK 0001340097 · Director · 10% owner

Invus, L.P. · CIK 0001404570 · Director · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · Director · 10% owner

Invus Advisors, L.L.C. · CIK 0001404553 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 0

Underlying: Common Stock · 57,546,100 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: On March 13, 2024, Artal International S.C.A. acquired 1,150,922 shares of Series A convertible preferred stock, $0.01 par value per share (the "Preferred Stock") of the Issuer at a price of $108.50 per share. Each share of Preferred Stock would automatically convert into 50 shares of the Issuer's common stock, par value $0.001 per share (the "Common Stock") upon receipt of shareholder approval and the satisfaction of certain other conditions (the "Conditions"); however, absent the satisfaction of such conditions, the shares were not convertible and as such, the Preferred Stock was originally reported on Table I. On May 10, 2024, all Conditions were met, and the 1,150,922 shares of Preferred Stock became derivative securities and automatically converted into 57,546,100 shares of Issuer Common Stock.

F1 · kind: On March 13, 2024, Artal International S.C.A. acquired 1,150,922 shares of Series A convertible preferred stock, $0.01 par value per share (the "Preferred Stock") of the Issuer at a price of $108.50 per share. Each share of Preferred Stock would automatically convert into 50 shares of the Issuer's common stock, par value $0.001 per share (the "Common Stock") upon receipt of shareholder approval and the satisfaction of certain other conditions (the "Conditions"); however, absent the satisfaction of such conditions, the shares were not convertible and as such, the Preferred Stock was originally reported on Table I. On May 10, 2024, all Conditions were met, and the 1,150,922 shares of Preferred Stock became derivative securities and automatically converted into 57,546,100 shares of Issuer Common Stock.

F1 · derivative.exercise_date: On March 13, 2024, Artal International S.C.A. acquired 1,150,922 shares of Series A convertible preferred stock, $0.01 par value per share (the "Preferred Stock") of the Issuer at a price of $108.50 per share. Each share of Preferred Stock would automatically convert into 50 shares of the Issuer's common stock, par value $0.001 per share (the "Common Stock") upon receipt of shareholder approval and the satisfaction of certain other conditions (the "Conditions"); however, absent the satisfaction of such conditions, the shares were not convertible and as such, the Preferred Stock was originally reported on Table I. On May 10, 2024, all Conditions were met, and the 1,150,922 shares of Preferred Stock became derivative securities and automatically converted into 57,546,100 shares of Issuer Common Stock.

F1 · derivative.expiration_date: On March 13, 2024, Artal International S.C.A. acquired 1,150,922 shares of Series A convertible preferred stock, $0.01 par value per share (the "Preferred Stock") of the Issuer at a price of $108.50 per share. Each share of Preferred Stock would automatically convert into 50 shares of the Issuer's common stock, par value $0.001 per share (the "Common Stock") upon receipt of shareholder approval and the satisfaction of certain other conditions (the "Conditions"); however, absent the satisfaction of such conditions, the shares were not convertible and as such, the Preferred Stock was originally reported on Table I. On May 10, 2024, all Conditions were met, and the 1,150,922 shares of Preferred Stock became derivative securities and automatically converted into 57,546,100 shares of Issuer Common Stock.

F2 · ownership.nature: These securities are directly held by Artal International S.C.A.

F5 · ownership.nature: Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P., and Invus Advisors, L.L.C. is the general partner of Invus, L.P. The Geneva branch of Artal International S.C.A. is the managing member of Invus Public Equities Advisors, LLC. Artal International S.C.A. is the managing member of Invus Advisors, L.L.C. The managing partner of Artal International S.C.A. is Artal International Management S.A. The sole stockholder of Artal International Management S.A. is Artal Group S.A. The parent company of Artal Group S.A. is Westend S.A. The majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend (the "Stichting"). Mr. Amaury Wittouck is the sole member of the board of the Stichting.

F6 · ownership.nature: Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0000950170-24-059789 · ownership.xml · derivative · entry 4

Artal International S.C.A. · CIK 0001218180 · Director · 10% owner

Wittouck Amaury · CIK 0001841311 · Director · 10% owner

Artal International Management S.A. · CIK 0001522131 · Director · 10% owner

Artal Group S.A. · CIK 0001053906 · Director · 10% owner

Westend S.A. · CIK 0001283968 · Director · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · Director · 10% owner

Invus Public Equities, L.P. · CIK 0001340097 · Director · 10% owner

Invus, L.P. · CIK 0001404570 · Director · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · Director · 10% owner

Invus Advisors, L.L.C. · CIK 0001404553 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 1,150,922

Underlying: Common Stock · 57,546,100 shares

Expires not disclosed

F1 · derivative.exercise_price: On March 13, 2024, Artal International S.C.A. acquired 1,150,922 shares of Series A convertible preferred stock, $0.01 par value per share (the "Preferred Stock") of the Issuer at a price of $108.50 per share. Each share of Preferred Stock would automatically convert into 50 shares of the Issuer's common stock, par value $0.001 per share (the "Common Stock") upon receipt of shareholder approval and the satisfaction of certain other conditions (the "Conditions"); however, absent the satisfaction of such conditions, the shares were not convertible and as such, the Preferred Stock was originally reported on Table I. On May 10, 2024, all Conditions were met, and the 1,150,922 shares of Preferred Stock became derivative securities and automatically converted into 57,546,100 shares of Issuer Common Stock.

F1 · kind: On March 13, 2024, Artal International S.C.A. acquired 1,150,922 shares of Series A convertible preferred stock, $0.01 par value per share (the "Preferred Stock") of the Issuer at a price of $108.50 per share. Each share of Preferred Stock would automatically convert into 50 shares of the Issuer's common stock, par value $0.001 per share (the "Common Stock") upon receipt of shareholder approval and the satisfaction of certain other conditions (the "Conditions"); however, absent the satisfaction of such conditions, the shares were not convertible and as such, the Preferred Stock was originally reported on Table I. On May 10, 2024, all Conditions were met, and the 1,150,922 shares of Preferred Stock became derivative securities and automatically converted into 57,546,100 shares of Issuer Common Stock.

F1 · price: On March 13, 2024, Artal International S.C.A. acquired 1,150,922 shares of Series A convertible preferred stock, $0.01 par value per share (the "Preferred Stock") of the Issuer at a price of $108.50 per share. Each share of Preferred Stock would automatically convert into 50 shares of the Issuer's common stock, par value $0.001 per share (the "Common Stock") upon receipt of shareholder approval and the satisfaction of certain other conditions (the "Conditions"); however, absent the satisfaction of such conditions, the shares were not convertible and as such, the Preferred Stock was originally reported on Table I. On May 10, 2024, all Conditions were met, and the 1,150,922 shares of Preferred Stock became derivative securities and automatically converted into 57,546,100 shares of Issuer Common Stock.

F1 · derivative.exercise_date: On March 13, 2024, Artal International S.C.A. acquired 1,150,922 shares of Series A convertible preferred stock, $0.01 par value per share (the "Preferred Stock") of the Issuer at a price of $108.50 per share. Each share of Preferred Stock would automatically convert into 50 shares of the Issuer's common stock, par value $0.001 per share (the "Common Stock") upon receipt of shareholder approval and the satisfaction of certain other conditions (the "Conditions"); however, absent the satisfaction of such conditions, the shares were not convertible and as such, the Preferred Stock was originally reported on Table I. On May 10, 2024, all Conditions were met, and the 1,150,922 shares of Preferred Stock became derivative securities and automatically converted into 57,546,100 shares of Issuer Common Stock.

F1 · derivative.expiration_date: On March 13, 2024, Artal International S.C.A. acquired 1,150,922 shares of Series A convertible preferred stock, $0.01 par value per share (the "Preferred Stock") of the Issuer at a price of $108.50 per share. Each share of Preferred Stock would automatically convert into 50 shares of the Issuer's common stock, par value $0.001 per share (the "Common Stock") upon receipt of shareholder approval and the satisfaction of certain other conditions (the "Conditions"); however, absent the satisfaction of such conditions, the shares were not convertible and as such, the Preferred Stock was originally reported on Table I. On May 10, 2024, all Conditions were met, and the 1,150,922 shares of Preferred Stock became derivative securities and automatically converted into 57,546,100 shares of Issuer Common Stock.

F2 · ownership.nature: These securities are directly held by Artal International S.C.A.

F5 · ownership.nature: Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P., and Invus Advisors, L.L.C. is the general partner of Invus, L.P. The Geneva branch of Artal International S.C.A. is the managing member of Invus Public Equities Advisors, LLC. Artal International S.C.A. is the managing member of Invus Advisors, L.L.C. The managing partner of Artal International S.C.A. is Artal International Management S.A. The sole stockholder of Artal International Management S.A. is Artal Group S.A. The parent company of Artal Group S.A. is Westend S.A. The majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend (the "Stichting"). Mr. Amaury Wittouck is the sole member of the board of the Stichting.

F6 · ownership.nature: Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0000950170-24-059789 · ownership.xml · nonDerivative · entry 1

Artal International S.C.A. · CIK 0001218180 · Director · 10% owner

Wittouck Amaury · CIK 0001841311 · Director · 10% owner

Artal International Management S.A. · CIK 0001522131 · Director · 10% owner

Artal Group S.A. · CIK 0001053906 · Director · 10% owner

Westend S.A. · CIK 0001283968 · Director · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · Director · 10% owner

Invus Public Equities, L.P. · CIK 0001340097 · Director · 10% owner

Invus, L.P. · CIK 0001404570 · Director · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · Director · 10% owner

Invus Advisors, L.L.C. · CIK 0001404553 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 136,180,481

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: On March 13, 2024, Artal International S.C.A. acquired 1,150,922 shares of Series A convertible preferred stock, $0.01 par value per share (the "Preferred Stock") of the Issuer at a price of $108.50 per share. Each share of Preferred Stock would automatically convert into 50 shares of the Issuer's common stock, par value $0.001 per share (the "Common Stock") upon receipt of shareholder approval and the satisfaction of certain other conditions (the "Conditions"); however, absent the satisfaction of such conditions, the shares were not convertible and as such, the Preferred Stock was originally reported on Table I. On May 10, 2024, all Conditions were met, and the 1,150,922 shares of Preferred Stock became derivative securities and automatically converted into 57,546,100 shares of Issuer Common Stock.

F1 · price: On March 13, 2024, Artal International S.C.A. acquired 1,150,922 shares of Series A convertible preferred stock, $0.01 par value per share (the "Preferred Stock") of the Issuer at a price of $108.50 per share. Each share of Preferred Stock would automatically convert into 50 shares of the Issuer's common stock, par value $0.001 per share (the "Common Stock") upon receipt of shareholder approval and the satisfaction of certain other conditions (the "Conditions"); however, absent the satisfaction of such conditions, the shares were not convertible and as such, the Preferred Stock was originally reported on Table I. On May 10, 2024, all Conditions were met, and the 1,150,922 shares of Preferred Stock became derivative securities and automatically converted into 57,546,100 shares of Issuer Common Stock.

F2 · ownership.nature: These securities are directly held by Artal International S.C.A.

F5 · ownership.nature: Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P., and Invus Advisors, L.L.C. is the general partner of Invus, L.P. The Geneva branch of Artal International S.C.A. is the managing member of Invus Public Equities Advisors, LLC. Artal International S.C.A. is the managing member of Invus Advisors, L.L.C. The managing partner of Artal International S.C.A. is Artal International Management S.A. The sole stockholder of Artal International Management S.A. is Artal Group S.A. The parent company of Artal Group S.A. is Westend S.A. The majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend (the "Stichting"). Mr. Amaury Wittouck is the sole member of the board of the Stichting.

F6 · ownership.nature: Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001127602-24-013558 · form4.xml · derivative · entry 2

Swain Judith L · CIK 0001413573 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,032 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-013558 · form4.xml · nonDerivative · entry 1

Swain Judith L · CIK 0001413573 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,364

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-24-013557 · form4.xml · derivative · entry 2

SOBECKI CHRISTOPHER J · CIK 0001053892 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,032 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-013557 · form4.xml · nonDerivative · entry 1

SOBECKI CHRISTOPHER J · CIK 0001053892 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 167,055

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-24-013556 · form4.xml · derivative · entry 2

LEFKOWITZ ROBERT J MD · CIK 0001226385 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,032 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-013556 · form4.xml · nonDerivative · entry 1

LEFKOWITZ ROBERT J MD · CIK 0001226385 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,364

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-24-013554 · form4.xml · derivative · entry 2

BARKER SAM L · CIK 0001226877 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,032 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-013554 · form4.xml · nonDerivative · entry 1

BARKER SAM L · CIK 0001226877 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 87,649

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-24-013555 · form4.xml · derivative · entry 3

DEBBANE RAYMOND · CIK 0001053890 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,032 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-013555 · form4.xml · nonDerivative · entry 1

DEBBANE RAYMOND · CIK 0001053890 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,348,879

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-24-013553 · form4.xml · derivative · entry 2

Amouyal Philippe · CIK 0001376854 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,032 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-013553 · form4.xml · nonDerivative · entry 1

Amouyal Philippe · CIK 0001376854 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 248,364

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-24-031072 · ownership.xml · nonDerivative · entry 1

Artal International S.C.A. · CIK 0001218180 · Director · 10% owner

Wittouck Amaury · CIK 0001841311 · Director · 10% owner

Artal International Management S.A. · CIK 0001522131 · Director · 10% owner

Artal Group S.A. · CIK 0001053906 · Director · 10% owner

Westend S.A. · CIK 0001283968 · Director · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · Director · 10% owner

Invus Public Equities, L.P. · CIK 0001340097 · Director · 10% owner

Invus, L.P. · CIK 0001404570 · Director · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · Director · 10% owner

Invus Advisors, L.L.C. · CIK 0001404553 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 1,150,922

F1 · kind: On March 11, 2024, Artal International S.C.A. entered into a purchase agreement (the "Purchase Agreement") with the Issuer pursuant to which Artal International S.C.A. agreed to purchase 1,150,922 shares of Series A convertible preferred stock, $0.01 par value per share (the "Preferred Stock") of the Issuer at a price of $108.50 per share (the "Purchase Price"). Each share of Preferred Stock will automatically convert into 50 shares of the Issuer's common stock, par value $0.001 per share (the "Common Stock") upon receipt of shareholder approval and the satisfaction of certain other conditions; however, absent the satisfaction of such conditions, the shares are not convertible. The purchase closed on March 13, 2024.

F2 · ownership.nature: These securities are directly held by Artal International S.C.A. The managing partner of Artal International S.C.A. is Artal International Management S.A. The sole stockholder of Artal International Management S.A. is Artal Group S.A. The parent company of Artal Group S.A. is Westend S.A. The majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend (the "Stichting"). Mr. Amaury Wittouck is the sole member of the board of the Stichting.

F3 · ownership.nature: Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001127602-24-007629 · form4.xml · derivative · entry 7

Alexander Kristen · CIK 0001878867 · VP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,853

Underlying: Common Stock · 15,927 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-24-007629 · form4.xml · derivative · entry 6

Alexander Kristen · CIK 0001878867 · VP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,617

Underlying: Common Stock · 10,616 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-24-007629 · form4.xml · derivative · entry 5

Alexander Kristen · CIK 0001878867 · VP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,700 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-24-007629 · form4.xml · nonDerivative · entry 4

Alexander Kristen · CIK 0001878867 · VP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,800

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.

SEC source: 0001127602-24-007629 · form4.xml · nonDerivative · entry 3

Alexander Kristen · CIK 0001878867 · VP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,593

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-007629 · form4.xml · nonDerivative · entry 2

Alexander Kristen · CIK 0001878867 · VP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,666

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-007629 · form4.xml · nonDerivative · entry 1

Alexander Kristen · CIK 0001878867 · VP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,050

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-007628 · form4.xml · derivative · entry 7

WADE JEFFREY L · CIK 0001225767 · President and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,227

Underlying: Common Stock · 49,113 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-24-007628 · form4.xml · derivative · entry 6

WADE JEFFREY L · CIK 0001225767 · President and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,273

Underlying: Common Stock · 37,274 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-24-007628 · form4.xml · derivative · entry 5

WADE JEFFREY L · CIK 0001225767 · President and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 11,177 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-24-007628 · form4.xml · nonDerivative · entry 4

WADE JEFFREY L · CIK 0001225767 · President and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 324,214

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.

SEC source: 0001127602-24-007628 · form4.xml · nonDerivative · entry 3

WADE JEFFREY L · CIK 0001225767 · President and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 361,905

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-007628 · form4.xml · nonDerivative · entry 2

WADE JEFFREY L · CIK 0001225767 · President and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 312,792

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-007628 · form4.xml · nonDerivative · entry 1

WADE JEFFREY L · CIK 0001225767 · President and CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 275,518

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-007625 · form4.xml · derivative · entry 5

McDermott Wendy · CIK 0001902760 · VP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,393

Underlying: Common Stock · 27,697 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-24-007625 · form4.xml · derivative · entry 4

McDermott Wendy · CIK 0001902760 · VP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,943

Underlying: Common Stock · 18,944 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-24-007625 · form4.xml · nonDerivative · entry 3

McDermott Wendy · CIK 0001902760 · VP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 52,694

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.

SEC source: 0001127602-24-007625 · form4.xml · nonDerivative · entry 2

McDermott Wendy · CIK 0001902760 · VP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 75,119

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-007625 · form4.xml · nonDerivative · entry 1

McDermott Wendy · CIK 0001902760 · VP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,422

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-007623 · form4.xml · derivative · entry 7

MAIN ALAN J · CIK 0001227372 · EVP, Innov & Chem Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,807

Underlying: Common Stock · 32,903 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-24-007623 · form4.xml · derivative · entry 6

MAIN ALAN J · CIK 0001227372 · EVP, Innov & Chem Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,667

Underlying: Common Stock · 25,666 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-24-007623 · form4.xml · derivative · entry 5

MAIN ALAN J · CIK 0001227372 · EVP, Innov & Chem Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,977 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-24-007623 · form4.xml · nonDerivative · entry 4

MAIN ALAN J · CIK 0001227372 · EVP, Innov & Chem Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 255,724

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.

SEC source: 0001127602-24-007623 · form4.xml · nonDerivative · entry 3

MAIN ALAN J · CIK 0001227372 · EVP, Innov & Chem Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 280,132

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-007623 · form4.xml · nonDerivative · entry 2

MAIN ALAN J · CIK 0001227372 · EVP, Innov & Chem Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 247,229

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-007623 · form4.xml · nonDerivative · entry 1

MAIN ALAN J · CIK 0001227372 · EVP, Innov & Chem Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 221,563

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-007621 · form4.xml · derivative · entry 7

Kassler-Taub Kenneth B. · CIK 0001885219 · SVP, Regulatory & QA

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,513

Underlying: Common Stock · 32,757 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-24-007621 · form4.xml · derivative · entry 6

Kassler-Taub Kenneth B. · CIK 0001885219 · SVP, Regulatory & QA

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,557

Underlying: Common Stock · 27,556 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-24-007621 · form4.xml · derivative · entry 5

Kassler-Taub Kenneth B. · CIK 0001885219 · SVP, Regulatory & QA

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,087 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-24-007621 · form4.xml · nonDerivative · entry 4

Kassler-Taub Kenneth B. · CIK 0001885219 · SVP, Regulatory & QA

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 162,672

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.

SEC source: 0001127602-24-007621 · form4.xml · nonDerivative · entry 3

Kassler-Taub Kenneth B. · CIK 0001885219 · SVP, Regulatory & QA

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 187,025

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-24-007621 · form4.xml · nonDerivative · entry 2

Kassler-Taub Kenneth B. · CIK 0001885219 · SVP, Regulatory & QA

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 154,268

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.