LXRX

SEC source: 0001193125-26-037644 · ownership.xml · nonDerivative · entry 1

Invus Global Management, LLC · CIK 0002005369 · Director · 10% owner

Siren, L.L.C. · CIK 0002005245 · Director · 10% owner

DEBBANE RAYMOND · CIK 0001053890 · Director

Artal Participations S.a r.l. · CIK 0002048403 · Director · 10% owner

Artal International S.C.A. · CIK 0001218180 · Director · 10% owner

Artal International Management S.A. · CIK 0001522131 · Director · 10% owner

Artal Group S.A. · CIK 0001053906 · Director · 10% owner

Westend S.A. · CIK 0001283968 · Director · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 154,734,327

F1 · kind: On January 29, 2026, Artal Participations S.a r.l. entered into a purchase agreement with the Issuer pursuant to which Artal Participations S.a r.l. agreed to purchase 22,400,000 shares of common stock par value $0.001 per share (the "Common Stock") of the Issuer at a price of $1.30 per share (the "Purchase Price"). On January 30, 2026, Artal Participations S.a r.l. assigned its right to purchase from the Issuer 3,846,154 shares of Issuer Common Stock to Invus Public Equities, L.P., and Invus Public Equities, L.P. agreed to purchase directly from the Issuer 3,846,154 shares of Issuer Common Stock at the Purchase Price. The purchase closed on February 2, 2026.

F4 · ownership.nature: These securities are directly held by Artal Participations S.a r.l.

F9 · ownership.nature: The sole shareholder of Artal Participations S.a r.l. is Artal International S.C.A. The managing partner of Artal International S.C.A. is Artal International Management S.A. The sole stockholder of Artal International Management S.A. is Artal Group S.A. The parent company of Artal Group S.A. is Westend S.A. The majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend (the "Stichting"). Mr. Amaury Wittouck is the sole member of the board of the Stichting.

F15 · ownership.nature: Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001127602-25-016480 · form4.xml · derivative · entry 2

Swain Judith L · CIK 0001413573 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,312

Underlying: Common Stock · 89,312 shares

Expires not disclosed

F2 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F3 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-016480 · form4.xml · derivative · entry 1

Swain Judith L · CIK 0001413573 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 103,806

Underlying: Common Stock · 103,806 shares

Expires 2035-06-03

F1 · derivative.exercise_date: Option vests with respect to one third of the shares subject to the option on each of the first three anniversaries of the grant date.

SEC source: 0001127602-25-016476 · form4.xml · derivative · entry 2

Sullivan Diane E. · CIK 0001968736 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,312

Underlying: Common Stock · 89,312 shares

Expires not disclosed

F2 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F3 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-016476 · form4.xml · derivative · entry 1

Sullivan Diane E. · CIK 0001968736 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 103,806

Underlying: Common Stock · 103,806 shares

Expires 2035-06-03

F1 · derivative.exercise_date: Option vests with respect to one third of the shares subject to the option on each of the first three anniversaries of the grant date.

SEC source: 0001127602-25-016471 · form4.xml · derivative · entry 2

Cheung Ivan · CIK 0002042690 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,312

Underlying: Common Stock · 89,312 shares

Expires not disclosed

F2 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F3 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-016471 · form4.xml · derivative · entry 1

Cheung Ivan · CIK 0002042690 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 103,806

Underlying: Common Stock · 103,806 shares

Expires 2035-06-03

F1 · derivative.exercise_date: Option vests with respect to one third of the shares subject to the option on each of the first three anniversaries of the grant date.

SEC source: 0001127602-25-016473 · form4.xml · derivative · entry 2

SOBECKI CHRISTOPHER J · CIK 0001053892 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,312

Underlying: Common Stock · 89,312 shares

Expires not disclosed

F2 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F3 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-016473 · form4.xml · derivative · entry 1

SOBECKI CHRISTOPHER J · CIK 0001053892 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 103,806

Underlying: Common Stock · 103,806 shares

Expires 2035-06-03

F1 · derivative.exercise_date: Option vests with respect to one third of the shares subject to the option on each of the first three anniversaries of the grant date.

SEC source: 0001127602-25-016465 · form4.xml · derivative · entry 2

BARKER SAM L · CIK 0001226877 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,312

Underlying: Common Stock · 89,312 shares

Expires not disclosed

F2 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F3 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-016465 · form4.xml · derivative · entry 1

BARKER SAM L · CIK 0001226877 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 103,806

Underlying: Common Stock · 103,806 shares

Expires 2035-06-03

F1 · derivative.exercise_date: Option vests with respect to one third of the shares subject to the option on each of the first three anniversaries of the grant date.

SEC source: 0001127602-25-016461 · form4.xml · derivative · entry 2

Amouyal Philippe · CIK 0001376854 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,312

Underlying: Common Stock · 89,312 shares

Expires not disclosed

F2 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F3 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-016461 · form4.xml · derivative · entry 1

Amouyal Philippe · CIK 0001376854 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 103,806

Underlying: Common Stock · 103,806 shares

Expires 2035-06-03

F1 · derivative.exercise_date: Option vests with respect to one third of the shares subject to the option on each of the first three anniversaries of the grant date.

SEC source: 0001127602-25-016458 · form4.xml · derivative · entry 2

DEBBANE RAYMOND · CIK 0001053890 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,312

Underlying: Common Stock · 89,312 shares

Expires not disclosed

F2 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F3 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-016458 · form4.xml · derivative · entry 1

DEBBANE RAYMOND · CIK 0001053890 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 103,806

Underlying: Common Stock · 103,806 shares

Expires 2035-06-03

F1 · derivative.exercise_date: Option vests with respect to one third of the shares subject to the option on each of the first three anniversaries of the grant date.

SEC source: 0001127602-25-014146 · form4.xml · derivative · entry 2

Swain Judith L · CIK 0001413573 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 36,810 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-014146 · form4.xml · nonDerivative · entry 1

Swain Judith L · CIK 0001413573 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,174

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-25-014145 · form4.xml · derivative · entry 2

Sullivan Diane E. · CIK 0001968736 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 36,810 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-014145 · form4.xml · nonDerivative · entry 1

Sullivan Diane E. · CIK 0001968736 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,810

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-25-014140 · form4.xml · derivative · entry 2

Amouyal Philippe · CIK 0001376854 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 36,810 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-014140 · form4.xml · nonDerivative · entry 1

Amouyal Philippe · CIK 0001376854 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 285,174

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-25-014144 · form4.xml · derivative · entry 2

SOBECKI CHRISTOPHER J · CIK 0001053892 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 36,810 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-014144 · form4.xml · nonDerivative · entry 1

SOBECKI CHRISTOPHER J · CIK 0001053892 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 203,865

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-25-014139 · form4.xml · derivative · entry 3

DEBBANE RAYMOND · CIK 0001053890 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 36,810 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-014139 · form4.xml · nonDerivative · entry 1

DEBBANE RAYMOND · CIK 0001053890 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,385,689

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-25-014143 · form4.xml · derivative · entry 2

BARKER SAM L · CIK 0001226877 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 36,810 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: Restricted stock unit vests with respect to 100% of the shares subject to the restricted stock unit on the first anniversary of the grant date.

F2 · derivative.expiration_date: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-014143 · form4.xml · nonDerivative · entry 1

BARKER SAM L · CIK 0001226877 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 124,459

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-25-007540 · form4.xml · derivative · entry 7

Alexander Kristen · CIK 0001878867 · VP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,773

Underlying: Common Stock · 19,887 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-25-007540 · form4.xml · derivative · entry 6

Alexander Kristen · CIK 0001878867 · VP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,927

Underlying: Common Stock · 15,926 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-25-007540 · form4.xml · derivative · entry 5

Alexander Kristen · CIK 0001878867 · VP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,617 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-25-007540 · form4.xml · nonDerivative · entry 4

Alexander Kristen · CIK 0001878867 · VP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,368

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.

SEC source: 0001127602-25-007540 · form4.xml · nonDerivative · entry 3

Alexander Kristen · CIK 0001878867 · VP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 94,230

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-007540 · form4.xml · nonDerivative · entry 2

Alexander Kristen · CIK 0001878867 · VP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,343

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-007540 · form4.xml · nonDerivative · entry 1

Alexander Kristen · CIK 0001878867 · VP, Finance and Accounting

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,417

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-007538 · form4.xml · derivative · entry 7

McDermott Wendy · CIK 0001902760 · SVP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 104,633

Underlying: Common Stock · 52,317 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-25-007538 · form4.xml · derivative · entry 6

McDermott Wendy · CIK 0001902760 · SVP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,697

Underlying: Common Stock · 27,696 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-25-007538 · form4.xml · derivative · entry 5

McDermott Wendy · CIK 0001902760 · SVP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 18,943 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-25-007538 · form4.xml · nonDerivative · entry 4

McDermott Wendy · CIK 0001902760 · SVP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 121,646

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.

SEC source: 0001127602-25-007538 · form4.xml · nonDerivative · entry 3

McDermott Wendy · CIK 0001902760 · SVP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 151,650

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-007538 · form4.xml · nonDerivative · entry 2

McDermott Wendy · CIK 0001902760 · SVP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 99,333

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-007538 · form4.xml · nonDerivative · entry 1

McDermott Wendy · CIK 0001902760 · SVP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 71,637

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-007534 · form4.xml · derivative · entry 7

MAIN ALAN J · CIK 0001227372 · EVP, Innov & Chem Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 136,487

Underlying: Common Stock · 68,243 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-25-007534 · form4.xml · derivative · entry 6

MAIN ALAN J · CIK 0001227372 · EVP, Innov & Chem Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,903

Underlying: Common Stock · 32,904 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-25-007534 · form4.xml · derivative · entry 5

MAIN ALAN J · CIK 0001227372 · EVP, Innov & Chem Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 25,667 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-25-007534 · form4.xml · nonDerivative · entry 4

MAIN ALAN J · CIK 0001227372 · EVP, Innov & Chem Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 339,104

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.

SEC source: 0001127602-25-007534 · form4.xml · nonDerivative · entry 3

MAIN ALAN J · CIK 0001227372 · EVP, Innov & Chem Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 382,538

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-007534 · form4.xml · nonDerivative · entry 2

MAIN ALAN J · CIK 0001227372 · EVP, Innov & Chem Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 314,295

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-007534 · form4.xml · nonDerivative · entry 1

MAIN ALAN J · CIK 0001227372 · EVP, Innov & Chem Sciences

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 281,391

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001127602-25-007527 · form4.xml · derivative · entry 3

DeFrancesco Lisa · CIK 0001846325 · SVP, IR and Corp Comm

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,347

Underlying: Common Stock · 24,673 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F4 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F4 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001127602-25-007527 · form4.xml · nonDerivative · entry 2

DeFrancesco Lisa · CIK 0001846325 · SVP, IR and Corp Comm

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,577

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.