JAGX

SEC source: 0001104659-22-043249 · tm2211739-2_4seq1.xml · nonDerivative · entry 1

Chaturvedi Pravin R · CIK 0001916935 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,333

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · balance_after: On September 8, 2021, the issuer effected a 3-for-1 reverse stock split of the issued and outstanding shares of its voting common stock (the "Reverse Stock Split). Upon effectiveness of the Reverse Stock Split, every 3 shares of voting common stock was automatically converted into one share of voting common stock.

SEC source: 0001104659-22-043245 · tm2211739-3_4seq1.xml · derivative · entry 2

Wolin Jonathan S. · CIK 0001787587 · Chief of Staff, CCO & GC

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,333

Underlying: Common Stock · 6,666 shares

Expires not disclosed

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · derivative.exercise_price: On September 8, 2021, the issuer effected a 3-for-1 reverse stock split of the issued and outstanding shares of its voting common stock (the "Reverse Stock Split). Upon effectiveness of the Reverse Stock Split, every 3 shares of voting common stock was automatically converted into one share of voting common stock.

F3 · derivative.exercise_date: The restricted stock units were previously reported as covering 60,000 shares, but were adjusted to reflect the Reverse Stock Split. Such restricted stock units were granted on April 5, 2021 and vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date.

F3 · derivative.expiration_date: The restricted stock units were previously reported as covering 60,000 shares, but were adjusted to reflect the Reverse Stock Split. Such restricted stock units were granted on April 5, 2021 and vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date.

SEC source: 0001104659-22-043245 · tm2211739-3_4seq1.xml · nonDerivative · entry 1

Wolin Jonathan S. · CIK 0001787587 · Chief of Staff, CCO & GC

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,666

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · balance_after: On September 8, 2021, the issuer effected a 3-for-1 reverse stock split of the issued and outstanding shares of its voting common stock (the "Reverse Stock Split). Upon effectiveness of the Reverse Stock Split, every 3 shares of voting common stock was automatically converted into one share of voting common stock.

SEC source: 0001104659-22-043247 · tm2211739-1_4seq1.xml · derivative · entry 2

Lizak Carol R. · CIK 0001785794 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,028

Underlying: Common Stock · 4,513 shares

Expires not disclosed

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · derivative.exercise_price: On September 8, 2021, the issuer effected a 3-for-1 reverse stock split of the issued and outstanding shares of its voting common stock (the "Reverse Stock Split). Upon effectiveness of the Reverse Stock Split, every 3 shares of voting common stock was automatically converted into one share of voting common stock.

F3 · derivative.exercise_date: The restricted stock units were previously reported as covering 40,625 shares, but were adjusted to reflect the Reverse Stock Split. Such restricted stock units were granted on April 5, 2021 and vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date.

F3 · derivative.expiration_date: The restricted stock units were previously reported as covering 40,625 shares, but were adjusted to reflect the Reverse Stock Split. Such restricted stock units were granted on April 5, 2021 and vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date.

SEC source: 0001104659-22-043247 · tm2211739-1_4seq1.xml · nonDerivative · entry 1

Lizak Carol R. · CIK 0001785794 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,481

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · balance_after: On September 8, 2021, the issuer effected a 3-for-1 reverse stock split of the issued and outstanding shares of its voting common stock (the "Reverse Stock Split). Upon effectiveness of the Reverse Stock Split, every 3 shares of voting common stock was automatically converted into one share of voting common stock.

SEC source: 0001104659-22-043243 · tm2211739-5_4seq1.xml · derivative · entry 2

King Steven R. · CIK 0001622052 · Chief of Sustainable Supply

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,666

Underlying: Common Stock · 13,333 shares

Expires not disclosed

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · derivative.exercise_price: On September 8, 2021, the issuer effected a 3-for-1 reverse stock split of the issued and outstanding shares of its voting common stock (the "Reverse Stock Split). Upon effectiveness of the Reverse Stock Split, every 3 shares of voting common stock was automatically converted into one share of voting common stock.

F3 · derivative.exercise_date: The restricted stock units were previously reported as covering 120,000 shares, but were adjusted to reflect the Reverse Stock Split. Such restricted stock units were granted on April 5, 2021 and vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date.

F3 · derivative.expiration_date: The restricted stock units were previously reported as covering 120,000 shares, but were adjusted to reflect the Reverse Stock Split. Such restricted stock units were granted on April 5, 2021 and vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date.

SEC source: 0001104659-22-043243 · tm2211739-5_4seq1.xml · nonDerivative · entry 1

King Steven R. · CIK 0001622052 · Chief of Sustainable Supply

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,333

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · balance_after: On September 8, 2021, the issuer effected a 3-for-1 reverse stock split of the issued and outstanding shares of its voting common stock (the "Reverse Stock Split). Upon effectiveness of the Reverse Stock Split, every 3 shares of voting common stock was automatically converted into one share of voting common stock.

SEC source: 0001104659-23-062821 · tm2316214-9_4aseq1.xml · derivative · entry 2

Chaturvedi Pravin R · CIK 0001916935 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 10,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · derivative.exercise_price: On September 8, 2021, the issuer effected a 3-for-1 reverse stock split of the issued and outstanding shares of its voting common stock (the "Reverse Stock Split). Upon effectiveness of the Reverse Stock Split, every 3 shares of voting common stock was automatically converted into one share of voting common stock.

F3 · derivative.exercise_date: On April 6, 2022, the reporting person filed a Form 4 that erroneously indicated that 3,333 restricted stock units had vested on April 5, 2022 and that the reporting person beneficially owned 6,666 restricted stock units following such vesting. In fact, 10,000 restricted stock units had vested on such date and the reporting person beneficially owned 20,000 restricted stock units following such vesting.

F3 · derivative.expiration_date: On April 6, 2022, the reporting person filed a Form 4 that erroneously indicated that 3,333 restricted stock units had vested on April 5, 2022 and that the reporting person beneficially owned 6,666 restricted stock units following such vesting. In fact, 10,000 restricted stock units had vested on such date and the reporting person beneficially owned 20,000 restricted stock units following such vesting.

SEC source: 0001104659-23-062821 · tm2316214-9_4aseq1.xml · nonDerivative · entry 1

Chaturvedi Pravin R · CIK 0001916935 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Restricted stock units convert into common stock on a one-for-one basis.

F2 · balance_after: On September 8, 2021, the issuer effected a 3-for-1 reverse stock split of the issued and outstanding shares of its voting common stock (the "Reverse Stock Split). Upon effectiveness of the Reverse Stock Split, every 3 shares of voting common stock was automatically converted into one share of voting common stock.

SEC source: 0001104659-22-040391 · tm2210715-10_4seq1.xml · derivative · entry 3

CONTE LISA A · CIK 0001008377 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires not disclosed

F2 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F4 · date: The restricted stock unit grants were approved by the issuer's board of directors on March 28, 2022.

F6 · derivative.exercise_date: The restricted stock units vest upon (i) successful completion of the pivotal trial of crofelemer (Mytesi) for cancer-therapy related diarrhea and (ii) successful completion of the investigator-initiated trials in support of the proof-of-concept requirement for early access program for patient access in Europe.

F6 · derivative.expiration_date: The restricted stock units vest upon (i) successful completion of the pivotal trial of crofelemer (Mytesi) for cancer-therapy related diarrhea and (ii) successful completion of the investigator-initiated trials in support of the proof-of-concept requirement for early access program for patient access in Europe.

SEC source: 0001104659-22-040391 · tm2210715-10_4seq1.xml · derivative · entry 2

CONTE LISA A · CIK 0001008377 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 606,280

Underlying: Common Stock · 606,280 shares

Expires not disclosed

F2 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F4 · date: The restricted stock unit grants were approved by the issuer's board of directors on March 28, 2022.

F5 · derivative.exercise_date: The restricted stock units vest in three equal annual installments beginning on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

F5 · derivative.expiration_date: The restricted stock units vest in three equal annual installments beginning on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

SEC source: 0001104659-22-040408 · tm2210715-2_4seq1.xml · derivative · entry 1

Divis Gregory J · CIK 0001410677 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,900

Underlying: Common Stock · 85,900 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · date: The restricted stock unit grants were approved by the issuer's board of directors on March 28, 2022.

F4 · derivative.exercise_date: The restricted stock units vest in full on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

F4 · derivative.expiration_date: The restricted stock units vest in full on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

SEC source: 0001104659-22-040402 · tm2210715-5_4seq1.xml · derivative · entry 1

MICEK JOHN · CIK 0001243187 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,900

Underlying: Common Stock · 85,900 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · date: The restricted stock unit grants were approved by the issuer's board of directors on March 28, 2022.

F4 · derivative.exercise_date: The restricted stock units vest in full on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

F4 · derivative.expiration_date: The restricted stock units vest in full on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

SEC source: 0001104659-22-040401 · tm2210715-3_4seq1.xml · derivative · entry 1

BOCHNOWSKI JAMES J · CIK 0001255743 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,015

Underlying: Common Stock · 96,015 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · date: The restricted stock unit grants were approved by the issuer's board of directors on March 28, 2022.

F4 · derivative.exercise_date: The restricted stock units vest in full on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

F4 · derivative.expiration_date: The restricted stock units vest in full on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

SEC source: 0001104659-22-040405 · tm2210715-4_4seq1.xml · derivative · entry 1

Siegel Jonathan B. · CIK 0001588209 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,900

Underlying: Common Stock · 85,900 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · date: The restricted stock unit grants were approved by the issuer's board of directors on March 28, 2022.

F4 · derivative.exercise_date: The restricted stock units vest in full on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

F4 · derivative.expiration_date: The restricted stock units vest in full on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

SEC source: 0001104659-22-040400 · tm2210715-7_4seq1.xml · derivative · entry 1

Chaturvedi Pravin R · CIK 0001916935 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 195,934

Underlying: Common Stock · 195,934 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · date: The restricted stock unit grants were approved by the issuer's board of directors on March 28, 2022.

F4 · derivative.exercise_date: The restricted stock units vest in three equal annual installments beginning on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

F4 · derivative.expiration_date: The restricted stock units vest in three equal annual installments beginning on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

SEC source: 0001104659-22-040397 · tm2210715-6_4seq1.xml · derivative · entry 2

Lizak Carol R. · CIK 0001785794 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 97,025

Underlying: Common Stock · 97,025 shares

Expires not disclosed

F2 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F3 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F4 · date: The restricted stock unit grants were approved by the issuer's board of directors on March 28, 2022.

F5 · derivative.exercise_date: The restricted stock units vest in three equal annual installments beginning on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

F5 · derivative.expiration_date: The restricted stock units vest in three equal annual installments beginning on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

SEC source: 0001104659-22-040395 · tm2210715-8_4seq1.xml · derivative · entry 1

Wolin Jonathan S. · CIK 0001787587 · Chief of Staff, CCO & GC

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 196,018

Underlying: Common Stock · 196,018 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · date: The restricted stock unit grants were approved by the issuer's board of directors on March 28, 2022.

F4 · derivative.exercise_date: The restricted stock units vest in three equal annual installments beginning on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

F4 · derivative.expiration_date: The restricted stock units vest in three equal annual installments beginning on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

SEC source: 0001104659-22-040393 · tm2210715-9_4seq1.xml · derivative · entry 1

King Steven R. · CIK 0001622052 · Chief of Sustainable Supply

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 137,685

Underlying: Common Stock · 137,685 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F3 · date: The restricted stock unit grants were approved by the issuer's board of directors on March 28, 2022.

F4 · derivative.exercise_date: The restricted stock units vest in three equal annual installments beginning on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

F4 · derivative.expiration_date: The restricted stock units vest in three equal annual installments beginning on May 17, 2023. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

SEC source: 0001104659-22-040391 · tm2210715-10_4seq1.xml · nonDerivative · entry 1

CONTE LISA A · CIK 0001008377 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,003

F1 · balance_after: On September 8, 2021, the issuer effected a 3-for-1 reverse stock split of the issued and outstanding shares of its voting common stock (the "Reverse Stock Split). Upon effectiveness of the Reverse Stock Split, every 3 shares of voting common stock was automatically converted into one share of voting common stock.

SEC source: 0001104659-22-040397 · tm2210715-6_4seq1.xml · nonDerivative · entry 1

Lizak Carol R. · CIK 0001785794 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 7,968

F1 · ownership.nature: Securities held directly by the Peter & Carol Lizak Revocable Trust. Ms. Lizak, by virtue of her position as a co-trustee and beneficiary of such trust and her sharing of voting and investment control over the securities held by the trust with her spouse, may be deemed to beneficially own the securities held by the Peter & Carol Lizak Trust for purposes of Section 16.

SEC source: 0001104659-21-077721 · a4.xml · nonDerivative · entry 2

BOCHNOWSKI JAMES J · CIK 0001255743 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 954,390

SEC source: 0001104659-21-077721 · a4.xml · nonDerivative · entry 1

BOCHNOWSKI JAMES J · CIK 0001255743 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 954,542

SEC source: 0001104659-21-069972 · a4.xml · derivative · entry 2

Divis Gregory J · CIK 0001410677 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,400

Underlying: Common Stock · 36,400 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F4 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on May 18, 2021.

F5 · derivative.exercise_date: The restricted stock units vest in full on May 18, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

F5 · derivative.expiration_date: The restricted stock units vest in full on May 18, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

SEC source: 0001104659-21-069972 · a4.xml · derivative · entry 1

Divis Gregory J · CIK 0001410677 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,750

Underlying: Common Stock · 72,750 shares

Expires 2031-05-18

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on May 18, 2021.

F3 · derivative.exercise_date: The options will vest in full on May 18, 2022, the first anniversary of the grant date, so long as the director continues to serve on the board of directors of the issuer.

SEC source: 0001104659-21-069977 · a4.xml · derivative · entry 2

MICEK JOHN · CIK 0001243187 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,400

Underlying: Common Stock · 36,400 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F4 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on May 18, 2021.

F5 · derivative.exercise_date: The restricted stock units vest in full on May 18, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

F5 · derivative.expiration_date: The restricted stock units vest in full on May 18, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

SEC source: 0001104659-21-069977 · a4.xml · derivative · entry 1

MICEK JOHN · CIK 0001243187 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,750

Underlying: Common Stock · 72,750 shares

Expires 2031-05-18

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on May 18, 2021.

F3 · derivative.exercise_date: The options will vest in full on May 18, 2022, the first anniversary of the grant date, so long as the director continues to serve on the board of directors of the issuer.

SEC source: 0001104659-21-069965 · a4.xml · derivative · entry 2

BOCHNOWSKI JAMES J · CIK 0001255743 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,400

Underlying: Common Stock · 39,400 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F4 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on May 18, 2021.

F5 · derivative.exercise_date: The restricted stock units vest in full on May 18, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

F5 · derivative.expiration_date: The restricted stock units vest in full on May 18, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

SEC source: 0001104659-21-069965 · a4.xml · derivative · entry 1

BOCHNOWSKI JAMES J · CIK 0001255743 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 78,750

Underlying: Common Stock · 78,750 shares

Expires 2031-05-18

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on May 18, 2021.

F3 · derivative.exercise_date: The options will vest in full on May 18, 2022, the first anniversary of the grant date, so long as the director continues to serve on the board of directors of the issuer.

SEC source: 0001104659-21-069991 · a4.xml · derivative · entry 2

Siegel Jonathan B. · CIK 0001588209 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,400

Underlying: Common Stock · 36,400 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F4 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on May 18, 2021.

F5 · derivative.exercise_date: The restricted stock units vest in full on May 18, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

F5 · derivative.expiration_date: The restricted stock units vest in full on May 18, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date provided in the grant notice.

SEC source: 0001104659-21-069991 · a4.xml · derivative · entry 1

Siegel Jonathan B. · CIK 0001588209 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 72,750

Underlying: Common Stock · 72,750 shares

Expires 2031-05-18

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on May 18, 2021.

F3 · derivative.exercise_date: The options will vest in full on May 18, 2022, the first anniversary of the grant date, so long as the director continues to serve on the board of directors of the issuer.

SEC source: 0001104659-21-047557 · a4.xml · derivative · entry 2

CONTE LISA A · CIK 0001008377 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 405,000

Underlying: Common Stock · 405,000 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F4 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on April 5, 2021.

F5 · derivative.exercise_date: The restricted stock units vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date or dates provided in the grant notice.

F5 · derivative.expiration_date: The restricted stock units vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date or dates provided in the grant notice.

SEC source: 0001104659-21-047557 · a4.xml · derivative · entry 1

CONTE LISA A · CIK 0001008377 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 810,000

Underlying: Common Stock · 810,000 shares

Expires 2031-04-05

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on April 5, 2021.

F3 · derivative.exercise_date: The option will vest ratably on a monthly basis over 36 months from the grant date, so long as the executive remains employed by the issuer.

SEC source: 0001104659-21-047567 · a4.xml · derivative · entry 2

Lizak Carol R. · CIK 0001785794 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,625

Underlying: Common Stock · 40,625 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F4 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on April 5, 2021.

F5 · derivative.exercise_date: The restricted stock units vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date or dates provided in the grant notice.

F5 · derivative.expiration_date: The restricted stock units vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date or dates provided in the grant notice.

SEC source: 0001104659-21-047567 · a4.xml · derivative · entry 1

Lizak Carol R. · CIK 0001785794 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 81,250

Underlying: Common Stock · 81,250 shares

Expires 2031-04-05

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on April 5, 2021.

F3 · derivative.exercise_date: The option will vest ratably on a monthly basis over 36 months from the grant date, so long as the executive remains employed by the issuer.

SEC source: 0001104659-21-047563 · a4.xml · derivative · entry 2

Wolin Jonathan S. · CIK 0001787587 · Chief of Staff, CCO & GC

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F4 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on April 5, 2021.

F5 · derivative.exercise_date: The restricted stock units vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date or dates provided in the grant notice.

F5 · derivative.expiration_date: The restricted stock units vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date or dates provided in the grant notice.

SEC source: 0001104659-21-047563 · a4.xml · derivative · entry 1

Wolin Jonathan S. · CIK 0001787587 · Chief of Staff, CCO & GC

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2031-04-05

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on April 5, 2021.

F3 · derivative.exercise_date: The option will vest ratably on a monthly basis over 36 months from the grant date, so long as the executive remains employed by the issuer.

SEC source: 0001104659-21-047560 · a4.xml · derivative · entry 2

King Steven R. · CIK 0001622052 · Chief of Sustainable Supply

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires not disclosed

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F4 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on April 5, 2021.

F5 · derivative.exercise_date: The restricted stock units vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date or dates provided in the grant notice.

F5 · derivative.expiration_date: The restricted stock units vest in three equal annual installments beginning on April 5, 2022, the first anniversary of the grant date. Vested shares will be delivered to the reporting person on the vesting date or dates provided in the grant notice.

SEC source: 0001104659-21-047560 · a4.xml · derivative · entry 1

King Steven R. · CIK 0001622052 · Chief of Sustainable Supply

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 240,000

Underlying: Common Stock · 240,000 shares

Expires 2031-04-05

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option and restricted stock unit grants were approved by the issuer's board of directors on April 5, 2021.

F3 · derivative.exercise_date: The option will vest ratably on a monthly basis over 36 months from the grant date, so long as the executive remains employed by the issuer.

SEC source: 0001104659-20-037925 · a4.xml · derivative · entry 1

CONTE LISA A · CIK 0001008377 · Director · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 238,293

Underlying: Common Stock · 238,293 shares

Expires 2030-03-20

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option grant was approved by the issuer's board of directors on March 20, 2020.

F3 · derivative.exercise_date: The option will vest ratably on a monthly basis over 36 months from the grant date, so long as the executive remains employed by the issuer.

SEC source: 0001104659-20-037929 · a4.xml · derivative · entry 1

Divis Gregory J · CIK 0001410677 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,533

Underlying: Common Stock · 26,533 shares

Expires 2030-03-20

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option grant was approved by the issuer's board of directors on March 20, 2020.

F3 · derivative.exercise_date: The option will vest ratably on a monthly basis over 36 months from the grant date, so long as the director remains employed by the issuer.

SEC source: 0001104659-20-037930 · a4.xml · derivative · entry 1

MICEK JOHN · CIK 0001243187 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,533

Underlying: Common Stock · 26,533 shares

Expires 2030-03-20

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option grant was approved by the issuer's board of directors on March 20, 2020.

F3 · derivative.exercise_date: The option will vest ratably on a monthly basis over 36 months from the grant date, so long as the director remains employed by the issuer.

SEC source: 0001104659-20-037936 · a4.xml · derivative · entry 1

King Steven R. · CIK 0001622052 · Executive VP and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,431

Underlying: Common Stock · 79,431 shares

Expires 2030-03-20

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option grant was approved by the issuer's board of directors on March 20, 2020.

F3 · derivative.exercise_date: The option will vest ratably on a monthly basis over 36 months from the grant date, so long as the executive remains employed by the issuer.

SEC source: 0001104659-20-037937 · a4.xml · derivative · entry 1

Lizak Carol R. · CIK 0001785794 · Chief Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2030-03-20

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option grant was approved by the issuer's board of directors on March 20, 2020.

F3 · derivative.exercise_date: The option will vest ratably on a monthly basis over 36 months from the grant date, so long as the executive remains employed by the issuer.

SEC source: 0001104659-20-037934 · a4.xml · derivative · entry 1

Wolin Jonathan S. · CIK 0001787587 · Chief of Staff, CCO & GC

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 59,753

Underlying: Common Stock · 59,753 shares

Expires 2030-03-20

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option grant was approved by the issuer's board of directors on March 20, 2020.

F3 · derivative.exercise_date: The option will vest ratably on a monthly basis over 36 months from the grant date, so long as the executive remains employed by the issuer.

SEC source: 0001104659-20-037933 · a4.xml · derivative · entry 1

Siegel Jonathan B. · CIK 0001588209 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,486

Underlying: Common Stock · 45,486 shares

Expires 2030-03-20

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option grant was approved by the issuer's board of directors on March 20, 2020.

F3 · derivative.exercise_date: The option will vest ratably on a monthly basis over 36 months from the grant date, so long as the director remains employed by the issuer.

SEC source: 0001104659-20-038337 · a4.xml · derivative · entry 1

BOCHNOWSKI JAMES J · CIK 0001255743 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,486

Underlying: Common Stock · 45,486 shares

Expires 2030-03-20

F1 · security: Granted pursuant to the issuer's 2014 Stock Incentive Plan.

F2 · date: The option grant was approved by the issuer's board of directors on March 20, 2020.

F3 · derivative.exercise_date: The option will vest ratably on a monthly basis over 36 months from the grant date, so long as the director remains employed by the issuer.

SEC source: 0001104659-19-041839 · a4.xml · derivative · entry 2

CONTE LISA A · CIK 0001008377 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,042,052

Underlying: Common Stock · 1,042,052 shares

Expires 2022-07-24

F3 · security: Granted pursuant to the issuer's 2014 Equity Incentive Plan.

F4 · date: The option grant was approved by the issuer's board of directors on July 19, 2019, subject to James J. Bochnowski, the chairman of the board of directors, and Karen S. Wright, the Chief Financial Officer of the issuer, determining the exact number of option shares to be granted per option based on the issuer's fully diluted shares outstanding following the issuer's underwritten public offering described in note 1 above. Mr. Bochnowski and Ms. Wright certified the exact number of option shares to be granted on 7/24/19, such that the effective date of the option grant was 7/24/19.

F5 · derivative.exercise_date: Vests in equal monthly installments beginning on July 24, 2019, with five months of options, or 144,729 options, vested as of the grant date based on the reporting person's number of years of employment with the issuer, such that the grant is vested in full on the 3-year anniversary of the grant date.

SEC source: 0001104659-19-041840 · a4.xml · derivative · entry 5

BOCHNOWSKI JAMES J · CIK 0001255743 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 208,410

Underlying: Common Stock · 208,410 shares

Expires 2022-07-24

F6 · security: Granted pursuant to the issuer's 2014 Equity Incentive Plan.

F7 · date: The option grant was approved by the issuer's board of directors on July 19, 2019, subject to the reporting person, in his capacity as the chairman of the board of directors, and Karen S. Wright, the Chief Financial Officer of the issuer, determining the exact number of option shares to be granted per option based on the issuer's fully diluted shares outstanding following the issuer's underwritten public offering described in note 1 above. The reporting person and Ms. Wright certified the exact number of option shares to be granted on 7/24/19, such that the effective date of the option grant was 7/24/19.

F8 · derivative.exercise_date: Vests in equal monthly installments beginning on July 24, 2019, with five months of options, or 28,945 options, vested as of the grant date based on the reporting person's number of years of service on the issuer's board of directors, such that the grant is vested in full on the 3-year anniversary of the grant date.

SEC source: 0001104659-19-041841 · a4.xml · derivative · entry 5

Siegel Jonathan B. · CIK 0001588209 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 208,410

Underlying: Common Stock · 208,410 shares

Expires 2022-07-24

F6 · security: Granted pursuant to the issuer's 2014 Equity Incentive Plan.

F7 · date: The option grant was approved by the issuer's board of directors on July 19, 2019, subject to James J. Bochnowski, the chairman of the board of directors, and Karen S. Wright, the Chief Financial Officer of the issuer, determining the exact number of option shares to be granted per option based on the issuer's fully diluted shares outstanding following the issuer's underwritten public offering described in note 1 above. Mr. Bochnowski and Ms. Wright certified the exact number of option shares to be granted on 7/24/19, such that the effective date of the option grant was 7/24/19.

F8 · derivative.exercise_date: Vests in equal monthly installments beginning on July 24, 2019, with one month of options, or 5,789 options, vested as of the grant date based on the reporting person's number of years of service on the issuer's board of directors, such that the grant is vested in full on the 3-year anniversary of the grant date.