ISRG

SEC source: 0001035267-24-000277 · edgardoc.xml · nonDerivative · entry 4

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,757

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

SEC source: 0001035267-24-000277 · edgardoc.xml · nonDerivative · entry 3

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,892

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

SEC source: 0001035267-24-000277 · edgardoc.xml · nonDerivative · entry 2

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,757

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

SEC source: 0001035267-24-000277 · edgardoc.xml · nonDerivative · entry 1

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,892

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

SEC source: 0001035267-24-000273 · edgardoc.xml · derivative · entry 6

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,410

Underlying: Common Stock · 94 shares

Expires 2029-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000273 · edgardoc.xml · derivative · entry 5

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,410

Underlying: Common Stock · 94 shares

Expires 2029-08-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-24-000273 · edgardoc.xml · nonDerivative · entry 4

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,757

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

SEC source: 0001035267-24-000273 · edgardoc.xml · nonDerivative · entry 3

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,851

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

SEC source: 0001035267-24-000273 · edgardoc.xml · nonDerivative · entry 2

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,757

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

SEC source: 0001035267-24-000273 · edgardoc.xml · nonDerivative · entry 1

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,851

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

SEC source: 0001035267-24-000275 · edgardoc.xml · derivative · entry 6

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,820

Underlying: Common Stock · 188 shares

Expires 2029-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000275 · edgardoc.xml · derivative · entry 5

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,820

Underlying: Common Stock · 188 shares

Expires 2029-08-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-24-000275 · edgardoc.xml · nonDerivative · entry 4

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,506

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000275 · edgardoc.xml · nonDerivative · entry 3

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,694

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000275 · edgardoc.xml · nonDerivative · entry 2

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,506

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000275 · edgardoc.xml · nonDerivative · entry 1

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,694

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000269 · edgardoc.xml · derivative · entry 6

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 597

Underlying: Common Stock · 198 shares

Expires 2031-08-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-24-000269 · edgardoc.xml · derivative · entry 5

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 597

Underlying: Common Stock · 198 shares

Expires 2031-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000269 · edgardoc.xml · nonDerivative · entry 4

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,506

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000269 · edgardoc.xml · nonDerivative · entry 3

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,704

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000269 · edgardoc.xml · nonDerivative · entry 2

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,506

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000269 · edgardoc.xml · nonDerivative · entry 1

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,704

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000271 · edgardoc.xml · derivative · entry 6

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 159

Underlying: Common Stock · 54 shares

Expires 2031-08-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-24-000271 · edgardoc.xml · derivative · entry 5

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 159

Underlying: Common Stock · 54 shares

Expires 2031-02-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

F2 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000271 · edgardoc.xml · nonDerivative · entry 4

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,757

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

SEC source: 0001035267-24-000271 · edgardoc.xml · nonDerivative · entry 3

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,811

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

SEC source: 0001035267-24-000271 · edgardoc.xml · nonDerivative · entry 2

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,757

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

SEC source: 0001035267-24-000271 · edgardoc.xml · nonDerivative · entry 1

Samath Jamie · CIK 0001330269 · CFO and Head of Business Techn

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,811

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

SEC source: 0001035267-24-000267 · edgardoc.xml · nonDerivative · entry 1

Rosa David J. · CIK 0001519593 · President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 211,080

F1 · kind: The filer gifted shares to The Rosa Donor Advised Fund.

SEC source: 0001035267-24-000265 · edgardoc.xml · derivative · entry 12

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,829

Underlying: Common Stock · 2,199 shares

Expires 2030-02-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

F5 · derivative.exercise_date: 12.5% of the shares subject to the option vest on the six-month anniversary measured from February 10, 2023, and 1/48th of the total number of shares vest in forty-two (42) successive and equal monthly installments thereafter, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001035267-24-000265 · edgardoc.xml · derivative · entry 11

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,005

Underlying: Common Stock · 4,010 shares

Expires 2029-08-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

F4 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. Option shall vest 7/48 one month after the date of grant and 1/48 each month thereafter.

SEC source: 0001035267-24-000265 · edgardoc.xml · derivative · entry 10

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,000 shares

Expires 2029-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000265 · edgardoc.xml · derivative · entry 9

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,257 shares

Expires 2030-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

F3 · derivative.exercise_date: Non-statutory stock option granted pursuant to the 2010 Incentive Award Plan. The option vests 1/8th six months after the date of grant and 1/48th monthly thereafter.

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 8

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $533.10 to $538.66 as follows: 4,510 shares sold at $533.10 to $534.07; 907 shares sold at $534.11 to $534.68; 200 shares sold at $535.34 to $536.28; 4,400 shares sold at $536.46 to $537.36; 3,437 shares sold at $537.49 to $538.36; and 12 shares sold at $538.66. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 7

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,308

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 6

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $533.10 to $538.66 as follows: 4,510 shares sold at $533.10 to $534.07; 907 shares sold at $534.11 to $534.68; 200 shares sold at $535.34 to $536.28; 4,400 shares sold at $536.46 to $537.36; 3,437 shares sold at $537.49 to $538.36; and 12 shares sold at $538.66. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 5

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,497

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 4

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $533.10 to $538.66 as follows: 4,510 shares sold at $533.10 to $534.07; 907 shares sold at $534.11 to $534.68; 200 shares sold at $535.34 to $536.28; 4,400 shares sold at $536.46 to $537.36; 3,437 shares sold at $537.49 to $538.36; and 12 shares sold at $538.66. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 3

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,298

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 2

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 298

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

F2 · price: The price reported in Column 4 is a weighted average sale price. These shares were sold in multiple transactions at prices ranging from $533.10 to $538.66 as follows: 4,510 shares sold at $533.10 to $534.07; 907 shares sold at $534.11 to $534.68; 200 shares sold at $535.34 to $536.28; 4,400 shares sold at $536.46 to $537.36; 3,437 shares sold at $537.49 to $538.36; and 12 shares sold at $538.66. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001035267-24-000265 · edgardoc.xml · nonDerivative · entry 1

Curet Myriam · CIK 0001632901 · EVP & Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,555

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on August 13, 2025.

SEC source: 0001035267-24-000261 · edgardoc.xml · derivative · entry 6

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,232

Underlying: Common Stock · 120 shares

Expires 2030-08-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

F3 · derivative.exercise_date: 7/48th of the shares subject to the option vest on the one-month anniversary measured from August 10, 2023, and 1/48th of the total number of shares vest in forty-one (41) successive and equal monthly installments thereafter, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001035267-24-000261 · edgardoc.xml · derivative · entry 5

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,233

Underlying: Common Stock · 119 shares

Expires 2030-02-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

F2 · derivative.exercise_date: 12.5% of the shares subject to the option vest on the six-month anniversary measured from February 10, 2023, and 1/48th of the total number of shares vest in forty-two (42) successive and equal monthly installments thereafter, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001035267-24-000261 · edgardoc.xml · nonDerivative · entry 4

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,506

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000261 · edgardoc.xml · nonDerivative · entry 3

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,625

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000261 · edgardoc.xml · nonDerivative · entry 2

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,506

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001035267-24-000261 · edgardoc.xml · nonDerivative · entry 1

DeSantis Robert · CIK 0001808942 · EVP & Chief Strategy & Corp Op

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,626

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These shares were sold in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on December 9, 2024.

SEC source: 0001610717-24-000519 · form4.xml · derivative · entry 30

Samath Jamie · CIK 0001330269 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,636

Underlying: Common Stock · 134 shares

Expires 2030-08-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

F6 · derivative.exercise_date: 7/48th of the shares subject to the option vest on the one-month anniversary measured from August 10, 2023, and 1/48th of the total number of shares vest in forty-one (41) successive and equal monthly installments thereafter, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001610717-24-000519 · form4.xml · derivative · entry 29

Samath Jamie · CIK 0001330269 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,636

Underlying: Common Stock · 135 shares

Expires 2030-02-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.

F5 · derivative.exercise_date: 12.5% of the shares subject to the option vest on the six-month anniversary measured from February 10, 2023, and 1/48th of the total number of shares vest in forty-two (42) successive and equal monthly installments thereafter, subject to Reporting Person's continuous service to the Issuer through each such vesting date.

SEC source: 0001610717-24-000519 · form4.xml · nonDerivative · entry 16

Samath Jamie · CIK 0001330269 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,757

F1 · kind: The transaction took place in accordance with a Trading Plan that complies with SEC Rule 10b5-1 and expires on May 6, 2025.