ISRG

SEC source: 0001035267-24-000169 · edgardoc.xml · nonDerivative · entry 12

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,507

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000169 · edgardoc.xml · nonDerivative · entry 11

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,627

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000169 · edgardoc.xml · nonDerivative · entry 10

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,507

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000169 · edgardoc.xml · nonDerivative · entry 9

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,627

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000169 · edgardoc.xml · nonDerivative · entry 8

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,507

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000169 · edgardoc.xml · nonDerivative · entry 7

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,597

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000169 · edgardoc.xml · nonDerivative · entry 6

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,507

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000169 · edgardoc.xml · nonDerivative · entry 5

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,903

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000169 · edgardoc.xml · nonDerivative · entry 4

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,507

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000169 · edgardoc.xml · nonDerivative · entry 3

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,903

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000169 · edgardoc.xml · nonDerivative · entry 2

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,507

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000169 · edgardoc.xml · nonDerivative · entry 1

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,695

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000143 · edgardoc.xml · derivative · entry 2

LEVY ALAN J · CIK 0001280627 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 569 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000143 · edgardoc.xml · nonDerivative · entry 1

LEVY ALAN J · CIK 0001280627 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,888

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-24-000145 · edgardoc.xml · derivative · entry 3

Reed Monica P · CIK 0001854171 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 739

Underlying: Common Stock · 739 shares

Expires not disclosed

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000145 · edgardoc.xml · derivative · entry 2

Reed Monica P · CIK 0001854171 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 569 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000145 · edgardoc.xml · nonDerivative · entry 1

Reed Monica P · CIK 0001854171 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,606

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-24-000147 · edgardoc.xml · derivative · entry 3

BARRATT CRAIG H · CIK 0001277620 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,043

Underlying: Common Stock · 1,043 shares

Expires not disclosed

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000147 · edgardoc.xml · derivative · entry 2

BARRATT CRAIG H · CIK 0001277620 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 804 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000147 · edgardoc.xml · nonDerivative · entry 1

BARRATT CRAIG H · CIK 0001277620 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · by Trust

Disclosed balance after: 26,155

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-24-000149 · edgardoc.xml · derivative · entry 3

Beery Joseph C · CIK 0001249557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 739

Underlying: Common Stock · 739 shares

Expires not disclosed

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000149 · edgardoc.xml · derivative · entry 2

Beery Joseph C · CIK 0001249557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 569 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000149 · edgardoc.xml · nonDerivative · entry 1

Beery Joseph C · CIK 0001249557 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,371

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-24-000151 · edgardoc.xml · derivative · entry 1

CHEW LEWIS · CIK 0001224994 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 739

Underlying: Common Stock · 739 shares

Expires not disclosed

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000153 · edgardoc.xml · derivative · entry 2

Leonard Keith R · CIK 0001416180 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 569 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000153 · edgardoc.xml · nonDerivative · entry 1

Leonard Keith R · CIK 0001416180 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,606

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-24-000155 · edgardoc.xml · derivative · entry 3

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 739

Underlying: Common Stock · 739 shares

Expires not disclosed

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000155 · edgardoc.xml · derivative · entry 2

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 569 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000155 · edgardoc.xml · nonDerivative · entry 1

Ladd Amy L · CIK 0001781750 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,271

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-24-000157 · edgardoc.xml · derivative · entry 3

Johnson Amal M · CIK 0001388397 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 739

Underlying: Common Stock · 739 shares

Expires not disclosed

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000157 · edgardoc.xml · derivative · entry 2

Johnson Amal M · CIK 0001388397 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 569 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000157 · edgardoc.xml · nonDerivative · entry 1

Johnson Amal M · CIK 0001388397 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,275

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-24-000159 · edgardoc.xml · derivative · entry 2

KANIA DON R · CIK 0001254028 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 569 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000159 · edgardoc.xml · nonDerivative · entry 1

KANIA DON R · CIK 0001254028 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,838

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-24-000161 · edgardoc.xml · derivative · entry 1

Leonard Keith R · CIK 0001416180 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 739

Underlying: Common Stock · 739 shares

Expires not disclosed

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000163 · edgardoc.xml · derivative · entry 3

Kolli Sreelakshmi · CIK 0001689392 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 739

Underlying: Common Stock · 739 shares

Expires not disclosed

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000163 · edgardoc.xml · derivative · entry 2

Kolli Sreelakshmi · CIK 0001689392 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 240 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000163 · edgardoc.xml · nonDerivative · entry 1

Kolli Sreelakshmi · CIK 0001689392 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 240

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-24-000165 · edgardoc.xml · derivative · entry 3

NACHTSHEIM JAMI K · CIK 0001223017 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 739

Underlying: Common Stock · 739 shares

Expires not disclosed

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000165 · edgardoc.xml · derivative · entry 2

NACHTSHEIM JAMI K · CIK 0001223017 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 569 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000165 · edgardoc.xml · nonDerivative · entry 1

NACHTSHEIM JAMI K · CIK 0001223017 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,632

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-24-000167 · edgardoc.xml · derivative · entry 3

RUBASH MARK J · CIK 0001209186 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 739

Underlying: Common Stock · 739 shares

Expires not disclosed

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000167 · edgardoc.xml · derivative · entry 2

RUBASH MARK J · CIK 0001209186 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 569 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

F1 · derivative.expiration_date: 100% of the RSUs shall vest on the earlier of the one year anniversary of the date of grant or the next Annual Meeting of Stockholders, subject to the Reporting Person's continued service.

SEC source: 0001035267-24-000167 · edgardoc.xml · nonDerivative · entry 1

RUBASH MARK J · CIK 0001209186 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,051

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001035267-24-000139 · edgardoc.xml · derivative · entry 6

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 2,500 shares

Expires 2029-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000139 · edgardoc.xml · derivative · entry 5

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,075

Underlying: Common Stock · 2,818 shares

Expires 2030-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000139 · edgardoc.xml · nonDerivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $368.86 to $371.98 as follows: 700 shares sold at $368.86 to $369.85; 3,321 shares sold at $369.99 to $370.94; and 1,297 shares sold at $371.03 to $371.98. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000139 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,798

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

SEC source: 0001035267-24-000139 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $368.86 to $371.98 as follows: 700 shares sold at $368.86 to $369.85; 3,321 shares sold at $369.99 to $370.94; and 1,297 shares sold at $371.03 to $371.98. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000139 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,116

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 12, 2024.