LXRX

SEC source: 0001062822-26-000037 · form4.xml · nonDerivative · entry 3

DeFrancesco Lisa · CIK 0001846325 · SVP, IR and Corp Comm

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,869

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.

SEC source: 0001062822-26-000037 · form4.xml · nonDerivative · entry 2

DeFrancesco Lisa · CIK 0001846325 · SVP, IR and Corp Comm

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 168,441

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001062822-26-000037 · form4.xml · nonDerivative · entry 1

DeFrancesco Lisa · CIK 0001846325 · SVP, IR and Corp Comm

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,251

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001062822-26-000038 · form4.xml · derivative · entry 7

Gopinathan Suma · CIK 0002071581 · SVP, Discovery

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 131,280

Underlying: Common Stock · 65,640 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000038 · form4.xml · derivative · entry 6

Gopinathan Suma · CIK 0002071581 · SVP, Discovery

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,310

Underlying: Common Stock · 20,310 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000038 · form4.xml · derivative · entry 5

Gopinathan Suma · CIK 0002071581 · SVP, Discovery

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 14,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000038 · form4.xml · nonDerivative · entry 4

Gopinathan Suma · CIK 0002071581 · SVP, Discovery

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,132

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.

SEC source: 0001062822-26-000038 · form4.xml · nonDerivative · entry 3

Gopinathan Suma · CIK 0002071581 · SVP, Discovery

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 174,470

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001062822-26-000038 · form4.xml · nonDerivative · entry 2

Gopinathan Suma · CIK 0002071581 · SVP, Discovery

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 108,830

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001062822-26-000038 · form4.xml · nonDerivative · entry 1

Gopinathan Suma · CIK 0002071581 · SVP, Discovery

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 88,520

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001062822-26-000036 · form4.xml · derivative · entry 7

Crum Brian T · CIK 0001792747 · SVP, General Counsel & Secr.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 340,327

Underlying: Common Stock · 170,163 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000036 · form4.xml · derivative · entry 6

Crum Brian T · CIK 0001792747 · SVP, General Counsel & Secr.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 33,457 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000036 · form4.xml · derivative · entry 5

Crum Brian T · CIK 0001792747 · SVP, General Counsel & Secr.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,387

Underlying: Common Stock · 69,386 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000036 · form4.xml · nonDerivative · entry 4

Crum Brian T · CIK 0001792747 · SVP, General Counsel & Secr.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 428,802

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.

SEC source: 0001062822-26-000036 · form4.xml · nonDerivative · entry 3

Crum Brian T · CIK 0001792747 · SVP, General Counsel & Secr.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 533,821

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001062822-26-000036 · form4.xml · nonDerivative · entry 2

Crum Brian T · CIK 0001792747 · SVP, General Counsel & Secr.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 330,201

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001062822-26-000036 · form4.xml · nonDerivative · entry 1

Crum Brian T · CIK 0001792747 · SVP, General Counsel & Secr.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 363,658

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001062822-26-000035 · form4.xml · derivative · entry 3

Coiante Scott M · CIK 0001608536 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 320,473

Underlying: Common Stock · 160,237 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000035 · form4.xml · nonDerivative · entry 2

Coiante Scott M · CIK 0001608536 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 105,356

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.

SEC source: 0001062822-26-000035 · form4.xml · nonDerivative · entry 1

Coiante Scott M · CIK 0001608536 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 160,237

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001062822-26-000034 · form4.xml · derivative · entry 3

Exton Michael · CIK 0002029249 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,006,527

Underlying: Common Stock · 503,263 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F3 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F3 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000034 · form4.xml · nonDerivative · entry 2

Exton Michael · CIK 0002029249 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 298,432

F2 · kind: Withholding of a portion of issued shares by the Company in satisfaction of shareholder's tax withholding obligations with respect thereto.

SEC source: 0001062822-26-000034 · form4.xml · nonDerivative · entry 1

Exton Michael · CIK 0002029249 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 503,263

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of common stock.

SEC source: 0001062822-26-000033 · form4.xml · nonDerivative · entry 1

DEBBANE RAYMOND · CIK 0001053890 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,906,186

SEC source: 0001062822-26-000032 · form4.xml · nonDerivative · entry 1

DEBBANE RAYMOND · CIK 0001053890 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,904,186

SEC source: 0001062822-26-000031 · form4.xml · nonDerivative · entry 2

DEBBANE RAYMOND · CIK 0001053890 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,804,186

F2 · price: Represents a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.47 to $1.49 per share. The reporting person hereby undertakes to provide to the issuer, a security holder of the issuer or the SEC staff, upon request, full information regarding the number of shares purchased at each respective price within the range set forth in this footnote.

SEC source: 0001062822-26-000031 · form4.xml · nonDerivative · entry 1

DEBBANE RAYMOND · CIK 0001053890 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,704,186

F1 · price: Represents a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.425 to $1.455 per share. The reporting person hereby undertakes to provide to the issuer, a security holder of the issuer or the SEC staff, upon request, full information regarding the number of shares purchased at each respective price within the range set forth in this footnote.

SEC source: 0001062822-26-000029 · form4.xml · nonDerivative · entry 3

DEBBANE RAYMOND · CIK 0001053890 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,654,186

F3 · price: Represents a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.315 to $1.32 per share. The reporting person hereby undertakes to provide to the issuer, a security holder of the issuer or the SEC staff, upon request, full information regarding the number of shares purchased at each respective price within the range set forth in this footnote.

SEC source: 0001062822-26-000029 · form4.xml · nonDerivative · entry 2

DEBBANE RAYMOND · CIK 0001053890 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,520,498

F2 · price: Represents a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.295 to $1.31 per share. The reporting person hereby undertakes to provide to the issuer, a security holder of the issuer or the SEC staff, upon request, full information regarding the number of shares purchased at each respective price within the range set forth in this footnote.

SEC source: 0001193125-26-059599 · ownership.xml · nonDerivative · entry 1

Artal Participations S.a r.l. · CIK 0002048403 · Director · 10% owner

Artal International S.C.A. · CIK 0001218180 · Director · 10% owner

Artal International Management S.A. · CIK 0001522131 · Director · 10% owner

Artal Group S.A. · CIK 0001053906 · Director · 10% owner

Westend S.A. · CIK 0001283968 · Director · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · Director · 10% owner

Wittouck Amaury · CIK 0001841311 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 408,434.7

F1 · kind: Pursuant to that certain preferred stock purchase agreement (the "Purchase Agreement") with the Issuer, dated as of January 29, 2026, in connection with the underwriter's partial exercise of their option to purchase additional shares of Issuer common stock par value $0.001 per share (the "Common Stock") in an underwritten public offering, Artal Participations S.a r.l. purchased an additional 41,289.58 shares of Issuer Series B Convertible Preferred Stock, par value $0.01 per share (the "Preferred Stock") at a price of $65.00 per share. Each share of Preferred Stock will automatically convert into 50 shares of Common Stock upon receipt of shareholder approval and the satisfaction of certain other conditions; however, absent the satisfaction of such conditions, the shares are not convertible.

F2 · ownership.nature: These securities are directly held by Artal Participations S.a r.l.

F3 · ownership.nature: The sole shareholder of Artal Participations S.a r.l. is Artal International S.C.A. The managing partner of Artal International S.C.A. is Artal International Management S.A. The sole stockholder of Artal International Management S.A. is Artal Group S.A. The parent company of Artal Group S.A. is Westend S.A. The majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend (the "Stichting"). Mr. Amaury Wittouck is the sole member of the board of the Stichting.

F4 · ownership.nature: Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001062822-26-000029 · form4.xml · nonDerivative · entry 1

DEBBANE RAYMOND · CIK 0001053890 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,443,641

F1 · price: Represents a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.29 to $1.31 per share. The reporting person hereby undertakes to provide to the issuer, a security holder of the issuer or the SEC staff, upon request, full information regarding the number of shares purchased at each respective price within the range set forth in this footnote.

SEC source: 0001062822-26-000026 · form4.xml · derivative · entry 2

McDermott Wendy · CIK 0001902760 · SVP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 375,300

Underlying: Common Stock · 375,300 shares

Expires 2036-02-12

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant, and vests 1/48th per month for each month of service thereafter.

SEC source: 0001062822-26-000026 · form4.xml · derivative · entry 1

McDermott Wendy · CIK 0001902760 · SVP, Human Resources

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 250,200

Underlying: Common Stock · 250,200 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F2 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000025 · form4.xml · derivative · entry 2

Martens Rachel Yap · CIK 0002071589 · SVP, Partnerships & Corp Strat

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 290,620

Underlying: Common Stock · 290,620 shares

Expires 2036-02-12

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant, and vests 1/48th per month for each month of service thereafter.

SEC source: 0001062822-26-000025 · form4.xml · derivative · entry 1

Martens Rachel Yap · CIK 0002071589 · SVP, Partnerships & Corp Strat

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 193,740

Underlying: Common Stock · 193,740 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F2 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000024 · form4.xml · derivative · entry 2

Granowitz Craig B · CIK 0001876655 · SVP, Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 519,920

Underlying: Common Stock · 519,920 shares

Expires 2036-02-12

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant, and vests 1/48th per month for each month of service thereafter.

SEC source: 0001062822-26-000024 · form4.xml · derivative · entry 1

Granowitz Craig B · CIK 0001876655 · SVP, Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 346,610

Underlying: Common Stock · 346,610 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F2 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000023 · form4.xml · derivative · entry 2

Gopinathan Suma · CIK 0002071581 · SVP, Discovery

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 357,680

Underlying: Common Stock · 357,680 shares

Expires 2036-02-12

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant, and vests 1/48th per month for each month of service thereafter.

SEC source: 0001062822-26-000023 · form4.xml · derivative · entry 1

Gopinathan Suma · CIK 0002071581 · SVP, Discovery

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 238,450

Underlying: Common Stock · 238,450 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F2 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000022 · form4.xml · derivative · entry 2

DeFrancesco Lisa · CIK 0001846325 · SVP, IR and Corp Comm

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 386,300

Underlying: Common Stock · 386,300 shares

Expires 2036-02-12

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant, and vests 1/48th per month for each month of service thereafter.

SEC source: 0001062822-26-000022 · form4.xml · derivative · entry 1

DeFrancesco Lisa · CIK 0001846325 · SVP, IR and Corp Comm

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 257,530

Underlying: Common Stock · 257,530 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F2 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000021 · form4.xml · derivative · entry 2

Crum Brian T · CIK 0001792747 · SVP, General Counsel & Secr.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 449,560

Underlying: Common Stock · 449,560 shares

Expires 2036-02-12

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant, and vests 1/48th per month for each month of service thereafter.

SEC source: 0001062822-26-000021 · form4.xml · derivative · entry 1

Crum Brian T · CIK 0001792747 · SVP, General Counsel & Secr.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 299,710

Underlying: Common Stock · 299,710 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F2 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000020 · form4.xml · derivative · entry 2

Coiante Scott M · CIK 0001608536 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 409,020

Underlying: Common Stock · 409,020 shares

Expires 2036-02-12

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant, and vests 1/48th per month for each month of service thereafter.

SEC source: 0001062822-26-000020 · form4.xml · derivative · entry 1

Coiante Scott M · CIK 0001608536 · SVP, Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 272,680

Underlying: Common Stock · 272,680 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F2 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001062822-26-000019 · form4.xml · derivative · entry 2

Exton Michael · CIK 0002029249 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,293,670

Underlying: Common Stock · 1,293,670 shares

Expires 2036-02-12

F3 · derivative.exercise_date: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant, and vests 1/48th per month for each month of service thereafter.

SEC source: 0001062822-26-000019 · form4.xml · derivative · entry 1

Exton Michael · CIK 0002029249 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 862,440

Underlying: Common Stock · 862,440 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of common stock.

F2 · derivative.exercise_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

F2 · derivative.expiration_date: Restricted stock units vest with respect to 1/3 of the shares subject to the restricted stock units on February 28 of each of the three years following the year of grant.

SEC source: 0001193125-26-037644 · ownership.xml · nonDerivative · entry 4

Invus Global Management, LLC · CIK 0002005369 · Director · 10% owner

Siren, L.L.C. · CIK 0002005245 · Director · 10% owner

DEBBANE RAYMOND · CIK 0001053890 · Director

Artal Participations S.a r.l. · CIK 0002048403 · Director · 10% owner

Artal International S.C.A. · CIK 0001218180 · Director · 10% owner

Artal International Management S.A. · CIK 0001522131 · Director · 10% owner

Artal Group S.A. · CIK 0001053906 · Director · 10% owner

Westend S.A. · CIK 0001283968 · Director · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 367,145.12

F3 · kind: On January 29, 2026, Artal Participations S.a r.l. entered into a preferred stock purchase agreement (the "Preferred Purchase Agreement") with the Issuer pursuant to which Artal Participations S.a r.l. agreed to purchase 367,145.12 shares of Series B Convertible Preferred Stock, par value $0.01 per share (the "Preferred Stock") of the Issuer at a price of $65.00 per share. The Preferred Purchase Agreement also provides Artal Participations S.a r.l. the right to purchase from the Issuer, up to an additional 94,854.88 shares of Preferred Stock at a price per share of $65.00. Each share of Preferred Stock will automatically convert into 50 shares of the Issuer's Common Stock upon receipt of shareholder approval and the satisfaction of certain other conditions; however, absent the satisfaction of such conditions, the shares are not convertible. The purchase closed on February 2, 2026.

F4 · ownership.nature: These securities are directly held by Artal Participations S.a r.l.

F9 · ownership.nature: The sole shareholder of Artal Participations S.a r.l. is Artal International S.C.A. The managing partner of Artal International S.C.A. is Artal International Management S.A. The sole stockholder of Artal International Management S.A. is Artal Group S.A. The parent company of Artal Group S.A. is Westend S.A. The majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend (the "Stichting"). Mr. Amaury Wittouck is the sole member of the board of the Stichting.

F15 · ownership.nature: Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001193125-26-037644 · ownership.xml · nonDerivative · entry 3

Invus Global Management, LLC · CIK 0002005369 · Director · 10% owner

Siren, L.L.C. · CIK 0002005245 · Director · 10% owner

DEBBANE RAYMOND · CIK 0001053890 · Director

Artal Participations S.a r.l. · CIK 0002048403 · Director · 10% owner

Artal International S.C.A. · CIK 0001218180 · Director · 10% owner

Artal International Management S.A. · CIK 0001522131 · Director · 10% owner

Artal Group S.A. · CIK 0001053906 · Director · 10% owner

Westend S.A. · CIK 0001283968 · Director · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 1,538,462

F2 · kind: On February 2, 2026, Avicenna Life Sci Master Fund LP purchased 1,538,462 shares of Common Stock as part of the Issuer's underwritten public offering.

F6 · ownership.nature: These securities are directly held by Avicenna Life Sci Master Fund LP

F11 · ownership.nature: The general partner of Avicenna Life Sci Master Fund LP is Avicenna Life Sci Master GP LLC. The managing member of Avicenna Life Sci Master GP LLC is Ulys, L.L.C. The managing member of Ulys, L.L.C. is Mr. Raymond Debbane.

F15 · ownership.nature: Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001193125-26-037644 · ownership.xml · nonDerivative · entry 2

Invus Global Management, LLC · CIK 0002005369 · Director · 10% owner

Siren, L.L.C. · CIK 0002005245 · Director · 10% owner

DEBBANE RAYMOND · CIK 0001053890 · Director

Artal Participations S.a r.l. · CIK 0002048403 · Director · 10% owner

Artal International S.C.A. · CIK 0001218180 · Director · 10% owner

Artal International Management S.A. · CIK 0001522131 · Director · 10% owner

Artal Group S.A. · CIK 0001053906 · Director · 10% owner

Westend S.A. · CIK 0001283968 · Director · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 7,362,368

F1 · kind: On January 29, 2026, Artal Participations S.a r.l. entered into a purchase agreement with the Issuer pursuant to which Artal Participations S.a r.l. agreed to purchase 22,400,000 shares of common stock par value $0.001 per share (the "Common Stock") of the Issuer at a price of $1.30 per share (the "Purchase Price"). On January 30, 2026, Artal Participations S.a r.l. assigned its right to purchase from the Issuer 3,846,154 shares of Issuer Common Stock to Invus Public Equities, L.P., and Invus Public Equities, L.P. agreed to purchase directly from the Issuer 3,846,154 shares of Issuer Common Stock at the Purchase Price. The purchase closed on February 2, 2026.

F5 · ownership.nature: These securities are directly held by Invus Public Equities, L.P.

F10 · ownership.nature: The general partner of Invus Public Equities, L.P. is Invus Public Equities Advisors, LLC. The managing member of Invus Public Equities Advisors, LLC is Invus Global Management, LLC. The managing member of Invus Global Management, LLC is Siren, L.L.C. The managing member of Siren, L.L.C. is Mr. Raymond Debbane.

F15 · ownership.nature: Each of the Reporting Persons (other than to the extent it directly holds securities reported herein) disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such Reporting Person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), each of the Reporting Persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.