ISRG

SEC source: 0001035267-25-000149 · edgardoc.xml · derivative · entry 1

Leonard Keith R · CIK 0001416180 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 531

Underlying: Common Stock · 531 shares

Expires not disclosed

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-25-000151 · edgardoc.xml · derivative · entry 4

NACHTSHEIM JAMI K · CIK 0001223017 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 531

Underlying: Common Stock · 531 shares

Expires not disclosed

F3 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F3 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-25-000151 · edgardoc.xml · derivative · entry 3

NACHTSHEIM JAMI K · CIK 0001223017 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,235

Underlying: Common Stock · 2,400 shares

Expires 2027-04-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 10, 2025.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the Non-Employee Directors' Stock Option Plan. Option shall vest 100% one year after the date of grant or at the next Shareholders Meeting, whichever should take place first, provided that vesting will cease on termination of the Directors service to the Company.

SEC source: 0001035267-25-000151 · edgardoc.xml · nonDerivative · entry 2

NACHTSHEIM JAMI K · CIK 0001223017 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,371

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 10, 2025.

SEC source: 0001035267-25-000151 · edgardoc.xml · nonDerivative · entry 1

NACHTSHEIM JAMI K · CIK 0001223017 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,771

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 10, 2025.

SEC source: 0001035267-25-000153 · edgardoc.xml · derivative · entry 1

Reed Monica P · CIK 0001854171 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 531

Underlying: Common Stock · 531 shares

Expires not disclosed

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-25-000137 · edgardoc.xml · derivative · entry 15

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,709 shares

Expires 2030-04-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

F3 · derivative.exercise_date: 100% of the shares subject to the option shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service as a director to the issuer.

SEC source: 0001035267-25-000137 · edgardoc.xml · derivative · entry 14

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,671 shares

Expires 2031-04-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

F3 · derivative.exercise_date: 100% of the shares subject to the option shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service as a director to the issuer.

SEC source: 0001035267-25-000137 · edgardoc.xml · derivative · entry 13

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,448 shares

Expires 2029-04-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

F3 · derivative.exercise_date: 100% of the shares subject to the option shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service as a director to the issuer.

SEC source: 0001035267-25-000137 · edgardoc.xml · derivative · entry 12

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,650 shares

Expires 2029-08-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

F3 · derivative.exercise_date: 100% of the shares subject to the option shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service as a director to the issuer.

SEC source: 0001035267-25-000137 · edgardoc.xml · derivative · entry 11

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,298 shares

Expires 2030-04-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

F3 · derivative.exercise_date: 100% of the shares subject to the option shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service as a director to the issuer.

SEC source: 0001035267-25-000137 · edgardoc.xml · nonDerivative · entry 10

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,410

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $502.49 to $509.99 as follows: 1,758 shares sold at $502.49 to $503.39; 1,542 shares sold at $503.81 to $504.79; 1,951 shares sold at $504.83 to $505.77; 1,845 shares sold at $505.88 to $506.53; 610 shares sold at $506.90 to $507.84; and 1,070 shares sold at $509.99. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-25-000137 · edgardoc.xml · nonDerivative · entry 9

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,119

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

SEC source: 0001035267-25-000137 · edgardoc.xml · nonDerivative · entry 8

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,410

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $502.49 to $509.99 as follows: 1,758 shares sold at $502.49 to $503.39; 1,542 shares sold at $503.81 to $504.79; 1,951 shares sold at $504.83 to $505.77; 1,845 shares sold at $505.88 to $506.53; 610 shares sold at $506.90 to $507.84; and 1,070 shares sold at $509.99. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-25-000137 · edgardoc.xml · nonDerivative · entry 7

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,060

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

SEC source: 0001035267-25-000137 · edgardoc.xml · nonDerivative · entry 6

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,410

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $502.49 to $509.99 as follows: 1,758 shares sold at $502.49 to $503.39; 1,542 shares sold at $503.81 to $504.79; 1,951 shares sold at $504.83 to $505.77; 1,845 shares sold at $505.88 to $506.53; 610 shares sold at $506.90 to $507.84; and 1,070 shares sold at $509.99. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-25-000137 · edgardoc.xml · nonDerivative · entry 5

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,708

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

SEC source: 0001035267-25-000137 · edgardoc.xml · nonDerivative · entry 4

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,410

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $502.49 to $509.99 as follows: 1,758 shares sold at $502.49 to $503.39; 1,542 shares sold at $503.81 to $504.79; 1,951 shares sold at $504.83 to $505.77; 1,845 shares sold at $505.88 to $506.53; 610 shares sold at $506.90 to $507.84; and 1,070 shares sold at $509.99. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-25-000137 · edgardoc.xml · nonDerivative · entry 3

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,081

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

SEC source: 0001035267-25-000137 · edgardoc.xml · nonDerivative · entry 2

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,410

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $502.49 to $509.99 as follows: 1,758 shares sold at $502.49 to $503.39; 1,542 shares sold at $503.81 to $504.79; 1,951 shares sold at $504.83 to $505.77; 1,845 shares sold at $505.88 to $506.53; 610 shares sold at $506.90 to $507.84; and 1,070 shares sold at $509.99. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-25-000137 · edgardoc.xml · nonDerivative · entry 1

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,858

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on January 29, 2026.

SEC source: 0001035267-25-000135 · edgardoc.xml · derivative · entry 14

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,880

Underlying: Common Stock · 188 shares

Expires 2029-08-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 12, 2025.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-25-000135 · edgardoc.xml · nonDerivative · entry 12

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,224

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 12, 2025.

SEC source: 0001035267-25-000135 · edgardoc.xml · nonDerivative · entry 11

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,412

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 12, 2025.

SEC source: 0001035267-25-000135 · edgardoc.xml · derivative · entry 17

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,880

Underlying: Common Stock · 188 shares

Expires 2029-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 12, 2025.

F4 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-25-000135 · edgardoc.xml · nonDerivative · entry 10

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,224

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 12, 2025.

SEC source: 0001035267-25-000135 · edgardoc.xml · nonDerivative · entry 9

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,412

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 12, 2025.

SEC source: 0001035267-25-000111 · edgardoc.xml · derivative · entry 2

Beery Joseph C · CIK 0001249557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 739 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-25-000111 · edgardoc.xml · nonDerivative · entry 1

Beery Joseph C · CIK 0001249557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,110

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-25-000113 · edgardoc.xml · derivative · entry 2

RUBASH MARK J · CIK 0001209186 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 739 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-25-000113 · edgardoc.xml · nonDerivative · entry 1

RUBASH MARK J · CIK 0001209186 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,790

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-25-000115 · edgardoc.xml · derivative · entry 2

Leonard Keith R · CIK 0001416180 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 739 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-25-000115 · edgardoc.xml · nonDerivative · entry 1

Leonard Keith R · CIK 0001416180 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,345

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-25-000117 · edgardoc.xml · derivative · entry 2

Kolli Sreelakshmi · CIK 0001689392 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 739 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-25-000117 · edgardoc.xml · nonDerivative · entry 1

Kolli Sreelakshmi · CIK 0001689392 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 979

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-25-000121 · edgardoc.xml · derivative · entry 2

BARRATT CRAIG H · CIK 0001277620 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,043 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-25-000121 · edgardoc.xml · nonDerivative · entry 1

BARRATT CRAIG H · CIK 0001277620 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · by Trust

Disclosed balance after: 27,198

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-25-000119 · edgardoc.xml · derivative · entry 2

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 739 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-25-000119 · edgardoc.xml · nonDerivative · entry 1

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,410

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-25-000123 · edgardoc.xml · derivative · entry 2

Reed Monica P · CIK 0001854171 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 739 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-25-000123 · edgardoc.xml · nonDerivative · entry 1

Reed Monica P · CIK 0001854171 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,345

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-25-000125 · edgardoc.xml · derivative · entry 2

Johnson Amal M · CIK 0001388397 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 739 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-25-000125 · edgardoc.xml · nonDerivative · entry 1

Johnson Amal M · CIK 0001388397 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,014

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-25-000127 · edgardoc.xml · derivative · entry 2

CHEW LEWIS · CIK 0001224994 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 739 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-25-000127 · edgardoc.xml · nonDerivative · entry 1

CHEW LEWIS · CIK 0001224994 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 783

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-25-000129 · edgardoc.xml · derivative · entry 2

NACHTSHEIM JAMI K · CIK 0001223017 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 739 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-25-000129 · edgardoc.xml · nonDerivative · entry 1

NACHTSHEIM JAMI K · CIK 0001223017 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,371

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-25-000131 · edgardoc.xml · nonDerivative · entry 1

LOEB GARY · CIK 0001561733 · EVP & Chief Legal and Complian

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,245

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 13, 2025.

SEC source: 0001035267-25-000133 · edgardoc.xml · derivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,530

Underlying: Common Stock · 4,000 shares

Expires 2030-08-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-25-000133 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 353

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.