ISRG

SEC source: 0001035267-19-000049 · edgardoc.xml · nonDerivative · entry 4

Samath Jamie · CIK 0001330269 · VP & Principal Accounting Offi

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 159

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 4, 2019.

SEC source: 0001035267-19-000049 · edgardoc.xml · nonDerivative · entry 3

Samath Jamie · CIK 0001330269 · VP & Principal Accounting Offi

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 230

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 4, 2019.

SEC source: 0001035267-19-000049 · edgardoc.xml · nonDerivative · entry 2

Samath Jamie · CIK 0001330269 · VP & Principal Accounting Offi

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 159

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 4, 2019.

SEC source: 0001035267-19-000049 · edgardoc.xml · nonDerivative · entry 1

Samath Jamie · CIK 0001330269 · VP & Principal Accounting Offi

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 278

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 4, 2019.

SEC source: 0001035267-19-000050 · edgardoc.xml · derivative · entry 3

Friedman Michael A · CIK 0001298083 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 996 shares

Expires 2028-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 6, 2019.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the Non-Employee Directors' Stock Option Plan. Option shall vest 100% one year after the date of grant or at the next Shareholders Meeting, whichever should take place first, provided that vesting will cease on termination of the Directors service to the Company.

SEC source: 0001035267-19-000050 · edgardoc.xml · nonDerivative · entry 2

Friedman Michael A · CIK 0001298083 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,751

F1 · kind: This transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 6, 2019.

SEC source: 0001035267-19-000050 · edgardoc.xml · nonDerivative · entry 1

Friedman Michael A · CIK 0001298083 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,747

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 6, 2019.

SEC source: 0001035267-19-000051 · edgardoc.xml · derivative · entry 4

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,450

Underlying: Common Stock · 2,200 shares

Expires 2023-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 30, 2019.

F4 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Employee Stock Option Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-19-000051 · edgardoc.xml · nonDerivative · entry 3

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,101

F2 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 30, 2019.

F3 · price: The average selling price for the transactions was $493.263182 The shares sold at: $488.00 - $488.99 = 200 shares; $490.00 - $490.99 = 200 shares; $491.00 - $491.99 = 400 shares; $492.00 to $492.99 = 400 shares; $493.00 - $493.99 = 100 shares; $494.00 - $494.99 = 100 shares; $495.00 to $495.99 = 600 shares;$496.00 to $496.99 = 100 shares;$497.00 to $497.99 = 100 shares.

SEC source: 0001035267-19-000051 · edgardoc.xml · nonDerivative · entry 2

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,301

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 30, 2019.

SEC source: 0001035267-19-000040 · edgardoc.xml · derivative · entry 2

BARRATT CRAIG H · CIK 0001277620 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 391 shares

Expires 2022-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

F2 · derivative.exercise_date: Restricted Stock Units (RSUs) are granted pursuant to the 2010 Incentive Award Plan. The RSUs fully vest on the first anniversary of the date of grant.

SEC source: 0001035267-19-000040 · edgardoc.xml · nonDerivative · entry 1

BARRATT CRAIG H · CIK 0001277620 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Trust

Disclosed balance after: 7,327

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

SEC source: 0001035267-19-000041 · edgardoc.xml · derivative · entry 2

Friedman Michael A · CIK 0001298083 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 332 shares

Expires 2022-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

F2 · derivative.exercise_date: 100% of the grant will vest on the anniversary date of the grant or the next Annual Shareholders Meeting, whichever takes place first, provided however that vesting will cease on termination of the Director's service to the company.

SEC source: 0001035267-19-000041 · edgardoc.xml · nonDerivative · entry 1

Friedman Michael A · CIK 0001298083 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,751

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

SEC source: 0001035267-19-000042 · edgardoc.xml · derivative · entry 2

Johnson Amal M · CIK 0001388397 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 332 shares

Expires 2022-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

F2 · derivative.exercise_date: Restricted Stock Units (RSUs) are granted pursuant to the 2010 Incentive Award Plan. The RSUs fully vest on the first anniversary of the date of grant.

SEC source: 0001035267-19-000042 · edgardoc.xml · nonDerivative · entry 1

Johnson Amal M · CIK 0001388397 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,206

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

SEC source: 0001035267-19-000043 · edgardoc.xml · derivative · entry 2

Leonard Keith R · CIK 0001416180 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 332 shares

Expires 2022-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

F2 · derivative.exercise_date: Restricted Stock Units (RSUs) are granted pursuant to the 2010 Incentive Award Plan. The RSUs fully vest on the first anniversary of the date of grant.

SEC source: 0001035267-19-000043 · edgardoc.xml · nonDerivative · entry 1

Leonard Keith R · CIK 0001416180 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 845

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

SEC source: 0001035267-19-000044 · edgardoc.xml · derivative · entry 2

LEVY ALAN J · CIK 0001280627 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 332 shares

Expires 2022-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

F2 · derivative.exercise_date: Restricted Stock Units (RSUs) are granted pursuant to the 2010 Incentive Award Plan. The RSUs fully vest on the first anniversary of the date of grant.

SEC source: 0001035267-19-000044 · edgardoc.xml · nonDerivative · entry 1

LEVY ALAN J · CIK 0001280627 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,577

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

SEC source: 0001035267-19-000045 · edgardoc.xml · derivative · entry 2

RUBASH MARK J · CIK 0001209186 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 332 shares

Expires 2022-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

F2 · derivative.exercise_date: Restricted Stock Units (RSUs) are granted pursuant to the 2010 Incentive Award Plan. The RSUs fully vest on the first anniversary of the date of grant.

SEC source: 0001035267-19-000045 · edgardoc.xml · nonDerivative · entry 1

RUBASH MARK J · CIK 0001209186 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,298

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

SEC source: 0001035267-19-000046 · edgardoc.xml · derivative · entry 3

SMITH LONNIE M · CIK 0001238937 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 450 shares

Expires 2022-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

F2 · derivative.exercise_date: Restricted Stock Units (RSUs) are granted pursuant to the 2010 Incentive Award Plan. The RSUs fully vest on the first anniversary of the date of grant.

SEC source: 0001035267-19-000046 · edgardoc.xml · nonDerivative · entry 1

SMITH LONNIE M · CIK 0001238937 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 359,696

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

SEC source: 0001035267-19-000047 · edgardoc.xml · derivative · entry 2

NACHTSHEIM JAMI K · CIK 0001223017 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 332 shares

Expires 2022-04-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

F2 · derivative.exercise_date: Restricted Stock Units (RSUs) are granted pursuant to the 2010 Incentive Award Plan. The RSUs fully vest on the first anniversary of the date of grant.

SEC source: 0001035267-19-000047 · edgardoc.xml · nonDerivative · entry 1

NACHTSHEIM JAMI K · CIK 0001223017 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 845

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The RSUs fully vest on the earlier of the first anniversary of the date of grant or the date of the next annual stockholders meeting.

SEC source: 0001035267-19-000051 · edgardoc.xml · nonDerivative · entry 1

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,101

F1 · kind: The filer gifted shares to the California-Nevada United Methodist Foundation.

SEC source: 0001035267-19-000029 · edgardoc.xml · derivative · entry 15

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,498

Underlying: Common Stock · 563 shares

Expires 2027-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Employee Stock Option Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-19-000029 · edgardoc.xml · derivative · entry 14

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,219

Underlying: Common Stock · 305 shares

Expires 2026-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Employee Stock Option Plan. Option shall vest 7/48 one month after the date of grant and 1/48th each month thereafter.

SEC source: 0001035267-19-000029 · edgardoc.xml · derivative · entry 13

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,219

Underlying: Common Stock · 305 shares

Expires 2026-02-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Employee Stock Option Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-19-000029 · edgardoc.xml · derivative · entry 12

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 458 shares

Expires 2025-08-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Employee Stock Option Plan. Option shall vest 7/48 one month after the date of grant and 1/48th each month thereafter.

SEC source: 0001035267-19-000029 · edgardoc.xml · derivative · entry 11

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 459 shares

Expires 2025-02-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Employee Stock Option Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-19-000029 · edgardoc.xml · nonDerivative · entry 10

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,371

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

SEC source: 0001035267-19-000029 · edgardoc.xml · nonDerivative · entry 9

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,830

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

SEC source: 0001035267-19-000029 · edgardoc.xml · nonDerivative · entry 8

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,371

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

SEC source: 0001035267-19-000029 · edgardoc.xml · nonDerivative · entry 7

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,829

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

SEC source: 0001035267-19-000029 · edgardoc.xml · nonDerivative · entry 6

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,371

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

SEC source: 0001035267-19-000029 · edgardoc.xml · nonDerivative · entry 5

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,676

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

SEC source: 0001035267-19-000029 · edgardoc.xml · nonDerivative · entry 4

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,371

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

SEC source: 0001035267-19-000029 · edgardoc.xml · nonDerivative · entry 3

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,676

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

SEC source: 0001035267-19-000029 · edgardoc.xml · nonDerivative · entry 2

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,371

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

SEC source: 0001035267-19-000029 · edgardoc.xml · nonDerivative · entry 1

Brogna Salvatore · CIK 0001519413 · EVP & Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,934

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on September 10, 2019.

SEC source: 0001035267-19-000028 · edgardoc.xml · nonDerivative · entry 3

SMITH LONNIE M · CIK 0001238937 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · by Trust

Disclosed balance after: 286,502

F2 · kind: The shares were sold from the Lonnie M. Smith 2013 Charitable Remainder Unitrust, from which Mr. Smith is not an Investment Advisor.

SEC source: 0001035267-19-000024 · edgardoc.xml · derivative · entry 26

Samath Jamie · CIK 0001330269 · VP & Principal Accounting Offi

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,294

Underlying: Common Stock · 431 shares

Expires 2028-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Employee Stock Option Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-19-000024 · edgardoc.xml · derivative · entry 25

Samath Jamie · CIK 0001330269 · VP & Principal Accounting Offi

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,424

Underlying: Common Stock · 238 shares

Expires 2027-08-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Employee Stock Option Plan. Option shall vest 7/48 one month after the date of grant and 1/48th each month thereafter.

SEC source: 0001035267-19-000024 · edgardoc.xml · nonDerivative · entry 19

Samath Jamie · CIK 0001330269 · VP & Principal Accounting Offi

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 4, 2019.

SEC source: 0001035267-19-000024 · edgardoc.xml · nonDerivative · entry 18

Samath Jamie · CIK 0001330269 · VP & Principal Accounting Offi

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 317

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-19-000024 · edgardoc.xml · nonDerivative · entry 17

Samath Jamie · CIK 0001330269 · VP & Principal Accounting Offi

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on November 4, 2019.

SEC source: 0001035267-19-000024 · edgardoc.xml · nonDerivative · entry 16

Samath Jamie · CIK 0001330269 · VP & Principal Accounting Offi

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 510

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-19-000017 · edgardoc.xml · nonDerivative · entry 5

Myriam Curet · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,062

F3 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on April 30, 2019.