LIANY

SEC source: 0001990498-24-000005 · wk-form4_1712866199.xml · nonDerivative · entry 2

Gu Ehong · CIK 0001990498 · Interim CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

SEC source: 0001062993-24-003732 · form4.xml · derivative · entry 11

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 0

Underlying: Ordinary Shares · 36,300 shares

Expires 2032-06-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · ownership.nature: Represents securities held by Konstanin Poukalov. Mr. Poukalov is affiliated with the Advisor. The Advisor may be deemed to have an indirect pecuniary interest in the securities of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Poukalov's board service through a partial management fee offset.

SEC source: 0001062993-24-003732 · form4.xml · derivative · entry 10

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Ordinary Shares · 36,300 shares

Expires 2032-06-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · ownership.nature: Represents securities held by Adam Stone. Mr. Stone is the Chief Investment Officer of Perceptive Advisors, LLC (the "Advisor"). The Advisor may be deemed to have an indirect pecuniary interest in the securities of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Stone's board service through a partial management fee offset.

SEC source: 0001062993-24-003732 · form4.xml · nonDerivative · entry 4

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 17,082

F2 · ownership.nature: Represents securities held by Konstanin Poukalov. Mr. Poukalov is affiliated with the Advisor. The Advisor may be deemed to have an indirect pecuniary interest in the securities of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Poukalov's board service through a partial management fee offset.

SEC source: 0001062993-24-003732 · form4.xml · nonDerivative · entry 3

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 36,300

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · ownership.nature: Represents securities held by Konstanin Poukalov. Mr. Poukalov is affiliated with the Advisor. The Advisor may be deemed to have an indirect pecuniary interest in the securities of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Poukalov's board service through a partial management fee offset.

SEC source: 0001062993-24-003732 · form4.xml · nonDerivative · entry 2

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 17,082

F1 · ownership.nature: Represents securities held by Adam Stone. Mr. Stone is the Chief Investment Officer of Perceptive Advisors, LLC (the "Advisor"). The Advisor may be deemed to have an indirect pecuniary interest in the securities of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Stone's board service through a partial management fee offset.

SEC source: 0001062993-24-003732 · form4.xml · nonDerivative · entry 1

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 36,300

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · ownership.nature: Represents securities held by Adam Stone. Mr. Stone is the Chief Investment Officer of Perceptive Advisors, LLC (the "Advisor"). The Advisor may be deemed to have an indirect pecuniary interest in the securities of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Stone's board service through a partial management fee offset.

SEC source: 0001062993-24-003733 · form4.xml · derivative · entry 3

Poukalov Konstantin · CIK 0001678736 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 36,300 shares

Expires 2032-06-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001062993-24-003733 · form4.xml · nonDerivative · entry 2

Poukalov Konstantin · CIK 0001678736 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,082

SEC source: 0001062993-24-003733 · form4.xml · nonDerivative · entry 1

Poukalov Konstantin · CIK 0001678736 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,300

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001062993-24-003729 · form4.xml · derivative · entry 3

Stone Adam Leo · CIK 0001727440 · Director · Interim CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 36,300 shares

Expires 2032-06-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001062993-24-003729 · form4.xml · nonDerivative · entry 2

Stone Adam Leo · CIK 0001727440 · Director · Interim CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,082

SEC source: 0001062993-24-003729 · form4.xml · nonDerivative · entry 1

Stone Adam Leo · CIK 0001727440 · Director · Interim CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,300

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001831283-24-000011 · wk-form4_1708463476.xml · derivative · entry 4

GIANAKAKOS ANASTASIOS · CIK 0001413822 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 36,300 shares

Expires 2032-06-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The shares underlying the option became exercisable in full on June 23, 2023.

SEC source: 0001831283-24-000011 · wk-form4_1708463476.xml · nonDerivative · entry 2

GIANAKAKOS ANASTASIOS · CIK 0001413822 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,630

SEC source: 0001831283-24-000011 · wk-form4_1708463476.xml · nonDerivative · entry 1

GIANAKAKOS ANASTASIOS · CIK 0001413822 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 72,848

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001831283-24-000010 · wk-form4_1708463411.xml · derivative · entry 3

Silbermann Susan Michele · CIK 0001887214 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 36,300 shares

Expires 2032-06-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The shares underlying the option became exercisable in full on June 23, 2023.

SEC source: 0001831283-24-000010 · wk-form4_1708463411.xml · nonDerivative · entry 2

Silbermann Susan Michele · CIK 0001887214 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,082

SEC source: 0001831283-24-000010 · wk-form4_1708463411.xml · nonDerivative · entry 1

Silbermann Susan Michele · CIK 0001887214 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,300

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001990498-24-000005 · wk-form4_1712866199.xml · nonDerivative · entry 1

Gu Ehong · CIK 0001990498 · Interim CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,762

F1 · balance_after: Represents the sale of shares to cover personal income tax obligations upon vesting of restricted share units ('RSUs') as required pursuant to the terms of Ms. Gu's RSU award agreement. 41,078 RSUs were granted to Ms. Gu under the LianBio 2021 Equity Incentive Plan (the 'Plan') on December 31, 2021, 25% of which vested on each of December 31, 2022 and 2023 with the remainder to vest in 25% annual installments and to be fully vested on December 31, 2025, subject to Ms. Gu's providing continuous service to the Issuer on each such date. On March 22, 2024, the board of directors of the Issuer resolved to terminate the Plan and any unvested RSUs granted thereunder in accordance with the terms of the Plan, effective as of March 24, 2024. In accordance with this determination, 58,873 unvested RSUs previously reported as beneficially owned by Ms. Gu were cancelled. Ms. Gu received no value in exchange for the cancellation of the unvested RSUs.

SEC source: 0001062993-23-013979 · form4.xml · derivative · entry 2

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 36,300

Underlying: Ordinary Shares · 36,300 shares

Expires 2033-06-21

F2 · derivative.exercise_date: The shares underlying the option shall vest and become exercisable in full on June 21, 2024, the first anniversary of the grant date, subject to Konstantin Poukalov providing continuous service to the Issuer through such date.

F4 · ownership.nature: Consists of options to purchase shares of the Issuer's ordinary shares awarded to Mr. Poukalov in connection with his role as a member of the Issuer's Board of Directors. Mr. Poukalov is affiliated with the Advisor. The Advisor may be deemed to have an indirect pecuniary interest in the options to purchase ordinary shares of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Poukalov's board service through a partial management fee offset.

F5 · ownership.nature: Joseph Edelman is the managing member of the Advisor. The Advisor serves as the investment manager of Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). Each of Mr. Edelman, the Master Fund and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of the securities reported on this form, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman, the Master Fund or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001062993-23-013979 · form4.xml · derivative · entry 1

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnotes

Disclosed balance after: 36,300

Underlying: Ordinary Shares · 36,300 shares

Expires 2033-06-21

F1 · derivative.exercise_date: The shares underlying the option shall vest and become exercisable in full on June 21, 2024, the first anniversary of the grant date, subject to Adam Stone providing continuous service to the Issuer through such date.

F3 · ownership.nature: Consists of options to purchase shares of the Issuer's ordinary shares awarded to Mr. Stone in connection with his role as a member of the Issuer's Board of Directors. Mr. Stone is the Chief Investment Officer of Perceptive Advisors, LLC (the "Advisor"). The Advisor may be deemed to have an indirect pecuniary interest in the options to purchase ordinary shares of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Stone's board service through a partial management fee offset.

F5 · ownership.nature: Joseph Edelman is the managing member of the Advisor. The Advisor serves as the investment manager of Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). Each of Mr. Edelman, the Master Fund and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of the securities reported on this form, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman, the Master Fund or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001831283-23-000095 · wk-form4_1687551779.xml · derivative · entry 1

Chen Wei Wei · CIK 0001919307 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,300

Underlying: Ordinary Shares · 36,300 shares

Expires 2033-06-21

F1 · derivative.exercise_date: The shares underlying the option shall vest and become exercisable in full on June 21, 2024, the first anniversary of the grant date, subject to the Reporting Person providing continuous service to the Issuer through such date.

SEC source: 0001831283-23-000094 · wk-form4_1687551713.xml · derivative · entry 1

GIANAKAKOS ANASTASIOS · CIK 0001413822 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,300

Underlying: Ordinary Shares · 36,300 shares

Expires 2033-06-21

F1 · derivative.exercise_date: The shares underlying the option shall vest and become exercisable in full on June 21, 2024, the first anniversary of the grant date, subject to the Reporting Person providing continuous service to the Issuer through such date.

SEC source: 0001831283-23-000093 · wk-form4_1687551598.xml · derivative · entry 1

Silbermann Susan Michele · CIK 0001887214 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,300

Underlying: Ordinary Shares · 36,300 shares

Expires 2033-06-21

F1 · derivative.exercise_date: The shares underlying the option shall vest and become exercisable in full on June 21, 2024, the first anniversary of the grant date, subject to the Reporting Person providing continuous service to the Issuer through such date.

SEC source: 0001062993-23-013981 · form4.xml · derivative · entry 1

Stone Adam Leo · CIK 0001727440 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,300

Underlying: Ordinary Shares · 36,300 shares

Expires 2033-06-21

F1 · derivative.exercise_date: The shares underlying the option shall vest and become exercisable in full on June 21, 2024, the first anniversary of the grant date, subject to the Reporting Person providing continuous service to the Issuer through such date.

SEC source: 0001062993-23-013980 · form4.xml · derivative · entry 1

Poukalov Konstantin · CIK 0001678736 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,300

Underlying: Ordinary Shares · 36,300 shares

Expires 2033-06-21

F1 · derivative.exercise_date: The shares underlying the option shall vest and become exercisable in full on June 21, 2024, the first anniversary of the grant date, subject to the Reporting Person providing continuous service to the Issuer through such date.

SEC source: 0001831283-23-000054 · wf-form4_168029408142979.xml · nonDerivative · entry 1

Jahn Brianne · CIK 0001885012 · Chief Business Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 224,005

F1 · shares: Represents restricted share units granted to the Reporting Person under the LianBio 2021 Equity Incentive Plan. Each restricted share unit represents the contingent right to receive one share of the Issuer's Ordinary Shares. 25% of the restricted share units shall vest on March 29, 2024; the remainder shall vest in 25% annual installments such that the restricted share units are fully vested on March 29, 2027, subject to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001831283-23-000053 · wf-form4_168029404088883.xml · nonDerivative · entry 1

QIAN JIANG · CIK 0001880938 · SVP, China General Manager

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 291,354

F1 · shares: Represents restricted share units granted to the Reporting Person under the LianBio 2021 Equity Incentive Plan. Each restricted share unit represents the contingent right to receive one share of the Issuer's Ordinary Shares. 25% of the restricted share units shall vest on March 29, 2024; the remainder shall vest in 25% annual installments such that the restricted share units are fully vested on March 29, 2027, subject to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001831283-23-000052 · wf-form4_168029388148981.xml · nonDerivative · entry 1

Wang Yizhe · CIK 0001884248 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 907,498

F1 · shares: Represents restricted share units granted to the Reporting Person under the LianBio 2021 Equity Incentive Plan. Each restricted share unit represents the contingent right to receive one share of the Issuer's Ordinary Shares. 25% of the restricted share units shall vest on March 29, 2024; the remainder shall vest in 25% annual installments such that the restricted share units are fully vested on March 29, 2027, subject to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001831283-23-000051 · wf-form4_168029382182313.xml · nonDerivative · entry 1

Larson Yi · CIK 0001785987 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 325,901

F1 · shares: Represents restricted share units granted to the Reporting Person under the LianBio 2021 Equity Incentive Plan. Each restricted share unit represents the contingent right to receive one share of the Issuer's Ordinary Shares. 25% of the restricted share units shall vest on March 29, 2024; the remainder shall vest in 25% annual installments such that the restricted share units are fully vested on March 29, 2027, subject to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001831283-23-000017 · wf-form4_167459467623989.xml · derivative · entry 1

Jahn Brianne · CIK 0001885012 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 318,995

Underlying: Ordinary Shares · 318,995 shares

Expires 2033-01-20

F1 · derivative.exercise_date: 25% of the shares underlying the option will vest and become exercisable on January 20, 2024; the remainder shall vest and become exercisable in 36 equal monthly installments such that the option shall be fully vested on January 20, 2027, subject to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001831283-23-000018 · wf-form4_167459472625760.xml · derivative · entry 1

Larson Yi · CIK 0001785987 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 464,099

Underlying: Ordinary Shares · 464,099 shares

Expires 2033-01-20

F1 · derivative.exercise_date: 25% of the shares underlying the option will vest and become exercisable on January 20, 2024; the remainder shall vest and become exercisable in 36 equal monthly installments such that the option shall be fully vested on January 20, 2027, subject to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001831283-23-000016 · wf-form4_167459457187041.xml · derivative · entry 1

QIAN JIANG · CIK 0001880938 · SVP, China General Manager

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 318,995

Underlying: Ordinary Shares · 318,995 shares

Expires 2033-01-20

F1 · derivative.exercise_date: 25% of the shares underlying the option will vest and become exercisable on January 20, 2024; the remainder shall vest and become exercisable in 36 equal monthly installments such that the option shall be fully vested on January 20, 2027, subject to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001831283-23-000015 · wf-form4_167459451349704.xml · derivative · entry 1

Wang Yizhe · CIK 0001884248 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,292,324

Underlying: Ordinary Shares · 1,292,324 shares

Expires 2033-01-20

F1 · derivative.exercise_date: 25% of the shares underlying the option will vest and become exercisable on January 20, 2024; the remainder shall vest and become exercisable in 36 equal monthly installments such that the option shall be fully vested on January 20, 2027, subject to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0001831283-23-000002 · wf-form4_167295415423471.xml · nonDerivative · entry 1

QIAN JIANG · CIK 0001880938 · SVP, China General Manager

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,349

F1 · shares: Sale of shares to cover personal income tax obligations upon vesting of restricted share units as required pursuant to the terms of Mr. Qian's restricted share unit award agreement.

SEC source: 0001062993-22-018544 · form4.xml · nonDerivative · entry 1

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner

LEV LB Holdings, LP · CIK 0001789443 · Director · 10% owner

Perceptive Xontogeny Venture Fund, LP · CIK 0001757940 · Director · 10% owner

C2 Life Sciences LLC · CIK 0001890152 · Director · 10% owner

Perceptive Venture Advisors, LLC · CIK 0001890130 · Director · 10% owner

LEV LB Holdings GP, LLC · CIK 0001890132 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 3,728,491

F5 · balance_after: Each American Depositary Share represents one Ordinary Share of the Issuer.

F1 · ownership.nature: The securities are directly held by Perceptive Life Sciences Master Fund, Ltd. ("Perceptive Life"). Perceptive Advisors, LLC (the "Advisor") serves as the investment advisor to Perceptive Life. Joseph Edelman is the managing member of the Advisor. The Advisor and Mr. Edelman disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his or its indirect pecuniary interest therein, and this report shall not be deemed an admission that they are the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001062993-22-015491 · form4.xml · derivative · entry 2

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 36,000

Underlying: Ordinary Shares · 36,000 shares

Expires 2032-06-23

F2 · derivative.exercise_date: The shares underlying the option shall vest and become exercisable in full on June 23, 2023, the first anniversary of the grant date, subject to Adam Stone providing continuous service to the Issuer through such date.

F4 · ownership.nature: Consists of options to purchase shares of the Issuer's ordinary shares awarded to Konstantin Poukalov in connection with his role as a member of the Issuer's Board of Directors. Mr. Poukalov is affiliated with the Advisor. The Advisor may be deemed to have an indirect pecuniary interest in the options to purchase ordinary shares of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Poukalov's board service through a partial management fee offset.

F5 · ownership.nature: Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of the securities reported on this form, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001062993-22-015491 · form4.xml · derivative · entry 1

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 36,000

Underlying: Ordinary Shares · 36,000 shares

Expires 2032-06-23

F1 · derivative.exercise_date: The shares underlying the option shall vest and become exercisable in full on June 23, 2023, the first anniversary of the grant date, subject to Konstantin Poukalov providing continuous service to the Issuer through such date.

F3 · ownership.nature: Consists of options to purchase shares of the Issuer's ordinary shares awarded to Adam Stone in connection with his role as a member of the Issuer's Board of Directors. Mr. Stone is the Chief Investment Officer of Perceptive Advisors, LLC (the "Advisor"). The Advisor may be deemed to have an indirect pecuniary interest in the options to purchase ordinary shares of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Stone's board service through a partial management fee offset.

F5 · ownership.nature: Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of the securities reported on this form, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001062993-22-015490 · form4.xml · derivative · entry 1

Poukalov Konstantin · CIK 0001678736 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,300

Underlying: Ordinary Shares · 36,300 shares

Expires 2032-06-23

F1 · derivative.exercise_date: The shares underlying the option shall vest and become exercisable in full on June 23, 2023, the first anniversary of the grant date, subject to the Reporting Person providing continuous service to the Issuer through such date.

SEC source: 0001062993-22-015489 · form4.xml · derivative · entry 1

Stone Adam Leo · CIK 0001727440 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,300

Underlying: Ordinary Shares · 36,300 shares

Expires 2032-06-23

F1 · derivative.exercise_date: The shares underlying the option shall vest and become exercisable in full on June 23, 2023, the first anniversary of the grant date, subject to the Reporting Person providing continuous service to the Issuer through such date.

SEC source: 0001831283-22-000050 · wf-form4_165636106038470.xml · derivative · entry 1

GIANAKAKOS ANASTASIOS · CIK 0001413822 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,300

Underlying: Ordinary Shares · 36,300 shares

Expires 2032-06-23

F1 · derivative.exercise_date: The shares underlying the option shall vest and become exercisable in full on June 23, 2023, the first anniversary of the grant date, subject to the Reporting Person providing continuous service to the Issuer through such date.

SEC source: 0001831283-22-000049 · wf-form4_165636102658025.xml · derivative · entry 1

Silbermann Susan Michele · CIK 0001887214 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,300

Underlying: Ordinary Shares · 36,300 shares

Expires 2032-06-23

F1 · derivative.exercise_date: The shares underlying the option shall vest and become exercisable in full on June 23, 2023, the first anniversary of the grant date, subject to the Reporting Person providing continuous service to the Issuer through such date.

SEC source: 0001062993-22-013616 · form4.xml · nonDerivative · entry 1

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner

LEV LB Holdings, LP · CIK 0001789443 · Director · 10% owner

Perceptive Xontogeny Venture Fund, LP · CIK 0001757940 · Director · 10% owner

C2 Life Sciences LLC · CIK 0001890152 · Director · 10% owner

Perceptive Venture Advisors, LLC · CIK 0001890130 · Director · 10% owner

LEV LB Holdings GP, LLC · CIK 0001890132 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,730,251

F5 · price: The reported price is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.065 to $3.20, inclusive. The reporting person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of purchased at each separate price within such range.

F6 · balance_after: Each American Depositary Share represents one Ordinary Share of the Issuer.

F1 · ownership.nature: The securities are directly held by Perceptive Life Sciences Master Fund, Ltd. ("Perceptive Life"). Perceptive Advisors, LLC (the "Advisor") serves as the investment advisor to Perceptive Life. Joseph Edelman is the managing member of the Advisor. The Advisor and Mr. Edelman disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his or its indirect pecuniary interest therein, and this report shall not be deemed an admission that they are the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001062993-22-013535 · form4.xml · nonDerivative · entry 3

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner

LEV LB Holdings, LP · CIK 0001789443 · Director · 10% owner

Perceptive Xontogeny Venture Fund, LP · CIK 0001757940 · Director · 10% owner

C2 Life Sciences LLC · CIK 0001890152 · Director · 10% owner

Perceptive Venture Advisors, LLC · CIK 0001890130 · Director · 10% owner

LEV LB Holdings GP, LLC · CIK 0001890132 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,661,251

F7 · price: The reported price is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.49 to $2.70, inclusive. The reporting person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of purchased at each separate price within such range.

F8 · balance_after: Each American Depositary Share represents one Ordinary Share of the Issuer.

F1 · ownership.nature: The securities are directly held by Perceptive Life Sciences Master Fund, Ltd. ("Perceptive Life"). Perceptive Advisors, LLC (the "Advisor") serves as the investment advisor to Perceptive Life. Joseph Edelman is the managing member of the Advisor. The Advisor and Mr. Edelman disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his or its indirect pecuniary interest therein, and this report shall not be deemed an admission that they are the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001062993-22-013535 · form4.xml · nonDerivative · entry 2

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner

LEV LB Holdings, LP · CIK 0001789443 · Director · 10% owner

Perceptive Xontogeny Venture Fund, LP · CIK 0001757940 · Director · 10% owner

C2 Life Sciences LLC · CIK 0001890152 · Director · 10% owner

Perceptive Venture Advisors, LLC · CIK 0001890130 · Director · 10% owner

LEV LB Holdings GP, LLC · CIK 0001890132 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,541,251

F6 · price: The reported price is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.36 to $2.53, inclusive. The reporting person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of purchased at each separate price within such range.

F8 · balance_after: Each American Depositary Share represents one Ordinary Share of the Issuer.

F1 · ownership.nature: The securities are directly held by Perceptive Life Sciences Master Fund, Ltd. ("Perceptive Life"). Perceptive Advisors, LLC (the "Advisor") serves as the investment advisor to Perceptive Life. Joseph Edelman is the managing member of the Advisor. The Advisor and Mr. Edelman disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his or its indirect pecuniary interest therein, and this report shall not be deemed an admission that they are the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0001062993-22-013535 · form4.xml · nonDerivative · entry 1

PERCEPTIVE ADVISORS LLC · CIK 0001224962 · Director · 10% owner

PERCEPTIVE LIFE SCIENCES MASTER FUND LTD · CIK 0001249675 · Director · 10% owner

LEV LB Holdings, LP · CIK 0001789443 · Director · 10% owner

Perceptive Xontogeny Venture Fund, LP · CIK 0001757940 · Director · 10% owner

C2 Life Sciences LLC · CIK 0001890152 · Director · 10% owner

Perceptive Venture Advisors, LLC · CIK 0001890130 · Director · 10% owner

LEV LB Holdings GP, LLC · CIK 0001890132 · Director · 10% owner

EDELMAN JOSEPH · CIK 0001164426 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 2,498,700

F5 · price: The reported price is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.46 to $2.51, inclusive. The reporting person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of purchased at each separate price within such range.

F8 · balance_after: Each American Depositary Share represents one Ordinary Share of the Issuer.

F1 · ownership.nature: The securities are directly held by Perceptive Life Sciences Master Fund, Ltd. ("Perceptive Life"). Perceptive Advisors, LLC (the "Advisor") serves as the investment advisor to Perceptive Life. Joseph Edelman is the managing member of the Advisor. The Advisor and Mr. Edelman disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his or its indirect pecuniary interest therein, and this report shall not be deemed an admission that they are the beneficial owner of such securities for purposes of Section 16 or for any other purposes.

SEC source: 0000899243-22-017091 · doc4.xml · derivative · entry 2

Yu Debra · CIK 0001869480 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 999,947

Underlying: Ordinary Shares · 1,000,000 shares

Expires 2030-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 1/3 of the shares underlying the option vested and became exercisable on January 1, 2020; 1/3 of the shares underlying the option vested and became exercisable on October 1, 2020 and 1/3 of the shares underlying the option vested and became exercisable on October 1, 2021, subject to the Reporting Person providing continuous service to the Issuer on each such date.

SEC source: 0000899243-22-017091 · doc4.xml · nonDerivative · entry 1

Yu Debra · CIK 0001869480 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,000,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-22-014353 · doc4.xml · derivative · entry 1

Chen Wei Wei · CIK 0001919307 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,600

Underlying: Ordinary Shares · 72,600 shares

Expires 2032-04-06

F1 · derivative.exercise_date: 1/36 of the shares underlying the option will become exercisable on 05/06/2022; the remainder shall vest and become exercisable in 35 equal monthly installments such that the option shall be fully vested on 04/06/2025, subject to the Reporting Person providing continuous service to the Issuer on each such date.